COMMITMENT

Combined Molecular Microscopy for Therapy and Personalized Medication in Rare Anaemias Treatments

 Coordinatore UNIVERSITAET DES SAARLANDES 

 Organization address address: CAMPUS
city: SAARBRUECKEN
postcode: 66041

contact info
Titolo: Dr.
Nome: Lars
Cognome: Kästner
Email: send email
Telefono: +49 68411626149
Fax: +49 68411626104

 Nazionalità Coordinatore Germany [DE]
 Totale costo 7˙730˙292 €
 EC contributo 5˙999˙982 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2013-INNOVATION-1
 Funding Scheme CP-FP
 Anno di inizio 2013
 Periodo (anno-mese-giorno) 2013-10-01   -   2018-09-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    UNIVERSITAET DES SAARLANDES

 Organization address address: CAMPUS
city: SAARBRUECKEN
postcode: 66041

contact info
Titolo: Dr.
Nome: Lars
Cognome: Kästner
Email: send email
Telefono: +49 68411626149
Fax: +49 68411626104

DE (SAARBRUECKEN) coordinator 1˙057˙440.00
2    OPTOROBOTIX APS

 Organization address address: N DALHOFFS VEJ 5
city: FREDERIKSBERG
postcode: 2000

contact info
Titolo: Mr.
Nome: Tue
Cognome: Roth
Email: send email
Telefono: +45 61712412

DK (FREDERIKSBERG) participant 922˙075.90
3    EPIGEM LIMITED

 Organization address address: MALMO COURT KIRKLEATHAM BUSINESS
city: REDCAR
postcode: TS10 5SQ

contact info
Titolo: Dr.
Nome: Timothy George
Cognome: Ryan
Email: send email
Telefono: +44 1642496306
Fax: +44 1642496301

UK (REDCAR) participant 716˙270.10
4    IONSCOPE LIMITED

 Organization address address: MELBOURN SCIENCE PARK ASH HOUSE A2
city: MELBOURN
postcode: SG8 6HB

contact info
Titolo: Dr.
Nome: Chris
Cognome: Moore
Email: send email
Telefono: +44 1763269070

UK (MELBOURN) participant 681˙206.60
5    UNIVERSITAET ZUERICH

 Organization address address: Raemistrasse 71
city: ZURICH
postcode: 8006

contact info
Titolo: Dr.
Nome: Anna
Cognome: Bogdanova
Email: send email
Telefono: +41 446358811
Fax: +41 446358932

CH (ZURICH) participant 575˙073.30
6    EUROPEAN RESEARCH AND PROJECT OFFICE GMBH

 Organization address address: Science Park 1, Stuhlsatzenhausweg 69
city: SAARBRUECKEN
postcode: 66123

contact info
Titolo: Dr.
Nome: Ulrike
Cognome: Trojahn
Email: send email
Telefono: +49 68195923352
Fax: +49 68195923370

DE (SAARBRUECKEN) participant 566˙800.00
7    CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER

 Organization address address: CALLE ROSSELLO 149 PUERTA BJS
city: BARCELONA
postcode: 8036

contact info
Titolo: Dr.
Nome: Pastora
Cognome: Martinez Samper
Email: send email
Telefono: +34 93 227 5707
Fax: +34 93 227 9205

ES (BARCELONA) participant 541˙219.75
8    UNIVERSITAIR MEDISCH CENTRUM UTRECHT

 Organization address address: HEIDELBERGLAAN 100
city: UTRECHT
postcode: 3584 CX

contact info
Titolo: Dr.
Nome: Richard
Cognome: Van Wijk
Email: send email
Telefono: +31 887558483

NL (UTRECHT) participant 509˙816.53
9    ARIVIS AG

 Organization address address: EINSTEINSTRASSE 10
city: UNTERSCHLEISSHEIM
postcode: 85716

contact info
Titolo: Mr.
Nome: Christian
Cognome: Götze
Email: send email
Telefono: +49 381 461393 11
Fax: +49 381 461393 99

DE (UNTERSCHLEISSHEIM) participant 430˙080.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

conductance    imaging    hereditary    clinical    sickle    therapeutic    enerca    anaemias    optofluidic    personalised    micro    scanning    spherocytosis    anaemia    proof    microscopy    interventions    technologies    diseases    commitment    ion    cell    rare    molecular    combined    cosmos   

 Obiettivo del progetto (Objective)

'The aim of CoMMiTMenT is the development of combined imaging technologies based on optofluidic microscopy and scanning ion conductance microscopy. An integrated, completely simultaneous device named µCOSMOS will be used as a proof-of-principle for therapeutic interventions in rare anaemias. Both techniques rely on molecular detection: optofluidic microscopy relies on molecular biomarkers, and scanning ion conductance microscopy on functional imaging of molecular structures. µCOSMOS allows for the exploration, diagnosis and development of therapeutic interventions for several rare anaemias, including hereditary xerocytosis, overhydrated hereditary stomatocytosis, familial pseudohyperkaliemia, cryohydrocytosis, certain types of spherocytosis, hereditary spherocytosis, sickle cell anaemia, thalassemia and phosphofructokinase deficiency. The non-invasive nature of the combined imaging technologies, which probe the function of molecular effectors, facilitates the testing of medications and their dosage in a personalised manner. For some of the rare anaemias, CoMMiTMenT will provide an initial proof-of-principle, whereas for others, such as sickle cell anaemia, personalised medical interventions should become available and will be tested in clinical practice within the project. CoMMiTMent will ensure an effective therapy with diminished undesirable adverse effects, largely replacing splenectomy.

CoMMiTMenT includes clinical partners and builds a strong relationship with the European Network for Rare and Congenital Anaemias (ENERCA). Furthermore, CoMMiTMenT acts as a bridge between the technology-driven SMEs and ENERCA and, as such, supports the competitiveness of Europe in this area. The applications will advance (personalised) treatment of rare anaemias and, therefore, contribute to the goal of the International Rare Diseases Research Consortium (IRDiRC) to deliver novel diagnostic modalities and 200 new therapies for rare diseases by 2020.'

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