Opendata, web and dolomites

EXECUT.ER SIGNED

Dissecting the molecular mechanisms that execute developmental programmed cell death in plants

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 EXECUT.ER project word cloud

Explore the words cloud of the EXECUT.ER project. It provides you a very rough idea of what is the project "EXECUT.ER" about.

despite    multicellular    compartmentalization    team    cell    pcd    final    crop    unprecedented    rapid    fragmentary    hypothesize    death    unexpected    me    super    resolution    preparation    endoplasmic    overcome    regulatory    irreversible    revealing    tissue    onset    mutagenesis    plant    lastly    temporal    hypothesis    proteomics    data    network    live    microscopy    acting    quantum    fundamental    model    organisms    molecular    succession    cap    electron    rna    developmentally    functions    permeabilization    multiplex    redundancy    protection    orderly    correlative    enabled    underlying    screens    technologies    gene    light    lethality    root    route    terminate    arabidopsis    shed    preliminary    mechanisms    significance    unknown    de    plants    avenues    vital    programmed    central    context    unparalleled    employ    developmental    events    single    breaks    spatial    reproduction    mechanism    genes    innovative    crispr    improvement    cells    reticulum    health    membrane    sequential    accessibility    direct    undoubted    genetic    leap    proteins    sequencing    techniques    vacuole   

Project "EXECUT.ER" data sheet

The following table provides information about the project.

Coordinator
VIB VZW 

Organization address
address: RIJVISSCHESTRAAT 120
city: ZWIJNAARDE - GENT
postcode: 9052
website: www.vib.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 1˙999˙963 €
 EC max contribution 1˙999˙963 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-COG
 Funding Scheme ERC-COG
 Starting year 2020
 Duration (year-month-day) from 2020-06-01   to  2025-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    VIB VZW BE (ZWIJNAARDE - GENT) coordinator 1˙999˙963.00

Map

 Project objective

Programmed Cell Death (PCD) is fundamental to the development and health of multicellular organisms. However, our knowledge on developmentally controlled PCD in plants remains fragmentary, despite its undoubted significance for plant growth and reproduction. My team has established the Arabidopsis root cap as a novel model system for developmental PCD in plants. This model has enabled us to identify a gene regulatory network controlling the preparation of PCD. However, the molecular processes that terminate the vital functions of a plant cell during the final steps of PCD execution remain unknown. Exploiting the accessibility of the root cap for live-cell analysis of PCD execution, we obtained preliminary data revealing an unexpected succession of distinct membrane permeabilization events in which the endoplasmic reticulum breaks up before the central vacuole. I hypothesize that this sequential de-compartmentalization is the mechanism underlying the irreversible and orderly execution of PCD. Recent advances in several key technologies provide unprecedented opportunities to test this hypothesis and make a quantum leap in our understanding of the mechanisms carrying out PCD execution. I will employ correlative super-resolution light and electron microscopy to analyse PCD execution in unparalleled spatial and temporal resolution. RNA sequencing of single cells at the onset of PCD execution will provide information on the genes that are required for this rapid process. Advanced proteomics techniques will provide a direct route to identify proteins acting on membrane permeabilization during PCD execution. Lastly, multiplex and tissue-specific mutagenesis via innovative CRISPR screens will enable me to overcome genetic redundancy and lethality in the PCD context. The detailed understanding of plant PCD execution generated by this research program will shed light on a fundamental principle of plant development and open new avenues for crop improvement and protection.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "EXECUT.ER" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "EXECUT.ER" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

inhibiTOR (2020)

Novel selective mTORC1 inhibitors

Read More  

E-DIRECT (2020)

Evolution of Direct Reciprocity in Complex Environments

Read More  

DOUBLE-TROUBLE (2020)

Replaying the ‘genome duplication’ tape of life: the importance of polyploidy for adaptation in a changing environment

Read More