EURO-PADNET

The Pathophysiology and Natural Course of Patients with Primary Antibody Deficiencies (PAD)

 Coordinatore UNIVERSITY COLLEGE LONDON 

 Organization address address: GOWER STREET
city: LONDON
postcode: WC1E 6BT

contact info
Titolo: Ms.
Nome: Greta
Cognome: Borg-Carbott
Email: send email
Telefono: +44 20 3108 3033
Fax: +44 20 7813 2849

 Nazionalità Coordinatore United Kingdom [UK]
 Sito del progetto http://www.europadnet.eu/
 Totale costo 3˙942˙625 €
 EC contributo 2˙986˙998 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2007-A
 Funding Scheme CP-FP
 Anno di inizio 2008
 Periodo (anno-mese-giorno) 2008-05-01   -   2011-04-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE LONDON

 Organization address address: GOWER STREET
city: LONDON
postcode: WC1E 6BT

contact info
Titolo: Ms.
Nome: Greta
Cognome: Borg-Carbott
Email: send email
Telefono: +44 20 3108 3033
Fax: +44 20 7813 2849

UK (LONDON) coordinator 0.00
2    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

 Organization address address: 101 Rue de Tolbiac
city: PARIS
postcode: 75654

contact info
Titolo: Ms.
Nome: Annick
Cognome: Bertault
Email: send email
Telefono: +33 1 40 78 49 01
Fax: +33 1 40 78 49 98

FR (PARIS) participant 0.00
3    KAROLINSKA INSTITUTET

 Organization address address: Nobels Vag 5
city: STOCKHOLM
postcode: 17177

contact info
Titolo: Ms.
Nome: Kim
Cognome: Von Schoultz
Email: send email
Telefono: +46 8 524 860 71
Fax: +46 8 524 837 01

SE (STOCKHOLM) participant 0.00
4    Masarykova univerzita

 Organization address address: Zerotinovo namesti 9
city: BRNO STRED
postcode: 60177

contact info
Titolo: Prof.
Nome: Petr
Cognome: Fiala
Email: send email
Telefono: +420 549 49 1000
Fax: +420 549 49 1060

CZ (BRNO STRED) participant 0.00
5    MEDIZINISCHE HOCHSCHULE HANNOVER

 Organization address address: Carl-Neuberg-Strasse 1
city: HANNOVER
postcode: 30625

contact info
Titolo: Mr.
Nome: Dieter
Cognome: Schmid
Email: send email
Telefono: +49 511 532 4234
Fax: +49 511 532 4253

DE (HANNOVER) participant 0.00
6    OSPEDALE PEDIATRICO BAMBINO GESU

 Organization address address: PIAZZA SAN ONOFRIO 4
city: ROMA
postcode: 165

contact info
Titolo: Dr.
Nome: Massimo
Cognome: Spina
Email: send email
Telefono: +39 06 6859 3601
Fax: +39 06 6859 3625

IT (ROMA) participant 0.00
7    THE BINDING SITE GMBH

 Organization address address: ROBERT BOSCH STRASSE 2A
city: SCHWETZINGEN
postcode: 68723

contact info
Titolo: Mr.
Nome: Lars
Cognome: Küehne
Email: send email
Telefono: +49 6202 92620
Fax: +49 620292 62222

DE (SCHWETZINGEN) participant 0.00
8    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

 Organization address address: University Offices, Wellington Square
city: OXFORD
postcode: OX1 2JD

contact info
Titolo: Ms.
Nome: Pam
Cognome: Nieto
Email: send email
Telefono: +44 553 21320
Fax: +44 553 22901

UK (OXFORD) participant 0.00
9    UNIVERSITA DEGLI STUDI DI BRESCIA

 Organization address address: Piazza Del Mercato 15
city: BRESCIA
postcode: 25121

contact info
Titolo: Dr.
Nome: Antonella
Cognome: Melito
Email: send email
Telefono: +39 030 2988241
Fax: +39 030 2988291

IT (BRESCIA) participant 0.00
10    UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA

 Organization address address: Piazzale Aldo Moro 5
city: ROMA
postcode: 185

contact info
Titolo: Ms.
Nome: Tiziana
Cognome: Grisorio
Email: send email
Telefono: +39 06 49970428
Fax: 39064463877

IT (ROMA) participant 0.00
11    UNIVERSITAETSKLINIKUM FREIBURG

 Organization address address: HUGSTETTER STRASSE 49
city: FREIBURG
postcode: 79106

contact info
Titolo: Mr.
Nome: Gerhard
Cognome: Henninger
Email: send email
Telefono: +49 761 1920
Fax: +49 761 1889

DE (FREIBURG) participant 0.00
12    UNIVERSITAETSMEDIZIN GOETTINGEN - GEORG-AUGUST-UNIVERSITAET GOETTINGEN - STIFTUNG OEFFENTLICHEN RECHTS

 Organization address address: Robert-Koch-Strasse 40
city: GOETTINGEN
postcode: 37075

contact info
Titolo: Ms.
Nome: Christiane
Cognome: Hennecke
Email: send email
Telefono: +49 551 398770
Fax: +49 551 392593

DE (GOETTINGEN) participant 0.00
13    VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG

 Organization address address: De Boelelaan 1105
city: AMSTERDAM
postcode: 1081 HV

contact info
Titolo: Ms.
Nome: S
Cognome: Tromp
Email: send email
Telefono: +31 20 4443100
Fax: +31 20 4443670

NL (AMSTERDAM) participant 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

clinical    patients    gene    mice    pad    pads    basic    wp    immune    vitro    defective    models    knock   

 Obiettivo del progetto (Objective)

'This medium-sized collaborative project will document and monitor the natural course and study the pathophysiology of Primary Antibody Deficiencies (PAD). PADs are rare inborn errors of the immune system with an estimated incidence of <1:25.000. The defective immunity in patients with PAD causes an increased susceptibility to recurrent infections of the respiratory- and gastro-intestinal tract as well as ill defined co-morbidity including granulomatous disease, lymphocytic organ infiltration and (paradoxically) autoimmunity. Our consortium cares for more than 1000 PAD patients, representing approx. 50% of the patients registered in Europe, many of them being children. We propose to: 1. Combine clinical and research data in a central online registry, complemented by a sample repository (WP1) 2. Elucidate the genetic cause of PADs by linkage analysis and candidate gene approaches (WP2) 3. Establish in vitro models for B cell differentiation steps that are defective in PADs such as in vitro class switch recombination, and siRNA knockdown models for PAD screening (WP3) 4. Create mouse models of PAD by using several technology platforms including knock-in and knock-out mice, shRNA mediated gene knock-down and humanised mice (WP4) 5. Perform translational research by taking the observations from the patients into the basic research projects and transfer these results back to the patients (WP5) The study of these immunodeficiencies represent an ‘experiment of nature’, uniquely enabling researchers to study the detrimental effects of mutations in specific genes involved in the immune system. Basic research results are translated into the development of new technologies, new knowledge, and new therapeutic tools. The clinical results will improve the diagnosis, management and quality of life of PAD patients, leading to future developments of new tests, preventive measures and treatment protocols.'

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