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ASTRALIS SIGNED

ASTRocyte Adrenoceptors: Light on Intracellular Signaling

Total Cost €

0

EC-Contrib. €

0

Partnership

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 ASTRALIS project word cloud

Explore the words cloud of the ASTRALIS project. It provides you a very rough idea of what is the project "ASTRALIS" about.

messengers    brain    light    naturally    vitro    signal    silent    noradrenergic    dynamics    intracellular    holes    incoming    disregarded    norepinephrine    function    governed    complexity    components    models    ne    pathophysiology    subcellular    coupled    combine    conceive    protein    releasing    lab    astralis    spatiotemporal    astrocytes    elucidating    probe    release    proposes    network    largely    spatiotemporally    interconnected    cells    outgoing    intrinsically    patterns    therapeutic    monitoring    astrocytic    activation    signaling    receptor    adrenoceptors    radically    fibers    heterogeneity    electrically    significance    understand    contribution    disorders    cellular    circuit    optical    receptors    compartmentalization    outputs    relevance    vivo    simultaneously    technologies    downstream    gpcrs    dissect    neuromodulators    neglect    ing    clarifying    afferent    dimension    exposed    understudied    host    shed    extrinsically    proteins    neuronal    signals    inputs    strategies   

Project "ASTRALIS" data sheet

The following table provides information about the project.

Coordinator
MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC) 

Organization address
address: ROBERT ROSSLE STRASSE 10
city: BERLIN
postcode: 13125
website: www.mdc-berlin.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 264˙669 €
 EC max contribution 264˙669 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-GF
 Starting year 2019
 Duration (year-month-day) from 2019-07-30   to  2022-07-29

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC) DE (BERLIN) coordinator 264˙669.00
2    THE REGENTS OF THE UNIVERSITY OF CALIFORNIA US (OAKLAND CA) partner 0.00

Map

 Project objective

ASTRALIS proposes all-optical strategies to shed light on holes in our understanding of how intracellular signaling complexity, downstream of specific G protein-coupled receptors (GPCRs), is generated in the brain. We focus on the understudied cells of the brain, astrocytes, which are highly interconnected but electrically silent, and signal through GPCRs and second messengers in response to norepinephrine (NE). We use them as models to study whether intracellular signaling in vivo is governed extrinsically, by noradrenergic afferent fibers releasing neuromodulators in defined spatiotemporal patterns –and therefore by receptor-specific activation dynamics– or rather intrinsically, by compartmentalization of cellular components, resulting in spatiotemporally different signaling outputs. During the outgoing phase, I will use advanced optical approaches to: (1) measure the spatiotemporal dimension of NE release in vivo, and (2) characterize the cellular and subcellular heterogeneity of astrocytic signals in response to NE in vitro and their relevance to the circuit, by simultaneously monitoring astrocytic and neuronal activity. During the incoming phase, I will (3) combine knowledge generated within the outgoing phase about in vivo noradrenergic signaling with the optical technologies developed by the host lab, in order to dissect the contribution of receptor dynamics to the spatiotemporally defined signaling of adrenoceptors. Significance: Current strategies to study intracellular signaling downstream of GPCRs widely neglect the spatiotemporal component of the inputs to which receptors are exposed naturally. Clarifying these aspects of receptor function would radically change the way we probe and study these proteins. In addition, elucidating the largely disregarded contribution of astrocytes in noradrenergic signaling at the cellular and network level will help understand the pathophysiology of related disorders and conceive better therapeutic strategies.

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The information about "ASTRALIS" are provided by the European Opendata Portal: CORDIS opendata.

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