ANDANTE
Multidisciplinary evaluation of the cancer risk from neutrons relative to photons using stem cells and the induction of second malignant neoplasms following paediatric radiation therapy
| Coordinatore | UNIVERSITA DEGLI STUDI DI PAVIA
Organization address
address: STRADA NUOVA 65 contact info |
| Nazionalità Coordinatore | Italy [IT] |
| Totale costo | 4˙465˙913 € |
| EC contributo | 3˙000˙000 € |
| Programma | FP7-EURATOM-FISSION
EURATOM: Nuclear fission and radiation protection |
| Code Call | FP7-Fission-2011 |
| Funding Scheme | CP-FP |
| Anno di inizio | 2012 |
| Periodo (anno-mese-giorno) | 2012-01-01 - 2015-12-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
UNIVERSITA DEGLI STUDI DI PAVIA
Organization address
address: STRADA NUOVA 65 contact info |
IT (PAVIA) | coordinator | 940˙000.00 |
| 2 |
ACADEMISCH ZIEKENHUIS GRONINGEN
Organization address
address: Hanzeplein 1 contact info |
NL (GRONINGEN) | participant | 605˙000.00 |
| 3 |
UNIVERSITAET ROSTOCK
Organization address
address: UNIVERSITATSPLATZ 1 contact info |
DE (ROSTOCK) | participant | 575˙000.00 |
| 4 |
PAUL SCHERRER INSTITUT
Organization address
address: Villigen contact info |
CH (VILLIGEN PSI) | participant | 350˙000.00 |
| 5 |
BUNDESAMT FUER STRAHLENSCHUTZ
Organization address
address: Willy-Brandt-Strasse 5 contact info |
DE (SALZGITTER) | participant | 150˙000.00 |
| 6 |
CHALMERS TEKNISKA HOEGSKOLA AB
Organization address
address: - contact info |
SE (GOETEBORG) | participant | 142˙884.00 |
| 7 |
LOMA LINDA UNIVERSITY
Organization address
city: LOMA LINDA contact info |
US (LOMA LINDA) | participant | 120˙000.00 |
| 8 |
EUROPEAN SOCIETY FOR RADIOTHERAPY AND ONCOLOGY
Organization address
address: Avenue E Mounierlaan 83 contact info |
BE (BRUXELLES) | participant | 100˙000.00 |
| 9 |
TECHNISCHE UNIVERSITAET WIEN
Organization address
address: Karlsplatz 13 contact info |
AT (WIEN) | participant | 17˙116.00 |
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Obiettivo del progetto (Objective)
'The ANDANTE project will investigate the relative risk of neutrons compared to photons for tumorigenesis, as a function of dose and energy. The approach will be multidisciplinary, including physics measurements and modelling, molecular biology, radiobiology, and epidemiology. The relative risk of neutrons will be studied using human and animal stem cells irradiated with either photons or neutrons in vitro and analysed for early indicators of malignant transformations. Irradiated stem cells will be transplanted into mice to investigate progression into tumours. The experimental irradiation setup will be fully characterised and modelled in order to compare predicted molecular damage with biological results, following controlled irradiation with either photons or neutrons. A corresponding predictive model of the relative risk of cancer induction from photons or neutrons following paediatric radiotherapy will be developed and tested on clinical data, as a proof of principle, leading to a proposal for a prospective epidemiological study to validate the relative risk of neutrons on humans.'
Introduzione (Teaser)
Neutrons are generated as a by-product in high-energy photon beams or proton beams during radiotherapy. There is a growing concern about associated possible long-term risks to radiotherapy patients.
Descrizione progetto (Article)
The usual approach to risk assessment from neutrons uses Monte Carlo simulation to estimate normal tissue exposure. It uses risk factors and radiation factors for neutrons published by the International Commission on Radiological Protection (ICRP). However, the ICRP risk factors are approximations to be used for radiation protection guidelines, and not for individual risk estimates.
The EU-funded http://www.andanteproject.eu/ (ANDANTE) international project will use radiation physics, stem cell radiobiology, systems biology modelling, and epidemiology to estimate cancer risk from exposure to neutrons. The project focuses on salivary gland, thyroid gland, and breast cancers as secondary malignant neoplasms following paediatric photon radiotherapy.
Consortium partners selected and prepared facilities for irradiation experiments. Initially a broad spectrum, high-dose-rate neutron beam will be used to determine stem cell response to neutrons. Based on the results, a further series will be carried out using low-dose, narrow spectrum beams to determine the dependence of response on neutron energy. The Monte Carlo simulation toolkit will be used to model the neutron fields generated by therapeutic proton machines.
Methods for the isolation of stem cells for salivary gland, thyroid gland, and breast tissue have been successfully developed. They are based on the formation of spheroids (multicellular 3D structures) which can be used in non-adherent cultivation as cell suspensions. The results of initial exposures of stem cell samples are currently being analysed.
Epidemiological studies of the risk of secondary malignant neoplasms occurring after radiotherapy for primary malignant neoplasms during childhood have been reviewed. The assembled data and the strategies used in these studies represent a starting point for the design of future epidemiological research in paediatric proton therapy.
The ANDANTE project will have a direct impact on the understanding of long term risks of secondary cancers following exposure to neutrons during proton therapy. It is expected to produce results that are important for any area of radiation protection where neutrons are a factor. This includes the nuclear power industry, high energy medical linear accelerators, and long-haul air flights.