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METABONE SIGNED

A new approach of metastatic bone fracture prediction using a patient-specific model including metastatic tissue, daily-life activities and local failure criteria

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 METABONE project word cloud

Explore the words cloud of the METABONE project. It provides you a very rough idea of what is the project "METABONE" about.

successful    fracture    experimental    diseased    responsible    femur    qct    segments    severely    hypothesised    surgery    located    qualitative    clinicians    mobility    accuracy    life    prevent    metastases    experimentally    proximal    mechanical    bone    computed    metastatic    loading    finite    quantitative    survival    specificity    risk    daily    completion    significantly    restricted    local    huge    combining    fragility    stance    socio    tomography    tumoral    vivo    medullar    evaluation    sensitivity    methodology    patients    determined    osteolytic    decision    efforts    oncology    locomotor    alter    patient    guide    accurate    hampered    clinical    criteria    compression    femoral    simulations    human    strength    scores    influential    single    model    global    scans    limited    economic    first    estimate    tissue    tool    lack    clinically    prediction    healthy    optimize    limitations    quality    material    strategy    made    composition    ex    lesions    predict    metabone    performed    numerical    models   

Project "METABONE" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE LYON 1 CLAUDE BERNARD 

Organization address
address: BOULEVARD DU 11 NOVEMBRE 1918 NUM43
city: VILLEURBANNE CEDEX
postcode: 69622
website: www.univ-Iyon1.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 184˙707 €
 EC max contribution 184˙707 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2022-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE LYON 1 CLAUDE BERNARD FR (VILLEURBANNE CEDEX) coordinator 184˙707.00

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 Project objective

Osteolytic bone metastases are responsible for long bone fracture leading to restricted mobility, surgery, or medullar compression that severely alter quality of life and have a huge socio-economic impact. Current fragility scores to estimate the fracture risk in patients with metastatic femur are based on qualitative evaluation from Quantitative Computed Tomography (QCT) scans and lack sensitivity and specificity. Efforts are now made towards the development of patient-specific finite element models to assess the strength of tumoral bone segments, but their accuracy is hampered by several limitations, including limited knowledge of metastatic bone mechanical properties, simulations performed only for single stance loading condition, and simulations providing a global failure criteria. The aim of METABONE is, therefore, to use a novel approach to better predict the fracture risk of metastatic femur. A patient-specific finite element model will be developed based on QCT scans, which will include the real material properties of ex vivo human metastatic bone determined experimentally in the first part of the project. The composition and mechanical behaviour of diseased bone tissue are hypothesised to be rather different from healthy tissue and influential of femoral strength. This model will be used clinically on patients with osteolytic lesions located in proximal femur to assess the fracture risk during daily life activities, using a local failure criteria and a range of different loading conditions. This novel methodology, combining experimental and numerical approaches, is expected to significantly improve the accuracy of fracture risk prediction. Successful completion of METABONE will have the potential to guide clinical decision making, by providing clinicians with a more accurate tool to optimize locomotor strategy and oncology program, in order to prevent bone fracture, improve survival and quality of life of the patients.

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The information about "METABONE" are provided by the European Opendata Portal: CORDIS opendata.

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