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DRIVOME

Multi-modal interrogation of instinctive behaviours and intrahypothalamic connectivity

Total Cost €

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EC-Contrib. €

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Partnership

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 DRIVOME project word cloud

Explore the words cloud of the DRIVOME project. It provides you a very rough idea of what is the project "DRIVOME" about.

2011    kingdom    2014    transgenic    manipulations    1981    deep    charge    imaging    evident    outlined    mouse    wakefulness    2007    drive    recording    sex    familiar    demonstrated    organization    drives    neuronal    dyscontrol    circuits    ethology    1951    encoded    excessive    brain    al    indicators    guide    wu    lorenz    animal    connectome    modern    potentially    network    displays    lin    hunger    episodic    adamantidis    drivome    instincts    swanson    context    opsins    2015    et    behaviours    sleep    daily    older    fundamental    hypothalamic    infidelity    feeding    coherent    wiring    populations    mammalian    probing    newer    syndrome    hypothalamus    anorexia    situations    marital    pace    2013    betley    2000    architecture    optrode    intrahypothalamic    anomalies    hypotheses    emotions    species    insights    everyone    sexual    mice    aggression    photon    possibly    techniques    instinctive    jego    uncovered    marlin    reside    adaptive    orchestrated    gaining    disorders    parental    ripe    cell    calcium    networks    tinbergen    psychologically    structures    elucidate    diagram    aponte    cruder    difficult    anatomical    genetically    lee   

Project "DRIVOME" data sheet

The following table provides information about the project.

Coordinator
KING'S COLLEGE LONDON 

Organization address
address: STRAND
city: LONDON
postcode: WC2R 2LS
website: www.kcl.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website https://kclpure.kcl.ac.uk/portal/en/persons/mahesh-karnani
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2016
 Duration (year-month-day) from 2016-03-01   to  2018-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KING'S COLLEGE LONDON UK (LONDON) coordinator 183˙454.00

Map

 Project objective

Mammalian behaviour is driven by instincts such as hunger, sex and aggression which are familiar to everyone from daily experience. Anomalies in these instincts cause disorders such as anorexia, excessive sexual drive and episodic dyscontrol syndrome, and potentially also psychologically difficult situations like marital infidelity. Neuronal circuits that drive these instincts reside in the hypothalamus where research is gaining pace rapidly. Recent work has uncovered hypothalamic neuronal populations in mouse, that can drive the following fundamental mammalian behaviours: feeding (Aponte et al., 2011, Betley et al., 2015), sex/aggression (Lee et al., 2014, Lin et al., 2011), sleep/wakefulness (Adamantidis et al., 2007, Jego et al., 2013) and parental behaviours (Marlin et al., 2015, Wu et al., 2014). Older work has demonstrated similar effects with cruder manipulations of the hypothalamus in several species. Classical work in ethology (Lorenz, 1981, Tinbergen, 1951) as well as newer anatomical insights (Swanson, 2000) have outlined hypotheses for how neuronal network architecture may guide the organization of instinctive behaviours into the coherent, adaptive, context-relevant displays evident throughout the animal kingdom. Modern techniques (opsins, genetically encoded calcium indicators, transgenic mice, multi photon imaging of deep brain structures and optrode recording) are now ripe for comprehensive cell-type specific probing of the hypothalamic networks in charge of fundamental drives and possibly emotions. We propose to use these methods to elucidate the intrahypothalamic wiring diagram (the connectome of drives, or 'DRIVOME') that can explain how instincts are orchestrated.

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