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EXECUT.ER SIGNED

Dissecting the molecular mechanisms that execute developmental programmed cell death in plants

Total Cost €

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EC-Contrib. €

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Partnership

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 EXECUT.ER project word cloud

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revealing    cells    breaks    central    vacuole    orderly    employ    cap    final    terminate    membrane    preliminary    proteomics    model    resolution    multiplex    shed    spatial    root    molecular    significance    direct    protection    compartmentalization    death    electron    organisms    improvement    crop    network    mutagenesis    quantum    tissue    endoplasmic    proteins    genes    cell    plant    hypothesis    hypothesize    overcome    arabidopsis    irreversible    super    avenues    regulatory    unknown    rna    enabled    redundancy    genetic    preparation    correlative    permeabilization    live    onset    leap    acting    rapid    plants    accessibility    pcd    multicellular    team    light    techniques    functions    mechanisms    sequential    health    unexpected    developmental    innovative    mechanism    de    despite    developmentally    gene    screens    lastly    crispr    lethality    underlying    reticulum    temporal    sequencing    undoubted    fundamental    single    data    technologies    microscopy    context    programmed    unparalleled    events    route    me    unprecedented    vital    fragmentary    reproduction    succession   

Project "EXECUT.ER" data sheet

The following table provides information about the project.

Coordinator
VIB VZW 

Organization address
address: RIJVISSCHESTRAAT 120
city: ZWIJNAARDE - GENT
postcode: 9052
website: www.vib.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 1˙999˙963 €
 EC max contribution 1˙999˙963 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-COG
 Funding Scheme ERC-COG
 Starting year 2020
 Duration (year-month-day) from 2020-06-01   to  2025-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    VIB VZW BE (ZWIJNAARDE - GENT) coordinator 1˙999˙963.00

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 Project objective

Programmed Cell Death (PCD) is fundamental to the development and health of multicellular organisms. However, our knowledge on developmentally controlled PCD in plants remains fragmentary, despite its undoubted significance for plant growth and reproduction. My team has established the Arabidopsis root cap as a novel model system for developmental PCD in plants. This model has enabled us to identify a gene regulatory network controlling the preparation of PCD. However, the molecular processes that terminate the vital functions of a plant cell during the final steps of PCD execution remain unknown. Exploiting the accessibility of the root cap for live-cell analysis of PCD execution, we obtained preliminary data revealing an unexpected succession of distinct membrane permeabilization events in which the endoplasmic reticulum breaks up before the central vacuole. I hypothesize that this sequential de-compartmentalization is the mechanism underlying the irreversible and orderly execution of PCD. Recent advances in several key technologies provide unprecedented opportunities to test this hypothesis and make a quantum leap in our understanding of the mechanisms carrying out PCD execution. I will employ correlative super-resolution light and electron microscopy to analyse PCD execution in unparalleled spatial and temporal resolution. RNA sequencing of single cells at the onset of PCD execution will provide information on the genes that are required for this rapid process. Advanced proteomics techniques will provide a direct route to identify proteins acting on membrane permeabilization during PCD execution. Lastly, multiplex and tissue-specific mutagenesis via innovative CRISPR screens will enable me to overcome genetic redundancy and lethality in the PCD context. The detailed understanding of plant PCD execution generated by this research program will shed light on a fundamental principle of plant development and open new avenues for crop improvement and protection.

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