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SUPD SIGNED

Sizing Up PD: Cavity-enhanced Characterisation of Single Biomarkers in Human Biofluids

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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Project "SUPD" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE 

Organization address
address: TRINITY LANE THE OLD SCHOOLS
city: CAMBRIDGE
postcode: CB2 1TN
website: www.cam.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 289˙732 €
 EC max contribution 289˙732 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-GF
 Starting year 2020
 Duration (year-month-day) from 2020-10-01   to  2023-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) coordinator 289˙732.00
2    THE BOARD OF REGENTS OF THE UNIVERSITY OF WISCONSIN SYSTEM US (MADISON WI) partner 0.00

Map

 Project objective

Parkinson’s disease is the most common movement disorder caused by neurodegeneration, for which there is no cure, no way of modifying the disease and no clinically accepted diagnostic tool. In the brain, the intrinsically disordered monomeric protein α-synuclein misfolds, aggregates and accumulates to form proteinaceous inclusions termed Lewy bodies. This process forms ‘oligomers’, intermediates in the aggregation pathway that are strongly implicated in the cellular toxicity that causes the disease. Oligomers are exceedingly challenging to study with traditional biophysical techniques because of their low abundance and variability in size, structure and stability. My research proposal aims to develop a new method capable of measuring the size and structural properties of single oligomers in human cerebral spinal fluid. By employing technologies in the field of cavity-enhanced spectroscopy and combining these with existing tools in single-molecule fluorescence I will investigate how the properties of oligomers in cerebral spinal fluid differ between healthy and Parkinson’s disease patients. In order to determine the molecular origins of Parkinson’s disease we need a comprehensive understanding of these pathogenic species. Achieving this goal will enable us to develop an early diagnostic tool which in turn will generate opportunities for therapeutic intervention.

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The information about "SUPD" are provided by the European Opendata Portal: CORDIS opendata.

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lastchecktime (2022-08-18 4:18:44) correctly updated