ANGELab
A New GEnetic LABortatory for non-invasive prenatal diagnosis
| Coordinatore | IKERLAN S.COOP.
Organization address
address: Paseo J.M. Arizmendiarrieta 2 contact info |
| Nazionalità Coordinatore | Spain [ES] |
| Totale costo | 10˙955˙292 € |
| EC contributo | 8˙265˙938 € |
| Programma | FP7-ICT
Specific Programme "Cooperation": Information and communication technologies |
| Code Call | FP7-ICT-2011-8 |
| Funding Scheme | CP |
| Anno di inizio | 2012 |
| Periodo (anno-mese-giorno) | 2012-10-01 - 2016-09-30 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
IKERLAN S.COOP.
Organization address
address: Paseo J.M. Arizmendiarrieta 2 contact info |
ES (MONDRAGON) | coordinator | 0.00 |
| 2 |
ADEMTECH SA
Organization address
address: ALLEE DU DOYEN GEORGES BRUS contact info |
FR (PESSAC) | participant | 0.00 |
| 3 |
ASOCIACION INSTITUTO BIODONOSTIA
Organization address
address: Paseo Dr. Beguiristain contact info |
ES (DONOSTIA-SAN SEBASTIAN) | participant | 0.00 |
| 4 |
BIOPHARMA TECHNOLOGY LTD
Organization address
address: WINNALL VALLEY ROAD contact info |
UK (WINCHESTER) | participant | 0.00 |
| 5 |
Centrum fur Angewandte Nanotechnologie (CAN) GmbH
Organization address
address: Grindelallee contact info |
DE (Hamburg) | participant | 0.00 |
| 6 |
DNA DATA SLP
Organization address
address: PASEO MIRAMON contact info |
ES (SAN SEBASTIAN GUIPUZCOA) | participant | 0.00 |
| 7 |
EV GROUP E. THALLNER GMBH
Organization address
address: DI ERICH THALLNER STRASSE contact info |
AT (ST. FLORIAN AM INN) | participant | 0.00 |
| 8 |
FUNDACION GAIKER
Organization address
address: Parque Tecnologico de Zamudio, Edificio 202 contact info |
ES (ZAMUDIO) | participant | 0.00 |
| 9 |
FUNDACION RIOJA SALUD-FRS
Organization address
address: Av Viana 1 contact info |
ES (Logrono) | participant | 0.00 |
| 10 |
HAHN-SCHICKARD-GESELLSCHAFT FUER ANGEWANDTE FORSCHUNG E.v.
Organization address
address: WILHELM-SCHICKARD-STRASSE contact info |
DE (Villingen) | participant | 0.00 |
| 11 |
NIPD GENETICS LIMITED
Organization address
address: AERODROMIOU 6 AGIOS DOMETIOS contact info |
CY (LEFKOSIA) | participant | 0.00 |
| 12 |
POC MICROSOLUTIONS SL
Organization address
address: GOIRU contact info |
ES (MONDRAGON) | participant | 0.00 |
| 13 |
POLITECHNIKA WROCLAWSKA
Organization address
address: WYBRZEZE WYSPIANSKIEGO 27 contact info |
PL (WROCLAW) | participant | 0.00 |
| 14 |
Servicio Vasco de Salud Osakidetza
Organization address
address: Alava contact info |
ES (Vitoria-Gasteiz) | participant | 0.00 |
| 15 |
THE CYPRUS FOUNDATION FOR MUSCULAR DYSTROPHY RESEARCH
Organization address
address: International Airport Avenue contact info |
CY (AYIOS DOMETIOS) | participant | 0.00 |
Mappa
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Obiettivo del progetto (Objective)
This project will develop a family of In-Vitro Diagnostic Systems that will transfer for the first time novel Non Invasive Prenatal Diagnostic (NIPD) methods in tube to a LabonaChip format. This family will consist of three research systems chosen to cover all prenatal diagnosis models:n- ANGELAB1. This system will use a LabonaChip to extract fetal DNA from the mother´s plasma based on differences in methylated pattern between fetus and mother and captured by specific magnetophoresis, plus qPCR for monogenic diseases with a known mutation for: Spinal Muscular Atrophy, Cystic Fibrosis (CF), and X-linked disorders. It will be used only for high risk population.n- ANGELAB2. It will use a LabonaChip to carry out immunoprecipitation (MeDIP) for fetal DNA extraction from mother´s blood and real time quantitative Polymerase Chain Reaction (real time qPCR) for Aneuploidies of chromosomes 13, 18, 21, X and Y. It will be used for population screening purposes.n- ANGELAB3. This system will use the DNA sample provided from ANGELAB1 or ANGELAB2 and it will carry out Digital PCR on a LabonaChip to detect: CF (unknown multiple mutations), b-thalassemia and achondroplasia. I will be used for population screening purposes.nAll systems can manage 8 samples at a time. They can be modularly assembled to themselves, offering a system adaptable to different throughput needs.nThe consortium will also develop and integrate a LabonaChip Pilot Production Line (LPPL):n- LPPL: This pilot line setup will provide a sustainable and economic LabonChip manufacturing. Materials, processes, and their life cycle will be considered. The environmental assessment will be carried out following ISO 14044. Quality control tools will be integrated along the entire production chain of LabonaChips.nThis project will end with the implementation of these three diagnostic systems as pilot routines in two Hospitals through a technical validation of 700 pregnancies.