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PIANISM SIGNED

Prefrontal Cortex Circuit Dynamics underlying Working Memory and its Serotonin Modulation

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EC-Contrib. €

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 PIANISM project word cloud

Explore the words cloud of the PIANISM project. It provides you a very rough idea of what is the project "PIANISM" about.

memory    raphe    ve    plan    alterations    cognitive    currents    mechanism    dependent    neurons    dysfunctional    ionic    intracellular    sodium    optical    pfc    circuits    signalling    coupled    experiments    regulation    dysfunctions    deficiencies    gabaergic    persistent    therapeutic    schizophrenia    maintenance    firing    acute    genetically    clamp    chronic    calcium    underlying    pyramidal    examine    5ht    fulfill    transmission    deficits    modulation    cell    mice    networks    optogenetically    electrophysiology    mental    outlasts    learning    mechanistic    serotonin    protein    disorders    na    encoded    mediated    indicators    deficiency    synaptic    supports    understand    initial    iuml    sensitive    action    sustained    subtypes    sst    slices    experimental    projected    patch    intrinsic    cellular    wm    inward    decision    poorly    deficient    gain    voltage    data    prefrontal    enabled    serotonergic    causing    drive    excitatory    axons    modulated    link    impaired    vip    pv    types    density    imaging    cells    pharmacologically    perform    model    ketamine    express    neuronal    receptor    nuclei    trpc    cortex    mechanisms   

Project "PIANISM" data sheet

The following table provides information about the project.

Coordinator		 IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE 

Organization address
address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD
city: LONDON
postcode: SW7 2AZ
website: http://www.imperial.ac.uk/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country United Kingdom [UK]
 Total cost 212˙933 €
 EC max contribution 212˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-05-01   to  2022-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE UK (LONDON) coordinator 212˙933.00

Map

 Project objective

The prefrontal cortex (PFC) is essential for higher cognitive tasks such as learning, decision making and, in particular, working memory (WM). To fulfill these tasks, PFC neurons express several serotonin (5HT) receptor subtypes that are modulated by a high density of serotonergic axons projected from the raphe nuclei. Alterations of the neuronal mechanisms within PFC lead to an impaired top-down regulation, causing cognitive dysfunctions in mental disorders such as schizophrenia. A key cellular mechanism related to WM formation and maintenance in the PFC is sustained action potential firing of neurons that outlasts the initial excitatory drive. Persistent firing is likely enabled by synaptic networks and intracellular ionic mechanisms, including voltage sensitive sodium and calcium inward currents or G-Protein-coupled receptor mediated TRPC/ CAN currents. Moreover, experimental data supports a link between dysfunctional serotonergic modulation in the PFC and WM deficits, but yet, the underlying mechanisms are poorly understood. Here, I plan to gain a mechanistic understanding of the serotonergic modulation of WM at the cellular level including the link between 5HT receptor activity and prefrontal cellular circuits dependent WM formation and the role of 5HT in WM-related persistent firing. I will perform patch-clamp electrophysiology and optical voltage imaging (genetically encoded voltage indicators) of prefrontal pyramidal and GABAergic cells (PV-, SST-, VIP-subtypes) in acute slices from naïve and WM deficient mice (chronic ketamine model of schizophrenia), and examine how the activity of these cell types are modulated by optogenetically and pharmacologically controlled 5HT signalling. These experiments aim to understand the serotonergic transmission and intrinsic properties within the PFC involved in WM formation, maintenance and deficiency. Better understanding of these mechanisms will help to develop new and specific therapeutic targets for WM deficiencies.

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The information about "PIANISM" are provided by the European Opendata Portal: CORDIS opendata.

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