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ASTRALIS SIGNED

ASTRocyte Adrenoceptors: Light on Intracellular Signaling

Total Cost €

0

EC-Contrib. €

0

Partnership

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 ASTRALIS project word cloud

Explore the words cloud of the ASTRALIS project. It provides you a very rough idea of what is the project "ASTRALIS" about.

ne    activation    monitoring    afferent    understand    holes    astralis    compartmentalization    neuronal    outputs    electrically    circuit    gpcrs    combine    brain    extrinsically    proteins    signaling    disorders    largely    exposed    radically    models    neuromodulators    optical    patterns    pathophysiology    dissect    network    dimension    noradrenergic    messengers    astrocytic    clarifying    host    technologies    protein    signal    interconnected    intracellular    spatiotemporal    downstream    astrocytes    receptors    norepinephrine    heterogeneity    therapeutic    cellular    outgoing    contribution    neglect    release    conceive    simultaneously    adrenoceptors    naturally    strategies    coupled    fibers    vitro    signals    components    vivo    understudied    probe    releasing    spatiotemporally    cells    dynamics    subcellular    elucidating    function    light    inputs    ing    disregarded    significance    incoming    shed    proposes    lab    intrinsically    governed    complexity    silent    relevance    receptor   

Project "ASTRALIS" data sheet

The following table provides information about the project.

Coordinator
MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC) 

Organization address
address: ROBERT ROSSLE STRASSE 10
city: BERLIN
postcode: 13125
website: www.mdc-berlin.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 264˙669 €
 EC max contribution 264˙669 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-GF
 Starting year 2019
 Duration (year-month-day) from 2019-07-30   to  2022-07-29

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC) DE (BERLIN) coordinator 264˙669.00
2    THE REGENTS OF THE UNIVERSITY OF CALIFORNIA US (OAKLAND CA) partner 0.00

Map

 Project objective

ASTRALIS proposes all-optical strategies to shed light on holes in our understanding of how intracellular signaling complexity, downstream of specific G protein-coupled receptors (GPCRs), is generated in the brain. We focus on the understudied cells of the brain, astrocytes, which are highly interconnected but electrically silent, and signal through GPCRs and second messengers in response to norepinephrine (NE). We use them as models to study whether intracellular signaling in vivo is governed extrinsically, by noradrenergic afferent fibers releasing neuromodulators in defined spatiotemporal patterns –and therefore by receptor-specific activation dynamics– or rather intrinsically, by compartmentalization of cellular components, resulting in spatiotemporally different signaling outputs. During the outgoing phase, I will use advanced optical approaches to: (1) measure the spatiotemporal dimension of NE release in vivo, and (2) characterize the cellular and subcellular heterogeneity of astrocytic signals in response to NE in vitro and their relevance to the circuit, by simultaneously monitoring astrocytic and neuronal activity. During the incoming phase, I will (3) combine knowledge generated within the outgoing phase about in vivo noradrenergic signaling with the optical technologies developed by the host lab, in order to dissect the contribution of receptor dynamics to the spatiotemporally defined signaling of adrenoceptors. Significance: Current strategies to study intracellular signaling downstream of GPCRs widely neglect the spatiotemporal component of the inputs to which receptors are exposed naturally. Clarifying these aspects of receptor function would radically change the way we probe and study these proteins. In addition, elucidating the largely disregarded contribution of astrocytes in noradrenergic signaling at the cellular and network level will help understand the pathophysiology of related disorders and conceive better therapeutic strategies.

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The information about "ASTRALIS" are provided by the European Opendata Portal: CORDIS opendata.

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