MEDIGENE
Genetic and environmental factors of insulin resistance syndrome and its long-term complications in immigrant Mediterranean populations
| Coordinatore | UNIVERSITE DE MONTPELLIER
Organization address
address: 163 RUE AUGUSTE BROUSSONNET contact info |
| Nazionalità Coordinatore | France [FR] |
| Sito del progetto | http://www.medigene-fp7.eu/ |
| Totale costo | 4˙320˙349 € |
| EC contributo | 2˙996˙907 € |
| Programma | FP7-HEALTH
Specific Programme "Cooperation": Health |
| Code Call | FP7-HEALTH-2011-two-stage |
| Funding Scheme | CP-FP-SICA |
| Anno di inizio | 2012 |
| Periodo (anno-mese-giorno) | 2012-01-01 - 2015-12-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
UNIVERSITE DE MONTPELLIER
Organization address
address: 163 RUE AUGUSTE BROUSSONNET contact info |
FR (MONTPELLIER) | coordinator | 326˙427.00 |
| 2 |
UNIVERSITE MONTPELLIER I
Organization address
address: BOULEVARD HENRI IV 5 contact info |
FR (MONTPELLIER) | participant | 585˙402.00 |
| 3 |
CENTRO DE INVESTIGACION BIOMEDICA EN RED DE DIABETES Y ENFERMEDADES METABOLICAS
Organization address
address: Passeig de la Bonanova 69 - 6A planta contact info |
ES (Barcelona) | participant | 278˙733.00 |
| 4 |
INSTITUT PASTEUR DE TUNIS
Organization address
address: Place Pasteur 13 contact info |
TN (TUNIS) | participant | 203˙280.00 |
| 5 |
UNIVERSITY OF IOANNINA
Organization address
address: "LEOFOROS STAVROS S NIARCHOS, PANEPISTIMIOUPOLI IOANNINON" contact info |
EL (IOANNINA) | participant | 190˙800.00 |
| 6 |
ALMA MATER STUDIORUM-UNIVERSITA DI BOLOGNA
Organization address
address: Via Zamboni 33 contact info |
IT (BOLOGNA) | participant | 161˙940.00 |
| 7 |
UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA
Organization address
address: VIA ORAZIO RAIMONDO 18 contact info |
IT (ROMA) | participant | 150˙000.00 |
| 8 |
BIOCOMPUTING PLATFORMS LTD OY
Organization address
address: TEKNIIKANTIE 14 contact info |
FI (ESPOO) | participant | 133˙854.00 |
| 9 |
UNIVERSITATEA DE MEDICINA SI FARMACIE'CAROL DAVILA' DIN BUCURESTI
Organization address
address: Dionisie Lupu 37 contact info |
RO (BUCHAREST) | participant | 132˙614.00 |
| 10 |
FONDAZIONE CASA SOLLIEVO DELLA SOFFERENZA
Organization address
address: VIALE CAPPUCCINI SC contact info |
IT (SAN GIOVANNI ROTONDO FG) | participant | 114˙000.00 |
| 11 |
Nome Ente NON disponibile
Organization address
city: Tarragona contact info |
ES (Tarragona) | participant | 110˙940.00 |
| 12 |
UNIVERSITA DEGLI STUDI MAGNA GRAECIA DI CATANZARO
Organization address
address: VIALE EUROPA LOCALITA GERMANETO contact info |
IT (CATANZARO) | participant | 96˙912.00 |
| 13 |
"INSTITUTE OF BIOCHEMISTRY AND GENETICS, UFA SCIENTIFIC CENTRE OF RAS"
Organization address
address: Prospekt Oktyabrya 71 contact info |
RU (UFA) | participant | 87˙705.00 |
| 14 |
UNIVERSITE LYON 1 CLAUDE BERNARD
Organization address
address: BOULEVARD DU 11 NOVEMBRE 1918 NUM43 contact info |
FR (VILLEURBANNE CEDEX) | participant | 84˙000.00 |
| 15 |
Institut Pasteur Du Maroc
Organization address
address: Place Louis Pasteur 1 contact info |
MA (Casablanca) | participant | 81˙195.00 |
| 16 |
UNIVERSITE D'ALGER 1
Organization address
address: RUE DIDOUCHE MOURAD 02 contact info |
DZ (ALGER) | participant | 75˙750.00 |
| 17 |
ISTANBUL UNIVERSITESI
Organization address
address: ISTANBUL UNIVERSITESI CENTER CAMPUS BEYAZIT EMINONU contact info |
TR (ISTANBUL) | participant | 71˙635.00 |
| 18 |
Intactile SAS
Organization address
address: 20 RUE DU CARRE DU ROI contact info |
FR (MONTPELLIER) | participant | 50˙880.00 |
| 19 |
UNIVERSITETI I TIRANES
Organization address
address: BOULEVARD ZOGUI contact info |
AL (TIRANA) | participant | 45˙900.00 |
| 20 |
INSTITUT ZA ANTROPOLOGIJU
Organization address
address: LJUDEVITA GAJA 32 contact info |
HR (ZAGREB) | participant | 14˙940.00 |
| 21 |
CENTRO DE INVESTIGACION BIOMEDICA EN RED
Organization address
address: CALLE MONFORTE DE LEMOS 5 contact info |
ES (MADRID) | participant | 0.00 |
| 22 |
PERSONMED KFT
Organization address
address: MORA FERENC UTCA 50 1 EM contact info |
HU (PECS) | participant | 0.00 |
Mappa
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Obiettivo del progetto (Objective)
'MEDIGENE project will study genetic and environmental (G x E) determinants of the metabolic syndrome (MetS) in recent immigrants in Europe by a novel approach integrating ancestry of Mediterranean populations in epidemiology, locus refining and Genome Wide Association Studies (GWAS). West Mediterranean shores are place of pre-historical termini of population expansion from Southern Europe and North Africa. Archaeogenetic studies in Europe indicated that Y chromosome and mitochondrial DNA patterns or Ancestry Informative Markers (AIMs) revealed a close relationship between genetic and geographic distances able to locate an individual DNA within few hundred kilometers. The project will use this information in mapping the genetic basis of insulin resistance, cardiovascular and metabolic complications in immigrants (Albanians, Romanians, Turkish, Tunisians, Algerians and Morocco) in host countries France, Spain, Italy and Greece. Ancestry markers and studies on ancient DNA from Roman historical migration in Catalonia will help to give a better picture of the genetic landscape of Europe and North Africa. Genes for MetS will be studied in existing samples from host and home countries by GWAS, locus refining by next-generation sequencing and haplotype mapping. Informative filtered SNPs will be then used in epidemiology and novel DNA samples to reveal G x E interactions and specificities of the pathogenesis of MetS. Genetic findings will be replicated in home countries (Anatolia and North Africa) in the goal to develop markers ethnic specific and significant at a clinical scale. Major impact is expected from dissemination of our findings to prevent the occurrence of MetS and obesity in children and adolescents or in descendants of modern immigration, understanding variability clinical manifestations of MetS in the context of malnutrition and from the novel approach of GWAS strategies by ameliorating the association signal and bursting R&D activities of SMEs.'
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