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The aging germ cell – biological pathways, risk factors and mechanisms underlying an increasing medical and socio-economic problem

Total Cost €


EC-Contrib. €






Project "GermAge" data sheet

The following table provides information about the project.


Organization address
postcode: 1069

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website
 Total cost 5˙350˙598 €
 EC max contribution 5˙350˙598 € (100%)
 Programme 1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
 Code Call H2020-PHC-2014-two-stage
 Funding Scheme RIA
 Starting year 2015
 Duration (year-month-day) from 2015-05-01   to  2020-04-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
3    THE UNIVERSITY OF EDINBURGH UK (EDINBURGH) participant 1˙284˙375.00
4    KAROLINSKA INSTITUTET SE (STOCKHOLM) participant 1˙263˙943.00


 Project objective

The main objective of GermAge is to understand the devastating decline in germ cell quality during aging, and thus to define the determinants, pathways and risk factors for age-dependent infertility, aneuploidy and inherited diseases. The aging population and the dramatically increasing age of parenthood are associated with grave medical problems, declining reproductive health, and severe consequences for the socio-economic well-being of our societies. These proboems will impact the demographic structure and societal welfare in the European population. Thus the urgent need to understand the biological basis and to identify risk factors and pathways of the steep age-dependent decline in female and male germ cell quality. GermAge will address mostly the aging female gametogenesis known to be most severely affected by aging, but also the important contribution of aging male germ cells to age-related fertility and inheritance problems. The decay of key chromosome proteins such as cohesins, the failure of quality control mechanisms such as the spindle assembly checkpoint, and the mutation load in aging spermatogonial stem cells are among the highly synergetic research topics of GermAge. Mouse and human germ cells will be analyzed by high-end and innovative techniques. The expected insights will eventually lead to much improved diagnostics in various reproductive medicine procedures such as quality control of germ cells frozen for delayed in vitro fertilization, development of new biomarkers for oocytes, risk assessment for inherited diseases including aneuploidie in carriers of specific mutations, and prognosis based on individualized genomics on age-related quality decline of oocytes and spermatocytes. We also expect that our findings will raise awareness of the risks associated with postponing parenthood, leading to a much-needed prioritization on the public health agenda.


List of deliverables.
Public web site Websites, patent fillings, videos etc. 2020-01-24 08:58:19

Take a look to the deliverables list in detail:  detailed list of GermAge deliverables.


year authors and title journal last update
List of publications.
2019 Anna Kouznetsova, Tomoya S Kitajima, Hjalmar Brismar, Christer Höög
Post‐metaphase correction of aberrant kinetochore‐microtubule attachments in mammalian eggs
published pages: , ISSN: 1469-221X, DOI: 10.15252/embr.201947905
EMBO reports 20/8 2020-01-24
2018 Ana Agostinho, Anna Kouznetsova, Abrahan Hernández-Hernández, Kristoffer Bernhem, Hans Blom, Hjalmar Brismar, Christer Höög
Sexual dimorphism in the width of the mouse synaptonemal complex
published pages: jcs212548, ISSN: 0021-9533, DOI: 10.1242/jcs.212548
Journal of Cell Science 131/5 2020-01-24
2018 Uddipta Biswas, Michelle Stevense, Rolf Jessberger
SMC1α Substitutes for Many Meiotic Functions of SMC1β but Cannot Protect Telomeres from Damage
published pages: 249-261.e4, ISSN: 0960-9822, DOI: 10.1016/j.cub.2017.12.020
Current Biology 28/2 2020-01-24
2016 Ana Agostinho, Otto Manneberg, Robin van Schendel, Abrahan Hernández‐Hernández, Anna Kouznetsova, Hans Blom, Hjalmar Brismar, Christer Höög
High density of REC8 constrains sister chromatid axes and prevents illegitimate synaptonemal complex formation
published pages: 901-913, ISSN: 1469-221X, DOI: 10.15252/embr.201642030
EMBO reports 17/6 2020-01-24
2017 Rolf Jessberger
GermAge, The aging germ cell ? biological pathways, risk factors and mechanisms underlying anincreasing medical and socio-economic problem, HORIZON2020
published pages: 15-17, ISSN: 2398-7073, DOI: 10.21820/23987073.2017.10.15
Impact 2017/10 2020-01-24
2017 Mary Herbert, Attila Toth
How Meiosis Creates the Single-Copy Genome
published pages: 3-4, ISSN: 1534-5807, DOI: 10.1016/j.devcel.2016.12.019
Developmental Cell 40/1 2020-01-24
2015 Mary Herbert, Dimitrios Kalleas, Daniel Cooney, Mahdi Lamb, Lisa Lister
Meiosis and Maternal Aging: Insights from Aneuploid Oocytes and Trisomy Births
published pages: a017970, ISSN: 1943-0264, DOI: 10.1101/cshperspect.a017970
Cold Spring Harbor Perspectives in Biology 7/4 2020-01-24
2017 Ahmed Rattani, Randy Ballesteros Mejia, Katherine Roberts, Maurici B. Roig, Jonathan Godwin, Michael Hopkins, Manuel Eguren, Luis Sanchez-Pulido, Elwy Okaz, Sugako Ogushi, Magda Wolna, Jean Metson, Alberto M. Pendás, Marcos Malumbres, Béla Novák, Mary Herbert, Kim Nasmyth
APC/C Cdh1 Enables Removal of Shugoshin-2 from the Arms of Bivalent Chromosomes by Moderating Cyclin-Dependent Kinase Activity
published pages: 1462-1476.e5, ISSN: 0960-9822, DOI: 10.1016/j.cub.2017.04.023
Current Biology 27/10 2020-01-24
2016 Abrahan Hernández-Hernández, Ingrid Lilienthal, Nanaho Fukuda, Niels Galjart, Christer Höög
CTCF contributes in a critical way to spermatogenesis and male fertility
published pages: , ISSN: 2045-2322, DOI: 10.1038/srep28355
Scientific Reports 6/1 2020-01-24

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