CARDIOGENET

Definition of a genetic network involved in congenital heart disease

 Coordinatore FONDAZIONE TELETHON 

 Organization address address: VIA VARESE 16/B
city: ROMA
postcode: 185

contact info
Titolo: Ms.
Nome: Irene
Cognome: Mearelli
Email: send email
Telefono: +39 06 44015308
Fax: +39 06 44119224

 Nazionalità Coordinatore Italy [IT]
 Sito del progetto http://www.cardiogenet.eu/
 Totale costo 3˙929˙129 €
 EC contributo 2˙680˙000 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2007-B
 Funding Scheme CP-FP
 Anno di inizio 2009
 Periodo (anno-mese-giorno) 2009-03-01   -   2013-02-28

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    FONDAZIONE TELETHON

 Organization address address: VIA VARESE 16/B
city: ROMA
postcode: 185

contact info
Titolo: Ms.
Nome: Irene
Cognome: Mearelli
Email: send email
Telefono: +39 06 44015308
Fax: +39 06 44119224

IT (ROMA) coordinator 667˙502.00
2    UNIVERSITY COLLEGE LONDON

 Organization address address: GOWER STREET
city: LONDON
postcode: WC1E 6BT

contact info
Titolo: Mr.
Nome: Kent
Cognome: Lee
Email: send email
Telefono: +44 20 76796296
Fax: +44 20 79052609

UK (LONDON) participant 485˙280.00
3    Academisch Medisch Centrum bij de Universiteit van Amsterdam

 Organization address address: MEIBERGDREEF 9
city: AMSTERDAM
postcode: 1105AZ

contact info
Nome: Andre
Cognome: De Graaf
Email: send email
Telefono: +31 20 5665404
Fax: +31 20 6976177

NL (AMSTERDAM) participant 473˙877.00
4    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

 Organization address address: Rue Michel -Ange 3
city: PARIS
postcode: 75794

contact info
Titolo: Ms.
Nome: Béatrice
Cognome: Saint-Cricq
Email: send email
Telefono: +33 4 91164008
Fax: +33 4 91779304

FR (PARIS) participant 471˙644.00
5    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

 Organization address address: University Offices, Wellington Square
city: OXFORD
postcode: OX1 2JD

contact info
Titolo: Mr.
Nome: Stephen
Cognome: Conway
Email: send email
Telefono: +44 1865 234653
Fax: +44 1865 223658

UK (OXFORD) participant 322˙415.00
6    MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.

 Organization address address: Hofgartenstrasse 8
city: MUENCHEN
postcode: 80539

contact info
Titolo: Ms.
Nome: Anke
Cognome: Badrow
Email: send email
Telefono: -84131403
Fax: -84131110

DE (MUENCHEN) participant 217˙001.45
7    CHARITE - UNIVERSITAETSMEDIZIN BERLIN

 Organization address address: Chariteplatz 1
city: BERLIN
postcode: 10117

contact info
Nome: Eveline
Cognome: Fräßdorf
Email: send email
Telefono: 4930450000000
Fax: 4930450000000

DE (BERLIN) participant 42˙280.54

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

interactions    data    genes    transcription    heart    oft    cardiac    cardiogenic    expression    models    gene    transcriptional    integrate    validated    normal    tbx    chd    networks   

 Obiettivo del progetto (Objective)

'This application focuses on transcriptional networks that govern the development of a heart region commonly affected by congenital heart disease (CHD). The major goal is to provide the clinical and basic science research communities with a validated list of interconnected genes required for normal heart development. To achieve this goal, we have recruited 6 European groups of scientists strongly committed to CHD research. The participants bring to the consortium significant resources and credible synergy. The entry point for the interrogation and perturbation of cardiogenic gene networks will be the transcription factor Tbx1, the major gene for 22q11.2 deletion syndrome, a common genetic cause of CHD. The project has three specific aims: 1) To define the roles and interactions of T-box transcription factors in cardiac outflow tract (OFT) development. Our hypothesis is that a critical balance of Tbx1, 2, and 3 is required to regulate homeostasis of a specific population of cardiac progenitors and their interactions with non-cardiogenic cells. 2) To define gene networks perturbed in OFT developmental defects. Innovative approaches will identify the transcriptional targets and protein interactors of Tbx1. Candidate genes will be validated in vitro and in vivo using mouse and zebrafish models. In addition, we will perform extensive transcriptome analyses using biopsy material from CHD patients in order to integrate animal and patient data. 3) To integrate gene expression, cell lineage distribution and phenotype data. Normal heart morphology is achieved through a concerted gene expression program and the integration of molecular signals and tissue interactions. Aided by 3-dimensional reconstruction of gene expression patterns and phenotypic information, we will integrate different types of data to develop models of CHD pathogenesis. Teamwork will be enhanced by shared technologies that provide homogeneity and comparability of data between the participating labs.'

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