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TAXi-ch SIGNED

Determination of transcription factor cooperativity driving expression from the inactive X chromosome

Total Cost €

0

EC-Contrib. €

0

Partnership

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 TAXi-ch project word cloud

Explore the words cloud of the TAXi-ch project. It provides you a very rough idea of what is the project "TAXi-ch" about.

regulating    expertise    infer    predictions    tools    ch    bind    effect    mechanisms    generate    question    environment    integration    controls    considering    genes    editing    understand    unknown    chromosomes    hallmarks    regulatory    algorithms    binding    interdisciplinary    leader    expressed    compensation    profiles    model    regulation    active    dual    innovative    contribution    small    combinations    inactivation    data    regions    heterochromatin    similarities    area    dosage    exact    functional    networks    experimentally    tfs    molecular    xi    linked    female    predict    feasibility    models    expression    programs    skills    learning    chromosome    allele    cooperativity    transcription    depletion    researcher    taxi    omics    transcriptional    transferable    classification    genome    hone    machine    validate    independent    previously    disorders    mammals    fraction    establishment    inactive    biology    gene    ensures    tf    genomics    driving    abolishing    techniques   

Project "TAXi-ch" data sheet

The following table provides information about the project.

Coordinator
EUROPEAN MOLECULAR BIOLOGY LABORATORY 

Organization address
address: Meyerhofstrasse 1
city: HEIDELBERG
postcode: 69117
website: http://www.embl.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 162˙806 €
 EC max contribution 162˙806 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-03-01   to  2022-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EUROPEAN MOLECULAR BIOLOGY LABORATORY DE (HEIDELBERG) coordinator 162˙806.00

Map

 Project objective

Transcription factor (TF) cooperativity controls gene expression and is essential to establish transcriptional programs during development. One of the hallmarks of development in female mammals is the inactivation of one of the two X chromosomes to achieve dosage compensation of X-linked genes. Although the inactive X (Xi) chromosome is a heterochromatin environment, a small fraction of genes is expressed from this chromosome. However, the exact mechanisms regulating their expression and the possible similarities in regulation between these genes and genes from the active X chromosome are unknown. TAXi-ch aims to determine the TFs driving the expression of genes from the Xi chromosome, as well as, the contribution of each TF to this process and their cooperativity. Specifically, an interdisciplinary approach based on functional genomics techniques, machine learning algorithms and genome editing tools will be applied to: 1) predict TFs that bind regulatory regions in the X chromosomes and generate their binding profiles, 2) assess the contribution of TFs to gene expression through classification models and targeted depletion of TFs, 3) infer regulatory networks of X-linked genes in the Xi chromosome, 4) model the transcriptional effect of abolishing binding of different combinations of TFs using 2 selected networks, and 5) experimentally validate the modelling predictions. The research is innovative, as this question has not previously been addressed using integration of allele-specific multi-omics data, and timely, considering the current interest to understand TF cooperativity. Furthermore, the results of this project will be important to the study of X-linked disorders. The dual expertise on data analysis and molecular biology of the experienced researcher ensures the feasibility of the project, and its implementation will hone her technical and transferable skills to facilitate her future establishment as an independent leader in the European Research Area.

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The information about "TAXI-CH" are provided by the European Opendata Portal: CORDIS opendata.

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