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Multi-modal interrogation of instinctive behaviours and intrahypothalamic connectivity

Total Cost €


EC-Contrib. €






 DRIVOME project word cloud

Explore the words cloud of the DRIVOME project. It provides you a very rough idea of what is the project "DRIVOME" about.

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Project "DRIVOME" data sheet

The following table provides information about the project.


Organization address
address: STRAND
city: LONDON
postcode: WC2R 2LS

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2016
 Duration (year-month-day) from 2016-03-01   to  2018-02-28


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KING'S COLLEGE LONDON UK (LONDON) coordinator 183˙454.00


 Project objective

Mammalian behaviour is driven by instincts such as hunger, sex and aggression which are familiar to everyone from daily experience. Anomalies in these instincts cause disorders such as anorexia, excessive sexual drive and episodic dyscontrol syndrome, and potentially also psychologically difficult situations like marital infidelity. Neuronal circuits that drive these instincts reside in the hypothalamus where research is gaining pace rapidly. Recent work has uncovered hypothalamic neuronal populations in mouse, that can drive the following fundamental mammalian behaviours: feeding (Aponte et al., 2011, Betley et al., 2015), sex/aggression (Lee et al., 2014, Lin et al., 2011), sleep/wakefulness (Adamantidis et al., 2007, Jego et al., 2013) and parental behaviours (Marlin et al., 2015, Wu et al., 2014). Older work has demonstrated similar effects with cruder manipulations of the hypothalamus in several species. Classical work in ethology (Lorenz, 1981, Tinbergen, 1951) as well as newer anatomical insights (Swanson, 2000) have outlined hypotheses for how neuronal network architecture may guide the organization of instinctive behaviours into the coherent, adaptive, context-relevant displays evident throughout the animal kingdom. Modern techniques (opsins, genetically encoded calcium indicators, transgenic mice, multi photon imaging of deep brain structures and optrode recording) are now ripe for comprehensive cell-type specific probing of the hypothalamic networks in charge of fundamental drives and possibly emotions. We propose to use these methods to elucidate the intrahypothalamic wiring diagram (the connectome of drives, or 'DRIVOME') that can explain how instincts are orchestrated.

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The information about "DRIVOME" are provided by the European Opendata Portal: CORDIS opendata.

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