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MingleIFT SIGNED

Multi-color and single-molecule fluorescence imaging of intraflagellar transport in the phasmid chemosensory cilia of C. Elegans

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MingleIFT project word cloud

Explore the words cloud of the MingleIFT project. It provides you a very rough idea of what is the project "MingleIFT" about.

encapsulated    motors    obtain    soluble    dynein    specialised    function    understand    machinery    eukaryotic    turnaround    grasp    proteins    protrude    template    signalling    overarching    normal    recycle    water    external    blocks    made    organism    contacts    adjustments    effectors    regulation    organelles    structure    connection    model    tip    moving    antennas    effect    sensory    intraflagellar    mechanistic    acting    initiating    elegans    tactic    trains    anterograde    complexes    components    cells    ciliary    maintenance    protein    building    length    ultimately    consist    environment    sense    axoneme    retrograde    transducers    base    characterised    chemosensory    cargoes    chemotaxis    cues    individual    waste    techniques    transport    cilia    phasmid    outwards    interlinked    cellular    signal    single    subtle    ift    acts    discovery    animal    imaging    mediate    intracellular    molecule    antenna    kinesins    motor    toolbox    color    chemical    membrane    dynamics    microtubule    core   

Project "MingleIFT" data sheet

The following table provides information about the project.

Coordinator
STICHTING VU 

Organization address
address: DE BOELELAAN 1105
city: AMSTERDAM
postcode: 1081 HV
website: www.vu.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 175˙572 €
 EC max contribution 175˙572 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-03-01   to  2022-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    STICHTING VU NL (AMSTERDAM) coordinator 175˙572.00

Map

 Project objective

Sensory cilia are essential ‘antenna-like’ organelles that protrude out of many eukaryotic cells, acting as signal transducers, enabling cells to sense and respond to the external environment. The model system for this proposed study, chemosensory cilia of C. elegans are well characterised and enable the animal to sense water soluble effectors in the environment for chemotaxis. Cilia consist of an axoneme encapsulated with a signalling protein-rich ciliary membrane. The axoneme, which is a microtubule-based core structure, acts as a template for a specialised intra-cellular transport, intraflagellar transport (IFT). IFT trains are large protein complexes that mediate contacts between motor proteins (IFT kinesins and IFT dynein) and ciliary cargoes, crucial for the formation and maintenance of the cilia, with anterograde IFT trains moving outwards from the ciliary base to deliver ciliary building blocks to the ciliary tip and retrograde IFT trains moving from the ciliary tip to the ciliary base to recycle the waste products. The overarching objective of this project is to grasp the connection between chemosensory function of cilia (initiating chemotaxis), IFT and ciliary length-regulation using single-molecule imaging techniques. In order to achieve this, (i) I will develop a multi-color and single-molecule imaging toolbox to study IFT in the phasmid chemosensory cilia of C. elegans. (ii) Using the toolbox, I will obtain a mechanistic understanding of turnaround dynamics of the IFT machinery (IFT motors and components of the IFT trains), during normal IFT. (iii) A comprehensive understanding of normal IFT will enable discovery of the subtle adjustments made by the IFT machinery, and its effect on the cilia length, in response to chemical cues in the external environment. Ultimately, the goal is to understand how organism level tactic response is interlinked with intracellular transport in the ciliary antennas of individual cells, using C. elegans as a model system.

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The information about "MINGLEIFT" are provided by the European Opendata Portal: CORDIS opendata.

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