NEUROCYPRES

"Neurotransmitter Cys-loop receptors: structure, function and disease"

 Coordinatore STICHTING VU-VUMC 

 Organization address address: DE BOELELAAN 1105
city: AMSTERDAM
postcode: 1081 HV

contact info
Titolo: Dr.
Nome: Yvonne
Cognome: Kops
Email: send email
Telefono: +31 20 5987304

 Nazionalità Coordinatore Netherlands [NL]
 Sito del progetto http://www.neurocypres.eu/
 Totale costo 14˙640˙209 €
 EC contributo 11˙025˙000 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2007-A
 Funding Scheme CP-IP
 Anno di inizio 2008
 Periodo (anno-mese-giorno) 2008-02-01   -   2012-07-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    STICHTING VU-VUMC

 Organization address address: DE BOELELAAN 1105
city: AMSTERDAM
postcode: 1081 HV

contact info
Titolo: Dr.
Nome: Yvonne
Cognome: Kops
Email: send email
Telefono: +31 20 5987304

NL (AMSTERDAM) coordinator 0.00
2    BEACTICA AB

 Organization address address: Box 567
city: UPPSALA
postcode: 751 22

contact info
Titolo: Prof.
Nome: Helena
Cognome: Danielson
Email: send email
Telefono: +46 18 4714545
Fax: +46 18 558431

SE (UPPSALA) participant 0.00
3    CONSIGLIO NAZIONALE DELLE RICERCHE

 Organization address address: Piazzale Aldo Moro 7
city: ROMA
postcode: 185

contact info
Titolo: Prof.
Nome: Lamberto
Cognome: Maffei
Email: send email
Telefono: +39 050 3153179
Fax: +39 050 31533210

IT (ROMA) participant 0.00
4    EUROPEAN MOLECULAR BIOLOGY LABORATORY

 Organization address address: Meyerhofstrasse 1
city: HEIDELBERG
postcode: 69117

contact info
Titolo: Mr.
Nome: Keith
Cognome: Williamson
Email: send email
Telefono: +49 6221 387 8295
Fax: +49 6221 387 8211

DE (HEIDELBERG) participant 0.00
5    FRIEDRICH-ALEXANDER-UNIVERSITAT ERLANGEN NURNBERG

 Organization address address: SCHLOSSPLATZ 4
city: ERLANGEN
postcode: 91054

contact info
Titolo: Ms.
Nome: Ulrike
Cognome: Herrmann
Email: send email
Telefono: +49 9131 8524043
Fax: +49 9131 8526239

DE (ERLANGEN) participant 0.00
6    HELLENIC PASTEUR INSTITUTE

 Organization address address: Vassilissis Sofias Avenue 127
city: ATHENS
postcode: 11521

contact info
Titolo: Prof.
Nome: Socrates
Cognome: Tzartos
Email: send email
Telefono: +30 210 6478844
Fax: +30 210 6478842

EL (ATHENS) participant 0.00
7    HIQSCREEN SARL

 Organization address address: RUE DE L'ATHENEE 15
city: GENEVE
postcode: 1211-12

contact info
Titolo: Prof.
Nome: Daniel
Cognome: Bertrand
Email: send email
Telefono: +41 223472622

CH (GENEVE) participant 0.00
8    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

 Organization address address: 101 Rue de Tolbiac
city: PARIS
postcode: 75654

contact info
Titolo: Ms.
Nome: Marie-France
Cognome: Tinland
Email: send email
Telefono: +33 4 91 82 81 04
Fax: +33 4 91 82 81 05

FR (PARIS) participant 0.00
9    INSTITUT PASTEUR

 Organization address address: RUE DU DOCTEUR ROUX 25-28
city: PARIS CEDEX 15
postcode: 75724

contact info
Titolo: Dr.
Nome: Nadia
Cognome: Khelef
Email: send email
Telefono: +33 1 40 61 33 78
Fax: +33 1 40 61 39 40

FR (PARIS CEDEX 15) participant 0.00
10    KATHOLIEKE UNIVERSITEIT LEUVEN

 Organization address address: Oude Markt 13
city: LEUVEN
postcode: 3000

contact info
Titolo: Ms.
Nome: Marion
Cognome: Wolpers
Email: send email
Telefono: +32 16 326520
Fax: +32 16 326515

BE (LEUVEN) participant 0.00
11    MEDIZINISCHE UNIVERSITAET WIEN

 Organization address address: SPITALGASSE 23
city: WIEN
postcode: 1090

contact info
Titolo: Prof.
Nome: Werner
Cognome: Sieghart
Email: send email
Telefono: +43 1 4277 62950
Fax: +43 1 4277 62959

AT (WIEN) participant 0.00
12    NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS

 Organization address address: CHRISTOU LADA 6
city: ATHENS
postcode: 10561

contact info
Titolo: Ms.
Nome: Efi
Cognome: Kafentzi
Email: send email
Telefono: +30 2103689038
Fax: +30 2103689008

EL (ATHENS) participant 0.00
13    PROTEOSYS AG

 Organization address address: CARL ZEISSSTRASSE 51
city: MAINZ
postcode: 55129

contact info
Nome: Bernd
Cognome: Matuschek
Email: send email
Telefono: +49 6131 5019223
Fax: +49 6131 5019211

DE (MAINZ) participant 0.00
14    REGULON AE

 Organization address address: "Grigoriou Afxentiou 7, Alimos"
city: ATHENS
postcode: 17455

contact info
Titolo: Dr.
Nome: Michael
Cognome: Roberts
Email: send email
Telefono: +30 210 9886502
Fax: +30 210 9858453

EL (ATHENS) participant 0.00
15    SHEMYAKIN AND OVCHINNIKOV INSTITUTE OF BIOORGANIC CHEMISTRY - RUSSIAN ACADEMY OF SCIENCE

 Organization address address: UL. MIKLUKHO MAKLAYA 16/10
city: MOSCOW
postcode: 117997

contact info
Titolo: Prof.
Nome: Victor
Cognome: Tsetlin
Email: send email
Telefono: +7 495 3355733
Fax: +7 495 3355733

RU (MOSCOW) participant 0.00
16    STICHTING HET NEDERLANDS KANKER INSTITUUT

 Organization address address: PLESMANLAAN 121
city: AMSTERDAM
postcode: 1066 CX

contact info
Titolo: Dr.
Nome: Henri
Cognome: Van Luenen
Email: send email
Telefono: 31205122097
Fax: 31206691383

NL (AMSTERDAM) participant 0.00
17    SYNAPTOLOGICS BV

 Organization address address: BURMANSTRAAT 7
city: AMSTERDAM
postcode: 1091 SG

contact info
Titolo: Prof.
Nome: Arjen
Cognome: Brussaard
Email: send email
Telefono: +31 20 5987098
Fax: +31 20 5987112

NL (AMSTERDAM) participant 0.00
18    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE

 Organization address address: The Old Schools, Trinity Lane
city: CAMBRIDGE
postcode: CB2 1TN

contact info
Titolo: Ms.
Nome: Dawn
Cognome: Barker
Email: send email
Telefono: +44 1223 333543
Fax: +44 1223 332988

UK (CAMBRIDGE) participant 0.00
19    UNIVERSITA DEGLI STUDI DI MODENA E REGGIO EMILIA

 Organization address address: VIA UNIVERSITA 4
city: MODENA
postcode: 41100

contact info
Titolo: Prof.
Nome: Sergio
Cognome: Ferrari
Email: send email
Telefono: +39 059 2055668
Fax: +39 059 2055363

IT (MODENA) participant 0.00
20    UNIVERSITAT KONSTANZ

 Organization address address: UNIVERSITATSSTRASSE 10
city: KONSTANZ
postcode: 78457

contact info
Titolo: Prof.
Nome: Wolfram
Cognome: Welte
Email: send email
Telefono: +49 7531 882206
Fax: +49 7531 883183

DE (KONSTANZ) participant 0.00
21    UNIVERSITE DE GENEVE

 Organization address address: Rue du General Dufour 24
city: GENEVE
postcode: 1211

contact info
Titolo: Prof.
Nome: Daniel
Cognome: Bertrand
Email: send email
Telefono: +41 22379 5356
Fax: +41 22 379 5402

CH (GENEVE) participant 0.00
22    UNIVERSITY COLLEGE LONDON

 Organization address address: GOWER STREET
city: LONDON
postcode: WC1E 6BT

contact info
Titolo: Mr.
Nome: Kent
Cognome: Lee
Email: send email
Telefono: 442077000000
Fax: 442077000000

UK (LONDON) participant 0.00
23    UNIVERSITY OF PATRAS

 Organization address address: UNIVERSITY CAMPUS RIO PATRAS
city: RIO PATRAS
postcode: 26500

contact info
Titolo: Prof.
Nome: Georgios A.
Cognome: Spyroulias
Email: send email
Telefono: +30 2610 969950
Fax: +30 2610 969950

EL (RIO PATRAS) participant 0.00
24    VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG

 Organization address address: De Boelelaan 1105
city: AMSTERDAM
postcode: 1081 HV

contact info
Titolo: Ms.
Nome: Margot
Cognome: Rijerse-Muller
Email: send email
Telefono: +31 20 5989561
Fax: +31 20 5989281

NL (AMSTERDAM) participant 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

function    schizophrenia    clr    loop    structure    nmr    nervous    binding    ht    ligand    neurotransmitter    ray    models    drug    workflow    clrs    receptors    functions    disease       diseases    cys    receptor    epilepsy   

 Obiettivo del progetto (Objective)

'Cys-loop receptors (CLRs) form a superfamily of structurally related neurotransmitter-gated ion channels, comprising nicotinic acetylcholine, glycine, GABA-A/C and serotonin (5HT3) receptors, crucial to function of the peripheral and central nervous system. CLRs cover a wide spectrum of functions, ranging from muscle contraction to cognitive functions. CLR (mal)function is linked to various disorders, including muscular dystrophies, neurodegenerative diseases, e.g. Alzheimer’s and Parkinson’s, and neuropsychiatric diseases, e.g. schizophrenia, epilepsy and addiction. CLRs are potentially important drug targets for treatment of disease. However, novel drug discovery strategies call for in depth understanding of ligand binding sites, the structure-function relationships of these receptors and insight into their actions in the nervous system. NeuroCypres assembles the expertise of leading European laboratories to provide a technology workflow, which enables to embark on this next step in CLR structure and function. A major target of this project is to obtain high-resolution X-ray and NMR structures for CLRs and their complexes with diverse ligands, agonists/antagonists, channel blockers and modulators, which will reveal basic mechanisms of receptor functioning from ligand binding to gating and open new avenues to rational drug design. In addition, the project aims at understanding receptor function in the context of the brain, focusing on receptor biosensors, receptor-protein interactions and transgenic models. This major challenge requires application and development of a multidisciplinary workflow of high-throughput (HT) crystallization and HT-electrophysiology technologies, X-ray analysis, NMR and computational modeling, fragment-based drug design, innovative quantitative methods of interaction-proteomics, sensitive methods for visualization of activity and localization of receptors and studies of in vitro and in vivo function in animal models of disease.'

Introduzione (Teaser)

European scientists worked to provide novel insight into the structure and function of the neurotransmitter receptors known as Cys-loop receptors (CLRs). The generated knowledge could be implemented towards the design of new effective treatments for various diseases such as myasthenia gravis, epilepsy and schizophrenia.

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