CARDIOGENET

Definition of a genetic network involved in congenital heart disease

Coordinatore	FONDAZIONE TELETHON    more  Organization address address: VIA VARESE 16/B city: ROMA postcode: 185 contact info Titolo: Ms. Nome: Irene Cognome: Mearelli Email: send email Telefono: +39 06 44015308 Fax: +39 06 44119224
Nazionalità Coordinatore	Italy [IT]
Sito del progetto	http://www.cardiogenet.eu/
Totale costo	3˙929˙129 €
EC contributo	2˙680˙000 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2007-B
Funding Scheme	CP-FP
Anno di inizio	2009
Periodo (anno-mese-giorno)	2009-03-01   -   2013-02-28

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	FONDAZIONE TELETHON  Organization address address: VIA VARESE 16/B city: ROMA postcode: 185 contact info Titolo: Ms. Nome: Irene Cognome: Mearelli Email: send email Telefono: +39 06 44015308 Fax: +39 06 44119224	IT (ROMA)	coordinator	667˙502.00
2	UNIVERSITY COLLEGE LONDON  Organization address address: GOWER STREET city: LONDON postcode: WC1E 6BT contact info Titolo: Mr. Nome: Kent Cognome: Lee Email: send email Telefono: +44 20 76796296 Fax: +44 20 79052609	UK (LONDON)	participant	485˙280.00
3	Academisch Medisch Centrum bij de Universiteit van Amsterdam  Organization address address: MEIBERGDREEF 9 city: AMSTERDAM postcode: 1105AZ contact info Nome: Andre Cognome: De Graaf Email: send email Telefono: +31 20 5665404 Fax: +31 20 6976177	NL (AMSTERDAM)	participant	473˙877.00
4	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE  Organization address address: Rue Michel -Ange 3 city: PARIS postcode: 75794 contact info Titolo: Ms. Nome: Béatrice Cognome: Saint-Cricq Email: send email Telefono: +33 4 91164008 Fax: +33 4 91779304	FR (PARIS)	participant	471˙644.00
5	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD  Organization address address: University Offices, Wellington Square city: OXFORD postcode: OX1 2JD contact info Titolo: Mr. Nome: Stephen Cognome: Conway Email: send email Telefono: +44 1865 234653 Fax: +44 1865 223658	UK (OXFORD)	participant	322˙415.00
6	MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.  Organization address address: Hofgartenstrasse 8 city: MUENCHEN postcode: 80539 contact info Titolo: Ms. Nome: Anke Cognome: Badrow Email: send email Telefono: -84131403 Fax: -84131110	DE (MUENCHEN)	participant	217˙001.45
7	CHARITE - UNIVERSITAETSMEDIZIN BERLIN  Organization address address: Chariteplatz 1 city: BERLIN postcode: 10117 contact info Nome: Eveline Cognome: Fräßdorf Email: send email Telefono: 4930450000000 Fax: 4930450000000	DE (BERLIN)	participant	42˙280.54

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 Obiettivo del progetto (Objective)

'This application focuses on transcriptional networks that govern the development of a heart region commonly affected by congenital heart disease (CHD). The major goal is to provide the clinical and basic science research communities with a validated list of interconnected genes required for normal heart development. To achieve this goal, we have recruited 6 European groups of scientists strongly committed to CHD research. The participants bring to the consortium significant resources and credible synergy. The entry point for the interrogation and perturbation of cardiogenic gene networks will be the transcription factor Tbx1, the major gene for 22q11.2 deletion syndrome, a common genetic cause of CHD. The project has three specific aims: 1) To define the roles and interactions of T-box transcription factors in cardiac outflow tract (OFT) development. Our hypothesis is that a critical balance of Tbx1, 2, and 3 is required to regulate homeostasis of a specific population of cardiac progenitors and their interactions with non-cardiogenic cells. 2) To define gene networks perturbed in OFT developmental defects. Innovative approaches will identify the transcriptional targets and protein interactors of Tbx1. Candidate genes will be validated in vitro and in vivo using mouse and zebrafish models. In addition, we will perform extensive transcriptome analyses using biopsy material from CHD patients in order to integrate animal and patient data. 3) To integrate gene expression, cell lineage distribution and phenotype data. Normal heart morphology is achieved through a concerted gene expression program and the integration of molecular signals and tissue interactions. Aided by 3-dimensional reconstruction of gene expression patterns and phenotypic information, we will integrate different types of data to develop models of CHD pathogenesis. Teamwork will be enhanced by shared technologies that provide homogeneity and comparability of data between the participating labs.'