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CiliaCircuits SIGNED

Molecular Principles of Mammalian Axonemal Dynein Assembly

Total Cost €

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EC-Contrib. €

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Partnership

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 CiliaCircuits project word cloud

Explore the words cloud of the CiliaCircuits project. It provides you a very rough idea of what is the project "CiliaCircuits" about.

regulation    dynamic    induction    motility    cytoplasm    human    surplus    expenditure    circuitry    nature    assembly    motors    specialized    transcriptional    millions    feedback    motile    genes    dyneins    molecular    create    additional    projections    molecules    fraction    proposes    super    implicated    toxic    underlying    translational    poses    trafficked    ciliacircuits    resolution    stoichiometry    candidate    subsequent    almost    powered    hundreds    construction    streamlined    time    unexplored    ciliogenesis    translation    sizeable    risk    differentiation    regulating    machinery    complexes    cellular    health    allocation    microtubule    tiny    global    code    primary    understand    movement    adaptive    action    enough    cells    tells    futile    aggregation    ciliary    proteome    dyskinesia    exists    space    question    dynein    correct    dynamics    biology    assembled    date    genetics    logic    cilia    disease    coordinated    macromolecular    exist    flow    pcd    vision    responsive    mechanisms    prevent    therapeutics    cure    subunits    fluid    extreme    elucidate    crowded    cell    pose    axonemal   

Project "CiliaCircuits" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF EDINBURGH 

Organization address
address: OLD COLLEGE, SOUTH BRIDGE
city: EDINBURGH
postcode: EH8 9YL
website: www.ed.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙965˙459 €
 EC max contribution 1˙965˙459 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-COG
 Funding Scheme ERC-COG
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2025-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF EDINBURGH UK (EDINBURGH) coordinator 1˙965˙459.00

Map

 Project objective

Motile cilia are tiny microtubule-based projections which create fluid flow and are essential to human health. Cilia movement is powered by coordinated action of complex macromolecular motors, the axonemal dyneins. During differentiation, as cells produce hundreds of motile cilia, millions of dynein subunits must be pre-assembled in the cytoplasm into very large complexes in the correct stoichiometry which are then trafficked into growing cilia. This poses a sizeable challenge for the cell in terms of allocation of a significant fraction of the global translational machinery for streamlined assembly of dyneins within a crowded cellular space.

The key question remains: How does the cell know how much is enough? This is an extreme example of a common problem in cell biology. Responsive and adaptive mechanisms must exist to prevent futile expenditure of cellular resources in making a surplus of large molecules like dyneins that may also pose a risk of toxic aggregation. While a well-defined transcriptional code for induction of cilia motility genes exists, the translational dynamics and subsequent feedback circuitry coordinating dynein pre-assembly with ciliogenesis remain unexplored.

The molecular logic underlying the construction of motile cilia assembly are still not fully understood. The ambitious nature of CiliaCircuits proposes to use super-resolution and systems approaches to elucidate key mechanisms regulating this process in health and disease.

Human genetics tells us that making cilia motile is a complex process. To date, almost 40 genes have been implicated in primary ciliary dyskinesia (PCD), the disease of motile cilia, for which there is no cure. The long-term vision is to understand this dynamic control operating over a specialized proteome in time and space in order to develop effective PCD therapeutics and identify additional candidate genes involved in this translation regulation.

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The information about "CILIACIRCUITS" are provided by the European Opendata Portal: CORDIS opendata.

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