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LongPlaNet SIGNED

Long-Range Plasticity of Neuronal Networks in the Adult Brain

Total Cost €

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EC-Contrib. €

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Partnership

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Project "LongPlaNet" data sheet

The following table provides information about the project.

Coordinator
INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE 

Organization address
address: BOULEVARD DE L'HOPITAL 47
city: PARIS
postcode: 75013
website: http://icm-institute.org/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 184˙707 €
 EC max contribution 184˙707 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2021-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE FR (PARIS) coordinator 184˙707.00

Map

 Project objective

Brain plasticity is well studied in the developing and early life, but how experiences can reshape the brain during adulthood is still poorly understood. Non-invasive medical imaging techniques point to the existence of broad functional readjustments in adult brain networks. However, a good understanding of the biological underpinnings of this phenomenon is lacking. Deciphering the nature of adult brain structural readjustments may lead to a breakthrough in our understanding of the mechanisms underlying many psychiatric and neurodegenerative disorders, and potentially lead to therapeutic alternatives for these highly prevalent diseases in a globally aging population. LongPlaNet seeks to study the dynamics of long-range projections in the adult brain. To reach this goal I will use an array of cutting-edge techniques allowing me to study WHOLE BRAIN CONNECTIVITY at a CELLULAR RESOLUTION in the context of ADULT BEHAVING MICE. I will start from a preliminary list I generated of candidate brain regions undergoing plastic readjustments following long-term sensory deprivation in the mouse. I will quantify using 3D whole brain imaging by light-sheet microscopy the structural changes of connectivity between these regions. I will then use RNA-seq and bioinformatic tools to find markers of neuronal plasticity. Finally, I will track by in vivo calcium imaging with two-photon microscopy the evolution of the receptor fields of neurons affected by plastic remodeling. The present action will pioneer the intersection of molecular, structural and functional characterization of a well known but poorly understood phenomenon of adult reorganization of neuronal networks.

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The information about "LONGPLANET" are provided by the European Opendata Portal: CORDIS opendata.

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