Opendata, web and dolomites

POL2-TERM SIGNED

Structural basis of co-transcriptional pre-mRNA 3’-end processing

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

Project "POL2-TERM" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: MUENCHEN
postcode: 80539
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 162˙806 €
 EC max contribution 162˙806 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2022-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) coordinator 162˙806.00

Map

 Project objective

RNAs transcribed by RNA polymerase II (Pol II) undergo numerous modifications before becoming export competent mature mRNA. One key step is the addition of the poly-adenine (poly-A) tail, which involves cleavage of the pre-mRNA from the growing RNA chain and the subsequent polyadenylation by poly-A polymerase. This cascade of events is known collectively as 3’-end processing and is one of the least understood steps of mRNA biogenesis. Pol II plays a vital role in recruiting and assembling the 3’-end processing machinery onto the nascent RNA, but the structural basis of transcription-coupled 3’-RNA processing is yet to be elucidated. This project aims to bring together the fields of transcription and 3’-end processing in order to understand how poly-A tails are added onto pre-mRNA in the context of actively transcribing Pol II. The most advanced methods of protein expression in recombinant systems as well as the extraction of complexes from native source will be coupled with state-of-the-art electron microscopy analysis to determine the structural basis of co-transcriptional 3’-end processing. Complementary biophysical methods will be used to map macromolecular interactions, and biochemical assays will be conducted to measure the impact of mutations introduced to characterize this fundamental biological process. The goal of this work is to provide the mechanistic basis for this essential step in mRNA biogenesis, and to understand human diseases that are resulted from aberrations in RNA production and processing.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "POL2-TERM" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "POL2-TERM" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

NaWaTL (2020)

Narrative, Writing, and the Teotihuacan Language: Exploring Language History Through Phylogenetics, Epigraphy and Iconography

Read More  

TOPOCIRCUS (2019)

Simulations of Topological Phases in Superconducting Circuits

Read More  

MingleIFT (2020)

Multi-color and single-molecule fluorescence imaging of intraflagellar transport in the phasmid chemosensory cilia of C. Elegans

Read More