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EXECUT.ER SIGNED

Dissecting the molecular mechanisms that execute developmental programmed cell death in plants

Total Cost €

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EC-Contrib. €

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Partnership

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 EXECUT.ER project word cloud

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microscopy    leap    correlative    mechanism    team    cap    permeabilization    significance    lastly    technologies    unparalleled    fundamental    pcd    improvement    temporal    cell    me    membrane    spatial    hypothesize    death    live    sequencing    single    arabidopsis    protection    revealing    gene    fragmentary    developmentally    de    sequential    accessibility    shed    rapid    orderly    root    multiplex    vital    breaks    preparation    plant    techniques    functions    events    proteomics    organisms    unknown    super    health    mutagenesis    reproduction    compartmentalization    hypothesis    genetic    electron    crispr    plants    avenues    irreversible    endoplasmic    screens    redundancy    employ    despite    vacuole    central    unprecedented    molecular    light    undoubted    final    proteins    route    mechanisms    enabled    preliminary    resolution    crop    multicellular    terminate    programmed    innovative    lethality    context    acting    onset    unexpected    direct    overcome    genes    underlying    quantum    cells    rna    succession    tissue    reticulum    network    data    model    developmental    regulatory   

Project "EXECUT.ER" data sheet

The following table provides information about the project.

Coordinator
VIB VZW 

Organization address
address: RIJVISSCHESTRAAT 120
city: ZWIJNAARDE - GENT
postcode: 9052
website: www.vib.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 1˙999˙963 €
 EC max contribution 1˙999˙963 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-COG
 Funding Scheme ERC-COG
 Starting year 2020
 Duration (year-month-day) from 2020-06-01   to  2025-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    VIB VZW BE (ZWIJNAARDE - GENT) coordinator 1˙999˙963.00

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 Project objective

Programmed Cell Death (PCD) is fundamental to the development and health of multicellular organisms. However, our knowledge on developmentally controlled PCD in plants remains fragmentary, despite its undoubted significance for plant growth and reproduction. My team has established the Arabidopsis root cap as a novel model system for developmental PCD in plants. This model has enabled us to identify a gene regulatory network controlling the preparation of PCD. However, the molecular processes that terminate the vital functions of a plant cell during the final steps of PCD execution remain unknown. Exploiting the accessibility of the root cap for live-cell analysis of PCD execution, we obtained preliminary data revealing an unexpected succession of distinct membrane permeabilization events in which the endoplasmic reticulum breaks up before the central vacuole. I hypothesize that this sequential de-compartmentalization is the mechanism underlying the irreversible and orderly execution of PCD. Recent advances in several key technologies provide unprecedented opportunities to test this hypothesis and make a quantum leap in our understanding of the mechanisms carrying out PCD execution. I will employ correlative super-resolution light and electron microscopy to analyse PCD execution in unparalleled spatial and temporal resolution. RNA sequencing of single cells at the onset of PCD execution will provide information on the genes that are required for this rapid process. Advanced proteomics techniques will provide a direct route to identify proteins acting on membrane permeabilization during PCD execution. Lastly, multiplex and tissue-specific mutagenesis via innovative CRISPR screens will enable me to overcome genetic redundancy and lethality in the PCD context. The detailed understanding of plant PCD execution generated by this research program will shed light on a fundamental principle of plant development and open new avenues for crop improvement and protection.

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