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ESPACE SIGNED

Human Cell Atlas of the Pancreas

Total Cost €

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EC-Contrib. €

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Partnership

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Project "ESPACE" data sheet

The following table provides information about the project.

Coordinator
CHARITE - UNIVERSITAETSMEDIZIN BERLIN 

Organization address
address: Chariteplatz 1
city: BERLIN
postcode: 10117
website: www.charite.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 4˙962˙494 €
 EC max contribution 4˙962˙494 € (100%)
 Programme 1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
 Code Call H2020-SC1-2019-Single-Stage-RTD
 Funding Scheme RIA
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2021-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CHARITE - UNIVERSITAETSMEDIZIN BERLIN DE (BERLIN) coordinator 1˙089˙173.00
2    FUNDACIO CENTRE DE REGULACIO GENOMICA ES (BARCELONA) participant 1˙162˙436.00
3    KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW NL (AMSTERDAM) participant 697˙000.00
4    KUNGLIGA TEKNISKA HOEGSKOLAN SE (STOCKHOLM) participant 556˙316.00
5    TECHNISCHE UNIVERSITAET MUENCHEN DE (MUENCHEN) participant 383˙568.00
6    ACADEMISCH ZIEKENHUIS LEIDEN NL (LEIDEN) participant 358˙250.00
7    OSPEDALE SAN RAFFAELE SRL IT (MILANO) participant 295˙750.00
8    RESEARCH FUND OF THE HADASSAH MEDICAL ORGANIZATION (R.A) IL (JERUSALEM) participant 190˙000.00
9    LINQ MANAGEMENT GMBH DE (BERLIN) participant 186˙250.00
10    STEINBEIS TRANSFER GMBH DE (STUTTGART) participant 43˙750.00

Map

 Project objective

The human pancreas is a physiologically unique organ involved in the secretion of several hormones, such as insulin, thus regulating blood sugar levels, as well as the secretion of enzymes for the digestive system. Several human diseases are associated with the pancreas: Pancreatic andenocarcinoma is one of the most aggressive cancers in humans and pancreatitis is a common potentially life-threatening disorder related to adverse lifestyle conditions. A very common chronical disease affecting the pancreas is Diabetes mellitus, a metabolic disorder that is characterised by high blood sugar levels due to the lack of insulin produced in the pancreas. Despite its high physiological importance, the high autolytic activity makes the pancreas a challenging tissue to study. The Expression and Spatial analysis Pancreas Atlas Consortium Europe, ESPACE, has formed as merger of three prior Human Cell Atlas (HCA) early pilot studies of the pancreas funded by the Chan Zuckerberg initiative. Based on the there developed methods and standards for sample procurement, single cell profiling, spatial proteomics, and computational pipelines we will here build a first version of the Human Cell Atlas of the Pancreas. We will integrate molecular profiles, including transcriptome and epigenomics data from more than 1 million single cells jointly together with tissue proteomics allowing to address fundamental questions of cell state and phenotype in healthy adults and during foetal development. Thus, we will provide a first version of an open single cell repository of the pancreas built upon the Data Coordination Platform of the HCA. Exploring the benefit of the HCA of the pancreas for tackling pancreatic diseases, ESPACE will reach out into types 2 diabetes. Besides creating a unique and first of its kind comprehensive atlas of the human pancreas the methods and standards developed by ESPACE will be of high relevance for HCA projects in other organs.

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The information about "ESPACE" are provided by the European Opendata Portal: CORDIS opendata.

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