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DRIVOME

Multi-modal interrogation of instinctive behaviours and intrahypothalamic connectivity

Total Cost €

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EC-Contrib. €

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Partnership

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 DRIVOME project word cloud

Explore the words cloud of the DRIVOME project. It provides you a very rough idea of what is the project "DRIVOME" about.

sleep    dyscontrol    mice    architecture    wiring    adamantidis    intrahypothalamic    mouse    sex    probing    demonstrated    infidelity    2015    cruder    charge    ripe    connectome    et    2014    marlin    al    aggression    outlined    networks    imaging    daily    ethology    drives    photon    coherent    syndrome    older    2011    recording    2013    betley    hypotheses    techniques    lee    context    psychologically    emotions    genetically    anomalies    network    transgenic    disorders    possibly    1951    newer    familiar    opsins    displays    calcium    insights    guide    uncovered    marital    fundamental    2007    organization    difficult    drive    excessive    wakefulness    instinctive    pace    evident    encoded    optrode    lin    circuits    gaining    manipulations    sexual    aponte    kingdom    1981    feeding    anatomical    instincts    indicators    drivome    behaviours    wu    swanson    species    episodic    deep    parental    modern    animal    structures    everyone    situations    populations    2000    mammalian    adaptive    cell    orchestrated    hypothalamus    reside    diagram    potentially    brain    hunger    lorenz    tinbergen    neuronal    elucidate    jego    anorexia    hypothalamic   

Project "DRIVOME" data sheet

The following table provides information about the project.

Coordinator
KING'S COLLEGE LONDON 

Organization address
address: STRAND
city: LONDON
postcode: WC2R 2LS
website: www.kcl.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website https://kclpure.kcl.ac.uk/portal/en/persons/mahesh-karnani
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2016
 Duration (year-month-day) from 2016-03-01   to  2018-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KING'S COLLEGE LONDON UK (LONDON) coordinator 183˙454.00

Map

 Project objective

Mammalian behaviour is driven by instincts such as hunger, sex and aggression which are familiar to everyone from daily experience. Anomalies in these instincts cause disorders such as anorexia, excessive sexual drive and episodic dyscontrol syndrome, and potentially also psychologically difficult situations like marital infidelity. Neuronal circuits that drive these instincts reside in the hypothalamus where research is gaining pace rapidly. Recent work has uncovered hypothalamic neuronal populations in mouse, that can drive the following fundamental mammalian behaviours: feeding (Aponte et al., 2011, Betley et al., 2015), sex/aggression (Lee et al., 2014, Lin et al., 2011), sleep/wakefulness (Adamantidis et al., 2007, Jego et al., 2013) and parental behaviours (Marlin et al., 2015, Wu et al., 2014). Older work has demonstrated similar effects with cruder manipulations of the hypothalamus in several species. Classical work in ethology (Lorenz, 1981, Tinbergen, 1951) as well as newer anatomical insights (Swanson, 2000) have outlined hypotheses for how neuronal network architecture may guide the organization of instinctive behaviours into the coherent, adaptive, context-relevant displays evident throughout the animal kingdom. Modern techniques (opsins, genetically encoded calcium indicators, transgenic mice, multi photon imaging of deep brain structures and optrode recording) are now ripe for comprehensive cell-type specific probing of the hypothalamic networks in charge of fundamental drives and possibly emotions. We propose to use these methods to elucidate the intrahypothalamic wiring diagram (the connectome of drives, or 'DRIVOME') that can explain how instincts are orchestrated.

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