OXYGREEN

Effective redesign of oxidative enzymes for green chemistry

 Coordinatore RIJKSUNIVERSITEIT GRONINGEN 

 Organization address address: Broerstraat 5
city: GRONINGEN
postcode: 9712CP

contact info
Titolo: Mr.
Nome: Jan
Cognome: Poutsma
Email: send email
Telefono: 31503634142
Fax: 31503634500

 Nazionalità Coordinatore Netherlands [NL]
 Sito del progetto http://www.rug.nl/oxygreen/index
 Totale costo 7˙435˙684 €
 EC contributo 5˙543˙249 €
 Programma FP7-KBBE
Specific Programme "Cooperation": Food, Agriculture and Biotechnology
 Code Call FP7-KBBE-2007-1
 Funding Scheme CP-IP
 Anno di inizio 2008
 Periodo (anno-mese-giorno) 2008-05-01   -   2013-04-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    RIJKSUNIVERSITEIT GRONINGEN

 Organization address address: Broerstraat 5
city: GRONINGEN
postcode: 9712CP

contact info
Titolo: Mr.
Nome: Jan
Cognome: Poutsma
Email: send email
Telefono: 31503634142
Fax: 31503634500

NL (GRONINGEN) coordinator 0.00
2    "BIOLOG LIFE SCIENCE INSTITUTE, FORSCHUNGSLABOR UND BIOCHEMICA- VERTRIEB GMBH"

 Organization address address: Flughafendamm 9a
city: BREMEN
postcode: 28199

contact info
Titolo: Dr.
Nome: Hans-Gottfried
Cognome: Genieser
Email: send email
Telefono: +49 421 591355
Fax: +49 421 5979713

DE (BREMEN) participant 0.00
3    BIOINFOBANK INSTITUTE

 Organization address address: Limanowskiego 24/a 16
city: POZNAN
postcode: 60744

contact info
Titolo: Dr.
Nome: Jadwiga
Cognome: Borowcyk
Email: send email
Telefono: +48 618653520
Fax: +48 618643350

PL (POZNAN) participant 0.00
4    DECHEMA GESELLSCHAFT FUER CHEMISCHE TECHNIK UND BIOTECHNOLOGIE E.V.

 Organization address address: Theodor-Heuss-Allee 25
city: FRANKFURT
postcode: 60486

contact info
Titolo: Dr.
Nome: Jens
Cognome: Schrader
Email: send email
Telefono: +49 69 7564 422
Fax: +49 69 7564 388

DE (FRANKFURT) participant 0.00
5    DSM INNOVATIVE SYNTHESIS BV

 Organization address address: POSTSTRAAT 1
city: SITTARD
postcode: 6135 KR

contact info
Titolo: Mrs.
Nome: Ine
Cognome: Weijer Van De
Email: send email
Telefono: 31630798316

NL (SITTARD) participant 0.00
6    DSM RESEARCH B.V.

 Organization address address: Urmonderbaan 22
city: GELEEN
postcode: 6167RD

contact info
Titolo: Dr.
Nome: Johan H.M.
Cognome: Jansen
Email: send email
Telefono: 31464763286

NL (GELEEN) participant 0.00
7    ENZYSCREEN

 Organization address address: Wassenaarseweg
city: LEIDEN
postcode: 2333 AL

contact info
Titolo: Dr.
Nome: Wouter
Cognome: Duetz
Email: send email
Telefono: 31715276348
Fax: 31715276158

NL (LEIDEN) participant 0.00
8    EVONIK REXIM

 Organization address address: Rue de Verdun 33
city: HAM
postcode: 80400

contact info
Titolo: Dr.
Nome: Dominique
Cognome: Frossard
Email: send email
Telefono: 33323814470
Fax: 33323811112

FR (HAM) participant 0.00
9    JACOBS UNIVERSITY BREMEN GGMBH

 Organization address address: Campus Ring 1
city: BREMEN
postcode: 28759

contact info
Titolo: Dr.
Nome: Ronald
Cognome: Kieschnick
Email: send email
Telefono: 494212000000
Fax: 49421200000000

DE (BREMEN) participant 0.00
10    RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHEN

 Organization address address: Templergraben 55
city: AACHEN
postcode: 52062

contact info
Titolo: Prof.
Nome: Ernst
Cognome: Schmachtenberg
Email: send email
Telefono: +49 241 8090490
Fax: +49 241 8092490

DE (AACHEN) participant 0.00
11    TECHNISCHE UNIVERSITAET GRAZ

 Organization address address: Rechbauerstrasse 12
city: GRAZ
postcode: 8010

contact info
Titolo: Prof.
Nome: Anton
Cognome: Glieder
Email: send email
Telefono: +43 3168734077
Fax: +43 3168734071

AT (GRAZ) participant 0.00
12    TECHNISCHE UNIVERSITAET WIEN

 Organization address address: Karlsplatz 13
city: WIEN
postcode: 1040

contact info
Titolo: Prof.
Nome: Marko
Cognome: Mihovilovic
Email: send email
Telefono: +43 1 58801 15420
Fax: +43 1 58801 15499

AT (WIEN) participant 0.00
13    TECHNISCHE UNIVERSITAT DORTMUND

 Organization address address: AUGUST SCHMIDT STRASSE 4
city: DORTMUND
postcode: 44227

contact info
Titolo: Mr.
Nome: Detlef
Cognome: Niehage
Email: send email
Telefono: 492318000000
Fax: 492318000000

DE (DORTMUND) participant 0.00
14    UNIVERSITA DEGLI STUDI DI PAVIA

 Organization address address: STRADA NUOVA 65
city: PAVIA
postcode: 27100

contact info
Titolo: Prof.
Nome: Andrea
Cognome: Mattevi
Email: send email
Telefono: +39 0382 985534
Fax: +39 0382 528496

IT (PAVIA) participant 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

enzyme    nature    powerful    fit    catalysts    catalytic    industrial    natural    chemical    designer    enzymes    catalyze    reactions    compounds    boundaries   

 Obiettivo del progetto (Objective)

'Enzymes are extremely powerful natural catalysts able to perform almost any type of chemical reaction while being mild by nature and highly specific. In fact, the delicate functioning of enzymes forms the basis of every living creature. The catalytic potential of enzymes is more and more appreciated by the industry as many industrial processes rely on these sophisticated catalysts. However, the number of reactions catalyzed by enzymes is restricted as enzymes only have evolved to catalyze reactions that are physiologically relevant. Furthermore, enzymes have adapted to the direct (cellular) environment in which they have to function (e.g. operative at ambient temperature, resilient towards proteolysis, catalytic turnover rate should fit with metabolic enzyme partners). This excludes the existence of enzymes that do not fit within boundaries set by nature. It is a great challenge to go beyond these natural boundaries and develop methodologies to design ‘unnatural’ tailor-made enzymes. Ideally it should become possible to (re)design enzymes to convert pre-defined substrates. Such designer enzymes could theoretically exhibit unsurpassed catalytic properties and, obviously, will be of significant interest for industrial biotechnology. The OXYGREEN project aims at the design and construction of novel oxygenating enzymes (designer oxygenases) for the production of compounds that can be used in medicine, food and agriculture and the development of novel powerful and generic enzyme redesign tools for this purpose. The enzymes and whole-cell biocatalysts that will be developed should catalyze the specific incorporation of oxygen to afford synthesis of bioactive compounds in a selective and clean way, with minimal side products and with no use of toxic materials. For this, generic platform technologies (novel high-throughput methodology and methods for engineering dedicated host cells) will be developed that allow effective structure-inspired directed evolution of enzyme.'

Introduzione (Teaser)

Enzymes act as catalysts in chemical reactions to produce useful chemicals. Selectively oxidative enzymes are particularly useful in industrial applications but issues with availability, reliability, yield and robustness need to be addressed.

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