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AMPLITUDE SIGNED

Advanced Multimodal Photonics Laser Imaging Tool for Urothelial Diagnosis in Endoscopy

Total Cost €

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EC-Contrib. €

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Partnership

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 AMPLITUDE project word cloud

Explore the words cloud of the AMPLITUDE project. It provides you a very rough idea of what is the project "AMPLITUDE" about.

capability    device    biological    tissue    biophotonics    biopsy    output    suitable    harmonic    breakthrough    possibilities    motivated    lesion    wavelengths    sources    850    window    1700    enhanced    appealing    nir    ultrafast    bio    modal    form    spectroscopic    limitations    medical    cellular    lasers    adoption    nm    functioning    overcoming    examined    multiple    tightly    reflectance    molecular    relatively    cancer    tandem    deeper    vivo    autofluorescence    technologies    photon    achievable    unexplored    absence    compact    wavelength    spectroscopy    1650    characterisation    generation    morphological    levels    diagnosis    pathohistological    techniques    region    endoscopic    spectral    amplitude    questions    spontaneous    performance    grading    twice    invasiveness    efficient    staging    depths    appropriate    of    exhaustive    outstanding    label    confocal    guide    microscopy    free    optical    imaging    laser    fibre    1870    instrument    metabolic    bladder    there    tumours    resolution    raman    urgent    meet    proposes    pioneering    combining    additional    linear    progressing   

Project "AMPLITUDE" data sheet

The following table provides information about the project.

Coordinator
TAMPEREEN KORKEAKOULUSAATIO SR 

Organization address
address: KALEVANTIE 4
city: TAMPERE
postcode: 33100
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Finland [FI]
 Total cost 4˙656˙750 €
 EC max contribution 4˙486˙750 € (96%)
 Programme 1. H2020-EU.2.1.1. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Information and Communication Technologies (ICT))
 Code Call H2020-ICT-2019-2
 Funding Scheme RIA
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TAMPEREEN KORKEAKOULUSAATIO SR FI (TAMPERE) coordinator 710˙000.00
2    ASTON UNIVERSITY UK (BIRMINGHAM) participant 620˙657.00
3    FEMTONICS KUTATO ES FEJLESZTO KORLATOLT FELELOSSEGU TARSASAG HU (BUDAPEST) participant 593˙740.00
4    CONSIGLIO NAZIONALE DELLE RICERCHE IT (ROMA) participant 512˙000.00
5    LEONI FIBER OPTICS GMBH DE (NEUHAUS SCHIERSCHNITZ) participant 451˙765.00
6    FUNDACIO INSTITUT DE CIENCIES FOTONIQUES ES (Castelldefels) participant 396˙250.00
7    AMPLICONYX OY FI (TAMPERE) participant 375˙687.00
8    UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA IT (MILANO) participant 330˙400.00
9    UNIVERSITA DEGLI STUDI DI FIRENZE IT (Florence) participant 262˙500.00
10    MODUS RESEARCH AND INNOVATION LIMITED UK (EDINBURGH) participant 233˙750.00
11    HC PHOTONICS CORPORATION LIMITED TW (HSINCHU) participant 0.00

Map

 Project objective

There is an absence of lasers with the necessary wavelengths and characteristics to access the possibilities for deeper high-resolution biological tissue imaging in the third bio-window between 1650 nm and 1870 nm. Motivated by recent breakthrough results in multi-photon imaging at twice the depths currently achievable, we will meet the urgent need for new sources to address the outstanding research questions in this spectral region. Results will guide and enable instrument development in this appealing and relatively unexplored biophotonics imaging wavelength range.

The AMPLITUDE consortium proposes a new concept of label-free, multi-modal microscopy and endoscopic imaging operating in this new wavelength region with multiple imaging and spectroscopic technologies, including NIR confocal reflectance microscopy, multi-photon microscopy and spontaneous Raman spectroscopy.

By progressing ultrafast fibre laser developments at 1700 nm, we will deliver new imaging capabilities in an appropriate form factor and at cost suitable for widespread adoption. This will be further enhanced by providing additional output at 850 nm using second harmonic generation from one integrated laser device.

This will enable a pioneering new compact and efficient multi-modal capability combining confocal and non-linear imaging techniques, overcoming performance limitations in medical and biological imaging applications, including improved pathohistological staging of tumours and in-vivo endoscopic assessment of depth of lesion invasiveness. Deeper multi-photon microscopy with autofluorescence imaging of cellular metabolic conditions, whose aspects are tightly related to cellular functioning and to cancer, implemented in tandem with Raman spectroscopy will provide exhaustive characterisation of the examined tissue at morphological, metabolic and molecular levels, allowing in-vivo optical biopsy for bladder cancer diagnosis, grading and staging.

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The information about "AMPLITUDE" are provided by the European Opendata Portal: CORDIS opendata.

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