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ALEC SIGNED

Aging Lungs in European Cohorts

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EC-Contrib. €

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Project "ALEC" data sheet

The following table provides information about the project.

Coordinator
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE 

Organization address
address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD
city: LONDON
postcode: SW7 2AZ
website: http://www.imperial.ac.uk/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://www.alecstudy.org/
 Twitter http://www.twitter.com/AlecStudy
 Total cost 7˙271˙433 €
 EC max contribution 5˙534˙094 € (76%)
 Programme 1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
 Code Call H2020-PHC-2014-two-stage
 Funding Scheme RIA
 Starting year 2015
 Duration (year-month-day) from 2015-05-01   to  2019-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE UK (LONDON) coordinator 2˙567˙232.00
2    UNIVERSITETET I BERGEN NO (BERGEN) participant 550˙000.00
3    FUNDACION PRIVADA INSTITUTO DE SALUD GLOBAL BARCELONA ES (BARCELONA) participant 496˙026.00
4    UNIVERSITA DEGLI STUDI DI VERONA IT (VERONA) participant 405˙000.00
5    UNIVERSITY OF BRISTOL UK (BRISTOL) participant 401˙243.00
6    UNIVERSITY OF SOUTHAMPTON UK (SOUTHAMPTON) participant 394˙712.00
7    LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN DE (MUENCHEN) participant 379˙000.00
8    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) participant 215˙880.00
9    LANDSPITALI UNIVERSITY HOSPITAL IS (REYKJAVIK) participant 125˙000.00
10    FUNDACIO CENTRE DE RECERCA EN EPIDEMIOLOGIA AMBIENTAL - CREAL ES (BARCELONA) participant 0.00
11    SCHWEIZERISCHES TROPEN- UND PUBLIC HEALTH-INSTITUT CH (Basel) participant 0.00
12    UNIVERSITY OF MELBOURNE AU (MELBOURNE) participant 0.00

Map

 Project objective

This programme of work will advance the understanding of the combined effects of factors that cause poor lung function, respiratory disability and the development of COPD . This will be achieved by examination of determinants of lung growth and lung function decline within existing cohorts that cover the whole life course, and which have followed, in detail, the respiratory health status of over 25000 European children and adults from the early 1990’s to the present day. Following a comprehensive programme of risk factor identification we will generate a predictive risk score. The programme includes 1) identification of behavioural, environmental, occupational, nutritional, other modifiable lifestyle, genetic determinant of poor lung growth, excess lung function decline and occurrence of low lung function, respiratory disability and COPD within existing child and adult cohorts 2) generation of new data to fill gaps in knowledge on pre-conception and transgenerational determinants and risk factors 3) validation of the role of risk factors by integration of data from relevant disciplines, integration of data from the cohort-related population-based biobanks and exploitation of appropriate statistical techniques 4) generation of information on change in DNA methylation patterns to identify epigenetic changes associated with both disease development and exposure to specific risk factors 5) generation of a predictive risk score for individual risk stratification that takes account of the combined effects of factors that cause poor lung growth, lung function decline, respiratory disability, and COPD and 6) implementation of an online interactive tool for personalised risk prediction based which will be disseminated freely and widely to the population, patients and health care providers. The work will provide an evidence base for risk identification at individual and population level that can underpin future preventive and therapeutic strategies and policies.

 Deliverables

List of deliverables.
Study Website Websites, patent fillings, videos etc. 2019-05-07 09:31:26
Pamphlet describing study aims and objectives available to partners for disemination Documents, reports 2019-05-07 09:31:26
Data Managment Plan (early) Documents, reports 2019-05-07 09:31:26
Consortium Publication Policy Documents, reports 2019-05-07 09:31:26
Directory of stakeholders Documents, reports 2019-05-07 09:31:26

Take a look to the deliverables list in detail:  detailed list of ALEC deliverables.

 Publications

year authors and title journal last update
List of publications.
2018 Toril Mørkve Knudsen, Faisal I. Rezwan, Yu Jiang, Wilfried Karmaus, Cecilie Svanes, John W. Holloway
Transgenerational and intergenerational epigenetic inheritance in allergic diseases
published pages: 765-772, ISSN: 0091-6749, DOI: 10.1016/j.jaci.2018.07.007
Journal of Allergy and Clinical Immunology 142/3 2019-08-05
2019 Imboden, M
Epigenome-wide association study of lung function level and its change
published pages: , ISSN: 0903-1936, DOI:
European Respiratory Journal 2019-08-05
2019 Gabriela P Peralta, Elaine Fuertes, Raquel Granell, Osama Mahmoud, Célina Roda, Ignasi Serra, Deborah Jarvis, John Henderson, Judith Garcia-Aymerich
Childhood Body Composition Trajectories and Adolescent Lung Function: Findings from the ALSPAC Study
published pages: , ISSN: 1073-449X, DOI: 10.1164/rccm.201806-1168oc
American Journal of Respiratory and Critical Care Medicine 2019-07-30
2019 Ayoung Jeong, Medea Imboden, Akram Ghantous, Alexei Novoloaca, Anne-Elie Carsin, Manolis Kogevinas, Christian Schindler, Gianfranco Lovison, Zdenko Herceg, Cyrille Cuenin, Roel Vermeulen, Deborah Jarvis, André Amaral, Florian Kronenberg, Paolo Vineis, Nicole Probst-Hensch
DNA Methylation in Inflammatory Pathways Modifies the Association between BMI and Adult-Onset Non-Atopic Asthma
published pages: 600, ISSN: 1660-4601, DOI: 10.3390/ijerph16040600
International Journal of Environmental Research and Public Health 16/4 2019-06-07
2019 Kai Triebner, Simone Accordini, Lucia Calciano, Ane Johannessen, Bryndís Benediktsdóttir, Ersilia Bifulco, Pascal Demoly, Shyamali C. Dharmage, Karl A. Franklin, Judith Garcia-Aymerich, José Antonio Gullón Blanco, Joachim Heinrich, Mathias Holm, Debbie Jarvis, Rain Jõgi, Eva Lindberg, Jesús Martínez-Moratalla, Nerea Muniozguren Agirre, Isabelle Pin, Nicole Probst-Hensch, Chantal Raherison,
Exogenous female sex steroids may reduce lung ageing after menopause: A 20-year follow-up study of a general population sample (ECRHS)
published pages: 29-34, ISSN: 0378-5122, DOI: 10.1016/j.maturitas.2018.11.007
Maturitas 120 2019-07-30
2019 Anne-Elie Carsin, Elaine Fuertes, Emmanuel Schaffner, Debbie Jarvis, Josep M. Antó, Joachim Heinrich, Valeria Bellisario, Cecilie Svanes, Dirk Keidel, Medea Imboden, Joost Weyler, Dennis Nowak, Jesus Martinez-Moratalla, José-Antonio Gullón, José Luis Sanchez Ramos, Seraina Caviezel, Anna Beckmeyer-Borowko, Chantal Raherison, Isabelle Pin, Pascal Demoly, Isa Cerveri, Simone Accordini, Thorarinn
Restrictive spirometry pattern is associated with low physical activity levels. A population based international study
published pages: 116-123, ISSN: 0954-6111, DOI: 10.1016/j.rmed.2018.11.017
Respiratory Medicine 146 2019-07-30
2018 Dinh S. Bui, Haydn E. Walters, John A. Burgess, Jennifer L. Perret, Minh Q. Bui, Gayan Bowatte, Adrian J. Lowe, Melissa A. Russell, Bruce R. Thompson, Garun S. Hamilton, Alan L. James, Graham G. Giles, Paul S. Thomas, Debbie Jarvis, Cecilie Svanes, Judith Garcia-Aymerich, Bircan Erbas, Peter A. Frith, Katrina J. Allen, Michael J. Abramson, Caroline J. Lodge, Shyamali C. Dharmage
Childhood Respiratory Risk Factor Profiles and Middle-Age Lung Function: A Prospective Cohort Study from the First to Sixth Decade
published pages: 1057-1066, ISSN: 2325-6621, DOI: 10.1513/annalsats.201806-374oc
Annals of the American Thoracic Society 15/9 2019-06-07
2018 Alessandro Marcon, Giancarlo Pesce, Lucia Calciano, Valeria Bellisario, Shyamali C. Dharmage, Judith Garcia-Aymerich, Thorarinn Gislasson, Joachim Heinrich, Mathias Holm, Christer Janson, Deborah Jarvis, Bénédicte Leynaert, Melanie C. Matheson, Pietro Pirina, Cecilie Svanes, Simona Villani, Torsten Zuberbier, Cosetta Minelli, Simone Accordini
Trends in smoking initiation in Europe over 40 years: A retrospective cohort study
published pages: e0201881, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0201881
PLOS ONE 13/8 2019-07-30
2019 Giancarlo Pesce, Alessandro Marcon, Lucia Calciano, Jennifer L. Perret, Michael J. Abramson, Roberto Bono, Jean Bousquet, Alessandro G. Fois, Christer Janson, Deborah Jarvis, Rain Jõgi, Bénédicte Leynaert, Dennis Nowak, Vivi Schlünssen, Isabel Urrutia-Landa, Giuseppe Verlato, Simona Villani, Torsten Zuberbier, Cosetta Minelli, Simone Accordini
Time and age trends in smoking cessation in Europe
published pages: e0211976, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0211976
PLOS ONE 14/2 2019-07-30
2019 Össur Ingi Emilsson, Shadi Amid Hägg, Eva Lindberg, Karl A. Franklin, Kjell Toren, Bryndis Benediktsdottir, Thor Aspelund, Francisco Gómez Real, Bénédicte Leynaert, Pascal Demoly, Torben Sigsgaard, Jennifer Perret, Andrei Malinovschi, Deborah Jarvis, Judith Garcia-Aymerich, Thorarinn Gislason, Christer Janson
Snoring and nocturnal reflux: association with lung function decline and respiratory symptoms
published pages: 00010-2019, ISSN: 2312-0541, DOI: 10.1183/23120541.00010-2019
ERJ Open Research 5/2 2019-07-30
2018 Osama Mahmoud, Raquel Granell, Kate Tilling, Cosetta Minelli, Judith Garcia-Aymerich, John W. Holloway, Adnan Custovic, Deborah Jarvis, Jonathan Sterne, John Henderson
Association of Height Growth in Puberty with Lung Function. A Longitudinal Study
published pages: 1539-1548, ISSN: 1073-449X, DOI: 10.1164/rccm.201802-0274oc
American Journal of Respiratory and Critical Care Medicine 198/12 2019-07-30
2019 Sheikh M Alif, Shyamali Dharmage, Geza Benke, Martine Dennekamp, John Burgess, Jennifer L Perret, Caroline Lodge, Stephen Morrison, David Peter Johns, Graham Giles, Lyle Gurrin, Paul S Thomas, John Llewelyn Hopper, Richard Wood-Baker, Bruce Thompson, Iain Feather, Roel Vermeulen, Hans Kromhout, Debbie Jarvis, Judith Garcia Aymerich, E Haydn Walters, Michael J Abramson, Melanie Claire Matheson
Occupational exposure to solvents and lung function decline: A population based study
published pages: thoraxjnl-2018-2, ISSN: 0040-6376, DOI: 10.1136/thoraxjnl-2018-212267
Thorax 2019-06-06
2018 Marianne Lønnebotn, Cecilie Svanes, Jannicke Igland, Karl A. Franklin, Simone Accordini, Bryndís Benediktsdóttir, Hayat Bentouhami, José A. G. Blanco, Roberto Bono, Angelo Corsico, Pascal Demoly, Shyamali Dharmage, Sandra Dorado Arenas, Judith Garcia, Joachim Heinrich, Mathias Holm, Christer Janson, Debbie Jarvis, Bénédicte Leynaert, Jesús Martinez-Moratalla, Dennis Nowak, Isabelle Pin, Chantal Raherison-Semjen, Jose Luis Sánchez-Ramos, Vivi Schlünssen, Svein Magne Skulstad, Julia Dratva, Francisco Gómez Real
Body silhouettes as a tool to reflect obesity in the past
published pages: e0195697, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0195697
PLOS ONE 13/4 2019-05-24
2017 Dipender Gill, Nuala A. Sheehan, Matthias Wielscher, Nick Shrine, Andre F. S. Amaral, John R. Thompson, Raquel Granell, Bénédicte Leynaert, Francisco Gómez Real, Ian P. Hall, Martin D. Tobin, Juha Auvinen, Susan M. Ring, Marjo-Riitta Jarvelin, Louise V. Wain, John Henderson, Deborah Jarvis, Cosetta Minelli
Age at menarche and lung function: a Mendelian randomization study
published pages: 701-710, ISSN: 0393-2990, DOI: 10.1007/s10654-017-0272-9
European Journal of Epidemiology 32/8 2019-05-24
2017 Erla Björnsdóttir, Christer Janson, Eva Lindberg, Erna Sif Arnardottir, Bryndís Benediktsdóttir, Judith Garcia-Aymerich, Anne Elie Carsin, Francisco Gómez Real, Kjell Torén, Joachim Heinrich, Dennis Nowak, José Luis Sánchez-Ramos, Pascal Demoly, Sandra Dorado Arenas, Ramon Coloma Navarro, Vivi Schlünssen, Chantal Raherison, Debbie L Jarvis, Thorarinn Gislason
Respiratory symptoms are more common among short sleepers independent of obesity
published pages: e000206, ISSN: 2052-4439, DOI: 10.1136/bmjresp-2017-000206
BMJ Open Respiratory Research 4/1 2019-05-24
2017 R. J. Bertelsen, M. Rava, A. E. Carsin, S. Accordini, B. Benediktsdóttir, J. Dratva, K. A. Franklin, J. Heinrich, M. Holm, C. Janson, A. Johannessen, D. L. Jarvis, R. Jogi, B. Leynaert, D. Norback, E. R. Omenaas, C. Raherison, J. L. Sánchez-Ramos, V. Schlünssen, T. Sigsgaard, S. C. Dharmage, C. Svanes
Clinical markers of asthma and IgE assessed in parents before conception predict asthma and hayfever in the offspring
published pages: 627-638, ISSN: 0954-7894, DOI: 10.1111/cea.12906
Clinical & Experimental Allergy 47/5 2019-05-24
2017 Dinh S. Bui, John A. Burgess, Adrian J. Lowe, Jennifer L. Perret, Caroline J. Lodge, Minh Bui, Stephen Morrison, Bruce R. Thompson, Paul S. Thomas, Graham G. Giles, Judith Garcia-Aymerich, Debbie Jarvis, Michael J. Abramson, E. Haydn Walters, Melanie C. Matheson, Shyamali C. Dharmage
Childhood Lung Function Predicts Adult Chronic Obstructive Pulmonary Disease and Asthma–Chronic Obstructive Pulmonary Disease Overlap Syndrome
published pages: 39-46, ISSN: 1073-449X, DOI: 10.1164/rccm.201606-1272oc
American Journal of Respiratory and Critical Care Medicine 196/1 2019-05-24
2018 Melanie Matheson, Gayan Bowatte, Jennifer Perret, Adrian Lowe, Chamara Senaratna, Graham Hall, Nick de Klerk, Louise Keogh, Christine McDonald, Nilakshi T Waidyatillake, Peter Sly, Deborah Jarvis, Michael Abramson, Caroline Lodge, Shyamali Dharmage
Prediction models for the development of COPD: a systematic review
published pages: 1927-1935, ISSN: 1178-2005, DOI: 10.2147/COPD.S155675
International Journal of Chronic Obstructive Pulmonary Disease Volume 13 2019-05-14
2017 Vanessa Garcia-Larsen, James F. Potts, Ernst Omenaas, Joachim Heinrich, Cecilie Svanes, Judith Garcia-Aymerich, Peter G. Burney, Deborah L. Jarvis
Dietary antioxidants and 10-year lung function decline in adults from the ECRHS survey
published pages: 1602286, ISSN: 0903-1936, DOI: 10.1183/13993003.02286-2016
European Respiratory Journal 50/6 2019-05-16
2017 Matthew Machin, André F. S. Amaral, Matthias Wielscher, Faisal I. Rezwan, Medea Imboden, Marjo-Riitta Jarvelin, Ian M. Adcock, Nicole Probst-Hensch, John W. Holloway, Deborah L. Jarvis
Systematic review of lung function and COPD with peripheral blood DNA methylation in population based studies
published pages: , ISSN: 1471-2466, DOI: 10.1186/s12890-017-0397-3
BMC Pulmonary Medicine 17/1 2019-05-16
2018 Cosetta Minelli, Diana A. van der Plaat, Bénédicte Leynaert, Raquel Granell, Andre F. S. Amaral, Miguel Pereira, Osama Mahmoud, James Potts, Nuala A. Sheehan, Jack Bowden, John Thompson, Debbie Jarvis, George Davey Smith, John Henderson
Age at puberty and risk of asthma: A Mendelian randomisation study
published pages: e1002634, ISSN: 1549-1676, DOI: 10.1371/journal.pmed.1002634
PLOS Medicine 15/8 2019-05-14
2018 Elaine Fuertes, Anne-Elie Carsin, Josep M Antó, Roberto Bono, Angelo Guido Corsico, Pascal Demoly, Thorarinn Gislason, José-Antonio Gullón, Christer Janson, Deborah Jarvis, Joachim Heinrich, Mathias Holm, Bénédicte Leynaert, Alessandro Marcon, Jesús Martinez-Moratalla, Dennis Nowak, Silvia Pascual Erquicia, Nicole M Probst-Hensch, Chantal Raherison, Wasif Raza, Francisco Gómez Real, Melissa Russell, José Luis Sánchez-Ramos, Joost Weyler, Judith Garcia Aymerich
Leisure-time vigorous physical activity is associated with better lung function: the prospective ECRHS study
published pages: 376-384, ISSN: 0040-6376, DOI: 10.1136/thoraxjnl-2017-210947
Thorax 73/4 2019-05-16
2015 Cosetta Minelli, Gianluca Baio
Value of Information: A Tool to Improve Research Prioritization and Reduce Waste
published pages: e1001882, ISSN: 1549-1676, DOI: 10.1371/journal.pmed.1001882
PLOS Medicine 12/9 2019-05-24

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