CASCADE

Cultivated Adult Stem Cells as Alternative for Damaged tissue

 Coordinatore ETABLISSEMENT FRANCAIS DU SANG 

 Organization address address: AVENUE DU STADE DE FRANCE 20
city: LA PLAINE SAINT DENIS CEDEX
postcode: 93218

contact info
Titolo: Mr.
Nome: Laurent
Cognome: Beauverger
Email: send email
Telefono: +33 2 47 36 21 60
Fax: +33 2 47 36 21 87

 Nazionalità Coordinatore France [FR]
 Totale costo 5˙130˙179 €
 EC contributo 2˙979˙667 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2007-B
 Funding Scheme CP-FP
 Anno di inizio 2009
 Periodo (anno-mese-giorno) 2009-01-01   -   2011-12-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    ETABLISSEMENT FRANCAIS DU SANG

 Organization address address: AVENUE DU STADE DE FRANCE 20
city: LA PLAINE SAINT DENIS CEDEX
postcode: 93218

contact info
Titolo: Mr.
Nome: Laurent
Cognome: Beauverger
Email: send email
Telefono: +33 2 47 36 21 60
Fax: +33 2 47 36 21 87

FR (LA PLAINE SAINT DENIS CEDEX) coordinator 430˙000.00
2    DRK-BLUTSPENDEDIENST BADEN-WURTTEMBERG-HESSEN GGMBH

 Organization address address: FRIEDRICH EBERT STRASSE 107
city: MANNHEIM
postcode: 68167

contact info
Titolo: Prof.
Nome: Hubert
Cognome: Schrezenmeier
Email: send email
Telefono: -731150511
Fax: 49731150500

DE (MANNHEIM) participant 599˙414.00
3    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

 Organization address address: 101 Rue de Tolbiac
city: PARIS
postcode: 75654

contact info
Titolo: Ms.
Nome: Annick
Cognome: Bertault
Email: send email
Telefono: + 33 1 40 78 49 01
Fax: +33 1 40 78 49 98

FR (PARIS) participant 243˙725.00
4    FONDAZIONE IRCCS CA' GRANDA - OSPEDALE MAGGIORE POLICLINICO

 Organization address address: VIA FRANCESCO SFORZA 28
city: MILANO
postcode: 20122

contact info
Titolo: Dr.
Nome: Rosaria
Cognome: Giordano
Email: send email
Telefono: 390255000000
Fax: 39025458129

IT (MILANO) participant 204˙578.00
5    ALCIMED

 Organization address address: BOULEVARD DE MONTMORENCY 57
city: PARIS
postcode: 75016

contact info
Titolo: Mr.
Nome: David
Cognome: Bariau
Email: send email
Telefono: +33 1 44 30 44 38
Fax: +33 1 44 30 44 32

FR (PARIS) participant 199˙861.00
6    UNIVERSITA DEGLI STUDI DI VERONA

 Organization address address: VIA DELL ARTIGLIERE 8
city: VERONA
postcode: 37129

contact info
Titolo: Dr.
Nome: Mauro
Cognome: Krampera
Email: send email
Telefono: 0
Fax: 0

IT (VERONA) participant 152˙800.00
7    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

 Organization address address: University Offices, Wellington Square
city: OXFORD
postcode: OX1 2JD

contact info
Titolo: Ms.
Nome: Samantha
Cognome: Hatzis
Email: send email
Telefono: -222176
Fax: -230801

UK (OXFORD) participant 143˙000.00
8    UNIVERSITAET ULM

 Organization address address: HELMHOLTZSTRASSE 16
city: ULM
postcode: 89081

contact info
Titolo: Mr.
Nome: Frank
Cognome: Gleixner
Email: send email
Telefono: -50067079
Fax: -50067074

DE (ULM) participant 142˙798.00
9    ABCELL-BIO Sarl

 Organization address address: rue Taitbout 85
city: PARIS
postcode: 75009

contact info
Titolo: Mr.
Nome: Jean-Pierre
Cognome: Mouscadet
Email: send email
Telefono: + 33 1 40 03 89 14
Fax: + 33 1 42 81 47 58

FR (PARIS) participant 135˙000.00
10    UNIVERSITATEA DE MEDICINA SI FARMACE VICTOR BABES TIMISOARA

 Organization address address: PIATA EFTIMIE MURGU 2A
city: TIMISOARA
postcode: 300041

contact info
Titolo: Ms.
Nome: Constanta
Cognome: Caplar
Email: send email
Telefono: -220695
Fax: -220695

RO (TIMISOARA) participant 132˙000.00
11    UNIVERSITAET DES SAARLANDES

 Organization address address: CAMPUS
city: SAARBRUECKEN
postcode: 66041

contact info
Titolo: Ms.
Nome: Mareike
Cognome: Schmitt
Email: send email
Telefono: 49-681-9592 3366
Fax: 49-681-9592 3370

DE (SAARBRUECKEN) participant 123˙000.00
12    BIOTRACK SRL

 Organization address address: Via Einstein 1
city: LODI
postcode: 26900

contact info
Titolo: Dr.
Nome: Elisa
Cognome: Filippi
Email: send email
Telefono: 3903710000000
Fax: -3903710000000

IT (LODI) participant 120˙249.00
13    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

 Organization address address: Rue Michel -Ange 3
city: PARIS
postcode: 75794

contact info
Titolo: Ms.
Nome: Armelle
Cognome: Barelli
Email: send email
Telefono: + 33 5 61336080
Fax: + 33 5 62 17 29 01

FR (PARIS) participant 115˙243.00
14    UNIVERSITAETSKLINIKUM HEIDELBERG

 Organization address address: IM NEUENHEIMER FELD 672
city: HEIDELBERG
postcode: 69120

contact info
Nome: Thorsten
Cognome: Brietz
Email: send email
Telefono: -573258
Fax: -571632

DE (HEIDELBERG) participant 83˙000.00
15    THE UNIVERSITY OF SHEFFIELD

 Organization address address: FIRTH COURT WESTERN BANK
city: SHEFFIELD
postcode: S10 2TN

contact info
Titolo: Ms.
Nome: Gill
Cognome: Wells
Email: send email
Telefono: +44 114 222 1434
Fax: +44 114 222 1455

UK (SHEFFIELD) participant 80˙000.00
16    ORGANES TISSUS REGENERATION REPARATION REMPLACEMENT

 Organization address address: RUE FRANCAISE 4
city: PARIS
postcode: 75001

contact info
Titolo: Prof.
Nome: Denis
Cognome: Barritault
Email: send email
Telefono: 33142334453
Fax: -33142334453

FR (PARIS) participant 74˙999.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

cord    therapeutic    standards    repair    expectations    clinical    innovative    membrane    good    medicine    bone    protocols    networks    efficacy    cascade    models    therapies    mscs    ethical    culture    damaged    treating    technologies    mesenchymal    blood    expertise    wounds    regenerative    quality    cells    stem    amniotic    gmp    trials    vivo    tissue    vitro    marrow    safety    compliant    corneal    primary    immunological    skin    manufacturing    msc    therapy    human    cell   

 Obiettivo del progetto (Objective)

'Rapid progress in stem cell research pave the way for the development and use of new cell therapy products in regenerative medicine. The objective of CASCADE is to provide the European Community with unique expertise which focuses on the GMP production of mesenchymal stem cells (MSC) and their use in treating skin and corneal wounds, so that quality and safety criteria are paramount and match therapeutic expectations. Commencing with known procedures, CASCADE will develop innovative technologies based on the expertise of its partners. Among our research themes, the specific issue of multiple recipients and universal donors will be investigated. To this end, human MSC will be derived from 4 tissues, bone marrow, fat tissue, cord blood and amniotic membrane, according to good manufacturing practice (GMP). Phenotypic identity of GMP produced MSC, their genetic status and their potential for transformation will constitute the basis for establishing standards for controlling cell production. The efficacy of GMP produced MSC will be tested in in vitro and in vivo models, and the immunological consequences of their use will be studied. Moreover, during the whole CASCADE initiative, ethical and legal issues raised as a result of MSC therapies will be considered. Direct collaboration with two clinical networks will allow CASCADE to finely tune production specifications, and define optimal clinical protocols for these MSC-based cellular therapies. CASCADE will therefore gather together leading European cell therapy laboratories with unrivalled expertise in the production of therapeutic cells and in MSC biology, four SMEs with specific know-how in GMP production of cells and two clinical networks in dermatology and ophthalmology. The outcome will be a consortium that encompasses all the technologies and skills required to efficiently develop innovative technologies for the production of clinical grade MSC and to translate this production into a cell drug to repair wounds.'

Introduzione (Teaser)

Stem cell research holds promise for advances in regenerative medicine. Tissue repair is one such area that stands to benefit as related research forges ahead.

Descrizione progetto (Article)

Setting quality standards in tissue repair is a primary concern for improved health solutions to Europe's ageing population in particular. The production processes of tissue and cell therapies are highly demanding and this ups their final cost.

The 'Cultivated adult stem cells as alternative for damaged tissue' (Cascade) project offers expertise focusing on the good manufacturing practice (GMP) of producing mesenchymal stem cells (MSCs). With a high capacity for self renewal and ability to differentiate into a variety of cell types, MSCs have great therapeutic potential for tissue repair. Their use in treating skin and corneal wounds demands that standards of quality and safety are of the highest order and live up to therapeutic expectations.

Cascade is working to develop innovative technologies based on the expertise of its partners. The consortium brings together non-profit organisations, higher education institutions, research centres and small and medium-sized enterprises from five European countries. The project's main objective is to develop standardised and GMP-compliant methods of collecting and cultivating MSC intended for clinical use in the repair of damaged human tissue.

in line with its primary objectives, in the first 18 months of the project Cascade developed and provided GMP-compliant processes for MSC culture from bone marrow and adipose tissue. It is now developing methods for MSC culture from cord blood and amniotic membrane. Researchers have established in vitro and in vivo models for immunological testing, migration and efficiency in wound healing. These will help define the conditions necessary for clinical trials investigating the use of MSCs for skin and cornea repair. Project partners have set up a legislative database that ensures the produced MSCs adhere to ethical needs and varying European regulations.

the ultimate goal is to prepare study protocols for various trials that can evaluate the safety and efficacy of MSC applications for the treatment of chronic skin wounds. Presently, talks are being held with the European Medicines Agency and the Committee for Advanced Therapies on preclinical data and new relevant controls for safety and release of MSC products.

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