HYPERDIFF

The Physiological Basis of Hypervirulence in Clostridium difficile: a Prerequisite for Effective Infection Control

 Coordinatore THE UNIVERSITY OF NOTTINGHAM 

 Organization address address: University Park
city: NOTTINGHAM
postcode: NG7 2RD

contact info
Titolo: Mr.
Nome: Paul
Cognome: Cartledge
Email: send email
Telefono: +44 115 951 5679
Fax: +44 115 951 3633

 Nazionalità Coordinatore United Kingdom [UK]
 Totale costo 3˙940˙839 €
 EC contributo 2˙992˙181 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2007-B
 Funding Scheme CP-FP
 Anno di inizio 2008
 Periodo (anno-mese-giorno) 2008-11-01   -   2011-10-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF NOTTINGHAM

 Organization address address: University Park
city: NOTTINGHAM
postcode: NG7 2RD

contact info
Titolo: Mr.
Nome: Paul
Cognome: Cartledge
Email: send email
Telefono: +44 115 951 5679
Fax: +44 115 951 3633

UK (NOTTINGHAM) coordinator 0.00
2    ACADEMISCH ZIEKENHUIS LEIDEN

 Organization address address: Albinusdreef 2
city: LEIDEN
postcode: 2333 ZA

contact info
Titolo: Ms.
Nome: Guillaine E.
Cognome: De Blécourt
Email: send email
Telefono: +31 71 5263323
Fax: +31 71 5266831

NL (LEIDEN) participant 0.00
3    ISTITUTO SUPERIORE DI SANITA

 Organization address address: Viale Regina Elena 299
city: ROMA
postcode: 161

contact info
Titolo: Dr.
Nome: Rosa Maria
Cognome: Martoccia
Email: send email
Telefono: -49902655
Fax: -49902974

IT (ROMA) participant 0.00
4    TGC BIOMICS GMBH

 Organization address address: CARL ZEISS STR 51
city: MAINZ
postcode: 55129

contact info
Titolo: Prof.
Nome: Christoph
Cognome: Von Eichel-Streiber
Email: send email
Telefono: -6281794
Fax: -6281800

DE (MAINZ) participant 0.00
5    UNIVERSITE PARIS-SUD

 Organization address address: RUE GEORGES CLEMENCEAU 15
city: ORSAY
postcode: 91405

contact info
Titolo: Ms.
Nome: Sandra
Cognome: Mereu
Email: send email
Telefono: -69153690
Fax: -69155567

FR (ORSAY) participant 0.00
6    UNIVERSITY COLLEGE LONDON

 Organization address address: GOWER STREET
city: LONDON
postcode: WC1E 6BT

contact info
Titolo: Mr.
Nome: Kent
Cognome: Lee
Telefono: +44 20 7679 6296
Fax: +44 20 7679 6502

UK (LONDON) participant 0.00
7    ZAVOD ZA ZDRAVSTVENO VARSTVO MARIBOR

 Organization address address: PRVOMAJSKA 1 1
city: MARIBOR
postcode: 2000

contact info
Titolo: Ms.
Nome: Melita
Cognome: Kores
Email: send email
Telefono: +386 2 4500 254
Fax: +386 2 4500 22

SI (MARIBOR) participant 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

prevalence    responsible    human    hyper    virulence    disease    healthcare    population    pathogenesis    hyperdiff    difficile    mortality    clostron   

 Obiettivo del progetto (Objective)

'Clostridium diffficile is currently wreaking havoc within European health systems due to the emergence of hyper virulent strains, responsible for more severe disease, higher relapse rates, increased mortality and greater resistance to antibiotics. Its impact in healthcare settings is considerable, in terms of morbidity, mortality and financial cost However, the physiological basis of pathogenesis is poorly understood due to an absence of mutational tools for functional genomic studies. This bottleneck has been solved by partner 1 who has developed the ‘ClosTron’, a highly efficient gene knock-out tool. This will be used to systematically inactivate those chromosomal genes which encode products hypothesised to be involved in pathogenesis, and an assessment of the consequences made in models of infection. To ascertain the prevalence of the identified hyper virulence traits in the human and animal population, epidemiological studies will be undertaken. Special attention will be paid to the wider human population to gauge the prevalence of community acquired C. difficile. The identity of the determinants responsible for hyper virulence would allow the derivation of diagnostic tests directed specifically at those factors directly responsible for their spread within the healthcare setting. They will also allow the formulation of therapeutic countermeasures that could be deployed to both prevent and treat disease outbreaks. The objectives of HYPERDIFF will be met by a consortium of the leading EU researchers on C. difficile. It brings together a multidisciplinary team from a range of sectors and 6 member states. They are composed of 4 Universities, 2 Government Institutes, and a commercial company, with the key skills needed to deliver the objectives of HYPERDIFF. In combination with the unique ClosTron system, these capabilities will propel Europe to the forefront of the field.'

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