SINGLE-BIOET

Single-molecule junction capabilities to map the electron pathways in redox bio-molecular architectures

Coordinatore	FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA    more  Organization address address: CARRER BALDIRI REIXAC PLANTA 2A 10-12 city: BARCELONA postcode: 8028 contact info Titolo: Prof. Nome: Pau Cognome: Gorostiza Email: send email Telefono: +34 934 011 463 Fax: +34 934 020 118
Nazionalità Coordinatore	Spain [ES]
Totale costo	100˙000 €
EC contributo	100˙000 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2010-RG
Funding Scheme	MC-IRG
Anno di inizio	2012
Periodo (anno-mese-giorno)	2012-03-09   -   2016-03-08

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA  Organization address address: CARRER BALDIRI REIXAC PLANTA 2A 10-12 city: BARCELONA postcode: 8028 contact info Titolo: Prof. Nome: Pau Cognome: Gorostiza Email: send email Telefono: +34 934 011 463 Fax: +34 934 020 118	ES (BARCELONA)	coordinator	100˙000.00

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 Obiettivo del progetto (Objective)

'This proposal presents a novel methodology to explore the mechanisms of different electron pathways in redox bio-molecular architectures at the single-molecule level. Single-molecule contacts have been shown to be experimentally realizable at room temperature. Scanning Probe Microscopies are the most employed techniques for creating contacts due to the high spatial resolution. A huge variety of molecular systems has been already explored bringing a more robust understanding of the critical parameters required to build and measure charge transport through single-molecule devices; stable molecule-electrode chemical binding, univocal detection of a single-molecule contact formation or the elucidation of the effect on charge transport by different chemical groups. Single-molecule junctions with more complex bio-molecular systems are less explored but their feasibility has been already demonstrated on well-know structures like DNA or alpha-helices. Sulfur-content chemical groups are targeted in these systems to allow long-lived electrical contacts to the metal electrodes. Here we propose to use the above methodologies to achieve a complete picture of the electron pathways on an individual bio-molecular redox structure. Different electron pathways can be selected by forming single-molecule junctions at different positions of the outer shell of the protein structure. Site-directed mutagenesis can be used for creating the specific sites. A step further in this project will be to explore the dominant parameters involved in the sequential-step hopping electron transfer (ET). Such a study will provide clues for the understanding of the structural effects on the long-range ET in living organisms. This proposal assures a novel pioneering research particularly designed for the present host institution specialized in Biochemistry to be led by an expert researcher in the field of Molecular Electronics.'

Introduzione (Teaser)

Electron transport within a cell is a simple yet fundamental process in living organisms. The ability to modulate it will open the door to novel bioelectronics devices that interface biological molecules and circuits.