HIGH THROUGHPUT TOMO

High Throughput Optical Tomography

Coordinatore	UNIVERSIDAD CARLOS III DE MADRID    more  Organization address address: CALLE MADRID 126 city: GETAFE (MADRID) postcode: 28903 contact info Titolo: Ms. Nome: García Beato Cognome: Regina Email: send email Telefono: +34 91 624 9931 Fax: +34 91 624 9930
Nazionalità Coordinatore	Spain [ES]
Totale costo	100˙000 €
EC contributo	100˙000 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2012-CIG
Funding Scheme	MC-CIG
Anno di inizio	2013
Periodo (anno-mese-giorno)	2013-06-15   -   2017-06-14

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSIDAD CARLOS III DE MADRID  Organization address address: CALLE MADRID 126 city: GETAFE (MADRID) postcode: 28903 contact info Titolo: Ms. Nome: García Beato Cognome: Regina Email: send email Telefono: +34 91 624 9931 Fax: +34 91 624 9930	ES (GETAFE (MADRID))	coordinator	100˙000.00

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 Obiettivo del progetto (Objective)

'In recent years the use of 3D imaging approaches is becoming a necessity, in particular now that research has moved onto dynamic imaging of biological processes in-vivo. In this context, novel tomography techniques such as Fluorescence Molecular Tomography (FMT) for imaging in highly scattering media, and Optical Projection Tomography (OPT) and Selective Plane Illumination Microscopy (SPIM) for imaging in low scattering specimens, are becoming extremely valuable tools in the biology and preclinical labs. However, all these approaches suffer from the same drawback: lack of throughput. This proposal addresses the issue of high-throughput which is currently the bottleneck for the translation of optical tomography as a mainstream imaging technique. The main goal is to improve these setups in order to ensure several subjects can be imaged simultaneously. These changes require significant advances at the software and theoretical levels in addition to specific hardware changes. Main changes will consist on the use of structured illumination and a collection of mirrors and beamsplitters for FMT, and the addition of a vertical displacement in OPT and SPIM to allow stacking of specimens. These changes in hardware need to be accounted for in new inverse models to recover the 3D distribution of fluorophores in-vivo, accounting for the presence of scattering. In order to ensure high-throughput fast inverse algorithms will be developed making use of parallel programming with Graphics Processing Unitgs (GPUs).'