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AMPLITUDE SIGNED

Advanced Multimodal Photonics Laser Imaging Tool for Urothelial Diagnosis in Endoscopy

Total Cost €

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EC-Contrib. €

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Partnership

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 AMPLITUDE project word cloud

Explore the words cloud of the AMPLITUDE project. It provides you a very rough idea of what is the project "AMPLITUDE" about.

efficient    absence    limitations    spectral    endoscopic    pioneering    performance    cancer    combining    outstanding    sources    microscopy    tandem    output    possibilities    nir    progressing    tumours    diagnosis    lasers    capability    molecular    reflectance    pathohistological    raman    autofluorescence    guide    tightly    depths    urgent    confocal    photon    window    additional    relatively    there    harmonic    exhaustive    enhanced    suitable    1870    lesion    overcoming    biological    medical    instrument    nm    bio    region    device    biophotonics    questions    free    proposes    characterisation    appealing    spectroscopy    spectroscopic    twice    1650    1700    optical    generation    cellular    metabolic    tissue    examined    modal    adoption    staging    850    unexplored    biopsy    compact    fibre    spontaneous    grading    ultrafast    of    vivo    form    functioning    linear    wavelength    techniques    meet    technologies    multiple    appropriate    achievable    label    wavelengths    resolution    invasiveness    morphological    imaging    deeper    motivated    breakthrough    laser    amplitude    bladder    levels   

Project "AMPLITUDE" data sheet

The following table provides information about the project.

Coordinator
TAMPEREEN KORKEAKOULUSAATIO SR 

Organization address
address: KALEVANTIE 4
city: TAMPERE
postcode: 33100
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Finland [FI]
 Total cost 4˙656˙750 €
 EC max contribution 4˙486˙750 € (96%)
 Programme 1. H2020-EU.2.1.1. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Information and Communication Technologies (ICT))
 Code Call H2020-ICT-2019-2
 Funding Scheme RIA
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TAMPEREEN KORKEAKOULUSAATIO SR FI (TAMPERE) coordinator 710˙000.00
2    ASTON UNIVERSITY UK (BIRMINGHAM) participant 620˙657.00
3    FEMTONICS KUTATO ES FEJLESZTO KORLATOLT FELELOSSEGU TARSASAG HU (BUDAPEST) participant 593˙740.00
4    CONSIGLIO NAZIONALE DELLE RICERCHE IT (ROMA) participant 512˙000.00
5    LEONI FIBER OPTICS GMBH DE (NEUHAUS SCHIERSCHNITZ) participant 451˙765.00
6    FUNDACIO INSTITUT DE CIENCIES FOTONIQUES ES (Castelldefels) participant 396˙250.00
7    AMPLICONYX OY FI (TAMPERE) participant 375˙687.00
8    UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA IT (MILANO) participant 330˙400.00
9    UNIVERSITA DEGLI STUDI DI FIRENZE IT (Florence) participant 262˙500.00
10    MODUS RESEARCH AND INNOVATION LIMITED UK (EDINBURGH) participant 233˙750.00
11    HC PHOTONICS CORPORATION LIMITED TW (HSINCHU) participant 0.00

Map

 Project objective

There is an absence of lasers with the necessary wavelengths and characteristics to access the possibilities for deeper high-resolution biological tissue imaging in the third bio-window between 1650 nm and 1870 nm. Motivated by recent breakthrough results in multi-photon imaging at twice the depths currently achievable, we will meet the urgent need for new sources to address the outstanding research questions in this spectral region. Results will guide and enable instrument development in this appealing and relatively unexplored biophotonics imaging wavelength range.

The AMPLITUDE consortium proposes a new concept of label-free, multi-modal microscopy and endoscopic imaging operating in this new wavelength region with multiple imaging and spectroscopic technologies, including NIR confocal reflectance microscopy, multi-photon microscopy and spontaneous Raman spectroscopy.

By progressing ultrafast fibre laser developments at 1700 nm, we will deliver new imaging capabilities in an appropriate form factor and at cost suitable for widespread adoption. This will be further enhanced by providing additional output at 850 nm using second harmonic generation from one integrated laser device.

This will enable a pioneering new compact and efficient multi-modal capability combining confocal and non-linear imaging techniques, overcoming performance limitations in medical and biological imaging applications, including improved pathohistological staging of tumours and in-vivo endoscopic assessment of depth of lesion invasiveness. Deeper multi-photon microscopy with autofluorescence imaging of cellular metabolic conditions, whose aspects are tightly related to cellular functioning and to cancer, implemented in tandem with Raman spectroscopy will provide exhaustive characterisation of the examined tissue at morphological, metabolic and molecular levels, allowing in-vivo optical biopsy for bladder cancer diagnosis, grading and staging.

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The information about "AMPLITUDE" are provided by the European Opendata Portal: CORDIS opendata.

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