NOVSEC-TB

Novel secretion systems of Mycobacterium tuberculosis and their role in host-pathogen interaction

 Coordinatore INSTITUT PASTEUR 

 Organization address address: RUE DU DOCTEUR ROUX 25-28
city: PARIS CEDEX 15
postcode: 75724

contact info
Titolo: Dr.
Nome: Nadia
Cognome: Khelef
Email: send email
Telefono: +33 1 40 61 33 78
Fax: +33 1 40 61 39 40

 Nazionalità Coordinatore France [FR]
 Totale costo 3˙762˙443 €
 EC contributo 2˙821˙726 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2007-A
 Funding Scheme CP-FP
 Anno di inizio 2008
 Periodo (anno-mese-giorno) 2008-01-01   -   2011-06-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    INSTITUT PASTEUR

 Organization address address: RUE DU DOCTEUR ROUX 25-28
city: PARIS CEDEX 15
postcode: 75724

contact info
Titolo: Dr.
Nome: Nadia
Cognome: Khelef
Email: send email
Telefono: +33 1 40 61 33 78
Fax: +33 1 40 61 39 40

FR (PARIS CEDEX 15) coordinator 0.00
2    ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE

 Organization address address: BATIMENT CE 3316 STATION 1
city: LAUSANNE
postcode: 1015

contact info
Titolo: Dr.
Nome: Iain
Cognome: Old
Email: send email
Telefono: +41 21 6931794
Fax: +41 21 6931790

CH (LAUSANNE) participant 0.00
3    SOUTH AFRICAN MEDICAL RESEARCH COUNCIL

 Organization address address: Francie van Zijl Drive - Parowvalley
city: TYGERBERG
postcode: 7505

contact info
Titolo: Mr.
Nome: Philip
Cognome: Du Plessis
Email: send email
Telefono: +27 21 938 0481
Fax: +27 21 938 0564

ZA (TYGERBERG) participant 0.00
4    UNIVERSITA CATTOLICA DEL SACRO CUORE

 Organization address address: Largo Agostino Gemelli 1
city: MILANO
postcode: 20123

contact info
Titolo: Mr.
Nome: Filippo
Cognome: Leone
Email: send email
Telefono: +39 630 156 099
Fax: +39 630 156 803

IT (MILANO) participant 0.00
5    UNIVERSITA DEGLI STUDI DI PADOVA

 Organization address address: VIA 8 FEBBRAIO 2
city: PADOVA
postcode: 35122

contact info
Titolo: Prof.
Nome: Giorgio
Cognome: Bressan
Email: send email
Telefono: 39 049 8272350
Fax: 39 049 8272355

IT (PADOVA) participant 0.00
6    UNIVERSITA DI PISA

 Organization address address: Lungarno Pacinotti 43/44
city: PISA
postcode: 56126

contact info
Titolo: Prof.
Nome: Gaetano
Cognome: Privitera
Email: send email
Telefono: +39 050 2213573
Fax: +39 050 2213575

IT (PISA) participant 0.00
7    UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN

 Organization address address: BELFIELD
city: DUBLIN
postcode: 4

contact info
Titolo: Mr.
Nome: Donal
Cognome: Doolan
Email: send email
Telefono: +35 317 161656
Fax: +35 317 161216

IE (DUBLIN) participant 0.00
8    VRIJE UNIVERSITEIT MEDISCH CENTRUM

 Organization address address: De Boelelaan 1117
city: AMSTERDAM
postcode: 1007 MB

contact info
Titolo: Ms.
Nome: Sylvia
Cognome: Tromp
Email: send email
Telefono: +31 20 4443100
Fax: +31 20 4443670

NL (AMSTERDAM) participant 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

proteins    interaction    families       host    esx    pathogen    kda    secretion    pe    ppe    gt    tuberculosis   

 Obiettivo del progetto (Objective)

'Tuberculosis is a major public health threat to the populations of Europe and the world. Mycobacterium tuberculosis, the etiological agent of the disease, can multiply and persist within phagocytic cells and this early event is of primary importance for the outcome of the infection. The main objectives of this proposal are to use highly innovative approaches in molecular and cell biology, biochemistry, immunology and imagery to elucidate the function and interplay of three families of immunogenic proteins of M. tuberculosis, the ESX, PE and PPE families. It was recently found that the ESX systems constitute novel secretion machineries that export major virulence factors and important diagnostic and protective antigens. While the ESX-1 system is responsible for the secretion of the prototypic ESX proteins, namely, the 6 kDa early secreted antigenic target (ESAT-6) and the 10 kDa culture filtrate protein (CFP-10), which are the most important proteins of M. tuberculosis involved in host-pathogen interaction, ESX-5 is implicated in the secretion of PE/PPE proteins. Restriction to pathogenic mycobacteria makes them highly interesting targets for host-pathogen interaction. The ESX-3 system appears to be essential. Thus, in this project we propose to --> analyse the global gene expression network of ESX-1, ESX-3 and ESX-5, --> determine the nature and diversity of the effector proteins they secrete, --> establish their mode of action and sub-cellular localisation, --> survey potential genetic variation in clinical isolates, --> assess their interaction with the immune system of the host, --> evaluate the suitability of ESX systems as drug targets, --> screen small molecules for their potential to inhibit ESX-mediated secretion. The proposed approach will generate major insights into the role of these proteins in pathogenicity that are of utmost importance for the development of new diagnostics, vaccines and therapeutic agents for tuberculosis prevention and control.'

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