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MingleIFT SIGNED

Multi-color and single-molecule fluorescence imaging of intraflagellar transport in the phasmid chemosensory cilia of C. Elegans

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MingleIFT project word cloud

Explore the words cloud of the MingleIFT project. It provides you a very rough idea of what is the project "MingleIFT" about.

chemotaxis    protrude    effect    animal    turnaround    trains    motor    eukaryotic    sensory    cargoes    overarching    transducers    environment    color    microtubule    contacts    base    ciliary    single    organelles    water    acts    effectors    discovery    ultimately    tactic    antenna    imaging    cellular    connection    dynein    cells    outwards    maintenance    consist    building    tip    membrane    intraflagellar    kinesins    cilia    subtle    interlinked    intracellular    recycle    complexes    cues    obtain    initiating    organism    specialised    template    function    protein    waste    adjustments    anterograde    mediate    proteins    encapsulated    chemosensory    model    techniques    motors    sense    toolbox    characterised    phasmid    individual    soluble    antennas    ift    made    signalling    length    structure    grasp    molecule    external    moving    acting    mechanistic    axoneme    core    signal    regulation    dynamics    elegans    components    blocks    chemical    normal    retrograde    transport    understand    machinery   

Project "MingleIFT" data sheet

The following table provides information about the project.

Coordinator
STICHTING VU 

Organization address
address: DE BOELELAAN 1105
city: AMSTERDAM
postcode: 1081 HV
website: www.vu.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 175˙572 €
 EC max contribution 175˙572 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-03-01   to  2022-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    STICHTING VU NL (AMSTERDAM) coordinator 175˙572.00

Map

 Project objective

Sensory cilia are essential ‘antenna-like’ organelles that protrude out of many eukaryotic cells, acting as signal transducers, enabling cells to sense and respond to the external environment. The model system for this proposed study, chemosensory cilia of C. elegans are well characterised and enable the animal to sense water soluble effectors in the environment for chemotaxis. Cilia consist of an axoneme encapsulated with a signalling protein-rich ciliary membrane. The axoneme, which is a microtubule-based core structure, acts as a template for a specialised intra-cellular transport, intraflagellar transport (IFT). IFT trains are large protein complexes that mediate contacts between motor proteins (IFT kinesins and IFT dynein) and ciliary cargoes, crucial for the formation and maintenance of the cilia, with anterograde IFT trains moving outwards from the ciliary base to deliver ciliary building blocks to the ciliary tip and retrograde IFT trains moving from the ciliary tip to the ciliary base to recycle the waste products. The overarching objective of this project is to grasp the connection between chemosensory function of cilia (initiating chemotaxis), IFT and ciliary length-regulation using single-molecule imaging techniques. In order to achieve this, (i) I will develop a multi-color and single-molecule imaging toolbox to study IFT in the phasmid chemosensory cilia of C. elegans. (ii) Using the toolbox, I will obtain a mechanistic understanding of turnaround dynamics of the IFT machinery (IFT motors and components of the IFT trains), during normal IFT. (iii) A comprehensive understanding of normal IFT will enable discovery of the subtle adjustments made by the IFT machinery, and its effect on the cilia length, in response to chemical cues in the external environment. Ultimately, the goal is to understand how organism level tactic response is interlinked with intracellular transport in the ciliary antennas of individual cells, using C. elegans as a model system.

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The information about "MINGLEIFT" are provided by the European Opendata Portal: CORDIS opendata.

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lastchecktime (2022-05-25 17:35:49) correctly updated