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DRIVOME

Multi-modal interrogation of instinctive behaviours and intrahypothalamic connectivity

Total Cost €

0

EC-Contrib. €

0

Partnership

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 DRIVOME project word cloud

Explore the words cloud of the DRIVOME project. It provides you a very rough idea of what is the project "DRIVOME" about.

lee    wiring    context    psychologically    diagram    possibly    behaviours    guide    everyone    betley    evident    disorders    2000    parental    orchestrated    charge    uncovered    marlin    optrode    modern    mouse    excessive    structures    displays    hypothalamus    wakefulness    reside    networks    neuronal    1951    infidelity    encoded    wu    probing    tinbergen    ripe    transgenic    connectome    elucidate    network    2007    feeding    et    older    organization    marital    calcium    anorexia    species    2013    syndrome    deep    drivome    coherent    instinctive    circuits    insights    animal    emotions    brain    fundamental    hypotheses    situations    potentially    mammalian    demonstrated    cruder    al    mice    familiar    populations    hypothalamic    indicators    drives    cell    dyscontrol    episodic    techniques    drive    lin    imaging    intrahypothalamic    manipulations    kingdom    adamantidis    lorenz    pace    outlined    aponte    aggression    genetically    sexual    1981    opsins    photon    difficult    anomalies    architecture    sleep    2015    sex    jego    anatomical    instincts    2011    recording    adaptive    hunger    2014    newer    ethology    gaining    daily    swanson   

Project "DRIVOME" data sheet

The following table provides information about the project.

Coordinator
KING'S COLLEGE LONDON 

Organization address
address: STRAND
city: LONDON
postcode: WC2R 2LS
website: www.kcl.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website https://kclpure.kcl.ac.uk/portal/en/persons/mahesh-karnani
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2016
 Duration (year-month-day) from 2016-03-01   to  2018-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KING'S COLLEGE LONDON UK (LONDON) coordinator 183˙454.00

Map

 Project objective

Mammalian behaviour is driven by instincts such as hunger, sex and aggression which are familiar to everyone from daily experience. Anomalies in these instincts cause disorders such as anorexia, excessive sexual drive and episodic dyscontrol syndrome, and potentially also psychologically difficult situations like marital infidelity. Neuronal circuits that drive these instincts reside in the hypothalamus where research is gaining pace rapidly. Recent work has uncovered hypothalamic neuronal populations in mouse, that can drive the following fundamental mammalian behaviours: feeding (Aponte et al., 2011, Betley et al., 2015), sex/aggression (Lee et al., 2014, Lin et al., 2011), sleep/wakefulness (Adamantidis et al., 2007, Jego et al., 2013) and parental behaviours (Marlin et al., 2015, Wu et al., 2014). Older work has demonstrated similar effects with cruder manipulations of the hypothalamus in several species. Classical work in ethology (Lorenz, 1981, Tinbergen, 1951) as well as newer anatomical insights (Swanson, 2000) have outlined hypotheses for how neuronal network architecture may guide the organization of instinctive behaviours into the coherent, adaptive, context-relevant displays evident throughout the animal kingdom. Modern techniques (opsins, genetically encoded calcium indicators, transgenic mice, multi photon imaging of deep brain structures and optrode recording) are now ripe for comprehensive cell-type specific probing of the hypothalamic networks in charge of fundamental drives and possibly emotions. We propose to use these methods to elucidate the intrahypothalamic wiring diagram (the connectome of drives, or 'DRIVOME') that can explain how instincts are orchestrated.

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