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AMPLITUDE SIGNED

Advanced Multimodal Photonics Laser Imaging Tool for Urothelial Diagnosis in Endoscopy

Total Cost €

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EC-Contrib. €

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Partnership

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 AMPLITUDE project word cloud

Explore the words cloud of the AMPLITUDE project. It provides you a very rough idea of what is the project "AMPLITUDE" about.

amplitude    autofluorescence    absence    confocal    techniques    generation    progressing    spectroscopic    diagnosis    depths    tandem    combining    1650    appealing    output    examined    ultrafast    compact    cancer    efficient    resolution    sources    there    molecular    free    technologies    window    limitations    overcoming    imaging    microscopy    pathohistological    fibre    morphological    grading    raman    tumours    adoption    characterisation    lasers    tightly    breakthrough    meet    motivated    invasiveness    pioneering    photon    twice    spontaneous    outstanding    suitable    biophotonics    multiple    spectral    cellular    guide    label    bladder    endoscopic    proposes    form    medical    lesion    biopsy    device    laser    additional    deeper    vivo    1870    functioning    achievable    harmonic    modal    region    wavelengths    nm    levels    optical    spectroscopy    capability    metabolic    nir    performance    questions    instrument    enhanced    unexplored    exhaustive    linear    biological    reflectance    tissue    1700    relatively    of    possibilities    urgent    appropriate    bio    wavelength    staging    850   

Project "AMPLITUDE" data sheet

The following table provides information about the project.

Coordinator
TAMPEREEN KORKEAKOULUSAATIO SR 

Organization address
address: KALEVANTIE 4
city: TAMPERE
postcode: 33100
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Finland [FI]
 Total cost 4˙656˙750 €
 EC max contribution 4˙486˙750 € (96%)
 Programme 1. H2020-EU.2.1.1. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Information and Communication Technologies (ICT))
 Code Call H2020-ICT-2019-2
 Funding Scheme RIA
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TAMPEREEN KORKEAKOULUSAATIO SR FI (TAMPERE) coordinator 710˙000.00
2    ASTON UNIVERSITY UK (BIRMINGHAM) participant 620˙657.00
3    FEMTONICS KUTATO ES FEJLESZTO KORLATOLT FELELOSSEGU TARSASAG HU (BUDAPEST) participant 593˙740.00
4    CONSIGLIO NAZIONALE DELLE RICERCHE IT (ROMA) participant 512˙000.00
5    LEONI FIBER OPTICS GMBH DE (NEUHAUS SCHIERSCHNITZ) participant 451˙765.00
6    FUNDACIO INSTITUT DE CIENCIES FOTONIQUES ES (Castelldefels) participant 396˙250.00
7    AMPLICONYX OY FI (TAMPERE) participant 375˙687.00
8    UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA IT (MILANO) participant 330˙400.00
9    UNIVERSITA DEGLI STUDI DI FIRENZE IT (Florence) participant 262˙500.00
10    MODUS RESEARCH AND INNOVATION LIMITED UK (EDINBURGH) participant 233˙750.00
11    HC PHOTONICS CORPORATION LIMITED TW (HSINCHU) participant 0.00

Map

 Project objective

There is an absence of lasers with the necessary wavelengths and characteristics to access the possibilities for deeper high-resolution biological tissue imaging in the third bio-window between 1650 nm and 1870 nm. Motivated by recent breakthrough results in multi-photon imaging at twice the depths currently achievable, we will meet the urgent need for new sources to address the outstanding research questions in this spectral region. Results will guide and enable instrument development in this appealing and relatively unexplored biophotonics imaging wavelength range.

The AMPLITUDE consortium proposes a new concept of label-free, multi-modal microscopy and endoscopic imaging operating in this new wavelength region with multiple imaging and spectroscopic technologies, including NIR confocal reflectance microscopy, multi-photon microscopy and spontaneous Raman spectroscopy.

By progressing ultrafast fibre laser developments at 1700 nm, we will deliver new imaging capabilities in an appropriate form factor and at cost suitable for widespread adoption. This will be further enhanced by providing additional output at 850 nm using second harmonic generation from one integrated laser device.

This will enable a pioneering new compact and efficient multi-modal capability combining confocal and non-linear imaging techniques, overcoming performance limitations in medical and biological imaging applications, including improved pathohistological staging of tumours and in-vivo endoscopic assessment of depth of lesion invasiveness. Deeper multi-photon microscopy with autofluorescence imaging of cellular metabolic conditions, whose aspects are tightly related to cellular functioning and to cancer, implemented in tandem with Raman spectroscopy will provide exhaustive characterisation of the examined tissue at morphological, metabolic and molecular levels, allowing in-vivo optical biopsy for bladder cancer diagnosis, grading and staging.

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The information about "AMPLITUDE" are provided by the European Opendata Portal: CORDIS opendata.

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