HYPERGENES

"European Network for Genetic-Epidemiological Studies: building a method to dissect complex genetic traits, using essential hypertension as a disease model"

 Coordinatore UNIVERSITA DEGLI STUDI DI MILANO 

 Organization address address: Via Festa Del Perdono 7
city: MILANO
postcode: 20122

contact info
Titolo: Prof.
Nome: Daniele Maria
Cognome: Cusi
Email: send email
Telefono: 390220959
Fax: 390250000000

 Nazionalità Coordinatore Italy [IT]
 Totale costo 14˙608˙340 €
 EC contributo 10˙213˙420 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2007-A
 Funding Scheme CP-IP
 Anno di inizio 2008
 Periodo (anno-mese-giorno) 2008-01-01   -   2011-12-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI MILANO

 Organization address address: Via Festa Del Perdono 7
city: MILANO
postcode: 20122

contact info
Titolo: Prof.
Nome: Daniele Maria
Cognome: Cusi
Email: send email
Telefono: 390220959
Fax: 390250000000

IT (MILANO) coordinator 0.00
2    "Institute of Internal Medicine, Siberian Branch of the Russian Academy of Medical Sciences"

 Organization address address: St. B. Bogatkova 175/5
city: Novosibirsk
postcode: 620089

contact info
Titolo: Prof.
Nome: Mikhail
Cognome: Voevoda
Email: send email
Telefono: +7 383 2642516
Fax: +7 383 2642516

RU (Novosibirsk) participant 0.00
3    "REFORM E.C., DRUZBA ZA MEDNARODNO TRGOVINO, D.O.O."

 Organization address address: Kidriceva Ulica 20
city: Nova Gorica
postcode: 5000

contact info
Titolo: Mr.
Nome: Teresio
Cognome: Rostagno
Email: send email
Telefono: -65330246
Fax: -653334890

SI (Nova Gorica) participant 0.00
4    GDANSKI UNIWERSYTET MEDYCZNY

 Organization address address: ULICA M SKLODOWSKIEJ CURIE 3A
city: GDANSK
postcode: 80210

contact info
Titolo: Ms.
Nome: Monika
Cognome: Nowinska-Retkowska
Email: send email
Telefono: 48583491207
Fax: 48583491029

PL (GDANSK) participant 0.00
5    I.M.S. - Istituto di Management Sanitario S.r.l.

 Organization address address: Via Podgora 7
city: Milan
postcode: 20128

contact info
Titolo: Dr.
Nome: Mariella
Cognome: D'alessio
Email: send email
Telefono: +39 02 55193912
Fax: +39 02 54124217

IT (Milan) participant 0.00
6    IBM ISRAEL - SCIENCE AND TECHNOLOGY LTD

 Organization address address: 94 DERECH EM-HAMOSHAVOT
city: PETACH TIKVA
postcode: 49527

contact info
Titolo: Ms.
Nome: Meirav
Cognome: Carmon
Email: send email
Telefono: 97248296542
Fax: 97248296111

IL (PETACH TIKVA) participant 0.00
7    IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE

 Organization address address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD
city: LONDON
postcode: SW7 2AZ

contact info
Titolo: Mr.
Nome: Michael
Cognome: Robinson
Email: send email
Telefono: +44 20 75943866
Fax: +44 20 75943868

UK (LONDON) participant 0.00
8    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

 Organization address address: 101 Rue de Tolbiac
city: PARIS
postcode: 75654

contact info
Titolo: Ms.
Nome: Céline
Cognome: Gaborit
Email: send email
Telefono: +33 1 40784960
Fax: +33 1 40784998

FR (PARIS) participant 0.00
9    KATHOLIEKE UNIVERSITEIT LEUVEN

 Organization address address: Oude Markt 13
city: LEUVEN
postcode: 3000

contact info
Titolo: Ms.
Nome: Sarah
Cognome: Malevé
Email: send email
Telefono: 3216320611
Fax: 3216326515

BE (LEUVEN) participant 0.00
10    Pharnext S.A.S.

 Organization address city: Paris
postcode: F 75008

contact info
Titolo: Mr.
Nome: Loic
Cognome: Heidsieck
Email: send email
Telefono: +33 1 55426202
Fax: +33 1 55426201

FR (Paris) participant 0.00
11    Shanghai Institute of Hypertension

 Organization address address: Ruijin 2nd Road 197
city: Shanghai
postcode: 200025

contact info
Titolo: Prof.
Nome: Ding-Liang
Cognome: Zhu
Email: send email
Telefono: +86 21 64370045
Fax: +86 21 64662193

CN (Shanghai) participant 0.00
12    SOFTECO SISMAT SRL

 Organization address address: VIA DE MARINI 1
city: GENOVA
postcode: 16149

contact info
Titolo: Mr.
Nome: Bruno
Cognome: Melagrano
Email: send email
Telefono: +39 010 60261
Fax: +39 010 6026350

IT (GENOVA) participant 0.00
13    STMICROELECTRONICS SRL

 Organization address address: VIA C.OLIVETTI 2
city: AGRATE BRIANZA
postcode: 20864

contact info
Titolo: Dr.
Nome: Cristina
Cognome: Di Gesù
Email: send email
Telefono: +39 095 7408306
Fax: +39 095 7407513

IT (AGRATE BRIANZA) participant 0.00
14    THE UNIVERSITY OF WARWICK

 Organization address address: Kirby Corner Road - University House -
city: COVENTRY
postcode: CV4 8UW

contact info
Titolo: Dr.
Nome: Peter
Cognome: Hedges
Email: send email
Telefono: 442477000000
Fax: 442477000000

UK (COVENTRY) participant 0.00
15    UNIVERSITA DEGLI STUDI DI PADOVA

 Organization address address: VIA 8 FEBBRAIO 2
city: PADOVA
postcode: 35122

contact info
Titolo: Prof.
Nome: Gianpietro Carlo
Cognome: Semenzato
Email: send email
Telefono: 390498000000
Fax: 390498000000

IT (PADOVA) participant 0.00
16    UNIVERSITA DEGLI STUDI DI SASSARI

 Organization address address: PIAZZA UNIVERSITA 21
city: SASSARI
postcode: 7100

contact info
Titolo: Dr.
Nome: Angela
Cognome: Ruiu
Email: send email
Telefono: +39 079 229008
Fax: +39 079 228248

IT (SASSARI) participant 0.00
17    UNIVERSITE DE LAUSANNE

 Organization address city: LAUSANNE
postcode: 1015

contact info
Titolo: Ms.
Nome: Suzanne
Cognome: Soto Eberlé
Email: send email
Telefono: 41216925456
Fax: 41216925455

CH (LAUSANNE) participant 0.00
18    UNIVERZITA KARLOVA V PRAZE

 Organization address address: Ovocny trh 5
city: PRAHA 1
postcode: 11636

contact info
Titolo: Prof.
Nome: Jaroslav
Cognome: Koutensky
Email: send email
Telefono: +42 0377 593440
Fax: +42 0377 593449

CZ (PRAHA 1) participant 0.00
19    UNIWERSYTET JAGIELLONSKI

 Organization address address: Ul. Golebia 24
city: KRAKOW
postcode: 31007

contact info
Titolo: Ms.
Nome: Barbara
Cognome: Radczak
Email: send email
Telefono: +48 123704356
Fax: +48 123704361

PL (KRAKOW) participant 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

trait    subjects    hypertension    machine    diagnostic    techniques    pathogenesis    validated    wga    replication    epidemiological    disease    epidemiology    traits    learning    genomic    cohorts    genetic    populations    tod    model    eh   

 Obiettivo del progetto (Objective)

'The project is focused on the definition of a comprehensive genetic epidemiological model of complex traits like Essential Hypertension (EH) and intermediate phenotypes of hypertension dependent/associated Target Organ Damages (TOD). To identify the common genetic variants relevant for the pathogenesis of EH and TODs, we will perform a Whole Genome Association (WGA) study of 4.000 subjects recruited from historical well-characterized European cohorts. Genotyping will be done with the Illumina Human 1M BeadChip. Well-established multi-variate techniques and innovative genomic analyses through machine learning techniques will be used for the WGA investigations. Using machine learning approach we aim at developing a disease model of EH integrating the available information on EH and TOD with relevant validated pathways and genetic/environmental information to mimic the clinician's recognition pattern of EH/TOD and their causes in an individual patient. Our statistical design is with two samples run in parallel, each with 1,000 cases and 1,000 controls, followed by a replication/joint analysis. This design is more powerful than replication alone and allows also a formal testing of the potential heterogeneity of findings compared to a single step (one large sample) design. The results represent the source to build a customized and inexpensive genetic diagnostic chip that can be validated in our existing cohorts (n=12,000 subjects). HYPERGENES is in the unique position to propose a ground-breaking project, improving the methodology of genetic epidemiology of chronic complex diseases that have a high prevalence among EU populations. Designing a comprehensive genetic epidemiological model of complex traits will also help us to translate genetic findings into improved diagnostic accuracy and new strategies for early detection, prevention and eventually personalised treatment of a complex trait. The ultimate goal will be to promote the quality of life of EU populations.'

Introduzione (Teaser)

A complex trait is phenotypically and genetically heterogeneous and thus requires a global genomic approach to understand its aetiology and pathogenesis. To this end, EU-funded researchers joined forces to disentangle the genetic bases of a complex disease using population genetic epidemiology.

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