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CiliaCircuits SIGNED

Molecular Principles of Mammalian Axonemal Dynein Assembly

Total Cost €


EC-Contrib. €






 CiliaCircuits project word cloud

Explore the words cloud of the CiliaCircuits project. It provides you a very rough idea of what is the project "CiliaCircuits" about.

pose    exist    fraction    question    proposes    understand    induction    motility    aggregation    expenditure    assembled    translation    complexes    action    movement    unexplored    subunits    ciliary    stoichiometry    therapeutics    underlying    elucidate    super    additional    extreme    genetics    dynamic    poses    motile    implicated    coordinated    molecules    toxic    cells    nature    dynamics    regulation    global    trafficked    regulating    biology    dyneins    assembly    fluid    pcd    disease    ciliogenesis    adaptive    molecular    mechanisms    specialized    flow    enough    correct    streamlined    risk    subsequent    responsive    millions    logic    exists    translational    prevent    cure    create    resolution    date    genes    proteome    human    almost    candidate    dynein    primary    sizeable    transcriptional    cytoplasm    construction    feedback    vision    tells    cilia    differentiation    macromolecular    code    futile    circuitry    cell    axonemal    projections    powered    tiny    surplus    dyskinesia    hundreds    ciliacircuits    time    cellular    microtubule    allocation    crowded    space    health    machinery    motors   

Project "CiliaCircuits" data sheet

The following table provides information about the project.


Organization address
postcode: EH8 9YL

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙965˙459 €
 EC max contribution 1˙965˙459 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-COG
 Funding Scheme ERC-COG
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2025-03-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF EDINBURGH UK (EDINBURGH) coordinator 1˙965˙459.00


 Project objective

Motile cilia are tiny microtubule-based projections which create fluid flow and are essential to human health. Cilia movement is powered by coordinated action of complex macromolecular motors, the axonemal dyneins. During differentiation, as cells produce hundreds of motile cilia, millions of dynein subunits must be pre-assembled in the cytoplasm into very large complexes in the correct stoichiometry which are then trafficked into growing cilia. This poses a sizeable challenge for the cell in terms of allocation of a significant fraction of the global translational machinery for streamlined assembly of dyneins within a crowded cellular space.

The key question remains: How does the cell know how much is enough? This is an extreme example of a common problem in cell biology. Responsive and adaptive mechanisms must exist to prevent futile expenditure of cellular resources in making a surplus of large molecules like dyneins that may also pose a risk of toxic aggregation. While a well-defined transcriptional code for induction of cilia motility genes exists, the translational dynamics and subsequent feedback circuitry coordinating dynein pre-assembly with ciliogenesis remain unexplored.

The molecular logic underlying the construction of motile cilia assembly are still not fully understood. The ambitious nature of CiliaCircuits proposes to use super-resolution and systems approaches to elucidate key mechanisms regulating this process in health and disease.

Human genetics tells us that making cilia motile is a complex process. To date, almost 40 genes have been implicated in primary ciliary dyskinesia (PCD), the disease of motile cilia, for which there is no cure. The long-term vision is to understand this dynamic control operating over a specialized proteome in time and space in order to develop effective PCD therapeutics and identify additional candidate genes involved in this translation regulation.

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The information about "CILIACIRCUITS" are provided by the European Opendata Portal: CORDIS opendata.

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