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B-CAST SIGNED

Breast CAncer STratification: understanding the determinants of risk and prognosis of molecular subtypes

Total Cost €

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EC-Contrib. €

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Partnership

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Project "B-CAST" data sheet

The following table provides information about the project.

Coordinator
STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS 

Organization address
address: PLESMANLAAN 121
city: AMSTERDAM
postcode: 1066 CX
website: www.nki.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website http://www.b-cast.eu
 Total cost 6˙120˙856 €
 EC max contribution 5˙983˙356 € (98%)
 Programme 1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
 Code Call H2020-PHC-2014-two-stage
 Funding Scheme RIA
 Starting year 2015
 Duration (year-month-day) from 2015-09-01   to  2020-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS NL (AMSTERDAM) coordinator 925˙687.00
2    FUNDACIO CENTRE DE REGULACIO GENOMICA ES (BARCELONA) participant 2˙308˙125.00
3    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) participant 1˙056˙118.00
4    UNIVERSIDAD DE SANTIAGO DE COMPOSTELA ES (SANTIAGO DE COMPOSTELA) participant 399˙000.00
5    THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL UK (LONDON) participant 383˙306.00
6    KAROLINSKA INSTITUTET SE (STOCKHOLM) participant 350˙000.00
7    DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG DE (HEIDELBERG) participant 268˙750.00
8    FOUNDATION FOR GENOMICS & POPULATION HEALTH UK (CAMBRIDGE) participant 228˙618.00
9    VIB VZW BE (ZWIJNAARDE - GENT) participant 63˙750.00
10    FUNDACIO PARC CIENTIFIC DE BARCELONA ES (BARCELONA) participant 0.00
11    HARVARD GLOBAL RESEARCH AND SUPPORT SERVICES INC. US (CAMBRIDGE) participant 0.00
12    QUEENSLAND INSTITUTE OF MEDICAL RESEARCH AU (HERSTON) participant 0.00
13    UNIVERSITE LAVAL CA (QUEBEC) participant 0.00

Map

 Project objective

Breast tumours are heterogeneous, and result from the complex interplay of multiple lifestyle/environmental and genetic risk factors. Through the EU-funded COGS project, we have identified a large number of germline variants that influence the risk of breast cancer. In combination, these variants can identify women at wide ranges of genetic risk, even in the absence of family history of breast cancer. Given that breast cancer is not one disease, it is now essential to better understand how risk factors act together to influence the development of pathologic-molecular subtypes of breast cancer. The aim of B-CAST is to identify women at moderate to high risk of breast cancer, the subtype of cancer that is most likely to develop and the prognosis of that particular subtype. This will be accomplished through large-scale pathologic-molecular analyses of over 20,000 breast tumours, and the integration of these data with unique resources from existing consortia, including germline, lifestyle/environmental, mammographic breast density, pathologic and clinical data. This information will inform the development of risk prediction and prognostication models that will be validated in longitudinal cohorts and clinical studies, and incorporated into online tools. We will also disseminate this knowledge to relevant stakeholders, and evaluate how to translate it into risk-stratified public health and clinical strategies. The current challenge for optimised prevention, early detection, and treatment decisions for breast cancer is understanding the genetic and lifestyle determinants of risk and prognosis of molecular subtypes. B-CAST will add to this understanding and will have immediate application with benefits to women by providing validated risk and prognostication tools. This will empower women and doctors with knowledge to tailor strategies for prevention and treatment. Ultimately, this work should result in reductions in the occurrence, morbidity and mortality of this disease.

 Deliverables

List of deliverables.
D8.1 Report on current public health and policy discourses on personalised breast cancer prevention Documents, reports 2019-12-17 15:41:31
D4.3 Description of genotyping database Documents, reports 2019-12-17 15:41:31
D4.2 Description of database for mammographic density Documents, reports 2019-12-17 15:41:31
D1.1. Website for internal and external communication Websites, patent fillings, videos etc. 2019-12-17 15:41:31
D3.1 List of genes in panel for targeted DNA sequencing Documents, reports 2019-12-17 15:41:31
D4.1 Description of database for environmental risk factors Documents, reports 2019-12-17 15:41:31

Take a look to the deliverables list in detail:  detailed list of B-CAST deliverables.

 Publications

year authors and title journal last update
List of publications.
2018 Mikael Eriksson, Jingmei Li, Karin Leifland, Kamila Czene, Per Hall
A comprehensive tool for measuring mammographic density changes over time
published pages: 371-379, ISSN: 0167-6806, DOI: 10.1007/s10549-018-4690-5
Breast Cancer Research and Treatment 169/2 2019-12-17
2018 Anne Brédart, Jean-Luc Kop, Antonis C. Antoniou, Alex P. Cunningham, Antoine De Pauw, Marc Tischkowitz, Hans Ehrencrona, Sylvie Dolbeault, Léonore Robieux, Kerstin Rhiem, Douglas F. Easton, Peter Devilee, Dominique Stoppa-Lyonnet, Rita Schmutlzer
Use of the BOADICEA Web Application in clinical practice: appraisals by clinicians from various countries
published pages: 31-41, ISSN: 1389-9600, DOI: 10.1007/s10689-017-0014-x
Familial Cancer 17/1 2019-12-17
2017 Mikael Eriksson, Kamila Czene, Yudi Pawitan, Karin Leifland, Hatef Darabi, Per Hall
A clinical model for identifying the short-term risk of breast cancer
published pages: , ISSN: 1465-542X, DOI: 10.1186/s13058-017-0820-y
Breast Cancer Research 19/1 2019-12-17
2018 Anja Rudolph, Minsun Song, Mark N Brook, Roger L Milne, Nasim Mavaddat, Kyriaki Michailidou, Manjeet K Bolla, Qin Wang, Joe Dennis, Amber N Wilcox, John L Hopper, Melissa C Southey, Renske Keeman, Peter A Fasching, Matthias W Beckmann, Manuela Gago-Dominguez, Jose E Castelao, Pascal Guénel, Thérèse Truong, Stig E Bojesen, Henrik Flyger, Hermann Brenner, Volker Arndt, Hiltrud Brauch, Thomas Brüning, Arto Mannermaa, Veli-Matti Kosma, Diether Lambrechts, Machteld Keupers, Fergus J Couch, Celine Vachon, Graham G Giles, Robert J MacInnis, Jonine Figueroa, Louise Brinton, Kamila Czene, Judith S Brand, Marike Gabrielson, Keith Humphreys, Angela Cox, Simon S Cross, Alison M Dunning, Nick Orr, Anthony Swerdlow, Per Hall, Paul D P Pharoah, Marjanka K Schmidt, Douglas F Easton, Nilanjan Chatterjee, Jenny Chang-Claude, Montserrat García-Closas
Joint associations of a polygenic risk score and environmental risk factors for breast cancer in the Breast Cancer Association Consortium
published pages: 526-536, ISSN: 0300-5771, DOI: 10.1093/ije/dyx242
International Journal of Epidemiology 47/2 2019-12-17
2017 Myrto Barrdahl, Anja Rudolph, John L. Hopper, Melissa C. Southey, Annegien Broeks, Peter A. Fasching, Matthias W. Beckmann, Manuela Gago-Dominguez, J. Esteban Castelao, Pascal Guénel, Thérèse Truong, Stig E. Bojesen, Susan M. Gapstur, Mia M. Gaudet, Hermann Brenner, Volker Arndt, Hiltrud Brauch, Ute Hamann, Arto Mannermaa, Diether Lambrechts, Lynn Jongen, Dieter Flesch-Janys, Kathrin Thoene, Fergus J. Couch, Graham G. Giles, Jacques Simard, Mark S. Goldberg, Jonine Figueroa, Kyriaki Michailidou, Manjeet K. Bolla, Joe Dennis, Qin Wang, Ursula Eilber, Sabine Behrens, Kamila Czene, Per Hall, Angela Cox, Simon Cross, Anthony Swerdlow, Minouk J. Schoemaker, Alison M. Dunning, Rudolf Kaaks, Paul D.P. Pharoah, Marjanka Schmidt, Montserrat Garcia-Closas, Douglas F. Easton, Roger L. Milne, Jenny Chang-Claude
Gene-environment interactions involving functional variants: Results from the Breast Cancer Association Consortium
published pages: 1830-1840, ISSN: 0020-7136, DOI: 10.1002/ijc.30859
International Journal of Cancer 141/9 2019-12-17

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