SMARTCELL

Rational design of plant systems for sustainable generation of value-added industrial products

 Coordinatore TEKNOLOGIAN TUTKIMUSKESKUS VTT 

 Organization address address: TEKNIIKANTIE 4 A
city: ESPOO
postcode: 02044 VTT

contact info
Titolo: Dr.
Nome: Kirsi-Marja
Cognome: Oksman-Caldentey
Email: send email
Telefono: +358 20 722 4459
Fax: +358 20 722 7071

 Nazionalità Coordinatore Finland [FI]
 Totale costo 8˙061˙603 €
 EC contributo 5˙901˙866 €
 Programma FP7-KBBE
Specific Programme "Cooperation": Food, Agriculture and Biotechnology
 Code Call FP7-KBBE-2007-2A
 Funding Scheme CP-IP
 Anno di inizio 2009
 Periodo (anno-mese-giorno) 2009-01-01   -   2013-09-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    TEKNOLOGIAN TUTKIMUSKESKUS VTT

 Organization address address: TEKNIIKANTIE 4 A
city: ESPOO
postcode: 02044 VTT

contact info
Titolo: Dr.
Nome: Kirsi-Marja
Cognome: Oksman-Caldentey
Email: send email
Telefono: +358 20 722 4459
Fax: +358 20 722 7071

FI (ESPOO) coordinator 1˙508˙209.00
2    VIB

 Organization address address: Rijvisschestraat 120
city: ZWIJNAARDE - GENT
postcode: 9052

contact info
Titolo: Mr.
Nome: Rik
Cognome: Audenaert
Email: send email
Telefono: +32 9 2446611
Fax: +32 9 2446610

BE (ZWIJNAARDE - GENT) participant 675˙377.00
3    FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V

 Organization address address: Hansastrasse 27C
city: MUENCHEN
postcode: 80686

contact info
Titolo: Mr.
Nome: Maximilian
Cognome: Steiert
Email: send email
Telefono: +49 89 12052721
Fax: +49 89 12057534

DE (MUENCHEN) participant 601˙770.00
4    UNIVERSITEIT LEIDEN

 Organization address address: RAPENBURG 70
city: LEIDEN
postcode: 2300 RA

contact info
Titolo: Mr.
Nome: Ton
Cognome: Brouwer
Email: send email
Telefono: +31 71 5273149
Fax: +31 71 5275269

NL (LEIDEN) participant 505˙540.00
5    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

 Organization address address: Rue Michel -Ange 3
city: PARIS
postcode: 75794

contact info
Titolo: Mr.
Nome: Denis
Cognome: Fix
Email: send email
Telefono: +33 388106719
Fax: +33 390241921

FR (PARIS) participant 448˙004.00
6    UNIVERSIDAD DE LLEIDA

 Organization address address: Placa Victor Siurana 1 1
city: LLEIDA
postcode: 25003

contact info
Titolo: Mr.
Nome: Josep M.
Cognome: Sentis Suñé
Email: send email
Telefono: +34 973702061
Fax: +34 973702237

ES (LLEIDA) participant 364˙725.00
7    WAGENINGEN UNIVERSITY

 Organization address address: DROEVENDAALSESTEEG 4
city: WAGENINGEN
postcode: 6708 PB

contact info
Titolo: Prof.
Nome: Harro
Cognome: Bouwmeester
Email: send email
Telefono: +31 317 475882
Fax: +31 317 418094

NL (WAGENINGEN) participant 308˙445.00
8    JOHN INNES CENTRE

 Organization address address: "Norwich Research Park, Colney"
city: NORWICH
postcode: NR4 7UH

contact info
Titolo: Dr.
Nome: Mary
Cognome: Anderson
Email: send email
Telefono: +44 1603 450244
Fax: +44 1603 450887

UK (NORWICH) participant 275˙619.00
9    UNIVERSITE CATHOLIQUE DE LOUVAIN

 Organization address address: Place De L'Universite 1
city: LOUVAIN LA NEUVE
postcode: 1348

contact info
Titolo: Prof.
Nome: Marc
Cognome: Boutry
Email: send email
Telefono: +32 10 473621
Fax: +32 10 473872

BE (LOUVAIN LA NEUVE) participant 222˙565.00
10 KOBENHAVNS UNIVERSITET DK participant 185˙852.00
11    UNIVERSITAET ZUERICH

 Organization address address: Raemistrasse 71
city: ZURICH
postcode: 8006

contact info
Titolo: Prof.
Nome: Enrico
Cognome: Martinoia
Email: send email
Telefono: +41 44 634 8222
Fax: +41 44 634 8204

CH (ZURICH) participant 184˙125.00
12    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

 Organization address address: University Offices, Wellington Square
city: OXFORD
postcode: OX1 2JD

contact info
Titolo: Mr.
Nome: Rufus
Cognome: Trotman
Email: send email
Telefono: +44 1865 275052
Fax: +44 1865 275074

UK (OXFORD) participant 146˙906.00
13    ZURCHER HOCHSCHULE FUR ANGEWANDTE WISSENSCHAFTEN

 Organization address address: GERTRUDSTRASSE 15
city: WINTERTHUR
postcode: 8401

contact info
Titolo: Prof.
Nome: Regine
Cognome: Eibl
Email: send email
Telefono: +41 58 934 57 13
Fax: +41 58 934 50 01

CH (WINTERTHUR) participant 142˙821.00
14    MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.

 Organization address address: Hofgartenstrasse 8
city: MUENCHEN
postcode: 80539

contact info
Titolo: Mr.
Nome: Lothar
Cognome: Grube
Email: send email
Telefono: +49 3315678400
Fax: +49 3315678408

DE (MUENCHEN) participant 140˙802.00
15    Plant Advanced Technologies

 Organization address address: Rue du bois de la Champelle 13
city: Vandoeuvre
postcode: 54500

contact info
Titolo: Mr.
Nome: Jean-Paul
Cognome: Fevre
Email: send email
Telefono: +33 677020774
Fax: +33 383585799

FR (Vandoeuvre) participant 120˙125.00
16    SoluCel Oy

 Organization address address: Tietotie 2
city: Espoo
postcode: 2150

contact info
Titolo: Dr.
Nome: Jan
Cognome: Pen
Email: send email
Telefono: +31 653861090
Fax: +358 20 722707

FI (Espoo) participant 70˙981.00
17    Dow AgroSciences LLC

 Organization address address: Zionsville Road 9330
city: INDIANAPOLIS
postcode: 46268-1054

contact info
Titolo: Mr.
Nome: Ronald
Cognome: Maciak
Email: send email
Telefono: +1 317-3374829
Fax: +1 317 337 4847

US (INDIANAPOLIS) participant 0.00
18    INSTITUT DE RECHERCHE PIERRE FABRESAS

 Organization address address: PLACE ABEL GANCE 45
city: BOULOGNE BILLANCOURT
postcode: 92100

contact info
Titolo: Mr.
Nome: Yves
Cognome: Barbin
Email: send email
Telefono: +33 5 63 81 2400
Fax: +33 5 63 57 32 07

FR (BOULOGNE BILLANCOURT) participant 0.00
19    Philip Morris Products S.A.

 Organization address address: Quai Jeanrenaud 56
city: Neuchatel
postcode: 2000

contact info
Titolo: Dr.
Nome: Markus
Cognome: Klein
Email: send email
Telefono: +41 582428056
Fax: +41 328887713

CH (Neuchatel) participant 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

molecules    industry    then    metabolic    biosynthetic    terpenoid    plants    plant    compounds    too    secondary    tools    pharmaceutical    pathway    small    root    genes    companies    highest    pathways    chemical    levels    techniques    metabolite    academic    valuable    periwinkle    cultures    door    cell    smartcell    metabolites    hairy    multigene    industrial    regulatory    tobacco    sustainable    engineering   

 Obiettivo del progetto (Objective)

'Plants sustainably produce low levels of secondary metabolites of high industrial value. However, they are often too complex to be economically manufactured by chemical synthesis. Advanced metabolic engineering and exploitation of plants as Green Factories has been prevented due to poorly understood metabolic pathways in plants and the regulation thereof. SmartCell brings together 14 leading European academic laboratories and four industrial partners in order to create a novel concept for rationally engineering plants towards improved economical production of high-value compounds for non-food industrial use. Although SmartCell focuses on terpenoids, the largest class of secondary metabolites, which exhibit extremely diverse biological and pharmaceutical activities, all knowledge, tools and resources developed in the project, are generic and broadly applicable to engineer any plant biosynthetic pathway. A systems biology approach using metabolomics and transcriptomics is taken to move beyond the state of the art. New multigene transfer technologies are developed. By screening and functionally categorizing genes at structural, regulatory and transport levels a comprehensive knowledge base of how secondary metabolite biosynthetic pathways operate in plants is developed. The case study component i.e. manufacturing a valuable terpenoid in an optimized large-scale system gives SmartCell a unique opportunity to directly make transition from fundamental science to application. For long-term exploitation an integrated database, compound library, cell culture collection and a genebank available for academic and industrial communities will be established. SmartCell provides new opportunities for SMEs and established European biotech companies, and the technology can also be transferred to other e.g. fine chemical and pharmaceutical industries. SmartCell will prove that plant-based resources can furnish the European society and industry far more than they presently do.'

Introduzione (Teaser)

Plants produce small quantities of tiny molecules that are of great value to the pharmaceutical industry. Novel metabolic engineering techniques are opening the door to sustainable large-scale plant-based bioproduction.

Descrizione progetto (Article)

While the quantity of compounds produced by plants is perfect for them, it is too little to be useful to pharmaceutical companies. These molecules are highly complex and often similar to other less useful ones produced by the plants, making them difficult and expensive to isolate and extract.

The EU-funded project 'Rational design of plant systems for sustainable generation of value-added industrial products' (http://www.smart-cell.org/ (SMARTCELL)) developed new enabling techniques for industrial-scale exploitation of valuable plant secondary metabolites.

Scientists applied novel techniques to untangle the genes and products of the terpenoid indole alkaloid pathway to obtain secondary metabolites with pharmaceutical properties. Starting with a medicinal periwinkle plant that produces small amounts of the compounds of interest, researchers were able to find functional links among genes, enzymes and molecules. Using multigene transformations developed by partners, they then introduced the relevant genes into plant cells to test activity. With advanced and innovative analytical techniques, the team confirmed gene functions and production of target compounds.

The genes were then expressed in organisms such as bacteria, fast-growing tobacco, as well as hairy root cultures and cell suspensions that can be grown continuously. Novel bioinformatics tools were developed to measure and characterise spectral differences between groups of tobacco and periwinkle with different genotypes and growth conditions. The hairy root and cell suspension cultures provided the highest yields of geraniol, a target secondary metabolite, with production of approximately one gram within 41 days.

Advanced techniques and cost-effective production pathways open the door to produce limitless number of chemicals from equally unlimited types of plants. SMARTCELL has thus laid the groundwork for development of industrial-scale sustainable production of plant-based molecules of pharmaceutical relevance using biotechnological systems while meeting the highest regulatory standards.

Altri progetti dello stesso programma (FP7-KBBE)

PROMYSE (2012)

Products from methanol by synthetic cell factories

Read More  

OPTICHINA (2011)

Breeding to Optimise Chinese Agriculture

Read More  

SMARTBEES (2014)

Sustainable Management of Resilient Bee populations

Read More