CAFFORCE

Physical forces driving fibroblast-led cancer cell migration

Coordinatore	FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA    more  Organization address address: CARRER BALDIRI REIXAC PLANTA 2A 10-12 city: BARCELONA postcode: 8028 contact info Titolo: Dr. Nome: Xavier Cognome: Trepat Email: send email Telefono: +34 934 020 265
Nazionalità Coordinatore	Spain [ES]
Totale costo	166˙336 €
EC contributo	166˙336 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2012-IEF
Funding Scheme	MC-IEF
Anno di inizio	2014
Periodo (anno-mese-giorno)	2014-01-01   -   2015-12-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA  Organization address address: CARRER BALDIRI REIXAC PLANTA 2A 10-12 city: BARCELONA postcode: 8028 contact info Titolo: Dr. Nome: Xavier Cognome: Trepat Email: send email Telefono: +34 934 020 265	ES (BARCELONA)	coordinator	166˙336.20

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 Obiettivo del progetto (Objective)

'Cancer cell invasion and metastasis remain the leading cause of cancer-associated death. It is now clear that invasion is not simply a cancer cell autonomous process but the result of complex interaction between tumour cells and their microenvironment. A number of studies have now shown that the presence of Cancer Associated Fibroblasts (CAFs) in the tumour microenvironment enhance cancer cell invasion within the surrounding tissue, thus highlighting the interaction between CAFs and cancer cells as a promising therapeutic target to counteract cancer progression. Recent evidence has established that CAFs are able to guide the collective migration of cancer cells. While the ability of CAFs to rearrange the matrix and favour invasion is well established, how CAFs guide the forward motion of cancer cells remains unknown. To decipher the biophysical features of this cellular interaction we propose here a multidisciplinary project to study the physical forces that drive fibroblast-led collective cancer cell migration. To achieve this goal, we will use novel techniques developed at the host laboratory to measure the physical forces that cells exert on each other and on their surrounding matrix. Next, we will combine these force measurements with genetic and biochemical interventions targeting the interaction between CAFs and cancer cells. As the collective movement of cancer cells into tumor microenvironment is the first step in the spread of metastatic cancer, deciphering the interplay between mechanics and biology at the CAF-cancer cell interface will bring crucial insight into metastatic processes and potentially new therapeutic targets.'