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FUSION SIGNED

Single Molecule Imaging-based design of HIV-1 vaccines

Total Cost €

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EC-Contrib. €

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Partnership

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 FUSION project word cloud

Explore the words cloud of the FUSION project. It provides you a very rough idea of what is the project "FUSION" about.

putative    living    combinations    rational    identification    env    families    molecule    bnabs    applies    action    emerged    surface    disrupt    polyclonal    resolved    insights    edge    transmission    recognition    neutralize    characterizing    3d    antibody    experiments    cells    ccr5    strains    antibodies    light    class    hiv    circulating    standard    conserved    dimensional    combining    fusion    mode    functional    drug    group    unveil    microscopy    tracking    last    vaccine    cd4    readouts    fluorescence    visualized    aid    single    virus    absence    block    reaction    technologies    simultaneously    receptors    macrophages    big    imaging    perturb    re    localization    receptor    smlm    gold    host    decipher    mechanism    drugs    systematically    avenues    multiplex    world    hope    quantified    laboratory    stoichiometry    neutralizing    deeper    ascertain    time    discovered    desig    cxcr4    molecular    nanometre    tropism    fluctuation    particles    mechanistic    precise    spectroscopy    oligomeric    cell    radically    co    few    cutting    interactions   

Project "FUSION" data sheet

The following table provides information about the project.

Coordinator		 KING'S COLLEGE LONDON 

Organization address
address: STRAND
city: LONDON
postcode: WC2R 2LS
website: www.kcl.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
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 Coordinator Country United Kingdom [UK]
 Total cost 2˙280˙390 €
 EC max contribution 2˙280˙390 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-COG
 Funding Scheme ERC-COG
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2025-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KING'S COLLEGE LONDON UK (LONDON) coordinator 2˙280˙390.00

Map

 Project objective

The HIV-1 vaccine research has re-emerged in the last few years due to the identification of antibodies that neutralize most HIV-1 circulating strains. A deeper understanding of the mechanistic mode of target recognition for these antibodies represents a big hope in the field. This project aims at understanding and characterizing polyclonal antibody responses to aid rational vaccine design via radically new technologies on light microscopy. The molecular mechanism of time-resolved HIV-1 fusion will be visualized and quantified on the surface of living cells by combining real-time single virus tracking, fluorescence fluctuation spectroscopy and 3D single molecule localization microscopy (SMLM) imaging. The implementation of a new technology that allows three-dimensional nanometre localization of single particles will allow us to multiplex single molecule experiments with functional readouts for single-virus HIV-1 fusion simultaneously. Here, I will systematically establish the mechanism of action of different families of neutralizing antibodies and how they disrupt the three-step HIV fusion reaction, conserved among different HIV tropism, recently discovered by our group. I will unveil the molecular insights on the precise Env-induced, time-resolved stoichiometry of CD4 and co-receptors (CCR5 or CXCR4) in the presence and absence of different combinations of bNAbs and study their impact on HIV transmission. FUSION will open new avenues to design putative drugs that target host-specific receptor and co-receptor oligomeric states to block HIV-1 fusion. This project systematically applies cutting-edge time-resolved imaging approaches as a gold standard to ascertain how different combinations of bNAbs perturb the HIV fusion mechanism in CD4 T cells and macrophages. I will establish a world-class laboratory in HIV-1 and single molecule microscopy. I will decipher several key virus–host cell interactions at molecular level and contribute to rational vaccine and drug desig

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The information about "FUSION" are provided by the European Opendata Portal: CORDIS opendata.

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