EARLYNUTRITION

Long-term effects of early nutrition on later health

 Coordinatore LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN 

 Organization address address: GESCHWISTER SCHOLL PLATZ 1
city: MUENCHEN
postcode: 80539

contact info
Titolo: Prof.
Nome: Berthold
Cognome: Koletzko
Email: send email
Telefono: +49 89 5160 2826
Fax: +49 89 5160 4938

 Nazionalità Coordinatore Germany [DE]
 Sito del progetto http://www.project-earlynutrition.eu/
 Totale costo 11˙558˙996 €
 EC contributo 8˙962˙771 €
 Programma FP7-KBBE
Specific Programme "Cooperation": Food, Agriculture and Biotechnology
 Code Call FP7-KBBE-2011-5
 Funding Scheme CP-IP
 Anno di inizio 2012
 Periodo (anno-mese-giorno) 2012-02-01   -   2017-01-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN

 Organization address address: GESCHWISTER SCHOLL PLATZ 1
city: MUENCHEN
postcode: 80539

contact info
Titolo: Prof.
Nome: Berthold
Cognome: Koletzko
Email: send email
Telefono: +49 89 5160 2826
Fax: +49 89 5160 4938

DE (MUENCHEN) coordinator 2˙890˙610.21
2    KING'S COLLEGE LONDON

 Organization address address: Strand
city: LONDON
postcode: WC2R 2LS

contact info
Titolo: Prof.
Nome: Lucilla
Cognome: Poston
Email: send email
Telefono: +44 20 7188 3639

UK (LONDON) participant 1˙097˙153.00
3    UNIVERSITY OF SOUTHAMPTON

 Organization address address: Highfield
city: SOUTHAMPTON
postcode: SO17 1BJ

contact info
Titolo: Prof.
Nome: Keith
Cognome: Godfrey
Email: send email
Telefono: +44 2380777624
Fax: +44 2380704021

UK (SOUTHAMPTON) participant 977˙264.00
4    UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN

 Organization address address: BELFIELD
city: DUBLIN
postcode: 4

contact info
Titolo: Mr.
Nome: Donal
Cognome: Doolan
Email: send email
Telefono: +353 1 7161656
Fax: +353 1 7161216

IE (DUBLIN) participant 459˙720.00
5    Medizinische Universitaet Graz

 Organization address address: AUENBRUGGERPLATZ 2
city: GRAZ
postcode: 8036

contact info
Titolo: Prof.
Nome: Gernot
Cognome: Desoye
Email: send email
Telefono: 4331640000000
Fax: 4331640000000

AT (GRAZ) participant 388˙200.00
6    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE

 Organization address address: The Old Schools, Trinity Lane
city: CAMBRIDGE
postcode: CB2 1TN

contact info
Titolo: Ms.
Nome: Renata
Cognome: Schaeffer
Email: send email
Telefono: 441223000000

UK (CAMBRIDGE) participant 284˙100.00
7    ACADEMISCH ZIEKENHUIS LEIDEN

 Organization address address: Albinusdreef 2
city: LEIDEN
postcode: 2333 ZA

contact info
Titolo: Dr.
Nome: Maria Luisa
Cognome: Mearin Manrique
Email: send email
Telefono: +31 71 5262806
Fax: +31 71 5248198

NL (LEIDEN) participant 252˙120.00
8    MEDSCINET UK LTD

 Organization address address: WESTMINSTER BRIDGE ROAD ST THOMAS
city: LONDON
postcode: SE1 7EH

contact info
Titolo: Ms.
Nome: Svetlana
Cognome: Mikliajewa
Email: send email
Telefono: 447853000000

UK (LONDON) participant 234˙579.00
9 KOBENHAVNS UNIVERSITET DK participant 223˙698.74
10    STICHTING VU-VUMC

 Organization address address: DE BOELELAAN 1105
city: AMSTERDAM
postcode: 1081 HV

contact info
Nome: Michel
Cognome: Telkamp
Email: send email
Telefono: +31 20 4448190

NL (AMSTERDAM) participant 218˙642.00
11    UNIVERSIDAD DE GRANADA

 Organization address address: CUESTA DEL HOSPICIO SN
city: GRANADA
postcode: 18071

contact info
Titolo: Prof.
Nome: Cristina
Cognome: Campoy Folgoso
Email: send email
Telefono: +34 958 240740

ES (GRANADA) participant 202˙140.00
12    BIOLUTION GMBH

 Organization address address: Karl-Farkas-Gasse 22
city: WIEN
postcode: 1030

contact info
Titolo: Dr.
Nome: Iris
Cognome: Grünert
Email: send email
Telefono: 4317869595

AT (WIEN) participant 190˙016.80
13    STATENS SERUM INSTITUT

 Organization address address: ARTILLERIVEJ 5
city: KOBENHAVN S
postcode: 2300

contact info
Titolo: Prof.
Nome: Sjurdur Frodi
Cognome: Olsen
Email: send email
Telefono: +45 32 68 39 55

DK (KOBENHAVN S) participant 161˙400.00
14    UNIVERSIDAD DE MURCIA

 Organization address address: AVENIDA TENIENTE FLOMESTA S/N - EDIFICIO CONVALECENCIA
city: MURCIA
postcode: 30003

contact info
Titolo: Prof.
Nome: Elvira
Cognome: Larque Daza
Email: send email
Telefono: +34 868 884239
Fax: +34 868 883963

ES (MURCIA) participant 157˙098.00
15    NASJONALT FOLKEHELSEINSTITUTT

 Organization address address: Lovisenberggata 8
city: OSLO
postcode: 403

contact info
Titolo: Dr.
Nome: Frederik
Cognome: Frøen
Email: send email
Telefono: +47 21078194
Fax: +47 21078252

NO (OSLO) participant 150˙115.00
16    UNIVERSITAT ROVIRA I VIRGILI

 Organization address address: CARRER DE ESCORXADOR
city: TARRAGONA
postcode: 43003

contact info
Titolo: Prof.
Nome: Rosa
Cognome: Solà Alberich
Email: send email
Telefono: +39 977 55 88 31
Fax: 349778000000

ES (TARRAGONA) participant 147˙240.00
17    ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM

 Organization address address: 's Gravendijkwal 230
city: ROTTERDAM
postcode: 3015CE

contact info
Titolo: Dr.
Nome: Vincent
Cognome: Jaddoe
Email: send email
Telefono: +31 10 7043405

NL (ROTTERDAM) participant 139˙800.00
18    UNIVERSITY COLLEGE CORK, NATIONAL UNIVERSITY OF IRELAND, CORK

 Organization address address: Western Road
city: CORK
postcode: -

contact info
Titolo: Dr.
Nome: David
Cognome: O Connell
Email: send email
Telefono: +353 214903501
Fax: +353 214903506

IE (CORK) participant 131˙688.00
19    INSTYTUT POMNIK CENTRUM ZDROWIA DZIECKA

 Organization address address: Aleja Dzieci Polskich 20
city: WARSZAWA
postcode: 4730

contact info
Titolo: Dr.
Nome: Dariusz
Cognome: Gruszfeld
Email: send email
Telefono: +4822 815 17 94
Fax: +4822 815 17 85

PL (WARSZAWA) participant 118˙380.00
20    UNIVERSITA DEGLI STUDI DI MILANO

 Organization address address: Via Festa Del Perdono 7
city: MILANO
postcode: 20122

contact info
Titolo: Ms.
Nome: Giuseppina
Cognome: Castelli
Email: send email
Telefono: +39 0250323021

IT (MILANO) participant 111˙060.00
21    WARSZAWSKI UNIWERSYTET MEDYCZNY

 Organization address address: UL. ZWIRKI I WIGURY 61
city: WARSZAWA
postcode: 2091

contact info
Titolo: Ms.
Nome: Joanna
Cognome: Sobczak
Email: send email
Telefono: +48 22 57 20 469
Fax: +48 22 57 20 405

PL (WARSZAWA) participant 103˙300.00
22    ServiceXS BV

 Organization address address: Plesmanlaan 1.d
city: Leiden
postcode: 2333 BZ

contact info
Titolo: Prof.
Nome: Bart
Cognome: Janssen
Email: send email
Telefono: +31 71 5681018

NL (Leiden) participant 98˙400.00
23    CENTRE HOSPITALIER CHRETIEN ASBL

 Organization address address: RUE DE HESBAYE 75
city: LIEGE
postcode: 4000

contact info
Nome: Dominique
Cognome: Masson
Email: send email
Telefono: +32 4 224 80 31

BE (LIEGE) participant 74˙315.78
24    NIZO FOOD RESEARCH BV

 Organization address address: KERNHEMSEWEG 2
city: EDE GLD
postcode: 6718 ZB

contact info
Titolo: Dr.
Nome: Nel
Cognome: Zoon
Email: send email
Telefono: 31318659577
Fax: 31318650400

NL (EDE GLD) participant 63˙806.25
25    THE UNIVERSITY OF NOTTINGHAM

 Organization address address: University Park
city: NOTTINGHAM
postcode: NG7 2RD

contact info
Titolo: Mr.
Nome: Paul
Cognome: Cartledge
Email: send email
Telefono: +44 115 9515679

UK (NOTTINGHAM) participant 59˙520.00
26    NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS

 Organization address address: CHRISTOU LADA 6
city: ATHENS
postcode: 10561

contact info
Titolo: Ms.
Nome: Efi
Cognome: Kafentzi
Email: send email
Telefono: +30 210 3689201
Fax: +30 210 3689008

EL (ATHENS) participant 25˙680.00
27    UNIVERSITE LIBRE DE BRUXELLES

 Organization address address: Avenue Franklin Roosevelt 50
city: BRUXELLES
postcode: 1050

contact info
Titolo: Prof.
Nome: Philippe
Cognome: Goyens
Email: send email
Telefono: +32 2 4772571
Fax: +32 2 4772563

BE (BRUXELLES) participant 2˙724.22
28    ABBOTT LABORATORIES SA

 Organization address address: AVENIDA DE BURGOS 91
city: MADRIDE
postcode: 28050

contact info
Nome: Cristina
Cognome: Cazorla
Email: send email
Telefono: +34 958 248 652

ES (MADRIDE) participant 0.00
29    BENEO GMBH

 Organization address address: MAXIMILIANSTRAAT 10
city: MANNHEIM
postcode: 68165

contact info
Titolo: Ms.
Nome: Ines
Cognome: Holub
Email: send email
Telefono: +49 6359 803 528
Fax: +49 6359 803 153

DE (MANNHEIM) participant 0.00
30    CASE WESTERN RESERVE UNIVERSITY CORPORATION - CWRU

 Organization address address: EUCLIDE AVENUE 10900
city: CLEVELAND
postcode: 44106 7037

contact info
Titolo: Prof.
Nome: Sylvie
Cognome: Hauguel De Mouzon
Email: send email
Telefono: +1 216 778 3148

US (CLEVELAND) participant 0.00
31    DANONE RESEARCH BV

 Organization address address: Bosrandweg 20
city: UTRECHT
postcode: 6700 CA

contact info
Titolo: Mrs.
Nome: Eline
Cognome: Van Der Beek
Email: send email
Telefono: +65 6213 9020
Fax: +65 65 6213 9077

NL (UTRECHT) participant 0.00
32    HARVARD PILGRIM HEALTH CARE INC CORP

 Organization address address: WORCESTER STREET 93
city: WELLESLEY MA
postcode: 248110

contact info
Nome: Celeste
Cognome: Perkins
Email: send email
Telefono: +1 617 509 9968
Fax: +1 617 509 9853

US (WELLESLEY MA) participant 0.00
33    MURDOCH CHILDRENS RESEARCH INSTITUTE

 Organization address address: FLEMINGTON ROAD RCH
city: PARKVILLE
postcode: 3052

contact info
Titolo: Ms.
Nome: Julia
Cognome: Malone
Email: send email
Telefono: +61 03 8341 6211
Fax: +61 03 9348 1391

AU (PARKVILLE) participant 0.00
34    TELETHON INSTITUTE FOR CHILD HEALTH RESEARCH

 Organization address address: ROBERTS ROAD 100
city: SUBIACO
postcode: 6008

contact info
Titolo: Prof.
Nome: Wendy
Cognome: Oddy
Email: send email
Telefono: +61 8 9489 7879
Fax: +61 894897700

AU (SUBIACO) participant 0.00
35    THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

 Organization address address: "FRANKLIN STREET 1111, 12 FLOOR"
city: OAKLAND CA
postcode: 94607

contact info
Nome: Lauren Rachelle
Cognome: Ryan
Email: send email
Telefono: +1 949 824 0446
Fax: +1 949 824 2094

US (OAKLAND CA) participant 0.00
36    THE UNIVERSITY OF ADELAIDE

 Organization address address: NORTH TERRACE
city: ADELAIDE
postcode: 5005

contact info
Titolo: Dr.
Nome: Don
Cognome: Mcmaster
Email: send email
Telefono: +61 8 83033347
Fax: +61 8 83033700

AU (ADELAIDE) participant 0.00
37    THE UNIVERSITY OF TEXAS SYSTEM

 Organization address address: COLORADO STREET 601
city: AUSTIN
postcode: 78701 2982

contact info
Titolo: Mr.
Nome: Chris
Cognome: Green
Email: send email
Telefono: 12105672340
Fax: 12105672344

US (AUSTIN) participant 0.00
38    VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG

 Organization address address: De Boelelaan 1105
city: AMSTERDAM
postcode: 1081 HV

contact info
Titolo: Prof.
Nome: Hans
Cognome: Van Goudoever
Email: send email
Telefono: +31 20 4445393

NL (AMSTERDAM) participant 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

optimal    weight    mechanisms    adiposity    individuals    impact    earlynutrition    populations    http    evidence    maternal    practical    obese    expertise    epigenetics    international    before    offspring    placental    scientific    gain    cohorts    intervention    pregnant       lifestyle    programming    women    prevention    pregnancy    recommendations    ongoing    molecular    disorders    data    cohort    placentas    nutrition    obesity    young    analysed    groups    infants    levels    correlate    linked    children    breastfeeding    life    animal    hypothesis    dietary    childhood    later    metabolomics    human    risk    health    cellular   

 Obiettivo del progetto (Objective)

'Nutrition during early development has an important impact on later health, particularly through greater obesity risk, as demonstrated by FP6 EARNEST. EarlyNutrition explores the current key hypotheses on likely causes and pathways to prevention of early life origins of obesity (specifically adiposity) and associated disorders. We bring extraordinary expertise and study populations of 470,000 individuals to investigate: • The fuel mediated in utero hypothesis • The accelerated postnatal weight gain hypothesis • The mismatch hypothesis. Scientific and technical expertise in placental biology, epigenetics and metabolomics will provide understanding at the cellular and molecular level, and refined strategies for intervention in pregnancy and early post natal life to prevent obesity. Using existing cohort studies, ongoing and novel intervention studies and a basic science programme, we will provide the scientific foundations for evidence based recommendations for optimal EarlyNutrition that incorporate long-term health outcomes, focusing on 4 Target Groups: women before pregnancy; pregnant women; infants (incl. breastfeeding); young children. Evidence is produced from animal and placental studies (Theme 1; T1), prospective cohort studies (T2), and randomised controlled trials in pregnant women and infants (T3). T4 covers scientific strategic integration, recommendation development and dissemination, including systematic reviews and behaviour change approaches. A strong multi-disciplinary team of international leaders in the field including collaborators from USA and Australia achieves balance and complementarity. The project’s impact comprises definitive evidence on early nutrition effects on health, enhanced EU and global policies, major economic benefits through obesity prevention and value-added nutritional products, and practical recommendations on optimal nutrition in Target Groups. Wide dissemination will be achieved through active engagement with stakeholders.'

Introduzione (Teaser)

The adage 'we are what we eat' applies to our long-term health and well-being. Predisposition to obesity and metabolic disorders can be linked to diet and lifestyle right from our time in the womb.

Descrizione progetto (Article)

The current obesity epidemic is clearly only in part of genetic origin, but unfavourable changes in environment and lifestyle that cause obesity and associated disorders remain elusive. Nutrition during early years has an important impact on later health, and might correlate with obesity risk.

An ongoing 5-year EU-funded project, http://www.project-earlynutrition.eu/ (EARLYNUTRITION) (Long-term effects of early nutrition on later health), is investigating this correlation on a collection of several cohorts of 470 000 individuals. The study populations include women before pregnancy, pregnant women, infants and young children. Alongside epidemiological and interventional approaches, advanced methods of bioinformatics, epigenetics and metabolomics are providing information also at the cellular and molecular levels.

The project is analysing the mechanisms for early nutrition programming by following up on human cohorts in childhood, adolescence and adulthood as one of the focus areas. For instance, new evidence reveals that greater childhood adiposity is associated with maternal vitamin D insufficiency and with low levels of activity in children.

EARLYNUTRITION linked maternal dietary glycaemic load in early (but not late) pregnancy with childhood adiposity. Greater abdominal circumference gain during early infancy was found to correlate with higher childhood blood pressure. Currently analysed data from major cohorts will establish the long-term effects of maternal pregnancy weight gain, body composition and smoking on offspring adiposity/co-morbidities.

Data from animal models and placental samples are also being collected and analysed. Thus, in vitro studies in perfused placentas are providing insights into biological mechanisms of fatty acid transport. A difference in target gene expression in human and animal placentas from obese compared to lean mothers is analysed using a microarray approach. In rodents, maternal obesity is associated with abnormal glucose homeostasis. New data suggests maternal dietary and exercise interventions can favourably influence the phenotype of their offspring.

Current recommendations for pregnant and particularly obese women and for young children do not take into account the long-term health consequences of nutrition. EARLYNUTRITION is reviewing the evidence to optimise recommendations on nutrition before and during pregnancy, the breastfeeding period and childhood, with special reference to later health development. Current recommendations and latest research findings are furthermore translated into practical application by the http://www.early-nutrition.org/ENeA (Early Nutrition eAcademy), an e-learning platform conceptualized for the continuing medical education of international health care professionals. State of the art research in the field and project achievements will be presented at the second EarlyNutrition conference in October 2016, http://munich2016.project-earlynutrition.eu/ (The Power of Programming 2016).

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