BESTAGEING

Biomarker Research Alliance for Diagnosing Heart Disease in the Ageing European Population

 Coordinatore UNIVERSITAETSKLINIKUM HEIDELBERG 

 Organization address address: IM NEUENHEIMER FELD 672
city: HEIDELBERG
postcode: 69120

contact info
Titolo: Mr.
Nome: Thomas
Cognome: Eisenhauer
Email: send email
Telefono: +49 6221 567324
Fax: +49 6221 565460

 Nazionalità Coordinatore Germany [DE]
 Totale costo 15˙184˙316 €
 EC contributo 10˙906˙368 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2012-INNOVATION-1
 Funding Scheme CP-IP
 Anno di inizio 2013
 Periodo (anno-mese-giorno) 2013-02-01   -   2017-01-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    UNIVERSITAETSKLINIKUM HEIDELBERG

 Organization address address: IM NEUENHEIMER FELD 672
city: HEIDELBERG
postcode: 69120

contact info
Titolo: Mr.
Nome: Thomas
Cognome: Eisenhauer
Email: send email
Telefono: +49 6221 567324
Fax: +49 6221 565460

DE (HEIDELBERG) coordinator 1˙730˙400.00
2    COMPREHENSIVE BIOMARKER CENTER GMBH

 Organization address address: IM NEUENHEIMER FELD 519
city: HEIDELBERG
postcode: 69120

contact info
Titolo: Dr.
Nome: Markus
Cognome: Beier
Email: send email
Telefono: +49 6221 6510 300
Fax: +49 6221 6510 329

DE (HEIDELBERG) participant 1˙872˙492.00
3    ACS BIOMARKER BV

 Organization address address: OXFORDLAAN 70
city: MAASTRICHT
postcode: 6229 EV

contact info
Titolo: Mr.
Nome: Guido
Cognome: Maertens
Email: send email
Telefono: +31 6 17 50 23 38

NL (MAASTRICHT) participant 1˙391˙200.00
4    METANOMICS GMBH

 Organization address address: TEGELER WEG 33
city: BERLIN
postcode: 10589

contact info
Titolo: Mrs.
Nome: Astrid
Cognome: Giese
Email: send email
Telefono: +49 30 34807104
Fax: +49 30 34807 300

DE (BERLIN) participant 783˙600.00
5    SIEMENS AKTIENGESELLSCHAFT

 Organization address address: Wittelsbacherplatz 2
city: MUNCHEN
postcode: 80333

contact info
Titolo: Mr.
Nome: Hans-Reiner
Cognome: Leikard
Email: send email
Telefono: +49 89 636 43651
Fax: +49 89 636 48322

DE (MUNCHEN) participant 683˙576.00
6    Academisch Medisch Centrum bij de Universiteit van Amsterdam

 Organization address address: MEIBERGDREEF 9
city: AMSTERDAM
postcode: 1105AZ

contact info
Titolo: Mrs.
Nome: Merel-Marlijn
Cognome: Sondervan
Email: send email
Telefono: +31 20 5666188

NL (AMSTERDAM) participant 534˙400.00
7    TARTU ULIKOOL

 Organization address address: ULIKOOLI 18
city: TARTU
postcode: 50090

contact info
Nome: Merike
Cognome: Leego
Email: send email
Telefono: +375 375 030

EE (TARTU) participant 531˙400.00
8    UNIVERSITAET DES SAARLANDES

 Organization address address: CAMPUS
city: SAARBRUECKEN
postcode: 66041

contact info
Nome: Melanie
Cognome: Paulus
Email: send email
Telefono: +49 681 95 92 3375
Fax: +49 681 95 92 3370

DE (SAARBRUECKEN) participant 453˙600.00
9    UPPSALA UNIVERSITET

 Organization address address: SANKT OLOFSGATAN 10 B
city: UPPSALA
postcode: 751 05

contact info
Titolo: Prof.
Nome: Bertil
Cognome: Lindahl
Email: send email
Telefono: +46 18 611 9505
Fax: +46 18 515570

SE (UPPSALA) participant 420˙400.00
10    MULTIPLICOM NV

 Organization address address: GALILEILAAN 18
city: NIEL
postcode: 2845

contact info
Titolo: Mr.
Nome: Luc
Cognome: Lammens
Email: send email
Telefono: +32 3 771 50 78
Fax: +32 3 401 72 18

BE (NIEL) participant 402˙400.00
11    JOHANN WOLFGANG GOETHE UNIVERSITAET FRANKFURT AM MAIN

 Organization address address: GRUNEBURGPLATZ 1
city: FRANKFURT AM MAIN
postcode: 60323

contact info
Titolo: Mrs.
Nome: Kristina
Cognome: Wege
Email: send email
Telefono: +49 69 798 25198
Fax: +49 69 798 25007

DE (FRANKFURT AM MAIN) participant 396˙400.00
12    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

 Organization address address: 101 Rue de Tolbiac
city: PARIS
postcode: 75654

contact info
Titolo: Mrs.
Nome: Isabelle
Cognome: Verdier
Email: send email
Telefono: +33 1 48 07 34 33
Fax: +33 1 48 07 34 26

FR (PARIS) participant 366˙400.00
13    Health in Code SL

 Organization address city: A CORUNA
postcode: 15006

contact info
Titolo: Mrs.
Nome: Angeles
Cognome: Gestal Lopez
Email: send email
Telefono: +34 881 600003
Fax: +34 981 167093

ES (A CORUNA) participant 295˙200.00
14    UNIVERSITA DEGLI STUDI DI PADOVA

 Organization address address: VIA 8 FEBBRAIO 2
city: PADOVA
postcode: 35122

contact info
Titolo: Dr.
Nome: Paola
Cognome: De Devitiis
Email: send email
Telefono: +39 049 8218652
Fax: +39 049 8218292

IT (PADOVA) participant 288˙000.00
15    NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS

 Organization address address: CHRISTOU LADA 6
city: ATHENS
postcode: 10561

contact info
Titolo: Mrs.
Nome: Efstathia
Cognome: Kafentzi
Email: send email
Telefono: +30 210 3689201
Fax: +30 210 3689008

EL (ATHENS) participant 162˙000.00
16    STATE INSTITUTION NATIONAL SCIENTIFIC CENTER INSTITUTE OF CARDIOLOGY NAMED AFTER ACADEMICIAN M. D. STRAZHESKO NATIONAL ACADEMY MEDICAL SCIENCES OF UKRAINE

 Organization address address: NARODNOGO OPOLCHENIA STREET 5
city: KYIV
postcode: 3151

contact info
Titolo: Mrs.
Nome: Irina
Cognome: Guseva
Email: send email
Telefono: +38 044 2756622
Fax: +38 044 2754209

UA (KYIV) participant 156˙000.00
17    AZIENDA COMPLESSO OSPEDALIERO SAN FILIPPO NERI*

 Organization address address: PIAZZA S MARIA DELLA PIETA 5
city: ROMA
postcode: 135

contact info
Titolo: Dr.
Nome: Giuseppe
Cognome: Neri
Email: send email
Telefono: +39 06 3306 2706
Fax: +39 06 3306 2785

IT (ROMA) participant 154˙500.00
18    UNIVERSITA CATTOLICA DEL SACRO CUORE

 Organization address address: Largo Agostino Gemelli 1
city: MILANO
postcode: 20123

contact info
Titolo: Mr.
Nome: Filippo
Cognome: Leone
Email: send email
Telefono: +39 06 30156099
Fax: +39 06 30156803

IT (MILANO) participant 144˙000.00
19    SERVICIO MADRILENO DE SALUD

 Organization address address: PLAZA CARLOS TRIAS BERTRAN 7
city: MADRID
postcode: 28020

contact info
Titolo: Mr.
Nome: Luis Julián
Cognome: Fernandez Vera
Email: send email
Telefono: +34 914 265 115
Fax: +34 914 008 115

ES (MADRID) participant 140˙400.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

diagnostic    life    biomarker    health    phenotype    patients    prospective    later    diagnose    disease    validation    bestageing    risk    population    omics    diagnosis    cardiovascular    healthy    biomarkers    economic    treatment    care    chronic    acute    diseases    clinical    prediction    elderly    retrospective    impact    ageing    markers    heart   

 Obiettivo del progetto (Objective)

'The ageing of the European population represents a rapidly rising social and economic challenge. Especially cardiovascular morbidity increases with age, but unfortunately, elderly patients are often difficult to diagnose due to confounding factors, leading to uncertainties in clinical decision making with huge impact on patients’ outcomes. Hence, there is an unmet need for novel biomarkers for more accurate diagnosis, risk assessment, and clinical outcome prediction for both acute and chronic cardiovascular diseases in the elderly. The BestAgeing consortium aims to improve this lack of diagnostic capabilities by developing and validating innovative omics-based biomarkers particularly for elderly patients – supporting healthy ageing in Europe. Our study design addresses the most frequent and severe cardiovascular diseases of elderly patients by incorporating the appropriate disease cohorts and biomaterials from European populations. We aim to develop new omics-assays to diagnose cardiovascular disease, estimate risk, and monitor the response to treatment in elderly. This is envisaged to enable a more stratified and economic delivery of medicine. We expect that BestAgeing will generate novel European medical technologies that can improve the efficacy and efficiency of our care for elderly patients, which will also impact on socioeconomic wealth in Europe.'

Descrizione progetto (Article)

Already due to remarkable progress in prevention and acute cardiac patient care, cardiovascular diseases now show up significantly later in life. However, when heart disease develops later it is often complicated and hidden by other diseases. The project 'Biomarker research alliance for diagnosing heart disease in the ageing European population' (http://www.bestageing.eu/home.htm (BESTAGEING)) is working on finding new, specific and sensitive biomarkers for diagnosis, risk prediction and treatment guidance. These new guidelines will help to accurately predict for acute and chronic cardiovascular diseases in the elderly who have other health issues.

The project's strategy capitalises on extensive previous work on established biomarkers and new markers of coronary artery disease, myocardial infarction and heart failure. Expertise in assay and technology development, experience in analytical and clinical validation, and the abilities of the researchers will translate into marketable solutions of the findings.

Preparatory work for the retrospective and prospective validation studies has been completed. The table of omics-based biomarkers for validation was updated with some additional markers of interest, and the definition of the clinical phenotypes addressed in BESTAGEING was refined. This phenotype characterisation is of major importance because the clinical phenotype must be very precise yet applicable for different clinical centres, for retrospective and prospective studies.

Researchers are testing the cost effectiveness of novel biomarkers on European health care systems and economics. Using relevant national and international data sources and economic measures of diagnostic and therapeutic procedures, activities continue for public outreach, communicating scientific work and the results of biomarker development.

Ultimately, successful validation and translation into clinical application of new biomarkers is expected to strongly and beneficially impact the European population and economy. This will mean reduced health care costs, and increased quality of life and healthy years.

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