PROCARDIO

Cardiovascular Risk from Exposure to Low-dose and Low-dose-rate Ionizing Radiation

 Coordinatore HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH 

 Organization address address: Ingolstaedter Landstrasse 1
city: MUENCHEN
postcode: 85764

contact info
Titolo: Dr.
Nome: Jürgen
Cognome: Ertel
Email: send email
Telefono: +49 89 3187 3022

 Nazionalità Coordinatore Germany [DE]
 Totale costo 5˙489˙075 €
 EC contributo 2˙998˙386 €
 Programma FP7-EURATOM-FISSION
EURATOM: Nuclear fission and radiation protection
 Code Call FP7-Fission-2011
 Funding Scheme CP-FP
 Anno di inizio 2011
 Periodo (anno-mese-giorno) 2011-10-01   -   2015-03-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH

 Organization address address: Ingolstaedter Landstrasse 1
city: MUENCHEN
postcode: 85764

contact info
Titolo: Dr.
Nome: Jürgen
Cognome: Ertel
Email: send email
Telefono: +49 89 3187 3022

DE (MUENCHEN) coordinator 679˙796.00
2    THE UNIVERSITY OF BIRMINGHAM

 Organization address address: Edgbaston
city: BIRMINGHAM
postcode: B15 2TT

contact info
Titolo: Ms.
Nome: May
Cognome: Chung
Email: send email
Telefono: 441214000000
Fax: 441214000000

UK (BIRMINGHAM) participant 330˙000.00
3    INSTITUT GUSTAVE ROUSSY

 Organization address address: Rue Camille Desmoulins 39
city: VILLEJUIF
postcode: 94805

contact info
Titolo: Mr.
Nome: Arnauld
Cognome: Forest
Email: send email
Telefono: +33 1 42 11 66 04
Fax: +33 1 42 11 61 50

FR (VILLEJUIF) participant 269˙560.00
4    GSI HELMHOLTZZENTRUM FUER SCHWERIONENFORSCHUNG GMBH

 Organization address address: PLANCKSTRASSE 1
city: DARMSTADT
postcode: 64291

contact info
Titolo: Ms.
Nome: Doris
Cognome: Scholz
Email: send email
Telefono: 496160000000
Fax: 496160000000

DE (DARMSTADT) participant 240˙000.00
5    STUDIECENTRUM VOOR KERNENERGIE

 Organization address address: Herrmann Debrouxlaan 40
city: Brussel
postcode: 1160

contact info
Titolo: Dr.
Nome: Nathalie
Cognome: Impens
Email: send email
Telefono: +32 14332845
Fax: +32 14314793

BE (Brussel) participant 231˙200.00
6    GABO:MI GESELLSCHAFT FUR ABLAUFORGANISATION:MILLIARIUM MBH & CO KG GAB O

 Organization address address: Oskar-von-Miller-Ring 29
city: MUENCHEN
postcode: 80333

contact info
Titolo: Ms.
Nome: Birgit
Cognome: Fuchs
Email: send email
Telefono: +49 89 28 81 04 14
Fax: +49 89 28 81 04 20

DE (MUENCHEN) participant 229˙999.60
7    FUNDACIO CENTRE DE RECERCA EN EPIDEMIOLOGIA AMBIENTAL - CREAL

 Organization address address: Calle Doctor Aiguader 88
city: BARCELONA
postcode: 8003

contact info
Titolo: Ms.
Nome: Joana
Cognome: Porcel
Email: send email
Telefono: +34 93 214 73 49
Fax: +34 93 214 73 02

ES (BARCELONA) participant 218˙800.00
8    Southern Urals Biophysics Institute

 Organization address address: Ozyorskoe shosse 19
city: Ozyorsk
postcode: 456780

contact info
Titolo: Dr.
Nome: Tamara
Cognome: Azizova
Email: send email
Telefono: +7 35130 29373
Fax: +7 35130 29190

RU (Ozyorsk) participant 200˙000.00
9    AGENZIA NAZIONALE PER LE NUOVE TECNOLOGIE,L'ENERGIA E LO SVILUPPO ECONOMICO SOSTENIBILE

 Organization address address: Lungotevere Grande Ammiraglio Thaon di Revel 76
city: ROMA
postcode: 196

contact info
Titolo: Dr.
Nome: Anna
Cognome: Saran
Email: send email
Telefono: 390630000000
Fax: 390630000000

IT (ROMA) participant 184˙995.00
10    RIJKSINSTITUUT VOOR VOLKSGEZONDHEIDEN MILIEU*NATIONAL INSTITUTEFOR PUBLIC HEALTH AND THE ENVIRONMENTEN

 Organization address address: Antonie Van Leeuwenhoeklaan 9
city: BILTHOVEN
postcode: 3721 MA

contact info
Titolo: Dr.
Nome: Thedo
Cognome: Blijdenstein
Email: send email
Telefono: +31 30 2743066
Fax: +31 30 2744428

NL (BILTHOVEN) participant 154˙998.00
11    Department of Health

 Organization address address: Quarry House, Quarry Hill
city: Leeds
postcode: LS2 7UE

contact info
Titolo: Mrs.
Nome: Anne
Cognome: Dempsey
Email: send email
Telefono: +44 1235 825433

UK (Leeds) participant 102˙699.96
12    Academisch Medisch Centrum bij de Universiteit van Amsterdam

 Organization address address: MEIBERGDREEF 9
city: AMSTERDAM
postcode: 1105AZ

contact info
Titolo: Dr.
Nome: Leontien
Cognome: Kremer
Email: send email
Telefono: +31 20 566 9111

NL (AMSTERDAM) participant 80˙000.00
13    HEALTH PROTECTION AGENCY HPA

 Organization address address: Central Office - 7th Floor, Holborn Gate - High Holborn 330
city: LONDON
postcode: WC1V 7PP

contact info
Titolo: Ms.
Nome: Anne
Cognome: Dempsey
Email: send email
Telefono: +44 1235 824856
Fax: +44 1235 833891

UK (LONDON) participant 76˙338.04

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

link    dose    molecular    models    data    vessels    proteomics    doses    lack    epidemiological    exposure    radiation    above    disease    mathematical    irradiation    mgy    evidence    heart    cardiovascular   

 Obiettivo del progetto (Objective)

'Epidemiological evidence has established a link between cardiovascular disease and exposure of the heart and major vessels to doses above 500mGy. At lower doses the evidence for a detrimental effect is inconclusive. In part, this is due to the lack of appropriate epidemiological studies, coupled with lack of knowledge of the processes involved that is needed for construction of mathematical models. The ProCardio consortium will study cardiovascular outcomes in childhood cancer survivors where the radiation doses given to the heart are available. These data will be interrogated using new mathematical models developed from the data from our molecular and biological studies. These will use state-of-the-art technologies to map cardiovascular changes after photon irradiation at both low doses and low dose rates. This will be complemented by comparative studies using high LET irradiation. We will apply an integrative approach to combine transcriptional (mRNA and miRNA) and translational (proteomics) studies to understand the disease processes. High throughput proteomics (ICPL, SILAC and label-free analysis) will be used to identify new biomarkers of radiation-induced cardiovascular disease for future molecular epidemiological studies. These will be validated using the archives of cardiovascular tissue samples from the Mayak facility.'

Introduzione (Teaser)

Epidemiological evidence has established a link between cardiovascular disease (CVD) and radiation exposure of the heart and major vessels to doses above 500 milligray (mGy). A new approach for epidemiological data processing is necessary to evaluate the effects of low-dose radiation.

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