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DRIVOME

Multi-modal interrogation of instinctive behaviours and intrahypothalamic connectivity

Total Cost €

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EC-Contrib. €

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Partnership

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 DRIVOME project word cloud

Explore the words cloud of the DRIVOME project. It provides you a very rough idea of what is the project "DRIVOME" about.

lorenz    2011    recording    2007    marlin    techniques    2015    demonstrated    hypothalamus    uncovered    reside    everyone    adaptive    animal    hunger    gaining    emotions    al    instinctive    adamantidis    modern    swanson    probing    lee    pace    cell    manipulations    populations    disorders    behaviours    displays    kingdom    wiring    structures    2014    dyscontrol    daily    coherent    1951    older    drive    tinbergen    et    anomalies    sleep    parental    imaging    excessive    lin    drives    instincts    familiar    ethology    optrode    neuronal    organization    ripe    aponte    calcium    orchestrated    betley    photon    anorexia    diagram    species    situations    wu    transgenic    hypothalamic    feeding    architecture    fundamental    intrahypothalamic    episodic    brain    indicators    potentially    sex    networks    anatomical    jego    elucidate    evident    insights    drivome    mice    newer    hypotheses    marital    genetically    sexual    network    wakefulness    cruder    connectome    psychologically    2013    circuits    possibly    encoded    mouse    deep    infidelity    charge    syndrome    2000    difficult    guide    context    outlined    aggression    opsins    mammalian    1981   

Project "DRIVOME" data sheet

The following table provides information about the project.

Coordinator
KING'S COLLEGE LONDON 

Organization address
address: STRAND
city: LONDON
postcode: WC2R 2LS
website: www.kcl.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website https://kclpure.kcl.ac.uk/portal/en/persons/mahesh-karnani
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2016
 Duration (year-month-day) from 2016-03-01   to  2018-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KING'S COLLEGE LONDON UK (LONDON) coordinator 183˙454.00

Map

 Project objective

Mammalian behaviour is driven by instincts such as hunger, sex and aggression which are familiar to everyone from daily experience. Anomalies in these instincts cause disorders such as anorexia, excessive sexual drive and episodic dyscontrol syndrome, and potentially also psychologically difficult situations like marital infidelity. Neuronal circuits that drive these instincts reside in the hypothalamus where research is gaining pace rapidly. Recent work has uncovered hypothalamic neuronal populations in mouse, that can drive the following fundamental mammalian behaviours: feeding (Aponte et al., 2011, Betley et al., 2015), sex/aggression (Lee et al., 2014, Lin et al., 2011), sleep/wakefulness (Adamantidis et al., 2007, Jego et al., 2013) and parental behaviours (Marlin et al., 2015, Wu et al., 2014). Older work has demonstrated similar effects with cruder manipulations of the hypothalamus in several species. Classical work in ethology (Lorenz, 1981, Tinbergen, 1951) as well as newer anatomical insights (Swanson, 2000) have outlined hypotheses for how neuronal network architecture may guide the organization of instinctive behaviours into the coherent, adaptive, context-relevant displays evident throughout the animal kingdom. Modern techniques (opsins, genetically encoded calcium indicators, transgenic mice, multi photon imaging of deep brain structures and optrode recording) are now ripe for comprehensive cell-type specific probing of the hypothalamic networks in charge of fundamental drives and possibly emotions. We propose to use these methods to elucidate the intrahypothalamic wiring diagram (the connectome of drives, or 'DRIVOME') that can explain how instincts are orchestrated.

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