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TAXi-ch SIGNED

Determination of transcription factor cooperativity driving expression from the inactive X chromosome

Total Cost €

0

EC-Contrib. €

0

Partnership

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 TAXi-ch project word cloud

Explore the words cloud of the TAXi-ch project. It provides you a very rough idea of what is the project "TAXi-ch" about.

biology    programs    functional    regions    environment    interdisciplinary    mammals    cooperativity    combinations    area    gene    regulating    considering    regulation    data    fraction    regulatory    independent    integration    unknown    inactivation    bind    ensures    depletion    genes    predict    inactive    experimentally    techniques    chromosomes    heterochromatin    transcriptional    leader    allele    xi    molecular    models    small    learning    editing    mechanisms    expressed    taxi    female    machine    classification    abolishing    omics    predictions    linked    dual    tf    tools    compensation    hallmarks    disorders    transcription    similarities    tfs    understand    establishment    chromosome    generate    ch    hone    dosage    validate    effect    genome    model    algorithms    genomics    previously    expertise    binding    feasibility    driving    researcher    exact    infer    contribution    profiles    active    transferable    controls    skills    question    expression    networks    innovative   

Project "TAXi-ch" data sheet

The following table provides information about the project.

Coordinator
EUROPEAN MOLECULAR BIOLOGY LABORATORY 

Organization address
address: Meyerhofstrasse 1
city: HEIDELBERG
postcode: 69117
website: http://www.embl.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 162˙806 €
 EC max contribution 162˙806 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-03-01   to  2022-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EUROPEAN MOLECULAR BIOLOGY LABORATORY DE (HEIDELBERG) coordinator 162˙806.00

Map

 Project objective

Transcription factor (TF) cooperativity controls gene expression and is essential to establish transcriptional programs during development. One of the hallmarks of development in female mammals is the inactivation of one of the two X chromosomes to achieve dosage compensation of X-linked genes. Although the inactive X (Xi) chromosome is a heterochromatin environment, a small fraction of genes is expressed from this chromosome. However, the exact mechanisms regulating their expression and the possible similarities in regulation between these genes and genes from the active X chromosome are unknown. TAXi-ch aims to determine the TFs driving the expression of genes from the Xi chromosome, as well as, the contribution of each TF to this process and their cooperativity. Specifically, an interdisciplinary approach based on functional genomics techniques, machine learning algorithms and genome editing tools will be applied to: 1) predict TFs that bind regulatory regions in the X chromosomes and generate their binding profiles, 2) assess the contribution of TFs to gene expression through classification models and targeted depletion of TFs, 3) infer regulatory networks of X-linked genes in the Xi chromosome, 4) model the transcriptional effect of abolishing binding of different combinations of TFs using 2 selected networks, and 5) experimentally validate the modelling predictions. The research is innovative, as this question has not previously been addressed using integration of allele-specific multi-omics data, and timely, considering the current interest to understand TF cooperativity. Furthermore, the results of this project will be important to the study of X-linked disorders. The dual expertise on data analysis and molecular biology of the experienced researcher ensures the feasibility of the project, and its implementation will hone her technical and transferable skills to facilitate her future establishment as an independent leader in the European Research Area.

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The information about "TAXI-CH" are provided by the European Opendata Portal: CORDIS opendata.

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