NAMDIATREAM

NANOTECHNOLOGICAL TOOLKITS FOR MULTI-MODAL DISEASE DIAGNOSTICS AND TREATMENT MONITORING

 Coordinatore THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN 

 Organization address address: College Green -
city: DUBLIN
postcode: 2

contact info
Titolo: Ms.
Nome: Deirdre
Cognome: Savage
Email: send email
Telefono: 35318961942
Fax: 35317071633

 Nazionalità Coordinatore Ireland [IE]
 Sito del progetto http://www.namdiatream.eu
 Totale costo 16˙519˙663 €
 EC contributo 11˙999˙205 €
 Programma FP7-NMP
Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies
 Code Call FP7-NMP-2009-LARGE-3
 Funding Scheme CP-IP
 Anno di inizio 2010
 Periodo (anno-mese-giorno) 2010-07-01   -   2014-06-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN

 Organization address address: College Green -
city: DUBLIN
postcode: 2

contact info
Titolo: Ms.
Nome: Deirdre
Cognome: Savage
Email: send email
Telefono: 35318961942
Fax: 35317071633

IE (DUBLIN) coordinator 2˙438˙666.00
2    UNIVERSITE DE GENEVE

 Organization address address: Rue du General Dufour 24
city: GENEVE
postcode: 1211

contact info
Titolo: Prof.
Nome: Pierre
Cognome: Spierer
Email: send email
Telefono: 41223797545
Fax: 41223791180

CH (GENEVE) participant 728˙240.00
3    AIT Austrian Institute of Technology GmbH

 Organization address address: Donau-City-Strasse 1
city: WIEN
postcode: 1220

contact info
Titolo: Mr.
Nome: Felix
Cognome: Schropfer
Email: send email
Telefono: 43505502069
Fax: 43505502097

AT (WIEN) participant 692˙912.00
4    Selective Antibodies Limited

 Organization address address: CELS at Newcastle William Leech Building Framlington Place
city: Newcastle upon Tyne
postcode: NE2 4HH

contact info
Titolo: Prof.
Nome: Colin
Cognome: Self
Email: send email
Telefono: +44 191 223 5604
Fax: +44 191 223 5601

UK (Newcastle upon Tyne) participant 677˙080.00
5    PROGENIKA BIOPHARMA SA

 Organization address address: "Parque Tecnologico de Zamudio, Edificio 801 -A-, Planta 2"
city: DERIO - VIZCAYA
postcode: 48160

contact info
Titolo: Ms.
Nome: Maria
Cognome: Martinez
Email: send email
Telefono: +34 94 406 4525
Fax: +34 94 406 4526

ES (DERIO - VIZCAYA) participant 667˙280.00
6    ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE

 Organization address address: BATIMENT CE 3316 STATION 1
city: LAUSANNE
postcode: 1015

contact info
Titolo: Prof.
Nome: Paul Joseph
Cognome: Dyson
Email: send email
Telefono: +41 21 693 9854
Fax: +41 21 693 9885

CH (LAUSANNE) participant 597˙633.00
7    Becton Dickinson France SAS

 Organization address address: Rue Aristide - Berges 11
city: Le Pont de Claix
postcode: 38800

contact info
Titolo: Mr.
Nome: Emiel
Cognome: Jans
Email: send email
Telefono: +32 53 720 367
Fax: +32 52 720 404

FR (Le Pont de Claix) participant 499˙200.00
8    UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN

 Organization address address: BELFIELD
city: DUBLIN
postcode: 4

contact info
Titolo: Mr.
Nome: Donal
Cognome: Doolan
Email: send email
Telefono: +353 1 716 1656
Fax: +353 1 716 1086

IE (DUBLIN) participant 496˙102.00
9    INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE TOULOUSE INSAT

 Organization address address: AVENUE DE RANGUEIL 135
city: TOULOUSE
postcode: 31077

contact info
Titolo: Prof.
Nome: Didier
Cognome: Marquis
Email: send email
Telefono: +33 561 559 9501
Fax: +33 561 559 9280

FR (TOULOUSE) participant 466˙583.00
10    Radisens Diagnostics Limited

 Organization address address: "The Rubicon Centre, CIT Campus, Bishopstown"
city: Cork

contact info
Titolo: Mr.
Nome: Jerry
Cognome: O'brien
Email: send email
Telefono: +353 21 492 8994
Fax: +353 21 492 8994

IE (Cork) participant 465˙650.00
11    TECHNISCHE UNIVERSITAT BRAUNSCHWEIG

 Organization address address: POCKELSSTRASSE 14
city: BRAUNSCHWEIG
postcode: 38106

contact info
Titolo: Prof.
Nome: Meinhard
Cognome: Schilling
Email: send email
Telefono: 495314000000
Fax: 495314000000

DE (BRAUNSCHWEIG) participant 464˙140.00
12    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

 Organization address address: 101 Rue de Tolbiac
city: PARIS
postcode: 75654

contact info
Titolo: Mr.
Nome: Dominique
Cognome: Nobile
Email: send email
Telefono: +33 491 827 000
Fax: +33 491 742 067

FR (PARIS) participant 463˙470.00
13    MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.

 Organization address address: Hofgartenstrasse 8
city: MUENCHEN
postcode: 80539

contact info
Titolo: Prof.
Nome: Nils
Cognome: Brose
Email: send email
Telefono: +49 551 389 9725
Fax: +49 551 389 9715

DE (MUENCHEN) participant 448˙500.00
14    PHILIPPS UNIVERSITAET MARBURG

 Organization address address: Biegenstrasse 10
city: MARBURG
postcode: 35032

contact info
Titolo: Prof.
Nome: Wolfgang
Cognome: Parak
Email: send email
Telefono: +49 6421 2824202
Fax: +49 6421 2824161

DE (MARBURG) participant 444˙400.00
15    INNOVA SPA

 Organization address address: Via della Scrofa 117
city: ROMA
postcode: 186

contact info
Titolo: Ms.
Nome: Francesca
Cognome: Stinelli
Email: send email
Telefono: 390640000000
Fax: 390640000000

IT (ROMA) participant 435˙257.50
16    CELLIX LIMITED

 Organization address address: LONG MILE ROAD UNIT 1
city: Dublin
postcode: 12

contact info
Titolo: Ms.
Nome: Vivienne
Cognome: Williams
Email: send email
Telefono: +353 1 896 3182
Fax: +353 1 896 2771

IE (Dublin) participant 435˙020.00
17    Advanced Accelerator Applications

 Organization address address: Rue Diesel 20
city: Saint Genis Pouilly
postcode: 1630

contact info
Titolo: Dr.
Nome: Heinz
Cognome: Mausli
Email: send email
Telefono: +33 4 50 99 30 70
Fax: +33 4 50 99 30 71

FR (Saint Genis Pouilly) participant 333˙954.00
18    NIKON FRANCE SAS

 Organization address address: RUE DU MARCHE ROLLAY 191
city: CHAMPIGNY SUR MARNE CEDEX
postcode: 94504

contact info
Titolo: Ms.
Nome: Valerie
Cognome: Le Lay
Email: send email
Telefono: +33 1 4516 4520
Fax: +33 1 4516 4509

FR (CHAMPIGNY SUR MARNE CEDEX) participant 319˙435.60
19    UNIVERSITE DE SAVOIE

 Organization address address: RUE MARCOZ 27
city: CHAMBERY
postcode: 73011

contact info
Titolo: Dr.
Nome: Philippe
Cognome: Carron
Email: send email
Telefono: 33479758457
Fax: 33479758585

FR (CHAMBERY) participant 278˙912.00
20    FORSCHUNGSINSTITUT FUR MINERALISCHEUND METALLISCHE WERKSTOFFE EDELSTEINE/EDELMETALLE GMBH

 Organization address address: STRUTHSTRASSE 2
city: IDAR OBERSTEIN
postcode: 55716

contact info
Titolo: Dr.
Nome: Daniel
Cognome: Rytz
Email: send email
Telefono: 49678121191
Fax: 49678170353

DE (IDAR OBERSTEIN) participant 274˙913.00
21    UNIVERSITE DE REIMS CHAMPAGNE-ARDENNE

 Organization address address: BOULEVARD DE LA PAIX 9 VILLA DOUCE
city: REIMS
postcode: 51100

contact info
Titolo: Mrs.
Nome: Nathalie
Cognome: Rau
Email: send email
Telefono: 33326913995

FR (REIMS) participant 204˙240.00
22    NANOSIGHT LIMITED

 Organization address address: LONDON ROAD MINTON PARK
city: WILTSHIRE
postcode: SP4 7RT

contact info
Titolo: Mr.
Nome: Jeremy
Cognome: Warren
Email: send email
Telefono: +44 1980 676 065
Fax: +44 1980 624 703

UK (WILTSHIRE) participant 97˙950.00
23    Asociacion - Centro de Investigacion Cooperativa en Nanociencias - CIC NANOGUNE

 Organization address address: Tolosa Hiribidea 76
city: San Sebastian
postcode: 20018

contact info
Titolo: Mr.
Nome: Miguel
Cognome: Odriozola
Email: send email
Telefono: 34943574009
Fax: 34943574001

ES (San Sebastian) participant 69˙667.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

diagnostic    linear    offers    signal    tools    efficiency    types    sensitive    namdiatream    point    diagnostics    modal    industrial    monitoring    photoluminescent    cells    segmented    nanomaterials    throughput    molecular    treatment    nanowires    disease    laboratory    related    nanotechnology    magnetic    lab    sensitivity    deaths    cancer    imaging    detection    nano    identification    optical    device    multiplexed    time    diagnosis    nanocrystals    clinical    specificity    screening       toolkits    tumour    care    stability    biomarkers   

 Obiettivo del progetto (Objective)

'NAMDIATREAM will develop a cutting edge nanotechnology-based toolkit for multi-modal detection of biomarkers of most common cancer types and cancer metastases, permitting identification of cells indicative of early disease onset in a high-specificity and throughput format in clinical, laboratory and point-of-care devices. The project is built on the innovative concepts of super-sensitive and highly specific “lab-on-a-bead”, “lab-on-a-chip” and “lab-on-a-wire” nano-devices utilizing photoluminescent, plasmonic, magnetic and non-linear optical properties of nanomaterials. This offers groundbreaking advantages over present technologies in terms of stability, sensitivity, time of analysis, probe multiplexing, assay miniaturisation and reproducibility. The ETP in Nanomedicine documents point out that nanotechnology has yet to deliver practical solutions for the patients and clinicians in their struggle against common, socially and economically important diseases such as cancer. Over 3.2M new cases and 1.7M cancer-related deaths are registered in Europe every year, largely because diagnostic methods have an insufficient level of sensitivity, limiting their potential for early disease identification. We will deliver •Photoluminescent nanoparticle-based reagents and diagnostic chips for high throughput early diagnosis of cancer and treatment efficiency assessment •Nanocrystals enabling plasmon-optical and nonlinear optical monitoring of molecular receptors within body fluids or on the surface of cancer cell •Multi-Parameter screening of cancer biomarkers in diagnostic material implementing segmented magnetic nanowires •Validation of nano-tools for early diagnosis and highly improved specificity in cancer research. •OECD-compliant nanomaterials with improved stability, signal strength and biocompatibility Direct lead users of the results will be the diagnostic and medical imaging device companies involved in the consortium, clinical and academic partners'

Introduzione (Teaser)

Lung, breast and prostate cancer are among the most common types of cancer, and early diagnosis plays a critical role in decreasing mortality. Non-invasive and highly sensitive nanotechnology-based tools will lead to simple preventative screening.

Descrizione progetto (Article)

Over 1.7 million cancer-related deaths per year are recorded in Europe alone. EU-funded scientists exploited the latest in nanotechnology to deliver nanotools for clinical, laboratory and point-of-care devices with work on the http://www.namdiatream.eu/joomla/ (NAMDIATREAM) (Nanotechnological toolkits for multi-modal disease diagnostics and treatment monitoring) project. The toolkits are based on four different technological platforms, each with unique nanotechnology feature applied for unprecedented efficiency of cancer diagnostics. They detect biomarkers of cancer and cancer cells in microlitre volumes of blood and urine.

Exploitation of fluorescent nanomaterials (quantum dots) enabled the creation of ultra-small diagnostic probes covered with single-domain antibodies against tumour biomarkers. This tool offers superior sensitivity and photostability compared to state-of-the-art alternatives, as well as the capability for multiplexed detection of tumour molecular signatures.

Another immunodiagnostic device relies on antibody-functionalised magnetic core/noble metal shell nanorods that bind tumour biomarkers. The resulting change in the optically observed dynamic response to an externally applied time-varying magnetic field enables the detection and quantification of target molecule concentration in a straightforward biological sample.

Nanocrystals with non-linear optical properties take the advantage of the infrared spectrum for unique deep tissue imaging with enhanced sharp contrast against the surrounding background. Selectively targeted to tumour cells, they provide a stable long lasting signal and therefore efficient cancer detection and monitoring. Three products based on this technology have already been licensed and commercialised.

Finally, segmented magnetic nanowires acting as barcode-type labels for disease marker detection were paired with unique optical-magnetic sensor detection platform for selective multiplexed detection of cancer biomarkers.

Such achievements were secured through the large consortium commitment to deliver high quality, safety-assured and scalable products validated in matching in vitro models for pre-clinical testing, and benchmarked against both clinical and industrial gold standards.

The outstanding work resulted in selection of NAMDIATREAM as the best of over 1,000 projects in the field of nanotechnologies and advanced materials funded by EU funding entities.

Contributing to the European industrial and societal improvement, these tools foster early detection of cancer with reduced invasiveness, cost effectiveness and ease of use with the objective to simplify routine population screening for prompt intervention with drastically improved patient treatment outcomes and reduced health care costs.

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