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MingleIFT SIGNED

Multi-color and single-molecule fluorescence imaging of intraflagellar transport in the phasmid chemosensory cilia of C. Elegans

Total Cost €

0

EC-Contrib. €

0

Partnership

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 MingleIFT project word cloud

Explore the words cloud of the MingleIFT project. It provides you a very rough idea of what is the project "MingleIFT" about.

function    axoneme    complexes    outwards    chemical    mechanistic    cargoes    machinery    consist    chemosensory    specialised    environment    cells    encapsulated    elegans    acting    normal    membrane    ultimately    retrograde    building    single    recycle    effect    signalling    turnaround    color    connection    antennas    ift    blocks    imaging    template    antenna    motors    regulation    discovery    animal    maintenance    kinesins    interlinked    anterograde    trains    length    intracellular    made    initiating    cilia    components    dynamics    acts    obtain    subtle    eukaryotic    phasmid    tactic    base    ciliary    sensory    chemotaxis    sense    soluble    mediate    organism    tip    transducers    individual    organelles    water    motor    protrude    waste    core    model    understand    microtubule    molecule    cellular    adjustments    effectors    toolbox    external    characterised    signal    proteins    protein    overarching    contacts    structure    dynein    intraflagellar    techniques    transport    moving    cues    grasp   

Project "MingleIFT" data sheet

The following table provides information about the project.

Coordinator		 STICHTING VU 

Organization address
address: DE BOELELAAN 1105
city: AMSTERDAM
postcode: 1081 HV
website: www.vu.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Netherlands [NL]
 Total cost 175˙572 €
 EC max contribution 175˙572 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-03-01   to  2022-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    STICHTING VU NL (AMSTERDAM) coordinator 175˙572.00

Map

 Project objective

Sensory cilia are essential ‘antenna-like’ organelles that protrude out of many eukaryotic cells, acting as signal transducers, enabling cells to sense and respond to the external environment. The model system for this proposed study, chemosensory cilia of C. elegans are well characterised and enable the animal to sense water soluble effectors in the environment for chemotaxis. Cilia consist of an axoneme encapsulated with a signalling protein-rich ciliary membrane. The axoneme, which is a microtubule-based core structure, acts as a template for a specialised intra-cellular transport, intraflagellar transport (IFT). IFT trains are large protein complexes that mediate contacts between motor proteins (IFT kinesins and IFT dynein) and ciliary cargoes, crucial for the formation and maintenance of the cilia, with anterograde IFT trains moving outwards from the ciliary base to deliver ciliary building blocks to the ciliary tip and retrograde IFT trains moving from the ciliary tip to the ciliary base to recycle the waste products. The overarching objective of this project is to grasp the connection between chemosensory function of cilia (initiating chemotaxis), IFT and ciliary length-regulation using single-molecule imaging techniques. In order to achieve this, (i) I will develop a multi-color and single-molecule imaging toolbox to study IFT in the phasmid chemosensory cilia of C. elegans. (ii) Using the toolbox, I will obtain a mechanistic understanding of turnaround dynamics of the IFT machinery (IFT motors and components of the IFT trains), during normal IFT. (iii) A comprehensive understanding of normal IFT will enable discovery of the subtle adjustments made by the IFT machinery, and its effect on the cilia length, in response to chemical cues in the external environment. Ultimately, the goal is to understand how organism level tactic response is interlinked with intracellular transport in the ciliary antennas of individual cells, using C. elegans as a model system.

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The information about "MINGLEIFT" are provided by the European Opendata Portal: CORDIS opendata.

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