NOPERSIST
Novel strategies for the prevention and control of persistent infections
| Coordinatore | LIONEX GMBH
Organization address
address: Salzdahlumer Strasse 196 contact info |
| Nazionalità Coordinatore | Germany [DE] |
| Sito del progetto | http://www.lionex.eu |
| Totale costo | 1˙714˙410 € |
| EC contributo | 1˙319˙990 € |
| Programma | FP7-SME
Specific Programme "Capacities": Research for the benefit of SMEs |
| Code Call | FP7-SME-2008-1 |
| Funding Scheme | BSG-SME |
| Anno di inizio | 2010 |
| Periodo (anno-mese-giorno) | 2010-01-01 - 2012-12-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
LIONEX GMBH
Organization address
address: Salzdahlumer Strasse 196 contact info |
DE (BRAUNSCHWEIG) | coordinator | 533˙984.00 |
| 2 |
PRIONICS AG
Organization address
address: WAGISTRASSE 27 A contact info |
CH (SCHLIEREN) | participant | 359˙000.00 |
| 3 |
IVD GESELLSCHAFT FUR INNOVATIVE VETERINARDIAGNOSTIK GMBH
Organization address
address: HEISTERBERGALLEE 12 contact info |
DE (Hannover) | participant | 276˙700.00 |
| 4 |
VICHEM CHEMIE KUTATO KFT
Organization address
address: HERMANN OTTO UTCA 15 contact info |
HU (BUDAPEST) | participant | 100˙410.00 |
| 5 |
PRINS LEOPOLD INSTITUUT VOOR TROPISCHE GENEESKUNDE
Organization address
address: Nationalestraat 155 contact info |
BE (ANTWERPEN) | participant | 11˙200.00 |
| 6 |
THE SECRETARY OF STATE FOR ENVIRONMENT, FOOD AND RURAL AFFAIRS
Organization address
address: Area 1A, Nobel House, Smith Square 17 contact info |
UK (LONDON) | participant | 11˙200.00 |
| 7 |
KAROLINSKA INSTITUTET
Organization address
address: Nobels Vag 5 contact info |
SE (STOCKHOLM) | participant | 9˙200.00 |
| 8 |
HELMHOLTZ-ZENTRUM FUER INFEKTIONSFORSCHUNG GMBH
Organization address
address: Inhoffenstrasse 7 contact info |
DE (BRAUNSCHWEIG) | participant | 8˙160.00 |
| 9 |
UNIVERSITA DEGLI STUDI DI FIRENZE
Organization address
address: Piazza San Marco 4 contact info |
IT (Florence) | participant | 5˙696.00 |
| 10 |
INSTITUT DE INVESTIGACIO EN CIENCIES DE LA SALUT GERMANS TRIAS I PUJOL
Organization address
address: Carretera de Canyet s/n contact info |
ES (BADALONA BARCELONA) | participant | 4˙440.00 |
| 11 |
STIFTUNG TIERAERZTLICHE HOCHSCHULE HANNOVER
Organization address
address: BUNTEWEG 2 contact info |
DE (HANNOVER) | participant | 0.00 |
| 12 |
TECHNISCHE UNIVERSITAET CLAUSTHAL
Organization address
address: ADOLPH-ROEMER-STRASSE 2A contact info |
DE (CLAUSTHAL-ZELLERFELD) | participant | 0.00 |
Mappa
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Obiettivo del progetto (Objective)
'Persistent infections such as HIV, tuberculosis´(TB) in humans and para-tuberculosis (ParaTB)-, mycoplasma- and Haemophilus-infections in farm animals are global health problems of immense social and economic importance . HIV-1 affects about 40 million people and M. tuberculosis infection is even higher world-wide. Co-infection with M. tuberculosis is estimated in about one-third of HIV-1 infected subjects. Globally, there are more than 14 million persons dually infected with TB and HIV. Drug resistance to HIV-treatment and appearance of multiple-drug resistance (MDR) and off late of Extra-Drug Resistance (XDR) strains of M. tuberculosis , the causative agent of human TB is steadily leading to a hopeless situation as far as therapy is concerned. To make things worse, there is no effective vaccine available against the persistent infections addresses in this proposal. The four SME members of this consortium with complimentary areas of research and business activities, LIONEX (in TB), Prionics (in ParaTB) , Vichem (in HIV) and IVD (in pig infections) are dedicated to solving the problems of the persistent infections mentioned above by employing novel strategies of product development for diagnosis, prevention and control of these global diseases by outsourcing demanding but feasible work to internationally known research organisations (RTDP) with highly positive track record. The SMEs alone cannot perform the outsourced work but shall validate and exploit the results provided by the RTDPs. Our novel but realistic objectives are: 1. To develop new drug candidates for drug resistant persistent infections (HIV and TB) 2. To identify and isolate novel antigens for the diagnosis of TB, ParaTB and infections in pigs 3. To identify antigens suitable for vaccine development for these persistent infections 4. To develop marketable, improved diagnostic products within a period of three years'
Introduzione (Teaser)
Persistent infections in farm animals have serious socioeconomic implications. The NOPERSIST study is focused on obtaining effective drug formulations and diagnostic reagents to combat the phenomenon.
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