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TAXi-ch SIGNED

Determination of transcription factor cooperativity driving expression from the inactive X chromosome

Total Cost €

0

EC-Contrib. €

0

Partnership

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 TAXi-ch project word cloud

Explore the words cloud of the TAXi-ch project. It provides you a very rough idea of what is the project "TAXi-ch" about.

bind    genes    functional    regulation    omics    researcher    environment    gene    programs    combinations    learning    small    tools    unknown    innovative    data    hallmarks    cooperativity    female    techniques    compensation    chromosomes    transferable    ch    editing    chromosome    inactive    regulating    tf    active    classification    models    tfs    leader    heterochromatin    ensures    binding    networks    hone    previously    genomics    inactivation    depletion    allele    biology    similarities    question    understand    effect    transcriptional    experimentally    algorithms    regions    interdisciplinary    transcription    disorders    genome    mechanisms    predictions    integration    area    machine    expression    driving    generate    controls    feasibility    dual    expressed    linked    skills    taxi    regulatory    xi    considering    establishment    molecular    predict    exact    independent    model    expertise    validate    dosage    mammals    profiles    contribution    infer    abolishing    fraction   

Project "TAXi-ch" data sheet

The following table provides information about the project.

Coordinator
EUROPEAN MOLECULAR BIOLOGY LABORATORY 

Organization address
address: Meyerhofstrasse 1
city: HEIDELBERG
postcode: 69117
website: http://www.embl.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 162˙806 €
 EC max contribution 162˙806 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-03-01   to  2022-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EUROPEAN MOLECULAR BIOLOGY LABORATORY DE (HEIDELBERG) coordinator 162˙806.00

Map

 Project objective

Transcription factor (TF) cooperativity controls gene expression and is essential to establish transcriptional programs during development. One of the hallmarks of development in female mammals is the inactivation of one of the two X chromosomes to achieve dosage compensation of X-linked genes. Although the inactive X (Xi) chromosome is a heterochromatin environment, a small fraction of genes is expressed from this chromosome. However, the exact mechanisms regulating their expression and the possible similarities in regulation between these genes and genes from the active X chromosome are unknown. TAXi-ch aims to determine the TFs driving the expression of genes from the Xi chromosome, as well as, the contribution of each TF to this process and their cooperativity. Specifically, an interdisciplinary approach based on functional genomics techniques, machine learning algorithms and genome editing tools will be applied to: 1) predict TFs that bind regulatory regions in the X chromosomes and generate their binding profiles, 2) assess the contribution of TFs to gene expression through classification models and targeted depletion of TFs, 3) infer regulatory networks of X-linked genes in the Xi chromosome, 4) model the transcriptional effect of abolishing binding of different combinations of TFs using 2 selected networks, and 5) experimentally validate the modelling predictions. The research is innovative, as this question has not previously been addressed using integration of allele-specific multi-omics data, and timely, considering the current interest to understand TF cooperativity. Furthermore, the results of this project will be important to the study of X-linked disorders. The dual expertise on data analysis and molecular biology of the experienced researcher ensures the feasibility of the project, and its implementation will hone her technical and transferable skills to facilitate her future establishment as an independent leader in the European Research Area.

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The information about "TAXI-CH" are provided by the European Opendata Portal: CORDIS opendata.

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