SYSTEQ
"The development, validation and implementation of human systemic Toxic Equivalencies (TEQs) as biomarkers for dioxin-like compounds"
| Coordinatore | UNIVERSITEIT UTRECHT
Organization address
address: Heidelberglaan 8 contact info |
| Nazionalità Coordinatore | Netherlands [NL] |
| Totale costo | 3˙532˙263 € |
| EC contributo | 2˙703˙596 € |
| Programma | FP7-ENVIRONMENT
Specific Programme "Cooperation": Environment (including Climate Change) |
| Code Call | FP7-ENV-2008-1 |
| Funding Scheme | CP-FP |
| Anno di inizio | 2009 |
| Periodo (anno-mese-giorno) | 2009-02-01 - 2013-11-30 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
UNIVERSITEIT UTRECHT
Organization address
address: Heidelberglaan 8 contact info |
NL (UTRECHT) | coordinator | 864˙141.00 |
| 2 |
UMEA UNIVERSITET
Organization address
address: UNIVERSITETOMRADET contact info |
SE (UMEA) | participant | 499˙800.00 |
| 3 |
KAROLINSKA INSTITUTET
Organization address
address: Nobels Vag 5 contact info |
SE (STOCKHOLM) | participant | 498˙600.00 |
| 4 |
TECHNISCHE UNIVERSITAET KAISERSLAUTERN
Organization address
address: GOTTLIEB-DAIMLER-STRASSE Geb. 47 contact info |
DE (KAISERSLAUTERN) | participant | 474˙295.70 |
| 5 |
VYZKUMNY USTAV VETERINARNIHO LEKARSTVI
Organization address
address: Hudcova 70 contact info |
CZ (BRNO) | participant | 318˙759.56 |
| 6 |
SLOVENSKA ZDRAVOTNICKA UNIVERZITA V BRATISLAVE
Organization address
address: LIMBOVA 12 contact info |
SK (BRATISLAVA) | participant | 48˙000.00 |
Mappa
Word cloud
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Obiettivo del progetto (Objective)
'Chlorinated dioxins and biphenyls (PCBs) commonly occur in the human food chain and can still be detected at levels that might cause long term health effects. Exposure to dioxin-like compounds involves a complex mixture with a common mechanism of action involving endocrine, developmental, carcinogenic, immuno and neurological effects. Risk assessment is done with an additive model for mixture toxicity. Based on this the Toxic Equivalency (TEQ) concept was developed as a biomarker for exposure and risk. TEQs are the sum of congener-specific toxic equivalency factors (TEFs) multiplied by the concentration in a matrix, e.g. blood. TEF values are a composite quantitative value from a range of biomarkers that are congener and endpoint specific. Present human TEQs have been derived from oral administration experiments providing ‘intake’ TEFs. Regulatory authorities frequently use ‘intake’ TEQs for blood and tissues considering it a biomarker for exposure or effect. Experimental evidence shows that using ‘uptake’ TEQs as ‘systemic’ biomarkers may lead to misinterpretation of risks. Therefore, development and validation of ‘systemic’ TEFs and TEQs as biomarkers is necessary. Major objectives of SYSTEQ are: i) establish ‘systemic’ TEFs and TEQs, ii) identify novel quantifiable biomarkers with newest molecular methods, e.g. genetic fingerprinting profiles, iii) extra focus on effects in peripheral lymphocytes as biomarkers, iv) identify differences between humans and experimental species. The ‘systemic’ TEFs and TEQs from SYSTEQ will be used in conjunction with results of the completed EU PCBRISK project, in which two populations from Slovakia with very different exposure were studied. Individual blood levels and different biomarkers are already available. Results of SYSTEQ are also going to be used to establish international consensus values of ‘systemic’ TEFs at WHO level, facilitating the global use of ‘systemic’ TEQs as biomarkers of effect and exposure.'
Introduzione (Teaser)
Assessing the risk associated with potentially toxic compounds is important to limit their impact on human health. A recent project has updated standard measures of toxicity for a common group of toxins.