HIPAD
"High-Density Peptide MicroArrays and high-throughput, label-free detection of peptides, modifications and interactions"
| Coordinatore | KOBENHAVNS UNIVERSITET
Organization address
postcode: 1017 contact info |
| Nazionalità Coordinatore | Denmark [DK] |
| Totale costo | 6˙382˙419 € |
| EC contributo | 4˙823˙014 € |
| Programma | FP7-HEALTH
Specific Programme "Cooperation": Health |
| Code Call | FP7-HEALTH-2011-two-stage |
| Funding Scheme | CP-FP |
| Anno di inizio | 2012 |
| Periodo (anno-mese-giorno) | 2012-01-01 - 2015-12-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 | KOBENHAVNS UNIVERSITET | DK | coordinator | 717˙609.90 |
| 2 |
SCHAFER -N APS
Organization address
address: KYSTVEJ 6 contact info |
DK (HUMLEBAEK) | participant | 1˙061˙166.80 |
| 3 |
PLASMORE SRL
Organization address
address: VIA G DELEDDA 4 contact info |
IT (RANCO VA) | participant | 697˙860.00 |
| 4 |
IMABIOTECH
Organization address
address: "CITE SCIENTIFIQUE BATIMENT SN 3, 1 ER ETAGE" contact info |
FR (VILLENEUVE D ASCQ) | participant | 658˙300.00 |
| 5 |
UNIVERSITY OF BATH
Organization address
address: CLAVERTON DOWN contact info |
UK (BATH) | participant | 444˙300.80 |
| 6 |
DANMARKS TEKNISKE UNIVERSITET
Organization address
address: Anker Engelundsvej 1, Building 101A contact info |
DK (KONGENS LYNGBY) | participant | 316˙547.25 |
| 7 |
JRC -JOINT RESEARCH CENTRE- EUROPEAN COMMISSION
Organization address
address: Rue de la Loi 200 contact info |
BE (BRUSSELS) | participant | 316˙510.80 |
| 8 |
THE UNIVERSITY OF MANCHESTER
Organization address
address: OXFORD ROAD contact info |
UK (MANCHESTER) | participant | 314˙070.00 |
| 9 |
BRUKER DALTONIK GMBH
Organization address
address: Fahrenheitstrasse 4 contact info |
DE (BREMEN) | participant | 148˙817.50 |
| 10 |
FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V
Organization address
address: Hansastrasse 27C contact info |
DE (MUENCHEN) | participant | 147˙831.00 |
Mappa
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Obiettivo del progetto (Objective)
'Proteins are extremely malleable building blocks of life involved in all aspects of biology. Many diseases are caused by proteins aberrations, and proteins are frequent targets of intervention. Mapping all proteins and their functions are expected to yield pervasive medical and biotechnological benefits. However, even the most comprehensive and high-throughput proteins discovery technologies are seriously challenged by the extreme diversity and low abundance of many proteome components; a problem, compounded by the lack of affinity reagents and validated probes for sample preparation and identification. Our concept is that shorter protein fragments, or peptides, may offer solutions to many of these problems as peptides may represent or mimic proteins. Using in situ solid-phase peptide synthesis, computerized photolithography and novel photochemistry, we have recently generated peptide microarrays of up to 2 million addressable peptides. This unprecedented high-density and high-content peptide microarray technology could make inroads into the kind of high-throughput analysis needed to address the entire human proteome. Here, we aim to exploit this potential by using and improving three different, yet complementary, label-free detection technologies allowing sensitive, high-resolution determinations of the identity, quality and/or modification of individual members of a peptide microarray, and real-time monitoring of any interacting molecular receptor. We will also develop peptides as rapid, specific, and renewable affinity reagents for complex sample preparation, and develop peptides as probes and complex biosensors. Three SME’s constitute the backbone of this collaboration, receiving 50% of the budget, and enjoying significant opportunities from the booming protein/peptide microarray market. Furthermore, solutions to these unmet needs of proteomics are believed to have incalculable benefits for European health, innovativeness and competiveness.'