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A new approach of metastatic bone fracture prediction using a patient-specific model including metastatic tissue, daily-life activities and local failure criteria

Total Cost €


EC-Contrib. €






 METABONE project word cloud

Explore the words cloud of the METABONE project. It provides you a very rough idea of what is the project "METABONE" about.

influential    strength    loading    composition    single    compression    femoral    qct    lesions    severely    life    methodology    locomotor    computed    lack    survival    prediction    successful    completion    qualitative    tool    metabone    tumoral    scans    experimental    material    quantitative    guide    specificity    huge    experimentally    medullar    limited    oncology    diseased    estimate    made    global    fragility    tomography    femur    restricted    risk    ex    economic    prevent    proximal    mechanical    mobility    accurate    limitations    human    efforts    tissue    healthy    fracture    performed    quality    clinical    criteria    optimize    accuracy    sensitivity    strategy    patients    models    bone    first    numerical    predict    clinically    metastases    segments    osteolytic    vivo    significantly    responsible    evaluation    combining    alter    surgery    scores    model    simulations    daily    determined    clinicians    stance    patient    decision    hampered    finite    located    hypothesised    socio    local    metastatic   

Project "METABONE" data sheet

The following table provides information about the project.


Organization address
address: BOULEVARD DU 11 NOVEMBRE 1918 NUM43
postcode: 69622

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 184˙707 €
 EC max contribution 184˙707 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2022-03-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Osteolytic bone metastases are responsible for long bone fracture leading to restricted mobility, surgery, or medullar compression that severely alter quality of life and have a huge socio-economic impact. Current fragility scores to estimate the fracture risk in patients with metastatic femur are based on qualitative evaluation from Quantitative Computed Tomography (QCT) scans and lack sensitivity and specificity. Efforts are now made towards the development of patient-specific finite element models to assess the strength of tumoral bone segments, but their accuracy is hampered by several limitations, including limited knowledge of metastatic bone mechanical properties, simulations performed only for single stance loading condition, and simulations providing a global failure criteria. The aim of METABONE is, therefore, to use a novel approach to better predict the fracture risk of metastatic femur. A patient-specific finite element model will be developed based on QCT scans, which will include the real material properties of ex vivo human metastatic bone determined experimentally in the first part of the project. The composition and mechanical behaviour of diseased bone tissue are hypothesised to be rather different from healthy tissue and influential of femoral strength. This model will be used clinically on patients with osteolytic lesions located in proximal femur to assess the fracture risk during daily life activities, using a local failure criteria and a range of different loading conditions. This novel methodology, combining experimental and numerical approaches, is expected to significantly improve the accuracy of fracture risk prediction. Successful completion of METABONE will have the potential to guide clinical decision making, by providing clinicians with a more accurate tool to optimize locomotor strategy and oncology program, in order to prevent bone fracture, improve survival and quality of life of the patients.

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The information about "METABONE" are provided by the European Opendata Portal: CORDIS opendata.

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