EXECUT.ER SIGNED
Dissecting the molecular mechanisms that execute developmental programmed cell death in plants
Total Cost €
0EC-Contrib. €
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Project "EXECUT.ER" data sheet
The following table provides information about the project.
| Coordinator |
VIB VZW
Organization address contact info |
| Coordinator Country | Belgium [BE] |
| Total cost | 1˙999˙963 € |
| EC max contribution | 1˙999˙963 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2019-COG |
| Funding Scheme | ERC-COG |
| Starting year | 2020 |
| Duration (year-month-day) | from 2020-06-01 to 2025-05-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | VIB VZW | BE (ZWIJNAARDE - GENT) | coordinator | 1˙999˙963.00 |
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Project objective
Programmed Cell Death (PCD) is fundamental to the development and health of multicellular organisms. However, our knowledge on developmentally controlled PCD in plants remains fragmentary, despite its undoubted significance for plant growth and reproduction. My team has established the Arabidopsis root cap as a novel model system for developmental PCD in plants. This model has enabled us to identify a gene regulatory network controlling the preparation of PCD. However, the molecular processes that terminate the vital functions of a plant cell during the final steps of PCD execution remain unknown. Exploiting the accessibility of the root cap for live-cell analysis of PCD execution, we obtained preliminary data revealing an unexpected succession of distinct membrane permeabilization events in which the endoplasmic reticulum breaks up before the central vacuole. I hypothesize that this sequential de-compartmentalization is the mechanism underlying the irreversible and orderly execution of PCD. Recent advances in several key technologies provide unprecedented opportunities to test this hypothesis and make a quantum leap in our understanding of the mechanisms carrying out PCD execution. I will employ correlative super-resolution light and electron microscopy to analyse PCD execution in unparalleled spatial and temporal resolution. RNA sequencing of single cells at the onset of PCD execution will provide information on the genes that are required for this rapid process. Advanced proteomics techniques will provide a direct route to identify proteins acting on membrane permeabilization during PCD execution. Lastly, multiplex and tissue-specific mutagenesis via innovative CRISPR screens will enable me to overcome genetic redundancy and lethality in the PCD context. The detailed understanding of plant PCD execution generated by this research program will shed light on a fundamental principle of plant development and open new avenues for crop improvement and protection.
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