BIOCHEMLIG

Bio-Orthogonal Chemo-Specific Ligation

 Coordinatore UNIVERSITE DE STRASBOURG 

 Organization address address: rue Blaise Pascal 4
city: Strasbourg
postcode: 67070

contact info
Titolo: Ms.
Nome: Laurence
Cognome: Petin-Monteil
Email: send email
Telefono: 33388414348
Fax: 33388414310

 Nazionalità Coordinatore France [FR]
 Totale costo 3˙322˙086 €
 EC contributo 3˙322˙086 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-ITN-2008
 Funding Scheme MC-ITN
 Anno di inizio 2009
 Periodo (anno-mese-giorno) 2009-10-01   -   2013-09-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    UNIVERSITE DE STRASBOURG

 Organization address address: rue Blaise Pascal 4
city: Strasbourg
postcode: 67070

contact info
Titolo: Ms.
Nome: Laurence
Cognome: Petin-Monteil
Email: send email
Telefono: 33388414348
Fax: 33388414310

FR (Strasbourg) coordinator 667˙996.70
2    ALMA MATER STUDIORUM-UNIVERSITA DI BOLOGNA

 Organization address address: Via Zamboni 33
city: BOLOGNA
postcode: 40126

contact info
Titolo: Dr.
Nome: Pier Paolo
Cognome: Palmieri
Email: send email
Telefono: +39 051 2099455
Fax: +39 051 2099456

IT (BOLOGNA) participant 579˙589.06
3    UNIVERSITAET BASEL

 Organization address address: Petersplatz 1
city: BASEL
postcode: 4003

contact info
Titolo: Prof.
Nome: Thomas
Cognome: Ward
Email: send email
Telefono: 41612671004
Fax: 41612671005

CH (BASEL) participant 434˙707.00
4    UNIVERSITAET BERN

 Organization address address: Hochschulstrasse 4
city: BERN
postcode: 3012

contact info
Titolo: Prof.
Nome: Jean-Louis
Cognome: Reymond
Email: send email
Telefono: 41316314325
Fax: 41316318057

CH (BERN) participant 434˙706.97
5    COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

 Organization address address: RUE LEBLANC 25
city: PARIS 15
postcode: 75015

contact info
Titolo: Dr.
Nome: Frédéric
Cognome: Taran
Email: send email
Telefono: +3301 69 08 26 85
Fax: +3301 69 08 79 91

FR (PARIS 15) participant 402˙474.75
6    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

 Organization address address: University Offices, Wellington Square
city: OXFORD
postcode: OX1 2JD

contact info
Titolo: Mr.
Nome: Stewart
Cognome: Deakin
Email: send email
Telefono: 441865000000
Fax: 441865000000

UK (OXFORD) participant 396˙892.28
7    KEMIJSKI INSTITUT

 Organization address address: HAJDRIHOVA 19
city: LJUBLJANA
postcode: 1000

contact info
Titolo: Ms.
Nome: Maja
Cognome: Miric
Email: send email
Telefono: +386 1 4760 419
Fax: +386 1 4760 300

SI (LJUBLJANA) participant 227˙216.19
8    caprotec bioanalytics GmbH

 Organization address address: Volmerstrasse 5
city: Berlin
postcode: 12489

contact info
Titolo: Dr.
Nome: Michael
Cognome: Sefkow
Email: send email
Telefono: +49 306 392 3947
Fax: +49 306 392 3985

DE (Berlin) participant 178˙504.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

chemo    biology    protein    macromolecule    environmentally    reactions    chemical    ligation    molecular    precision    bio    chemistry    disciplines    cellular    post   

 Obiettivo del progetto (Objective)

'The Post-genomic era calls for a deep understanding of protein structure and function. The elucidation of protein structures, localization, post-translation modifications, and protein-macromolecule interactions are important to establish their role in the biology of the cell. To establish their role and investigate the protein functions requires the integration of various complementary disciplines. Among all disciplines, chemistry is central in establishing new effective ways to manipulate a biological entity to understand cellular processes with molecular precision. For studying, analyzing and manipulating a macromolecule, the site-specific incorporation of reporter molecules, by virtue of ligation reactions, is a key factor. The BioChemLig research project presented herein describes novel approaches for the discovery of new bio-compatible and chemo-specific ligation reactions. The aim of this project is to develop new ligation processes with high efficiency, large scope of application, high chemoselectivity and high rates. Through a well established network, with demonstrated success (IBAAC Project: FP6-505020), we propose to focus our efforts in a highly combined and integrated training research action conducting research and using: unusual organic chemical functionalities for ligation, environmentally benign “on water” ligation reactions, specific 18F radiolabelled reagents, dendrimers conjugation methodologies, high-throughput screening for bond forming reactions, bio-chemo informatics platform for theoretical investigations, artificial metalo-enzymes for template-directed ligation, templated ligation reactions and HTS. This high quality integrated research should ultimately allow scientists to dissect cellular processes with molecular precision, speed up preparation of library of bioconjugates and deliver innovatives approaches to chemical biology.'

Introduzione (Teaser)

Bioorthogonal chemistry uses covalent chemistry to track biomolecules in their native environment. An EU project prioritised development of new, environmentally friendly and versatile chemical ligation methods.

Altri progetti dello stesso programma (FP7-PEOPLE)

SYNRESH (2012)

Synchronous Regime Shifts Across European Seas

Read More  

P.R.I.M.E. (2014)

Postdoctoral Researchers International Mobility Experience

Read More  

CRISI (2014)

Cross-Border Regional Innovation System Integration

Read More