DEVELAGE

Pathways common to brain development and ageing: defining strategies for preventive therapy and diagnostics

 Coordinatore MEDIZINISCHE UNIVERSITAET WIEN 

 Organization address address: SPITALGASSE 23
city: WIEN
postcode: 1090

contact info
Titolo: Dr.
Nome: Gabor Geza
Cognome: Kovacs
Email: send email
Telefono: +43 1 404005504
Fax: +43 1 404005511

 Nazionalità Coordinatore Austria [AT]
 Sito del progetto http://www.develage.eu/
 Totale costo 3˙881˙830 €
 EC contributo 2˙994˙137 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2011-two-stage
 Funding Scheme CP-FP
 Anno di inizio 2012
 Periodo (anno-mese-giorno) 2012-01-01   -   2014-12-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    MEDIZINISCHE UNIVERSITAET WIEN

 Organization address address: SPITALGASSE 23
city: WIEN
postcode: 1090

contact info
Titolo: Dr.
Nome: Gabor Geza
Cognome: Kovacs
Email: send email
Telefono: +43 1 404005504
Fax: +43 1 404005511

AT (WIEN) coordinator 632˙040.00
2    UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA

 Organization address address: Piazzale Aldo Moro 5
city: ROMA
postcode: 185

contact info
Titolo: Prof.
Nome: Adriano
Cognome: Tocchi
Email: send email
Telefono: +39 06 49972162
Fax: +39 06 4957672

IT (ROMA) participant 404˙320.00
3    INSTITUT CATALA DE LA SALUT

 Organization address address: GRAN VIA DE LES CORTS CATALANES 587
city: BARCELONA
postcode: 8007

contact info
Titolo: Ms.
Nome: Laia
Cognome: Lagunas
Email: send email
Telefono: +34 932607109
Fax: +34 93 260 72 24

ES (BARCELONA) participant 348˙852.00
4    STIFTUNG TIERAERZTLICHE HOCHSCHULE HANNOVER

 Organization address address: BUNTEWEG 2
city: HANNOVER
postcode: 30559

contact info
Nome: Peter
Cognome: Joppe
Email: send email
Telefono: +49 511 953 8020
Fax: +49 511 953 828020

DE (HANNOVER) participant 342˙000.00
5    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

 Organization address address: 101 Rue de Tolbiac
city: PARIS
postcode: 75654

contact info
Titolo: Ms.
Nome: Isabelle
Cognome: Pires
Email: send email
Telefono: +33 1 43 62 27 16
Fax: +33 1 43 62 27 01

FR (PARIS) participant 337˙080.00
6    Academisch Medisch Centrum bij de Universiteit van Amsterdam

 Organization address address: MEIBERGDREEF 9
city: AMSTERDAM
postcode: 1105AZ

contact info
Titolo: Mrs.
Nome: Frank J.M.
Cognome: Groen
Email: send email
Telefono: +31 20 5663198

NL (AMSTERDAM) participant 333˙600.00
7    UNIVERSITE MONTPELLIER 2 SCIENCES ET TECHNIQUES

 Organization address address: PLACE EUGENE BATAILLON 2
city: MONTPELLIER
postcode: 34095

contact info
Titolo: Mr.
Nome: Jean-Michel
Cognome: Portefaix
Email: send email
Telefono: +33 4 67 14 49 71
Fax: +33 4 67 14 93 25

FR (MONTPELLIER) participant 327˙885.00
8    BIOLUTION GMBH

 Organization address address: Karl-Farkas-Gasse 22
city: WIEN
postcode: 1030

contact info
Titolo: Dr.
Nome: Iris
Cognome: Grünert
Email: send email
Telefono: +43 1 7869595
Fax: +43 1 7869595 20

AT (WIEN) participant 268˙360.00
9    FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE

 Organization address address: AVENIDA GRAN VIA HOSPITALET 199-203
city: L'HOSPITALET DE LLOBREGAT
postcode: 8908

contact info
Titolo: Ms.
Nome: Laia
Cognome: Lagunas
Email: send email
Telefono: +34 932607109
Fax: +34 93 260 72 24

ES (L'HOSPITALET DE LLOBREGAT) participant 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

related    develage    experimental    samples    proteins    alzheimer    disorders    developmental    humans    pathways    genes    age    brain    ageing    disease    ad    models    neurodegeneration    human    animal    molecular   

 Obiettivo del progetto (Objective)

'The increasing number of elderly people will have a major impact on the prevalence of age-related diseases, which will pose major challenges to keep health systems in Europe sustainable. Current knowledge is insufficient to identify the transition of normal brain ageing into Alzheimer`s Disease (AD)-like brain damage. Elucidation of the genes and pathways contributing to the earliest stages of AD pathology and associated neurodegeneration should be instrumental to allow intervention when the condition is still reversible. The aim of the DEVELAGE project is to characterise shared molecular pathways between early developmental processes in the brain and brain ageing. Our concept is based on the hypothesis that disorders of neural development contribute to age-related neurodegeneration, that developmentally essential proteins might have a role in neurodegeneration, and that neurodegeneration-related proteins and genes are important during the development of the brain. The DEVELAGE approach is unique in that it is brain tissue-based, derived from neuropathological diagnosis with detailed molecular analysis of the spectrum of developmental and ageing changes in the very same brain samples used for a comprehensive array of investigations in humans as well as in experimental models at genetic, epigenetic, transcription and protein levels. DEVELAGE contributes to the understanding of biological variation by examining relevant number of cases with different phases of ageing and neurodegeneration as well as developing brains with or without developmental disorders. Pathways examined in humans will be validated in animal models, including a non-human primate, and vice versa. The combination of human samples and animal models susceptible to experimental manipulation will promote the translation of clinically relevant data into experimentally testable predictions and promotes the exploitation of therapeutically relevant targets to reverse or halt disease progresssion.'

Introduzione (Teaser)

Understanding the process of ageing could provide solutions for many age-related problems, including neurodegenerative disorders. A European consortium is looking into the pathological aetiology of Alzheimer's disease (AD) by examining molecular mechanisms common during brain development and ageing.

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