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Multi-color and single-molecule fluorescence imaging of intraflagellar transport in the phasmid chemosensory cilia of C. Elegans

Total Cost €


EC-Contrib. €






 MingleIFT project word cloud

Explore the words cloud of the MingleIFT project. It provides you a very rough idea of what is the project "MingleIFT" about.

techniques    adjustments    obtain    components    moving    dynamics    understand    contacts    organelles    ciliary    characterised    signal    effectors    antenna    environment    transducers    chemosensory    molecule    soluble    membrane    motors    structure    water    normal    tip    outwards    acts    ultimately    waste    motor    subtle    sense    transport    effect    overarching    complexes    proteins    intraflagellar    anterograde    cellular    animal    blocks    made    retrograde    tactic    signalling    color    trains    antennas    intracellular    interlinked    chemotaxis    function    grasp    regulation    cells    turnaround    individual    chemical    acting    discovery    initiating    consist    organism    template    sensory    connection    encapsulated    recycle    imaging    toolbox    cargoes    length    machinery    specialised    maintenance    cilia    microtubule    base    cues    axoneme    phasmid    single    elegans    protein    model    core    dynein    eukaryotic    ift    kinesins    protrude    building    mechanistic    external    mediate   

Project "MingleIFT" data sheet

The following table provides information about the project.


Organization address
address: DE BOELELAAN 1105
postcode: 1081 HV

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 175˙572 €
 EC max contribution 175˙572 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-03-01   to  2022-02-28


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    STICHTING VU NL (AMSTERDAM) coordinator 175˙572.00


 Project objective

Sensory cilia are essential ‘antenna-like’ organelles that protrude out of many eukaryotic cells, acting as signal transducers, enabling cells to sense and respond to the external environment. The model system for this proposed study, chemosensory cilia of C. elegans are well characterised and enable the animal to sense water soluble effectors in the environment for chemotaxis. Cilia consist of an axoneme encapsulated with a signalling protein-rich ciliary membrane. The axoneme, which is a microtubule-based core structure, acts as a template for a specialised intra-cellular transport, intraflagellar transport (IFT). IFT trains are large protein complexes that mediate contacts between motor proteins (IFT kinesins and IFT dynein) and ciliary cargoes, crucial for the formation and maintenance of the cilia, with anterograde IFT trains moving outwards from the ciliary base to deliver ciliary building blocks to the ciliary tip and retrograde IFT trains moving from the ciliary tip to the ciliary base to recycle the waste products. The overarching objective of this project is to grasp the connection between chemosensory function of cilia (initiating chemotaxis), IFT and ciliary length-regulation using single-molecule imaging techniques. In order to achieve this, (i) I will develop a multi-color and single-molecule imaging toolbox to study IFT in the phasmid chemosensory cilia of C. elegans. (ii) Using the toolbox, I will obtain a mechanistic understanding of turnaround dynamics of the IFT machinery (IFT motors and components of the IFT trains), during normal IFT. (iii) A comprehensive understanding of normal IFT will enable discovery of the subtle adjustments made by the IFT machinery, and its effect on the cilia length, in response to chemical cues in the external environment. Ultimately, the goal is to understand how organism level tactic response is interlinked with intracellular transport in the ciliary antennas of individual cells, using C. elegans as a model system.

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The information about "MINGLEIFT" are provided by the European Opendata Portal: CORDIS opendata.

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