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FUSION SIGNED

Single Molecule Imaging-based design of HIV-1 vaccines

Total Cost €

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EC-Contrib. €

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Partnership

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 FUSION project word cloud

Explore the words cloud of the FUSION project. It provides you a very rough idea of what is the project "FUSION" about.

rational    avenues    putative    dimensional    nanometre    discovered    fusion    spectroscopy    absence    edge    mode    standard    mechanism    molecule    action    characterizing    cells    tracking    insights    antibody    multiplex    world    hope    laboratory    resolved    mechanistic    host    deeper    neutralize    drugs    receptor    particles    identification    light    combining    recognition    fluorescence    circulating    cutting    drug    neutralizing    receptors    readouts    reaction    fluctuation    block    strains    3d    ascertain    virus    precise    polyclonal    conserved    experiments    hiv    systematically    quantified    gold    cell    localization    imaging    vaccine    emerged    ccr5    desig    macrophages    decipher    simultaneously    applies    antibodies    cxcr4    transmission    microscopy    radically    bnabs    re    smlm    single    living    families    class    combinations    stoichiometry    big    molecular    surface    technologies    few    tropism    env    functional    group    disrupt    time    cd4    unveil    co    perturb    aid    oligomeric    interactions    visualized    last   

Project "FUSION" data sheet

The following table provides information about the project.

Coordinator
KING'S COLLEGE LONDON 

Organization address
address: STRAND
city: LONDON
postcode: WC2R 2LS
website: www.kcl.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 2˙280˙390 €
 EC max contribution 2˙280˙390 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-COG
 Funding Scheme ERC-COG
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2025-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KING'S COLLEGE LONDON UK (LONDON) coordinator 2˙280˙390.00

Map

 Project objective

The HIV-1 vaccine research has re-emerged in the last few years due to the identification of antibodies that neutralize most HIV-1 circulating strains. A deeper understanding of the mechanistic mode of target recognition for these antibodies represents a big hope in the field. This project aims at understanding and characterizing polyclonal antibody responses to aid rational vaccine design via radically new technologies on light microscopy. The molecular mechanism of time-resolved HIV-1 fusion will be visualized and quantified on the surface of living cells by combining real-time single virus tracking, fluorescence fluctuation spectroscopy and 3D single molecule localization microscopy (SMLM) imaging. The implementation of a new technology that allows three-dimensional nanometre localization of single particles will allow us to multiplex single molecule experiments with functional readouts for single-virus HIV-1 fusion simultaneously. Here, I will systematically establish the mechanism of action of different families of neutralizing antibodies and how they disrupt the three-step HIV fusion reaction, conserved among different HIV tropism, recently discovered by our group. I will unveil the molecular insights on the precise Env-induced, time-resolved stoichiometry of CD4 and co-receptors (CCR5 or CXCR4) in the presence and absence of different combinations of bNAbs and study their impact on HIV transmission. FUSION will open new avenues to design putative drugs that target host-specific receptor and co-receptor oligomeric states to block HIV-1 fusion. This project systematically applies cutting-edge time-resolved imaging approaches as a gold standard to ascertain how different combinations of bNAbs perturb the HIV fusion mechanism in CD4 T cells and macrophages. I will establish a world-class laboratory in HIV-1 and single molecule microscopy. I will decipher several key virus–host cell interactions at molecular level and contribute to rational vaccine and drug desig

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The information about "FUSION" are provided by the European Opendata Portal: CORDIS opendata.

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