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ImmUniverse SIGNED

Better control and treatment of immune-mediated diseases by exploring the universe of microenvironment imposed tissue signatures and their correlates in liquid biopsies

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 ImmUniverse project word cloud

Explore the words cloud of the ImmUniverse project. It provides you a very rough idea of what is the project "ImmUniverse" about.

burden    omics    profiling    signatures    tailor    understand    treatment    recirculating    heterogeneity    atopic    combine    tackle    combination    time    medical    ulcerative    predictive    datasets    observational    significantly    interactions    circulating    limitations    diagnostics    progression    tissue    corresponding    monitoring    worldwide    imid    disruptive    systematically    industrialized    biomarkers    microenvironment    detectable    reduce    diseases    respective    prerequisites    clinical    fill    biomarker    patient    biopsies    formed    improvement    methodology    hence    implementing    transdisciplinary    realization    disease    cohorts    severity    immune    biopsy    unmet    liquid    employing    enormous    diagnosis    immuniverse    medicine    colitis    prospective    invasive    dermatitis    mechanistic    course    mediated    monitor    signature    outcome    adequately    crosstalk    therapy    inform    cells    cross    technologies    imids    anticipated    regard    assays    countries    compare    precision    socioeconomic    gap    individual    validated    therapies   

Project "ImmUniverse" data sheet

The following table provides information about the project.

Coordinator
HUMANITAS UNIVERSITY 

Organization address
address: VIA RITA LEVI MONTALCINI SNC
city: PIEVE EMANUELE
postcode: 20090
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 31˙110˙000 €
 EC max contribution 15˙500˙000 € (50%)
 Programme 1. H2020-EU.3.1.7. (Innovative Medicines Initiative 2 (IMI2))
 Code Call H2020-JTI-IMI2-2018-15-two-stage
 Funding Scheme IMI2-RIA
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2024-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    HUMANITAS UNIVERSITY IT (PIEVE EMANUELE) coordinator 1˙970˙093.00
2    CHRISTIAN-ALBRECHTS-UNIVERSITAET ZU KIEL DE (KIEL) participant 2˙613˙900.00
3    AIT AUSTRIAN INSTITUTE OF TECHNOLOGY GMBH AT (WIEN) participant 2˙133˙236.00
4    STICHTING KATHOLIEKE UNIVERSITEIT NL (NIJMEGEN) participant 1˙248˙421.00
5    JOANNEUM RESEARCH FORSCHUNGSGESELLSCHAFT MBH AT (GRAZ) participant 834˙408.00
6    KATHOLIEKE UNIVERSITEIT LEUVEN BE (LEUVEN) participant 740˙000.00
7    UNIVERSITE DU LUXEMBOURG LU (ESCH-SUR-ALZETTE) participant 687˙000.00
8    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) participant 659˙793.00
9    VIB VZW BE (ZWIJNAARDE - GENT) participant 652˙500.00
10    EURICE EUROPEAN RESEARCH AND PROJECT OFFICE GMBH DE (ST INGBERT) participant 626˙062.00
11    ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM NL (AMSTERDAM) participant 564˙047.00
12    ISTITUTO SUPERIORE DI SANITA IT (ROMA) participant 504˙988.00
13    LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN DE (MUENCHEN) participant 492˙475.00
14    INFORMATION TECHNOLOGY FOR TRANSLATIONAL MEDICINE (ITTM) SA LU (Esch-sur-Alzette) participant 402˙501.00
15    SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI PERFEZIONAMENTO S ANNA IT (PISA) participant 362˙000.00
16    AARHUS UNIVERSITETSHOSPITAL DK (AARHUS) participant 355˙596.00
17    CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE NANCY FR (NANCY CEDEX) participant 340˙783.00
18    AARHUS UNIVERSITET DK (AARHUS C) participant 199˙847.00
19    EUROPEAN FEDERATION OF CROHN'S AND ULCERATIVE COLITIS ASSOCIATIONS BE (BRUXELLES) participant 50˙312.00
20    EUROPEAN FEDERATION OF ASTHMA &ALLERGY ASSOCIATIONS IDEELL FORENING BE (Brussels) participant 50˙250.00
21    FORUM EUROPEEN DES PATIENTS (FPE) LU (LUXEMBOURG) participant 11˙781.00
22    Eli Lilly and Company Limited UK (Basingstoke) participant 0.00
23    GLAXOSMITHKLINE RESEARCH AND DEVELOPMENT LTD. UK (BRENTFORD) participant 0.00
24    NOVARTIS PHARMA AG CH (BASEL) participant 0.00
25    PFIZER LIMITED UK (SANDWICH) participant 0.00
26    SANOFI-AVENTIS DEUTSCHLAND GMBH DE (FRANKFURT AM MAIN) participant 0.00

Map

 Project objective

Immune-mediated diseases (IMIDs) are an increasing medical burden in industrialized countries worldwide. IMIDs are characterized by an enormous heterogeneity with regard to disease outcome and response to targeted therapies, which currently cannot be adequately anticipated to tailor individual patient management. Hence, mechanistic understanding of this heterogeneity and biomarkers predictive for disease control and therapy response over time are important prerequisites of a future precision medicine in IMIDs. ImmUniverse has been formed as a European transdisciplinary consortium to tackle these unmet needs and to understand the role of the crosstalk between tissue microenvironment and immune cells in disease progression and response to therapy of two different IMIDs: ulcerative colitis and atopic dermatitis. Following this unique cross-disease approach ImmUniverse will fill the gap and the limitations of current studies, which do not systematically compare the complex interactions between recirculating immune cells and the respective tissue microenvironment. The consortium will combine analysis of tissue-derived signatures with “circulating signatures” detectable in liquid biopsies, employing state-of-the-art profiling technologies corresponding to multi-Omics datasets. The project will also bring diagnostics in IMID to a new level by implementing disruptive non-invasive liquid-biopsy methodology in combination with novel, validated circulating biomarker assays which are expected to improve diagnosis, inform early in the clinical course on disease severity and progression and enable treatment response monitoring. The identified signature will be validated to monitor state/progression and response to therapy in prospective observational cohorts. Realization of these objectives will result in improvement of patient management, lead to increased patient well-being and will significantly reduce the socioeconomic burden of these diseases.

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The information about "IMMUNIVERSE" are provided by the European Opendata Portal: CORDIS opendata.

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