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FUSION SIGNED

Single Molecule Imaging-based design of HIV-1 vaccines

Total Cost €

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EC-Contrib. €

0

Partnership

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 FUSION project word cloud

Explore the words cloud of the FUSION project. It provides you a very rough idea of what is the project "FUSION" about.

fusion    mode    visualized    3d    drugs    multiplex    antibody    fluctuation    avenues    co    few    living    decipher    standard    tropism    identification    combinations    host    hope    tracking    microscopy    desig    disrupt    deeper    oligomeric    mechanism    neutralizing    receptors    quantified    characterizing    emerged    big    edge    ccr5    re    bnabs    last    functional    world    stoichiometry    drug    imaging    ascertain    precise    class    perturb    applies    radically    vaccine    aid    simultaneously    technologies    light    recognition    readouts    insights    transmission    molecule    single    particles    laboratory    experiments    cxcr4    cd4    virus    nanometre    time    circulating    antibodies    putative    systematically    surface    cutting    unveil    polyclonal    fluorescence    strains    cell    dimensional    cells    spectroscopy    receptor    neutralize    molecular    families    action    reaction    smlm    resolved    combining    rational    absence    localization    hiv    gold    macrophages    interactions    discovered    group    block    mechanistic    env    conserved   

Project "FUSION" data sheet

The following table provides information about the project.

Coordinator
KING'S COLLEGE LONDON 

Organization address
address: STRAND
city: LONDON
postcode: WC2R 2LS
website: www.kcl.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 2˙280˙390 €
 EC max contribution 2˙280˙390 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-COG
 Funding Scheme ERC-COG
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2025-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KING'S COLLEGE LONDON UK (LONDON) coordinator 2˙280˙390.00

Map

 Project objective

The HIV-1 vaccine research has re-emerged in the last few years due to the identification of antibodies that neutralize most HIV-1 circulating strains. A deeper understanding of the mechanistic mode of target recognition for these antibodies represents a big hope in the field. This project aims at understanding and characterizing polyclonal antibody responses to aid rational vaccine design via radically new technologies on light microscopy. The molecular mechanism of time-resolved HIV-1 fusion will be visualized and quantified on the surface of living cells by combining real-time single virus tracking, fluorescence fluctuation spectroscopy and 3D single molecule localization microscopy (SMLM) imaging. The implementation of a new technology that allows three-dimensional nanometre localization of single particles will allow us to multiplex single molecule experiments with functional readouts for single-virus HIV-1 fusion simultaneously. Here, I will systematically establish the mechanism of action of different families of neutralizing antibodies and how they disrupt the three-step HIV fusion reaction, conserved among different HIV tropism, recently discovered by our group. I will unveil the molecular insights on the precise Env-induced, time-resolved stoichiometry of CD4 and co-receptors (CCR5 or CXCR4) in the presence and absence of different combinations of bNAbs and study their impact on HIV transmission. FUSION will open new avenues to design putative drugs that target host-specific receptor and co-receptor oligomeric states to block HIV-1 fusion. This project systematically applies cutting-edge time-resolved imaging approaches as a gold standard to ascertain how different combinations of bNAbs perturb the HIV fusion mechanism in CD4 T cells and macrophages. I will establish a world-class laboratory in HIV-1 and single molecule microscopy. I will decipher several key virus–host cell interactions at molecular level and contribute to rational vaccine and drug desig

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The information about "FUSION" are provided by the European Opendata Portal: CORDIS opendata.

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