UBSPECIFIC

Specificity in the ubiquitin system

 Coordinatore MEDICAL RESEARCH COUNCIL 

Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.

 Nazionalità Coordinatore United Kingdom [UK]
 Totale costo 1˙480˙285 €
 EC contributo 1˙480˙285 €
 Programma FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call ERC-2012-StG_20111109
 Funding Scheme ERC-SG
 Anno di inizio 2012
 Periodo (anno-mese-giorno) 2012-10-01   -   2017-09-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    MEDICAL RESEARCH COUNCIL

 Organization address address: NORTH STAR AVENUE POLARIS HOUSE
city: SWINDON
postcode: SN2 1FL

contact info
Titolo: Dr.
Nome: David
Cognome: Komander
Email: send email
Telefono: -403479
Fax: -413357

UK (SWINDON) hostInstitution 1˙480˙285.00
2    MEDICAL RESEARCH COUNCIL

 Organization address address: NORTH STAR AVENUE POLARIS HOUSE
city: SWINDON
postcode: SN2 1FL

contact info
Titolo: Mrs.
Nome: Samantha
Cognome: Skehel
Email: send email
Telefono: +44 122 340 2357

UK (SWINDON) hostInstitution 1˙480˙285.00

Mappa


 Word cloud

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binding    cells    otu    atypical    distinct    chains    linkage    functions    types    roles    reveal    ubiquitination    specificity    cellular    dubs    ubiquitin    chain   

 Obiettivo del progetto (Objective)

'Protein ubiquitination is an important posttranslational modification that regulates virtually all cellular processes. Its versatility arises from the ability of ubiquitin to form eight structurally and functionally distinct polymeric chains. It is clear that all chain types exist in cells. The two chain types that have been studied in detail have distinct, non-overlapping cellular functions. A lack of tools has hindered progress to define roles of the remaining ‘atypical’ ubiquitin chains. The objective of my laboratory is to understand specificity in the ubiquitin system, and to reveal the cellular roles of atypical ubiquitin chains. To achieve this aim, we have to define the cellular machineries that assemble atypical ubiquitin chains specifically (AIM 1). Our recent advances in enzymatic and chemical biology synthesis have made all chain types available, enabling structural and biophysical characterisation of all ubiquitin polymers (AIM 2). We will use the newly generated atypical ubiquitin chains to identify and characterise linkage-specific ubiquitin binding proteins, using mass-spectrometry. This will reveal the receptors of atypical chains in cells, as well as novel ubiquitin binding domains (AIM 3). Access to all linkage types further allows comprehensive analysis of specificity in the ubiquitin system for the first time. We recently discovered that the Ovarian Tumour (OTU) family of deubiquitinating enzymes (DUBs) comprises specific members for each linkage-type. OTU domain DUBs hence represent a great starting point to understand mechanism of linkage specificity and to define substrates modified with atypical chains in cells (AIM 4). Finally, studying cellular functions of linkage-specific OTU DUBs will uncover novel physiological roles of atypical chains (AIM 5). We are only beginning to understand the full potential of ubiquitin in cellular regulation. Our studies on atypical ubiquitination will contribute to these exciting emerging areas of research.'

Altri progetti dello stesso programma (FP7-IDEAS-ERC)

UBIQUITIN BALANCE (2010)

The balance of ubiquitin conjugation and deconjugation

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LUCIFER (2010)

Low-background Underground Cryogenic Installation For Elusive Rates

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SUBLRN (2013)

Information-optimal machine learning

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