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SAPHIR

Strengthening Animal Production and Health through the Immune Response

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

SAPHIR project word cloud

Explore the words cloud of the SAPHIR project. It provides you a very rough idea of what is the project "SAPHIR" about.

strategies bovine responsible losses perinatal rtl6 immunity perfringens multivalent basal applicable earlier welfare diva viral pathogens affordable health chinese clostridium demonstration animal pharmaceutical mucosal reduce breeding platforms virus organization brings vectors adjuvants institutes competence hyopneumoniae cattle website saphir workshops issue syncytial stakeholders period endemic dendritic representative fourteen cutting outputs market eimeria bovis cells smes companies syndrome skin creation line longer profitability alliance proof veterinary xenobiotic rtl3 expertise protection respiratory strengthen immuno interdisciplinary optimal academic immune launch formulations global training directed generation translation individual replicon pigs mechanisms farming safe perspective efficient vaccines edge porcine economic vaccine reproductive dna livestock biomarkers socio food chickens mycoplasma

Project "SAPHIR" data sheet

The following table provides information about the project.

Coordinator	INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT Organization address address: Rue De L'Universite 147 city: PARIS CEDEX 07 postcode: 75338 website: www.inra.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	France [FR]
Project website	http://www.h2020-saphir.eu/
Total cost	10˙549˙121 €
EC max contribution	8˙999˙996 € (85%)
Programme	1. H2020-EU.3.2. (SOCIETAL CHALLENGES - Food security, sustainable agriculture and forestry, marine, maritime and inland water research, and the bioeconomy)
Code Call	H2020-SFS-2014-2
Funding Scheme	RIA
Starting year	2015
Duration (year-month-day)	from 2015-03-01 to 2019-02-28

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT Organization address address: Rue De L'Universite 147 city: PARIS CEDEX 07 postcode: 75338 website: www.inra.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS CEDEX 07)	coordinator	2˙191˙579.00
2	UNIVERSITEIT GENT UNIVERSITEIT GENT Organization address address: SINT PIETERSNIEUWSTRAAT 25 city: GENT postcode: 9000 website: http://www.ugent.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (GENT)	participant	1˙234˙978.00
3	THE UNIVERSITY OF EDINBURGH THE UNIVERSITY OF EDINBURGH Organization address address: OLD COLLEGE, SOUTH BRIDGE city: EDINBURGH postcode: EH8 9YL website: www.ed.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (EDINBURGH)	participant	802˙187.00
4	STICHTING WAGENINGEN RESEARCH STICHTING WAGENINGEN RESEARCH Organization address address: DROEVENDAALSESTEEG 4 city: WAGENINGEN postcode: 6708 PB website: http://www.wageningenur.nl/nl.htm contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (WAGENINGEN)	participant	772˙092.00
5	THE ROYAL VETERINARY COLLEGE THE ROYAL VETERINARY COLLEGE Organization address address: ROYAL COLLEGE STREET city: LONDON postcode: NW1 OTU website: www.rvc.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	458˙846.00
6	INMUNOLOGIA Y GENETICA APLICADA SA INMUNOLOGIA Y GENETICA APLICADA SA Organization address address: C/ HERMANOS GARCIA NOBLEJAS 41-2 city: MADRID postcode: 28037 website: www.ingenasa.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (MADRID)	participant	445˙193.00
7	XEOLAS PHARMACEUTICALS LIMITED XEOLAS PHARMACEUTICALS LIMITED Organization address address: 97 FURRY PARK ROAD city: KILLESTER postcode: 5 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (KILLESTER)	participant	391˙993.00
8	INRA TRANSFERT SAS INRA TRANSFERT SAS Organization address address: RUE DU DOCTEUR FINLAY 28 city: PARIS postcode: 75015 website: www.inra-transfert.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	365˙176.00
9	VACCIBODY AS VACCIBODY AS Organization address address: GAUSTADALLEEN 21 city: OSLO postcode: 349 website: www.vaccibody.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NO (OSLO)	participant	334˙368.00
10	SVERIGES LANTBRUKSUNIVERSITET SVERIGES LANTBRUKSUNIVERSITET Organization address address: ALMAS ALLE 8 city: UPPSALA postcode: 750 07 website: http://www.slu.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (UPPSALA)	participant	323˙788.00
11	CARDIFF UNIVERSITY CARDIFF UNIVERSITY Organization address address: NEWPORT ROAD 30-36 city: CARDIFF postcode: CF24 ODE website: www.cardiff.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CARDIFF)	participant	319˙743.00
12	THE UNIVERSITY OF LIVERPOOL THE UNIVERSITY OF LIVERPOOL Organization address address: BROWNLOW HILL 765 FOUNDATION BUILDING city: LIVERPOOL postcode: L69 7ZX website: www.liverpool.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LIVERPOOL)	participant	290˙855.00
13	THE PIRBRIGHT INSTITUTE LBG THE PIRBRIGHT INSTITUTE LBG Organization address address: ASH ROAD PIRBRIGHT city: WOKING postcode: GU24 0NF website: www.pirbright.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (WOKING)	participant	289˙067.00
14	PARCO TECNOLOGICO PADANO S.R.L. PARCO TECNOLOGICO PADANO S.R.L. Organization address address: Via Einstein - Localita Cascina Codazza city: LODI postcode: 26900 website: http://www.tecnoparco.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (LODI)	participant	278˙868.00
15	SPOREGEN LIMITED SPOREGEN LIMITED Organization address address: QUEENS ROAD 3 WESTLEY GATE city: READING BERKSHIRE postcode: RG1 4AP website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (READING BERKSHIRE)	participant	224˙993.00
16	EUROPEAN FORUM OF FARM ANIMAL BREEDERS EUROPEAN FORUM OF FARM ANIMAL BREEDERS Organization address address: DREIJENLAAN 2K 1060 1061 city: WAGENINGEN postcode: 6703 HA website: www.effab.info contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (WAGENINGEN)	participant	150˙893.00
17	SZKOLA GLOWNA GOSPODARSTWA WIEJSKIEGO SZKOLA GLOWNA GOSPODARSTWA WIEJSKIEGO Organization address address: UL. NOWOURSYNOWSKA 166 city: WARSZAWA postcode: 02 787 website: www.sggw.waw.pl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PL (WARSZAWA)	participant	92˙731.00
18	UNIVERSITAET BERN UNIVERSITAET BERN Organization address address: HOCHSCHULSTRASSE 6 city: BERN postcode: 3012 website: http://www.unibe.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (BERN)	participant	31˙437.00
19	EIDGENOESSISCHES DEPARTEMENT DES INNERN EIDGENOESSISCHES DEPARTEMENT DES INNERN Organization address address: Inselgasse 1 city: BERN postcode: 3003 website: http://www.edi.admin.ch/index.html?lang=de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (BERN)	participant	1˙200.00
20	Shanghai Veterinary Research Institute - Chinese Academy of Agricultural Sciences Shanghai Veterinary Research Institute - Chinese Academy of Agricultural Sciences Organization address address: ZIYUE ROAD 518 city: SHANGHAI postcode: 200241 website: http://www.shvri.ac.cn contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CN (SHANGHAI)	participant	0.00
21	UNIVERSITE DE LAUSANNE UNIVERSITE DE LAUSANNE Organization address address: Quartier Unil-Centre Bâtiment Unicentre city: LAUSANNE postcode: 1015 website: www.unil.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (LAUSANNE)	participant	0.00
22	VIRBAC SA VIRBAC SA Organization address address: RUE 13EME LID city: CARROS postcode: 6511 website: www.virbac.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (CARROS)	participant	0.00

Map

Project objective

SAPHIR aims to develop vaccine strategies effective against endemic pathogens responsible for high economic losses in livestock in order to strengthen the profitability of food animal systems, improve animal welfare and reduce xenobiotic usage in farming with a One Health perspective.

SAPHIR will bring novel vaccine strategies to the market i) at short term, with several promising vaccines brought to demonstration (RTL6), ii) at long term, with cutting edge strategies brought at proof of concept (RTL3) and iii) in line with socio-economic requirements. SAPHIR has selected two representative pathogens of pigs (Porcine Reproductive and Respiratory Syndrome Virus and Mycoplasma hyopneumoniae), chickens (Eimeria and Clostridium perfringens) and cattle (Bovine Respiratory Syncytial Virus, Mycoplasma bovis) to develop generic vaccine approaches applicable to other pathogens.

SAPHIR will issue i) knowledge of immune mechanisms of protection, ii) affordable, safe and multivalent vaccines with DIVA properties, iii) efficient adjuvants targeting dendritic cells, optimal formulations, new mucosal and skin delivery systems, a new generation of DNA vectors and viral replicon platforms for fostering an earlier and longer duration of immunity including the perinatal period, and iv) basal biomarkers of individual immuno-competence for future breeding strategies. The SAPHIR dissemination and training programme includes creation of an integrated health management website, launch of a Global Alliance for Veterinary Vaccines and organization of workshops directed at food animal system stakeholders. This will ensure optimal research translation of SAPHIR outputs to market and field applications. SAPHIR brings together interdisciplinary expertise from fourteen academic institutes including a Chinese partner, five SMEs and two pharmaceutical companies.

Deliverables

List of deliverables.
Protection against PRRSV by transfer of T and enriched CD8+ T cells	Documents, reports	2020-02-13 14:41:01
Age-related innate responses to different adjuvants in cattle in vitro	Documents, reports	2020-02-13 14:41:01
Identification of age categories of cattle that need to be targeted for vaccination in order to prevent virus circulation	Documents, reports	2020-02-13 14:41:01
Launching of the Global Alliance for Veterinary Vaccinolog	Other	2020-02-13 14:41:01
Identification of the candidate risk factors of existing and new vaccines against the SAPHIR pathogens (wiki-website)	Other	2020-02-13 14:41:01
Effect of TLR-L on vaccine-induced immune responses and their protective value	Documents, reports	2020-02-13 14:41:01
Knowledge on the role of antibodies in protection	Documents, reports	2020-02-13 14:41:01
Workshop NÂ°2 with stakeholders	Other	2020-02-13 14:41:01
Responsiveness of porcine DC and B cells, and chicken DC, to individual and combined TLR ligands	Documents, reports	2020-02-13 14:40:59
Collected data for analysis of the factors involved in vaccine perception	Documents, reports	2020-02-13 14:40:59
Production losses caused by SAPHIR diseases and pathogens	Documents, reports	2020-02-13 14:40:59
Project website on-line	Websites, patent fillings, videos etc.	2020-02-13 14:40:59
Identification of the key factors that influence livestock producersâ€™ behaviours towards vaccination and control of SAPHIR diseases, including information relevant to economic modelling for WP1	Documents, reports	2020-02-13 14:40:59
Optimized formulation for co-delivery of TLR-L and antigen in pigs and chickens	Documents, reports	2020-02-13 14:40:59
Identification of immune correlates of protection that can be used to estimate the level of protection against infection by BRSV in the field	Documents, reports	2020-02-13 14:40:59
Farm-level impacts of SAPHIR diseases and pathogens	Documents, reports	2020-02-13 14:40:59
Workshop NÂ°1 with stakeholders	Other	2020-02-13 14:40:59
Integrated animal health management website on-line	Websites, patent fillings, videos etc.	2020-02-13 14:40:59
Outreach, training and dissemination plan	Documents, reports	2020-02-13 14:40:59
Age-related innate responses to different TLR ligands in pig in vitro	Documents, reports	2020-02-13 14:40:59
Chicken DC and macrophage gene expression profiling in response to TLR ligands	Documents, reports	2020-02-13 14:40:59
Economic analysis the SAPHIR diseases and their existing control measures	Documents, reports	2020-02-13 14:40:59
Biorepository of biological samples and construction of a database data management	Other	2020-02-13 14:40:59
Identification of CD8+ T cell PRRSV protein targets	Documents, reports	2020-02-13 14:40:59
Conceptual framework of the factors involved in livestock producersâ€™ attitude towards the intervention strategies against SAPHIR diseases, including vaccination	Documents, reports	2020-02-13 14:40:59
SAPHIR project management guidelines	Documents, reports	2020-02-13 14:40:59
Production and characterisation of the pre-fusion form of the BRSV F protein	Documents, reports	2020-02-13 14:40:59

Take a look to the deliverables list in detail: detailed list of SAPHIR deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Anneleen M. F. Matthijs, GaÃ«l Auray, Virginie Jakob, Obdulio GarcÃa-NicolÃ¡s, Roman O. Braun, Irene Keller, RÃ©my Bruggman, Bert Devriendt, Filip Boyen, Carlos A. Guzman, Annelies Michiels, Freddy Haesebrouck, Nicolas Collin, Christophe Barnier-Quer, Dominiek Maes, Artur Summerfield Systems Immunology Characterization of Novel Vaccine Formulations for Mycoplasma hyopneumoniae Bacterins published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2019.01087	Frontiers in Immunology 10	2020-02-13
2019	Cindy Bernelin-Cottet, CÃ©line Urien, Maxence Fretaud, Christelle Langevin, Ivan Trus, Luc Jouneau, Fany Blanc, Jean-Jacques Leplat, CÃ©line Barc, Olivier Boulesteix, MickaÃ«l Riou, Marilyn Dysart, Sophie MahÃ©, Elisabeth Studsrub, Hans Nauwynck, Nicolas Bertho, Olivier Bourry, Isabelle Schwartz-Cornil A DNA Prime Immuno-Potentiates a Modified Live Vaccine against the Porcine Reproductive and Respiratory Syndrome Virus but Does Not Improve Heterologous Protection published pages: 576, ISSN: 1999-4915, DOI: 10.3390/v11060576	Viruses 11/6	2020-02-13
2015	Ivan Pastor-Fernandez, Virginia Marugan-Hernandez, Tatiana Kuster Multi-valent vaccines in poultry: can Eimeria parasites be used as broad spectrum vaccine delivery vectors for chickens? published pages: , ISSN: , DOI:		2020-02-13
2017	A.Doeschl-Wilson New PRRS disease phenotypes as vaccine & genetic improvement targets published pages: , ISSN: , DOI:	international PRRS symposium 2017 2.12.2017	2020-02-13
2017	Roman Othmar Braun, Sylvie Python, Artur Summerfield Porcine B Cell Subset Responses to Toll-like Receptor Ligands published pages: 1-14, ISSN: 1664-3224, DOI: 10.3389/fimmu.2017.01044	Frontiers in Immunology 8	2020-02-13
2018	Sandra Vreman, Gael Auray, Huub F.J. Savelkoul, Annemarie Rebel, Artur Summerfield, Norbert Stockhofe-Zurwieden Neonatal porcine blood derived dendritic cell subsets show activation after TLR2 or TLR9 stimulation published pages: 361-370, ISSN: 0145-305X, DOI: 10.1016/j.dci.2018.03.012	Developmental & Comparative Immunology 84	2020-02-13
2017	Sabine Riffault - published pages: , ISSN: , DOI:	12 December 2017	2020-02-13
2016	Danille Culik Bovine respiratory disease: A retrospective pilot study of treatment and prevention costs in unweaned calves in Welsh dairy farms published pages: , ISSN: , DOI:	MSc Dissertation	2020-02-13
2016	Bettina TrÃ¼eb, Elena Catelli, Adrian Luehrs, Heiko Nathues, Peter Kuhnert Genetic variability and limited clonality of Mycoplasma hyorhinis in pig herds published pages: 9-14, ISSN: 0378-1135, DOI: 10.1016/j.vetmic.2016.05.015	Veterinary Microbiology 191	2020-02-13
2016	Fei Gao, Zehui Qu, Liwei Li, Lingxue Yu, Yifeng Jiang, Yanjun Zhou, Shen Yang, Hao Zheng, Qinfeng Huang, Wu Tong, Guangzhi Tong Recombinant porcine reproductive and respiratory syndrome virus expressing luciferase genes provide a new indication of viral propagation in both permissive and target cells published pages: 132-140, ISSN: 0034-5288, DOI: 10.1016/j.rvsc.2016.05.014	Research in Veterinary Science 107	2020-02-13
2017	Sara HÃ¤gglund, Krister BlodÃ¶rn, Katarina NÃ¤slund, Karin Vargmar, Sara BergstrÃ¶m Lind, Jia Mi, Mariluz AraÃnga, Sabine Riffault, Geraldine Taylor, John Pringle, Jean FranÃ§ois Valarcher Proteome analysis of bronchoalveolar lavage from calves infected with bovine respiratory syncytial virusâ€”Insights in pathogenesis and perspectives for new treatments published pages: e0186594, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0186594	PLOS ONE 12/10	2020-02-13
2018	IvÃ¡n Pastor-FernÃ¡ndez, Sungwon Kim, Karen Billington, Janene Bumstead, Virginia MarugÃ¡n-HernÃ¡ndez, Tatiana KÃ¼ster, David J.P. Ferguson, Lonneke Vervelde, Damer P. Blake, Fiona M. Tomley Development of cross-protective Eimeria -vectored vaccines based on apical membrane antigens published pages: , ISSN: 0020-7519, DOI: 10.1016/j.ijpara.2018.01.003	International Journal for Parasitology	2020-02-13
2017	Alexis Delabouglise, Andrew James, Jean-FranÃ§ois Valarcher, Sara HagglÃ¼nd, Didier Raboisson, Jonathan Rushton Linking disease epidemiology and livestock productivity: The case of bovine respiratory disease in France published pages: e0189090, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0189090	PLOS ONE 12/12	2020-02-13
2017	Fany Blanc, GaÃ«tan Lemonnier, Jean-Jacques Leplat, Edwige Bouguyon, Yvon Billon, Jordi EstellÃ© and Claire Rogel-Gaillard Genetic individual variability of vaccine responses in pigs published pages: 22, ISSN: , DOI:	Abstract Book of the 36th International Society for Animal Genetics (ISAG) Conference July 16-21, 2017	2020-02-13
2016	J. McCaffrey, C. Bernelin, N. Bertho, I. Schwartz, V. Jakob, C. Barnier, D.McDaid, A.Moore Development of a dissolving microneedle patch for delivery of a veterinary DNA vaccine published pages: 18, ISSN: , DOI:	The 4th International Conference on Microneedles may 2016	2020-02-13
2017	Zehui Qu, Fei Gao, Liwei Li, Yujiao Zhang, Yifeng Jiang, Lingxue Yu, Yanjun Zhou, Hao Zheng, Wu Tong, Guoxin Li, Guangzhi Tong Label-Free Quantitative Proteomic Analysis of Differentially Expressed Membrane Proteins of Pulmonary Alveolar Macrophages Infected with Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus and Its Attenuated Strain published pages: 1700101, ISSN: 1615-9853, DOI: 10.1002/pmic.201700101	PROTEOMICS 17/23-24	2020-02-13
2017	Marie-HÃ©lÃ¨ne Pinard-van der Laan Deciphering host responses to Eimeria infections for implementing integrated breeding strategies for improved resistance to coccidiosis published pages: 41-42, ISSN: , DOI:	Abstract Book of the 12th International Coccidiosis Conference (ICC-12) June 26-30, 2017	2020-02-13
2017	Gabriela Pretre, Marie-Claude Hygonenq, StÃ©phane Claverol, Christine Citti and Eric Baranowski Le protÃ©ome membranaire de Mycoplasma bovis: Ã la recherche dâ€™antigÃ¨nes stables chez un pathogÃ¨ne hypervariable published pages: 37, ISSN: , DOI:	Abstract Book of the 7e Colloque International Francophone de Microbiologie Animale 26-27 March 2017	2020-02-13
2017	S. Vremen, J. McCaffrey, N. Stochofe, A.C, Moore Dissolving microneedle patches adjuvanted with different Toll like receptor agonists in pigs: local immune response by macroscopic and histologic evaluation published pages: 36, ISSN: , DOI:	Skin Vaccination Summit may 2017	2020-02-13
2017	N.Go, S. Touzeau, C.Belloc, A. Doeschl-Wilson How to prevent viremia rebound? Evidence from a PRRSv data-supported model of the immune response published pages: , ISSN: , DOI:	ModAH Modelling in Animal Health 07.6.2017	2020-02-13
2017	Gabriela Pretre, StÃ©phane Claverol, Marie-Claude Hygonenq, Christine Citti1 and Eric Baranowski A one health perspective for vaccine strategies against bronchiolitis published pages: , ISSN: , DOI:	Abstract Book of the UK Veterinary Vaccinology Network Conference 2017 16-17 January 2017	2020-02-13
2016	J. McCaffrey, C. Bernelin, C.Urien, V. Jakob, C. Barnier, N. Bertho, I. Schwartz, D. McDaid, A.Moore Development of a DNA-loaded dissolving microneedle platform for veterinary vaccination published pages: 54, ISSN: , DOI:	Focused Meeting 2016 â€“ Irish Division: Exploring the Microbeâ€“Immune System Interface september 2016	2020-02-13
2016	Joana Silva Bovine Respiratory Disease published pages: , ISSN: , DOI:	DVM dissertation	2020-02-13
2017	Damer P. Blake, IvÃ¡n Pastor-FernÃ¡ndez, Matthew J. Nolan, Fiona M. Tomley Recombinant anticoccidial vaccines - a cup half full? published pages: 358-365, ISSN: 1567-1348, DOI: 10.1016/j.meegid.2017.10.009	Infection, Genetics and Evolution 55	2020-02-13
2017	Chan, R. and Enticott, G. \"â€œExploring the thinking of â€˜Good Farmingâ€™ in pig production industries between Europe and China: a sociological analysis of farmersâ€™ attitudes towards animal diseases and vaccination practices\"\"\" published pages: , ISSN: , DOI:	n/a 2017	2020-02-13
2016	JONATHAN RUSHTON, MIEGHAN BRUCE Using a One Health approach to assess the impact of parasitic disease in livestock: how does it add value? published pages: 1-11, ISSN: 0031-1820, DOI: 10.1017/S0031182016000196	Parasitology	2020-02-13
2018	Kuan Zhao, Li-Wei Li, Yu-Jiao Zhang, Yi-Feng Jiang, Fei Gao, Guo-Xin Li, Ling-Xue Yu, Wen-Ying Zhao, Tong-Ling Shan, Yan-Jun Zhou, Guang-Zhi Tong MOV10 inhibits replication of porcine reproductive and respiratory syndrome virus by retaining viral nucleocapsid protein in the cytoplasm of Marc-145â€¯cells published pages: 157-163, ISSN: 0006-291X, DOI: 10.1016/j.bbrc.2018.08.148	Biochemical and Biophysical Research Communications 504/1	2020-02-13
2018	Liwei Li, Fei Gao, Hao Zheng, Yifeng Jiang, Wu Tong, Yanjun Zhou, Guangzhi Tong Utilizing host endogenous microRNAs to negatively regulate the replication of porcine reproductive and respiratory syndrome virus in MARC-145 cells published pages: e0200029, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0200029	PLOS ONE 13/7	2020-02-13
2019	Cindy Bernelin DÃ©veloppement dâ€™un vaccin Ã ADN contre le Syndrome DysgÃ©nÃ©sique et Respiratoire Porcin (PRRSV) published pages: , ISSN: , DOI:		2020-02-13
2018	Marie-HÃ©lÃ¨ne Pinard Multi-disciplinary approaches for improving sustainable livestock production: research needs, opportunities and difficulties. published pages: , ISSN: , DOI:	Abstract book of 69th Annual Meeting of the European Federation of Animal Science (EAAP)	2020-02-13
2018	Sandra Vreman, Joanne McCaffrey, Ivan Trus, Annemarie Rebel, Hans Nauwynck, Anne Moore, Norbert Stockhofe-Zurwieden Inactivated porcine reproductive and respiratory syndrome virus adjuvanted with single Toll Like receptor 2, 7 and 9 ligands induces low antibody responses and limited protection published pages: , ISSN: , DOI:		2020-02-13
2018	Marie-HÃ©lÃ¨ne Pinard Multidisciplinary approaches to livestock production in SAPHIR published pages: , ISSN: , DOI:	Abstract book of 69th Annual Meeting of the European Federation of Animal Science (EAAP)	2020-02-13
2018	BORDET E, MAISONNASSE P, RENSON P, BOUGUYON E, CRISCI E, TIRET M, DESCAMPS D, BERNELIN-COTTET C, URIEN C, LEFÃˆVRE F, JOUNEAU L, BOURRY O, LEPLAT JJ, SCHWARTZ-CORNIL I, BERTHO N. Porcine Alveolar Macrophage-like cells are pro-inflammatory Pulmonary Intravascular Macrophages that produce large titers of Porcine Reproductive and Respiratory Syndrome Virus. published pages: , ISSN: , DOI:	\"Abstract book of the \"\"Immunology of Domestic Animals\"\"\"	2020-02-13
2018	Fei Gao, Yifeng Jiang, Guoxin Li, Yanjun Zhou, Lingxue Yu, Liwei Li, Wu Tong, Hao Zheng, Yujiao Zhang, Hai Yu, Tongling Shan, Shen Yang, Huan Liu, Kuan Zhao, Guangzhi Tong Porcine reproductive and respiratory syndrome virus expressing E2 of classical swine fever virus protects pigs from a lethal challenge of highly-pathogenic PRRSV and CSFV published pages: 3269-3277, ISSN: 0264-410X, DOI: 10.1016/j.vaccine.2018.04.079	Vaccine 36/23	2020-02-13
2018	Liwei Li, Yanjun Zhou, Yifeng Jiang, Fei Gao, Tongling Shan, Kuan Zhao, Yujiao Zhang, Lin Li, Guangzhi Tong Galectin-3 inhibits replication of porcine reproductive and respiratory syndrome virus by interacting with viral Nsp12 in vitro published pages: 87-91, ISSN: 0168-1702, DOI: 10.1016/j.virusres.2018.06.006	Virus Research 253	2020-02-13
2018	Bernelin-Cottet C., Urien C., Blanc F., Jakob V., Bordet E., Barc C., Contreras V., Bertho N., Barnier C., Collin N., Studsrub E., Brunsvik Fredriksen A., Trus I., Nauwynck H., and Schwartz-Cornil I. A prime with naked DNA improves the immune responses induced by a modified live vaccine against Porcine Reproductive and Respiratory Syndrome Virus published pages: , ISSN: , DOI:	Abstract book of European congress in Immunonology	2020-02-13
2018	Blanc F, Maroilley T, Lemonnier G, Leplat JJ, Bouguyon E, Billon, Bouchez O, Bidanel JP, Bedâ€™Hom 1, EstellÃ© J and Rogel-Gaillard C Individual genetic variability of vaccine responses in pigs. published pages: , ISSN: , DOI:	\"Abstract book of the \"\"Immunology of Domestic Animals\"\"\"	2020-02-13
2018	Kinga Biernacka, Katarzyna PodgÃ³rska, Anna Tyszka, Tomasz Stadejek Comparison of six commercial ELISAs for the detection of antibodies against porcine reproductive and respiratory syndrome virus (PRRSV) in field serum samples published pages: 40-45, ISSN: 0034-5288, DOI: 10.1016/j.rvsc.2018.10.005	Research in Veterinary Science 121	2020-02-13
2018	Elise Bordet, Pauline Maisonnasse, Patricia Renson, Edwige Bouguyon, Elisa Crisci, Mathieu Tiret, Delphyne Descamps, Cindy Bernelin-Cottet, CÃ©line Urien, FranÃ§ois LefÃ¨vre, Luc Jouneau, Olivier Bourry, Jean-Jacques Leplat, Isabelle Schwartz-Cornil, Nicolas Bertho Porcine Alveolar Macrophage-like cells are pro-inflammatory Pulmonary Intravascular Macrophages that produce large titers of Porcine Reproductive and Respiratory Syndrome Virus published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-28234-y	Scientific Reports 8/1	2020-02-13
2018	Bernelin-Cottet C., Urien C., Blanc F., Leplat J.J., McCaffrey J., Collins D., Jakob V., Bordet E., Barc C., Contreras V., Bertho N., McDaid D., Collin N., Barnier-Quer C., Moore A., Schwartz-Cornil I. Immunogenicity of DNA vaccines delivered by patches and electroporation in pig skin published pages: , ISSN: , DOI:	Abstract book of European congress in Immunonology	2020-02-13
2017	Vreman S., McCaffrey J., Rebel A., Moore A., Stockhofe-Zurwieden N. Vaccination with different Toll-like receptor agonist by dissolving microneedle patches to pigs published pages: Poster, ISSN: , DOI:		2020-02-13
2018	Elise Bordet, Fany Blanc, Mathieu Tiret, Elisa Crisci, Edwige Bouguyon, Patricia Renson, Pauline Maisonnasse, Mickael Bourge, Jean-Jacques Leplat, Elisabetta Giuffra, Luc Jouneau, Isabelle Schwartz-Cornil, Olivier Bourry, Nicolas Bertho Porcine Reproductive and Respiratory Syndrome Virus Type 1.3 Lena Triggers Conventional Dendritic Cells 1 Activation and T Helper 1 Immune Response Without Infecting Dendritic Cells published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.02299	Frontiers in Immunology 9	2020-02-13
2018	Bernelin-Cottet C., Urien C., Blanc F., Jakob V., Bordet E., Barc C., Contreras V., Bertho N., Barnier C., Collin N., Studsrub E., Brunsvik Fredriksen A., Trus I., Nauwynck H., and Schwartz-Cornil I. A prime with naked DNA improves the immune responses induced by a modified live vaccine against Porcine Reproductive and Respiratory Syndrome Virus published pages: , ISSN: , DOI:	Abstract book of European Workshop in Veterinary Immunology	2020-02-13
2017	Vreman S., Auray G., Savelkoul HFJ, Rebel A., Summerfield A., Stockhofe-Zurwieden N. Differential responsiveness of neonatal and adult porcine dendritic cells and monocytes after TLR2 and TLR9 stimulation of PBMCs published pages: Poster, ISSN: , DOI:		2020-02-13
2018	Bernelin-Cottet C., Urien C., Blanc F., Leplat J.J., McCaffrey J., Collins D., Jakob V., Bordet E., Barc C., Contreras V., Bertho N., McDaid D., Collin N., Barnier-Quer C., Moore A., Schwartz-Cornil I. Immunogenicity of DNA vaccines delivered by patches and electroporation in pig skin published pages: , ISSN: , DOI:	Abstract book of European Workshop in Veterinary Immunology	2020-02-13
2018	Liwei Li, Fei Gao, Yifeng Jiang, Wu Tong, Hao Zheng, Tongling Shan, Ning Kong, Hai Yu, Deqiang Yang, Kuan Zhao, Yujiao Zhang, Guangzhi Tong Development of Monoclonal Antibodies Specifically Recognizing the Nonstructural Protein 12 of Type 2 Porcine Reproductive and Respiratory Syndrome Virus published pages: 73-77, ISSN: 2167-9436, DOI: 10.1089/mab.2017.0060	Monoclonal Antibodies in Immunodiagnosis and Immunotherapy 37/2	2020-02-13
2018	Blanc F, Maroilley T, Pinard-van der Laan MH, Lemonnier G, Leplat JJ, Bouguyon E, Billon Y, Bidanel JP, Bedâ€™Hom B, EstellÃ© J, Kim S, Vervelde L, Blake D, and Rogel-Gaillard C What potential of genome-wide integrative approaches to predict vaccine responses? published pages: , ISSN: , DOI:	Abstract book of 69th Annual Meeting of the European Federation of Animal Science (EAAP)	2020-02-13
2018	Blanc F, Maroilley T, Lemonnier G, Leplat JJ, Bouguyon E, Billon, Bouchez O, Bidanel JP, Bedâ€™Hom B, EstellÃ© J and Rogel-Gaillard C Genetic variability of vaccine responses in pigs: application to vaccines against Mycoplasma hyopneumonia and Influenza A virus published pages: , ISSN: , DOI:	Abstract book of 6th European Veterinary Immunology Workshop (EVIW)	2020-02-13
2018	Pretre G, Maillard R, Foucras G, AssiÃ© S, Hygonenq MC, Claverol S, Giammarinaro P, Nouvel LX, Guo A, Citti C, Baranowski E. The membrane core proteome of Mycoplasma bovis: A conserved set of antigens within a rapidly changing pathogen published pages: , ISSN: , DOI:	22th Congress of the International Organization for Mycoplasmology (IOM2018)	2020-02-13
2018	BORDET E, BLANC F, TIRET M, CRISCI E, BOUGUYON E, RENSON P, MAISONNASSE P, BOURGE M, LEPLAT JJ, GIUFFRA E, JOUNEAU L, SCHWARTZ-CORNIL I, BOURRY O, BERTHO N. Dendritic cells and Porcine Reproductive and Respiratory Syndrome Virus interactions in the lung and their impact on the T helper immune response. published pages: , ISSN: , DOI:	\"Abstract book of the \"\"Immunology of Domestic Animals\"\"\"	2020-02-13

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