NANOANTENNA

Development of a high sensitive and specific nanobiosensor based on surface enhanced vibrational spectroscopy dedicated to the in vitro proteins detection and disease diagnosis

 Coordinatore CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE 

 Organization address address: Rue Michel -Ange 3
city: PARIS
postcode: 75794

contact info
Titolo: Mr.
Nome: Gilles
Cognome: Traimond
Email: send email
Telefono: +33 1 45075017
Fax: +33 1 45075819

 Nazionalità Coordinatore France [FR]
 Totale costo 5˙920˙214 €
 EC contributo 3˙999˙925 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2009-single-stage
 Funding Scheme CP-FP
 Anno di inizio 2009
 Periodo (anno-mese-giorno) 2009-10-01   -   2013-03-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

 Organization address address: Rue Michel -Ange 3
city: PARIS
postcode: 75794

contact info
Titolo: Mr.
Nome: Gilles
Cognome: Traimond
Email: send email
Telefono: +33 1 45075017
Fax: +33 1 45075819

FR (PARIS) coordinator 599˙491.00
2    TECHNOCLONE HERSTELLUNG DIAGNOSTIKAUND ARZNEIMITTELN GMBH

 Organization address address: BRUNNERSTRASSE 59/5
city: WIEN
postcode: 1230

contact info
Titolo: Mrs.
Nome: Veronika
Cognome: Binder
Email: send email
Telefono: +43 1 863730

AT (WIEN) participant 399˙959.00
3    HORIBA JOBIN YVON S.A.S.

 Organization address address: Rue du Canal 16-18
city: LONGJUMEAU
postcode: 91160

contact info
Titolo: Ms.
Nome: Blandine
Cognome: Mariot
Email: send email
Telefono: +33 1 64 54 13 90
Fax: +33 1 64 54 13 67

FR (LONGJUMEAU) participant 367˙092.00
4    FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA

 Organization address address: VIA MOREGO 30
city: GENOVA
postcode: 16163

contact info
Titolo: Mr.
Nome: Gabriele
Cognome: Ballero
Email: send email
Telefono: +39 01071781445
Fax: +39 010720321

IT (GENOVA) participant 340˙131.00
5    RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG

 Organization address address: SEMINARSTRASSE 2
city: HEIDELBERG
postcode: 69117

contact info
Titolo: Dr.
Nome: Verena
Cognome: Schultz-Coulon
Email: send email
Telefono: +49 6221 542424
Fax: +49 6221 543599

DE (HEIDELBERG) participant 319˙946.00
6    BEN-GURION UNIVERSITY OF THE NEGEV

 Organization address address: Office of the President - Main Campus
city: BEER SHEVA
postcode: 84105

contact info
Titolo: Ms.
Nome: Daphna
Cognome: Tripto
Email: send email
Telefono: +972 8 6472425
Fax: +972 8 6472930

IL (BEER SHEVA) participant 319˙897.00
7    CONSIGLIO NAZIONALE DELLE RICERCHE

 Organization address address: Piazzale Aldo Moro 7
city: ROMA
postcode: 185

contact info
Titolo: Ms.
Nome: Giovanna
Cognome: Toscano
Email: send email
Telefono: +39 090 39762 201
Fax: +39 090 3974 130

IT (ROMA) participant 282˙165.00
8    AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS

 Organization address address: CALLE SERRANO 117
city: MADRID
postcode: 28006

contact info
Titolo: Mr.
Nome: Carlos M.
Cognome: Abad Ruiz
Email: send email
Telefono: +3491566 8852
Fax: +34 915668913

ES (MADRID) participant 279˙891.50
9    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

 Organization address address: 101 Rue de Tolbiac
city: PARIS
postcode: 75654

contact info
Titolo: Dr.
Nome: Nathalie
Cognome: Charnaux
Email: send email
Telefono: +33 1 48 38 73 53
Fax: +33 1 48 38 77 77

FR (PARIS) participant 277˙718.30
10    UNIVERSITE DE TECHNOLOGIE DE TROYES

 Organization address address: rue Marie Curie 12
city: TROYES
postcode: 10010

contact info
Titolo: Prof.
Nome: Dominique
Cognome: Barchiesi
Email: send email
Telefono: +33 3 25 715 826
Fax: +33 3 25 715 649

FR (TROYES) participant 273˙950.00
11    Asociacion - Centro de Investigacion Cooperativa en Nanociencias - CIC NANOGUNE

 Organization address address: Tolosa Hiribidea 76
city: San Sebastian
postcode: 20018

contact info
Titolo: Mr.
Nome: Miguel
Cognome: Odriozola Braconier
Email: send email
Telefono: +34 943574000
Fax: +34 943574001

ES (San Sebastian) participant 270˙036.00
12    ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES

 Organization address address: PASEO MIRAMON PARQUE TECNOLOGICO DE SAN SEBASTIAN EDIFICIO EMPRESARIAL C 182
city: SAN SEBASTIAN
postcode: 20009

contact info
Titolo: Dr.
Nome: Valery
Cognome: Pavlov
Email: send email
Telefono: +34 943005300
Fax: +34 943005301

ES (SAN SEBASTIAN) participant 269˙649.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

threshold    detection    protein    device    nanobiosensor    corresponds    functionalisation    enhanced    sensitivity    proteins    diagnosis    nanoparticle    lower    sensor    then    nanoantenna    detected    optical    vibrational    enhancement    signal   

 Obiettivo del progetto (Objective)

'The main goal of our proposal is to develop a novel optical nanobiosensor based on extraordinary vibrational signal enhancement of the proteins to be detected. To reach vibrational signal enhancement, we will exploit the optical properties of specially designed metallic nanoparticles which should act as nanoantenna and the associated field enhancement to obtain a direct detection of proteins bound to the nanoparticle. Thus, our sensor will reach high sensitivity provided by the recently established large enhancement of vibration signals due to the resonant excitation of the nanoantenna device used as substrates. The aim is to detect only a few proteins with concentration much lower than 1pM and finally to reach detection threshold such as femtomole or lower. High molecular selectivity will be reached with the functionalisation of the nanoantenna. Such functionalisation will selectively favour the immobilisation of the protein to be detected at the vicinity of the nanoparticle surface, providing the best enhancement and then the detection of the targeted protein. Our nanobiosensor will include two main components: the nanoantenna device which corresponds to our sensor transducer and the functionalisation which corresponds to its bioreceptor. And then, each functionalised nanoantenna device used as vibrational signal enhanced system is an individual and specific nanosensor of proteins. As a consequence, our nanobiosensor integrated in a vibrational spectroscope will allow the detection and the analysis of the enhanced vibrational signal from the targeted proteins and thus corresponds to our diagnosis instrument. Our nanobiosensor will be validated on the detection of proteins on body fluids.These proteins have been chosen since they have been identified as specific biomarkers of common pathologies. This validation will be applied it to improve their detection (better sensitivity, decrease of the detection threshold) and open the way to the early diagnosis.'

Introduzione (Teaser)

EU-funded scientists have developed highly sensitive and specific detectors of disease-associated proteins. Technology paves the way to simple blood tests that identify the onset of important diseases for more effective treatment.

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