Explore the words cloud of the LongPlaNet project. It provides you a very rough idea of what is the project "LongPlaNet" about.
The following table provides information about the project.
Coordinator |
INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE
Organization address contact info |
Coordinator Country | France [FR] |
Total cost | 184˙707 € |
EC max contribution | 184˙707 € (100%) |
Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
Code Call | H2020-MSCA-IF-2018 |
Funding Scheme | MSCA-IF-EF-ST |
Starting year | 2019 |
Duration (year-month-day) | from 2019-10-01 to 2021-09-30 |
Take a look of project's partnership.
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1 | INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE | FR (PARIS) | coordinator | 184˙707.00 |
Brain plasticity is well studied in the developing and early life, but how experiences can reshape the brain during adulthood is still poorly understood. Non-invasive medical imaging techniques point to the existence of broad functional readjustments in adult brain networks. However, a good understanding of the biological underpinnings of this phenomenon is lacking. Deciphering the nature of adult brain structural readjustments may lead to a breakthrough in our understanding of the mechanisms underlying many psychiatric and neurodegenerative disorders, and potentially lead to therapeutic alternatives for these highly prevalent diseases in a globally aging population. LongPlaNet seeks to study the dynamics of long-range projections in the adult brain. To reach this goal I will use an array of cutting-edge techniques allowing me to study WHOLE BRAIN CONNECTIVITY at a CELLULAR RESOLUTION in the context of ADULT BEHAVING MICE. I will start from a preliminary list I generated of candidate brain regions undergoing plastic readjustments following long-term sensory deprivation in the mouse. I will quantify using 3D whole brain imaging by light-sheet microscopy the structural changes of connectivity between these regions. I will then use RNA-seq and bioinformatic tools to find markers of neuronal plasticity. Finally, I will track by in vivo calcium imaging with two-photon microscopy the evolution of the receptor fields of neurons affected by plastic remodeling. The present action will pioneer the intersection of molecular, structural and functional characterization of a well known but poorly understood phenomenon of adult reorganization of neuronal networks.
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The information about "LONGPLANET" are provided by the European Opendata Portal: CORDIS opendata.
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