ARIMMORA

Advanced Research on Interaction Mechanisms of electroMagnetic exposures with Organisms for Risk Assessment

 Coordinatore Foundation for Research on Information Technologies in Society 

 Organization address address: Zeughausstrasse 43
city: Zurich
postcode: 8004

contact info
Titolo: Dr.
Nome: Iris
Cognome: Szankowski
Email: send email
Telefono: 41442459686
Fax: 41442459699

 Nazionalità Coordinatore Switzerland [CH]
 Totale costo 4˙577˙320 €
 EC contributo 3˙249˙970 €
 Programma FP7-ENVIRONMENT
Specific Programme "Cooperation": Environment (including Climate Change)
 Code Call FP7-ENV-2011
 Funding Scheme CP-FP
 Anno di inizio 2011
 Periodo (anno-mese-giorno) 2011-10-01   -   2015-03-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    Foundation for Research on Information Technologies in Society

 Organization address address: Zeughausstrasse 43
city: Zurich
postcode: 8004

contact info
Titolo: Dr.
Nome: Iris
Cognome: Szankowski
Email: send email
Telefono: 41442459686
Fax: 41442459699

CH (Zurich) coordinator 231˙958.00
2    UNIVERSITAET BASEL

 Organization address address: Petersplatz 1
city: BASEL
postcode: 4003

contact info
Titolo: Prof.
Nome: Primo
Cognome: Schär
Email: send email
Telefono: +41 61 2670767
Fax: +41 61 2673566

CH (BASEL) participant 725˙244.80
3    AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS

 Organization address address: CALLE SERRANO 117
city: MADRID
postcode: 28006

contact info
Titolo: Mr.
Nome: Eusebio
Cognome: Jiménez Arroyo
Email: send email
Telefono: +34 91 566 8852
Fax: +34 91 566 89 13

ES (MADRID) participant 666˙529.50
4    Schmid & Partner Engineering AG

 Organization address address: Zeughausstrasse 43
city: Zurich
postcode: 8004

contact info
Titolo: Dr.
Nome: Katja
Cognome: Pokovic
Email: send email
Telefono: 41442459707
Fax: 41442459779

CH (Zurich) participant 490˙489.20
5    FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V

 Organization address address: Hansastrasse 27C
city: MUENCHEN
postcode: 80686

contact info
Titolo: Ms.
Nome: Andrea
Cognome: Zeumann
Email: send email
Telefono: +49 89 1205 2723
Fax: +49 89 1205 7534

DE (MUENCHEN) participant 433˙245.00
6    WEIZMANN INSTITUTE OF SCIENCE

 Organization address address: HERZL STREET 234
city: REHOVOT
postcode: 7610001

contact info
Titolo: Ms.
Nome: Talia
Cognome: Tzahor
Email: send email
Telefono: +972 8 934 4026
Fax: +972 8934 4165

IL (REHOVOT) participant 277˙049.60
7    CENTRE INTERNATIONAL DE RECHERCHE SUR LE CANCER

 Organization address address: Cours Albert-Thomas 150
city: LYON CEDEX 08
postcode: 69372

contact info
Titolo: Dr.
Nome: Olaf
Cognome: Kelm
Email: send email
Telefono: +33 4 727 384 94
Fax: +33 4 727 385 75

FR (LYON CEDEX 08) participant 173˙766.00
8    STIFTUNG TIERAERZTLICHE HOCHSCHULE HANNOVER

 Organization address address: BUNTEWEG 2
city: HANNOVER
postcode: 30559

contact info
Titolo: Mr.
Nome: Peter
Cognome: Joppe
Email: send email
Telefono: +49 511 953 8020
Fax: +49 511 953 828020

DE (HANNOVER) participant 156˙153.60
9    CONSIGLIO NAZIONALE DELLE RICERCHE

 Organization address address: Piazzale Aldo Moro 7
city: ROMA
postcode: 185

contact info
Titolo: Dr.
Nome: Paolo
Cognome: Ravazzani
Email: send email
Telefono: +39 02 23993344
Fax: +39 02 23993367

IT (ROMA) participant 95˙535.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

risks    epigenetic    cells    cancer    epidemiological    biophysical    extremely    mfs    evidence    techniques    exposure    childhood    models    experimental    mechanisms    underlying    elf    humans    carcinogenic    magnetic    leukaemia    frequency    mf    vivo   

 Obiettivo del progetto (Objective)

'Based on epidemiological evidence supporting an ssociation between residential exposure to extremely low frequency magnetic fields (ELF MF) and childhood leukaemia, ELF MF have been classified as possibly carcinogenic to humans. The proposed project aims to scrutinize the underlying biophysical mechanisms and to clarify a possible causal relationship between ELF MF exposure and cancer, especially childhood leukaemia. This will be achieved by 1) developing and applying novel experimental and computational techniques to close knowledge gaps in the exposure assessment to ELF MF and 2) applying advanced biological in vitro, ex vivo and in vivo models and techniques under well-defined exposure conditions to test likely interaction mechanisms. The selected experimental approach is based on epidemiological evidence and current knowledge about the molecular processes underlying acute leukaemia in children. It aims to investigate the possible impact of ELF-MF exposure: 1) on the epigenetic dynamics associated with hematopoietic cell lineage commitment and differentiation; epigenetic signatures will be monitored genome-wide, and mechanisms underlying eventual “misprogramming” will be addressed in gene promoter models; 2) on the alteration of signalling processes in cells; 3) on the induction of possible cytotoxic effects on CD8 positive T cells; and 4) on the genesis or evolution of childhood leukaemia by generating genetically modified advanced animal models. Advanced biophysical simulations with efficient numerical solvers combined with the latest tissue and cellular models will be implemented to support the bioexperiments. A risk assessment will be performed at the end based on studies conducted within the project and correlated to recent studies conducted outside the consortium by adapting and applying procedures as outlined by the International Agency for Research on Cancer (IARC) Monographs on the Evaluation of Carcinogenic Risks to Humans.'

Introduzione (Teaser)

The link between extremely-low-frequency magnetic fields (ELF-MFs) and cancer is still unproven. An EU-funded project is working to assess the risks of childhood leukaemia in association with exposure to ELF-MFs.

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