DOPAMINET

Molecular Networks of Dopaminergic Neurons in Chordates

Coordinatore	SCUOLA INTERNAZIONALE SUPERIORE DI STUDI AVANZATI    more  Organization address address: VIA BONOMEA 265 city: TRIESTE postcode: 34136 contact info Titolo: Mr. Nome: Luca Cognome: Bardi Email: send email Telefono: 390404000000 Fax: 390404000000
Nazionalità Coordinatore	Italy [IT]
Sito del progetto	http://www.dopaminet.eu/
Totale costo	3˙831˙030 €
EC contributo	2˙967˙180 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2007-B
Funding Scheme	CP-FP
Anno di inizio	2009
Periodo (anno-mese-giorno)	2009-02-01   -   2012-07-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	SCUOLA INTERNAZIONALE SUPERIORE DI STUDI AVANZATI  Organization address address: VIA BONOMEA 265 city: TRIESTE postcode: 34136 contact info Titolo: Mr. Nome: Luca Cognome: Bardi Email: send email Telefono: 390404000000 Fax: 390404000000	IT (TRIESTE)	coordinator	406˙400.00
2	Karlsruher Institut fuer Technologie  Organization address address: Kaiserstrasse 12 city: Karlsruhe postcode: 76131 contact info Titolo: Ms. Nome: Natascha Cognome: Wallburg Email: send email Telefono: +49 7247 825414 Fax: +49 7247 825403	DE (Karlsruhe)	participant	565˙980.00
3	THE UNIVERSITY OF BIRMINGHAM  Organization address address: Edgbaston city: BIRMINGHAM postcode: B15 2TT contact info Titolo: Mr. Nome: Robert Cognome: Fekete Email: send email Telefono: 441214000000 Fax: 441214000000	UK (BIRMINGHAM)	participant	398˙400.00
4	Consorzio per il Centro di Biomedicina Molecolare S.c.r.l.  Organization address address: STRADA STATALE 14 KM 163 5 city: TRIESTE postcode: 34149 contact info Titolo: Mr. Nome: Nicola Cognome: Dorigo Salamon Email: send email Telefono: +39 040 3757707 Fax: +39 040 3757710	IT (TRIESTE)	participant	357˙200.00
5	ALBERT-LUDWIGS-UNIVERSITAET FREIBURG  Organization address address: FAHNENBERGPLATZ city: FREIBURG postcode: 79085 contact info Titolo: Prof. Nome: Wolfgang Cognome: Driever Email: send email Telefono: 497612000000 Fax: 497612000000	DE (FREIBURG)	participant	297˙400.00
6	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE  Organization address address: Rue Michel -Ange 3 city: PARIS postcode: 75794 contact info Titolo: Ms. Nome: Beatrice Cognome: Saint-Cricq Email: send email Telefono: +33 491 164008 Fax: +33 491 779304	FR (PARIS)	participant	279˙400.00
7	RIKEN THE INSTITUTE OF PHYSICAL AND CHEMICAL RESEARCH  Organization address address: HIROSAWA 2-1 city: WAKO SHI SAITAMA postcode: 351 0198 contact info Titolo: Mr. Nome: Haruo Cognome: Yamaguchi Email: send email Telefono: +81 48 467 9299 Fax: +81 48 467 2634	JP (WAKO SHI SAITAMA)	participant	277˙400.00
8	UNIVERSITY COLLEGE LONDON  Organization address address: GOWER STREET city: LONDON postcode: WC1E 6BT contact info Titolo: Ms. Nome: Greta Cognome: Borg-Carbott Email: send email Telefono: +44 20 3108 3033 Fax: +44 20 7813 2849	UK (LONDON)	participant	230˙400.00
9	YH YOUHEALTH AB  Organization address address: FOGDEVRETEN 2 KAROLINSKA SCIENCE city: STOCKHOLM postcode: 171 77 contact info Titolo: Prof. Nome: Jesper Cognome: Tegnér Email: send email Telefono: +46 70 680 4989	SE (STOCKHOLM)	participant	85˙309.60
10	CLINICAL GENE NETWORKS AB  Organization address address: Karolinska Sience Park - FOGDEVRETEN 2 city: STOCKHOLM postcode: 171 77 contact info Titolo: Prof. Nome: Jesper Cognome: Tegner Email: send email Telefono: +46 733 56 81 81 Fax: +46 8 31 12 98	SE (STOCKHOLM)	participant	69˙290.40

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 Obiettivo del progetto (Objective)

'Background. Parkinson Disease is the second most common progressive neurodegenerative disorder. The selective degeneration of subsets of midbrain dopaminergic neurons is believed to be the primary cause for disruption of the ability to control movements. Objective. We propose to apply a highly interdisciplinary approach to construct complex networks consisting of protein coding genes, non-protein-coding genes and cis-regulatory elements within dopaminergic neurons in the brain across three chordate organisms (Mouse, Zebrafish and Ciona) to identify and compare gene regulatory networks in these neurons. This will be achieved by: • Expression profiling of genes on single dopaminergic neurons via laser microdissection and transgenic lines in Mouse, Ciona and Zebrafish • HT-Sequencing of microCAGE assays on dopaminergic neurons, providing TSS usage and transcript discovery • Microscopy HTS of cis-regulatory elements • siRNA and morpholino network perturbation experiments • Innovative systems biology approaches to decipher and define molecular networks Data generated by microCAGE and microarray will define a set of key genes in dopaminergic neurons, in which cis-regulatory elements will be predicted and screened utilizing HTS in zebrafish. The data will aid network reconstruction, which will be validated by perturbation experiments. This project relies also on the availability of data produced through the many existing collaborations among consortium partners such as FP6 funded TRANSCODE project as well as the international Fantom3 consortium. Potential impact: The prevalence of PD in Europe today is ~2 million people. Within the next 50 years, the number is expected to rise to 5 million. Thus, the burden placed by dementia on the working-age population will rise dramatically. No treatments are known to slow the progression of the disease. Deciphering the basic networks of dopaminergic neurons will generate novel diagnostic and therapeutic candidates.'