ASSET

ASSET: Analysing and Striking the Sensitivities of Embryonal Tumours

 Coordinatore  

 Organization address address: BELFIELD
city: DUBLIN
postcode: 4

contact info
Titolo: Mr.
Nome: Donal
Cognome: Doolan
Email: send email
Telefono: +353 1 716 1656
Fax: +353 1 716 1216

 Nazionalità Coordinatore Non specificata
 Totale costo 16˙155˙200 €
 EC contributo 11˙999 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Anno di inizio 2010
 Periodo (anno-mese-giorno) 2010-11-01   -   2016-04-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN

 Organization address address: BELFIELD
city: DUBLIN
postcode: 4

contact info
Titolo: Mr.
Nome: Donal
Cognome: Doolan
Email: send email
Telefono: +353 1 716 1656
Fax: +353 1 716 1216

IE (DUBLIN) coordinator 1˙924˙743.53
2    DEUTSCHES KREBSFORSCHUNGSZENTRUM

 Organization address address: Im Neuenheimer Feld 280
city: HEIDELBERG
postcode: 69120

contact info
Titolo: Dr.
Nome: Ina
Cognome: Krischek
Email: send email
Telefono: +49 6221 42 2700
Fax: +49 6221 42 2708

DE (HEIDELBERG) participant 1˙481˙309.75
3 KOBENHAVNS UNIVERSITET DK participant 1˙200˙351.60
4    INSTITUT CURIE

 Organization address address: 26, rue d'Ulm
city: PARIS
postcode: 75248

contact info
Titolo: Ms.
Nome: Corinne
Cognome: Cumin
Email: send email
Telefono: +33 1 56 24 66 20
Fax: +33 1 56 24 66 27

FR (PARIS) participant 860˙800.00
5    ST. ANNA KINDERKREBSFORSCHUNG

 Organization address address: ZIMMERMANNPLATZ 10
city: WIEN
postcode: 1090

contact info
Titolo: Dr.
Nome: Karla Maria
Cognome: Valdes Rodriguez
Email: send email
Telefono: 431405000000
Fax: 4314050000000

AT (WIEN) participant 822˙392.00
6    CEMM - FORSCHUNGSZENTRUM FUER MOLEKULARE MEDIZIN GMBH

 Organization address address: Dr. Ignaz Seipel-Platz 2
city: WIEN
postcode: 1010

contact info
Titolo: Prof.
Nome: Giulio
Cognome: Superti-Furga
Email: send email
Telefono: 4314020000000
Fax: 43140200000000

AT (WIEN) participant 803˙818.25
7    UNIVERSITEIT GENT

 Organization address address: SINT PIETERSNIEUWSTRAAT 25
city: GENT
postcode: 9000

contact info
Titolo: Ms.
Nome: Nathalie
Cognome: Vandepitte
Email: send email
Telefono: +32 9 264 3029
Fax: +32 9 264 3583

BE (GENT) participant 790˙400.00
8    UNIVERSITAET BERN

 Organization address address: Hochschulstrasse 4
city: BERN
postcode: 3012

contact info
Titolo: Dr.
Nome: Alexandre
Cognome: Arcaro
Email: send email
Telefono: +41 31 308 8029
Fax: +41 31 308 8028

CH (BERN) participant 730˙800.00
9    TEKNOLOGIAN TUTKIMUSKESKUS VTT

 Organization address address: TEKNIIKANTIE 4 A
city: ESPOO
postcode: 02044 VTT

contact info
Titolo: Ms.
Nome: Jaana
Cognome: Heino
Email: send email
Telefono: +358 20 722 3301
Fax: +358 20 722 3499

FI (ESPOO) participant 652˙908.00
10    WEIZMANN INSTITUTE OF SCIENCE

 Organization address address: HERZL STREET 234
city: REHOVOT
postcode: 7610001

contact info
Titolo: Ms.
Nome: Talia
Cognome: Tzahor
Email: send email
Telefono: +972 8 934 4026
Fax: +972 8934 4165

IL (REHOVOT) participant 486˙912.00
11    UNIVERSITAETSKLINIKUM ESSEN

 Organization address address: HUFELANDSTRASSE 55
city: ESSEN
postcode: 45147

contact info
Titolo: Prof.
Nome: Eggert
Cognome: Angelika
Email: send email
Telefono: +49 201 723 3755
Fax: 492017000000

DE (ESSEN) participant 470˙603.56
12    FUNDACION CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

 Organization address address: CALLE MELCHOR FERNANDEZ ALMAGRO 3
city: MADRID
postcode: 28029

contact info
Titolo: Ms.
Nome: Laura
Cognome: Bertolini
Email: send email
Telefono: +34 917 328 000
Fax: +34 912 246 980

ES (MADRID) participant 419˙774.00
13    RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN

 Organization address address: REGINA PACIS WEG 3
city: BONN
postcode: 53113

contact info
Titolo: Ms.
Nome: Daniela
Cognome: Hasenpusch
Email: send email
Telefono: +49 228737274
Fax: +49 228736479

DE (BONN) participant 320˙529.00
14    CHARITE - UNIVERSITAETSMEDIZIN BERLIN

 Organization address address: Chariteplatz 1
city: BERLIN
postcode: 10117

contact info
Titolo: Ms.
Nome: Eveline
Cognome: Frassdorf
Email: send email
Telefono: +49 30 450 576024
Fax: +49 30 450 576954

DE (BERLIN) participant 306˙816.44
15    BAYER SCHWEIZ AG

 Organization address address: GRUBENSTRASSE 6
city: ZURICH
postcode: 8045

contact info
Titolo: Dr.
Nome: Markus
Cognome: Ehrat
Email: send email
Telefono: +41 61 726 81 81
Fax: +41 61 726 81 71

CH (ZURICH) participant 276˙532.00
16    THE UNIVERSITY OF WARWICK

 Organization address address: Kirby Corner Road - University House -
city: COVENTRY
postcode: CV4 8UW

contact info
Titolo: Mr.
Nome: Trevor
Cognome: Brown
Email: send email
Telefono: 4402480000000
Fax: 4402480000000

UK (COVENTRY) participant 261˙676.67
17    UNIVERSITY COLLEGE LONDON

 Organization address address: GOWER STREET
city: LONDON
postcode: WC1E 6BT

contact info
Titolo: Ms.
Nome: Greta
Cognome: Borg-Carbott
Email: send email
Telefono: 442031000000
Fax: 442078000000

UK (LONDON) participant 188˙789.40
18    BAYER TECHNOLOGY SERVICES GMBH

 Organization address address: Kaiser-Wilhelm-Allee
city: LEVERKUSEN
postcode: 51368

contact info
Titolo: Mr.
Nome: Peter
Cognome: Steudtner
Email: send email
Telefono: 492143000000
Fax: 492143000000

DE (LEVERKUSEN) participant 0.00
19    Teknologian tutkimuskeskus VTT Oy

 Organization address address: Vuorimiehentie 3
city: Espoo
postcode: 2150

contact info
Titolo: Ms.
Nome: Jaana
Cognome: Heino
Email: send email
Telefono: +358 20 722 3301
Fax: +358 20 722 3499

FI (Espoo) participant 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

model    adulthood    throughput    asset    options    embryonal    core    tumours    sarcoma    life    diagnosis    functional    tumour    pathogenetic    medulloblastoma    combining    signalling    proteome    ewing    mutations    mathematical    transcriptome    aberrations    treatment    neuroblastoma    ets    genomic    networks    rational   

 Obiettivo del progetto (Objective)

'Cancer is hallmarked by multiple genetic aberrations that lead to a functional derangement of cellular signalling networks. Embryonal tumours (ETs) comprising neuroblastoma, medulloblastoma and Ewing sarcoma, occur early in life, and thus may reveal pathogenetically relevant lesions clearer than adulthood tumours which carry passenger mutations accumulated during life. ASSET will exploit this fact by focussing on unravelling the signalling networks and their alterations in ETs. The basic hypothesis is that ETs share common pathogenetic principles that can be captured and made accessible to rational analysis by combining high-throughput and high content analysis of the genome, transcriptome and proteome with mathematical modelling. ASSET builds on a previous FP6 consortium, the European Embryonal Tumour Pipeline (EEPT), which generated high-throughput genomic and transcriptomic data on ETs. ASSET is the next logical step to add crucial functional information that will allow us to generate (i) defined in vitro and in vivo tumour systems; (ii) combined analysis of genomic mutations, transcriptome, miRNA expression and dynamic proteome changes; (iii) systematic perturbations; (iv) mathematical modelling to elucidate pathogenetic networks and their emergent behaviour; (v) the virtuous cycle of model validation in relevant biological model systems and clinical samples towards a major goal. This goal is to identify mechanistically understood network vulnerabilities that can be exploited for new approaches to the diagnosis and treatment of major paediatric tumours. Elucidating such core mechanisms will (i) improve understanding of and therapeutic options for these devastating childhood malignancies and (ii) enable a rational approach to deal with the complexity of the pathogenesis of adulthood cancers.'

Introduzione (Teaser)

Embryonal tumours (ETs) such as neuroblastoma (NB), medulloblastoma (MB) and Ewing sarcoma family tumours (ESFTs) occur in babies and children and have limited treatment options. ASSET, an EU-funded project, will find common ET-specific aberrations in core signalling networks by combining genomics, proteomics and mathematical modelling for effective diagnosis and therapy.

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