Explore the words cloud of the GermAge project. It provides you a very rough idea of what is the project "GermAge" about.
The following table provides information about the project.
TECHNISCHE UNIVERSITAET DRESDEN
|Coordinator Country||Germany [DE]|
|Total cost||5˙350˙598 €|
|EC max contribution||5˙350˙598 € (100%)|
1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
|Duration (year-month-day)||from 2015-05-01 to 2020-04-30|
Take a look of project's partnership.
|1||TECHNISCHE UNIVERSITAET DRESDEN||DE (DRESDEN)||coordinator||1˙330˙000.00|
|2||UNIVERSITY OF NEWCASTLE UPON TYNE||UK (NEWCASTLE UPON TYNE)||participant||1˙472˙280.00|
|3||THE UNIVERSITY OF EDINBURGH||UK (EDINBURGH)||participant||1˙284˙375.00|
|4||KAROLINSKA INSTITUTET||SE (STOCKHOLM)||participant||1˙263˙943.00|
The main objective of GermAge is to understand the devastating decline in germ cell quality during aging, and thus to define the determinants, pathways and risk factors for age-dependent infertility, aneuploidy and inherited diseases. The aging population and the dramatically increasing age of parenthood are associated with grave medical problems, declining reproductive health, and severe consequences for the socio-economic well-being of our societies. These proboems will impact the demographic structure and societal welfare in the European population. Thus the urgent need to understand the biological basis and to identify risk factors and pathways of the steep age-dependent decline in female and male germ cell quality. GermAge will address mostly the aging female gametogenesis known to be most severely affected by aging, but also the important contribution of aging male germ cells to age-related fertility and inheritance problems. The decay of key chromosome proteins such as cohesins, the failure of quality control mechanisms such as the spindle assembly checkpoint, and the mutation load in aging spermatogonial stem cells are among the highly synergetic research topics of GermAge. Mouse and human germ cells will be analyzed by high-end and innovative techniques. The expected insights will eventually lead to much improved diagnostics in various reproductive medicine procedures such as quality control of germ cells frozen for delayed in vitro fertilization, development of new biomarkers for oocytes, risk assessment for inherited diseases including aneuploidie in carriers of specific mutations, and prognosis based on individualized genomics on age-related quality decline of oocytes and spermatocytes. We also expect that our findings will raise awareness of the risks associated with postponing parenthood, leading to a much-needed prioritization on the public health agenda.
|Public web site||Websites, patent fillings, videos etc.||2020-01-24 08:58:19|
Take a look to the deliverables list in detail: detailed list of GermAge deliverables.
|year||authors and title||journal||last update|
Anna Kouznetsova, Tomoya S Kitajima, Hjalmar Brismar, Christer HÃ¶Ã¶g
Postâ€metaphase correction of aberrant kinetochoreâ€microtubule attachments in mammalian eggs
published pages: , ISSN: 1469-221X, DOI: 10.15252/embr.201947905
|EMBO reports 20/8||2020-01-24|
Ana Agostinho, Anna Kouznetsova, Abrahan HernÃ¡ndez-HernÃ¡ndez, Kristoffer Bernhem, Hans Blom, Hjalmar Brismar, Christer HÃ¶Ã¶g
Sexual dimorphism in the width of the mouse synaptonemal complex
published pages: jcs212548, ISSN: 0021-9533, DOI: 10.1242/jcs.212548
|Journal of Cell Science 131/5||2020-01-24|
Uddipta Biswas, Michelle Stevense, Rolf Jessberger
SMC1Î± Substitutes for Many Meiotic Functions of SMC1Î² but Cannot Protect Telomeres from Damage
published pages: 249-261.e4, ISSN: 0960-9822, DOI: 10.1016/j.cub.2017.12.020
|Current Biology 28/2||2020-01-24|
Ana Agostinho, Otto Manneberg, Robin van Schendel, Abrahan HernÃ¡ndezâ€HernÃ¡ndez, Anna Kouznetsova, Hans Blom, Hjalmar Brismar, Christer HÃ¶Ã¶g
High density of REC8 constrains sister chromatid axes and prevents illegitimate synaptonemal complex formation
published pages: 901-913, ISSN: 1469-221X, DOI: 10.15252/embr.201642030
|EMBO reports 17/6||2020-01-24|
GermAge, The aging germ cell ? biological pathways, risk factors and mechanisms underlying anincreasing medical and socio-economic problem, HORIZON2020
published pages: 15-17, ISSN: 2398-7073, DOI: 10.21820/23987073.2017.10.15
Mary Herbert, Attila Toth
How Meiosis Creates the Single-Copy Genome
published pages: 3-4, ISSN: 1534-5807, DOI: 10.1016/j.devcel.2016.12.019
|Developmental Cell 40/1||2020-01-24|
Mary Herbert, Dimitrios Kalleas, Daniel Cooney, Mahdi Lamb, Lisa Lister
Meiosis and Maternal Aging: Insights from Aneuploid Oocytes and Trisomy Births
published pages: a017970, ISSN: 1943-0264, DOI: 10.1101/cshperspect.a017970
|Cold Spring Harbor Perspectives in Biology 7/4||2020-01-24|
Ahmed Rattani, Randy Ballesteros Mejia, Katherine Roberts, Maurici B. Roig, Jonathan Godwin, Michael Hopkins, Manuel Eguren, Luis Sanchez-Pulido, Elwy Okaz, Sugako Ogushi, Magda Wolna, Jean Metson, Alberto M. PendÃ¡s, Marcos Malumbres, BÃ©la NovÃ¡k, Mary Herbert, Kim Nasmyth
APC/C Cdh1 Enables Removal of Shugoshin-2 from the Arms of Bivalent Chromosomes by Moderating Cyclin-Dependent Kinase Activity
published pages: 1462-1476.e5, ISSN: 0960-9822, DOI: 10.1016/j.cub.2017.04.023
|Current Biology 27/10||2020-01-24|
Abrahan HernÃ¡ndez-HernÃ¡ndez, Ingrid Lilienthal, Nanaho Fukuda, Niels Galjart, Christer HÃ¶Ã¶g
CTCF contributes in a critical way to spermatogenesis and male fertility
published pages: , ISSN: 2045-2322, DOI: 10.1038/srep28355
|Scientific Reports 6/1||2020-01-24|
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "GERMAGE" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (firstname.lastname@example.org) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "GERMAGE" are provided by the European Opendata Portal: CORDIS opendata.