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ASTRALIS SIGNED

ASTRocyte Adrenoceptors: Light on Intracellular Signaling

Total Cost €

0

EC-Contrib. €

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Partnership

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 ASTRALIS project word cloud

Explore the words cloud of the ASTRALIS project. It provides you a very rough idea of what is the project "ASTRALIS" about.

radically    function    neuromodulators    inputs    technologies    signal    compartmentalization    proposes    relevance    silent    significance    downstream    understudied    neuronal    intracellular    complexity    elucidating    receptors    exposed    clarifying    monitoring    release    dimension    cellular    cells    optical    light    naturally    astrocytes    components    gpcrs    fibers    disorders    activation    subcellular    astrocytic    neglect    disregarded    models    shed    strategies    vitro    largely    host    signals    brain    signaling    network    conceive    governed    electrically    extrinsically    releasing    contribution    spatiotemporal    proteins    understand    dynamics    dissect    coupled    outgoing    simultaneously    ne    pathophysiology    messengers    therapeutic    interconnected    ing    protein    probe    afferent    outputs    incoming    heterogeneity    adrenoceptors    circuit    combine    intrinsically    patterns    noradrenergic    lab    receptor    norepinephrine    holes    spatiotemporally    astralis    vivo   

Project "ASTRALIS" data sheet

The following table provides information about the project.

Coordinator
MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC) 

Organization address
address: ROBERT ROSSLE STRASSE 10
city: BERLIN
postcode: 13125
website: www.mdc-berlin.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 264˙669 €
 EC max contribution 264˙669 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-GF
 Starting year 2019
 Duration (year-month-day) from 2019-07-30   to  2022-07-29

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC) DE (BERLIN) coordinator 264˙669.00
2    THE REGENTS OF THE UNIVERSITY OF CALIFORNIA US (OAKLAND CA) partner 0.00

Map

 Project objective

ASTRALIS proposes all-optical strategies to shed light on holes in our understanding of how intracellular signaling complexity, downstream of specific G protein-coupled receptors (GPCRs), is generated in the brain. We focus on the understudied cells of the brain, astrocytes, which are highly interconnected but electrically silent, and signal through GPCRs and second messengers in response to norepinephrine (NE). We use them as models to study whether intracellular signaling in vivo is governed extrinsically, by noradrenergic afferent fibers releasing neuromodulators in defined spatiotemporal patterns –and therefore by receptor-specific activation dynamics– or rather intrinsically, by compartmentalization of cellular components, resulting in spatiotemporally different signaling outputs. During the outgoing phase, I will use advanced optical approaches to: (1) measure the spatiotemporal dimension of NE release in vivo, and (2) characterize the cellular and subcellular heterogeneity of astrocytic signals in response to NE in vitro and their relevance to the circuit, by simultaneously monitoring astrocytic and neuronal activity. During the incoming phase, I will (3) combine knowledge generated within the outgoing phase about in vivo noradrenergic signaling with the optical technologies developed by the host lab, in order to dissect the contribution of receptor dynamics to the spatiotemporally defined signaling of adrenoceptors. Significance: Current strategies to study intracellular signaling downstream of GPCRs widely neglect the spatiotemporal component of the inputs to which receptors are exposed naturally. Clarifying these aspects of receptor function would radically change the way we probe and study these proteins. In addition, elucidating the largely disregarded contribution of astrocytes in noradrenergic signaling at the cellular and network level will help understand the pathophysiology of related disorders and conceive better therapeutic strategies.

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The information about "ASTRALIS" are provided by the European Opendata Portal: CORDIS opendata.

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