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nEUROSTRESSPEP SIGNED

Novel biocontrol agents for insect pests from neuroendocrinology

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

nEUROSTRESSPEP project word cloud

Explore the words cloud of the nEUROSTRESSPEP project. It provides you a very rough idea of what is the project "nEUROSTRESSPEP" about.

validating hormones carry demonstrating population actor assembled greener agriculture stress pressing country hormone neuropeptide horticultural combat member propagate advisors economic insect designing mimetic agencies functional ultimately damaging encoded sparing ones artificial forestry sectors generating biology technologies payloads unparalleled laboratory times rational market physiology green genetically utilising class earth beneficial neuropeptides genetic agents biocontrol relevance candidates neuroendocrinology sme globally bridging compounds candidate diverse synthetic genetics horticulture outstanding analogs chemistry insecticides analogues links agricultural forest genomics turning translational life transgenic insects survival deleterious pest international resistance tools

Project "nEUROSTRESSPEP" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITY OF GLASGOW Organization address address: UNIVERSITY AVENUE city: GLASGOW postcode: G12 8QQ website: www.gla.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Project website	http://www.neurostresspep.eu/home
Total cost	6˙995˙053 €
EC max contribution	6˙995˙052 € (100%)
Programme	1. H2020-EU.3.2. (SOCIETAL CHALLENGES - Food security, sustainable agriculture and forestry, marine, maritime and inland water research, and the bioeconomy)
Code Call	H2020-SFS-2014-2
Funding Scheme	RIA
Starting year	2015
Duration (year-month-day)	from 2015-06-01 to 2019-05-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITY OF GLASGOW UNIVERSITY OF GLASGOW Organization address address: UNIVERSITY AVENUE city: GLASGOW postcode: G12 8QQ website: www.gla.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (GLASGOW)	coordinator	2˙318˙875.00
2	THE PIRBRIGHT INSTITUTE LBG THE PIRBRIGHT INSTITUTE LBG Organization address address: ASH ROAD PIRBRIGHT city: WOKING postcode: GU24 0NF website: www.pirbright.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (WOKING)	participant	719˙860.00
3	THE AGRICULTURAL RESEARCH ORGANISATION OF ISRAEL - THE VOLCANI CENTRE THE AGRICULTURAL RESEARCH ORGANISATION OF ISRAEL - THE VOLCANI CENTRE Organization address address: Derech Hamcabim 68 city: BET DAGAN postcode: 50250 website: www.agri.gov.il contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IL (BET DAGAN)	participant	679˙687.00
4	KATHOLIEKE UNIVERSITEIT LEUVEN KATHOLIEKE UNIVERSITEIT LEUVEN Organization address address: OUDE MARKT 13 city: LEUVEN postcode: 3000 website: www.kuleuven.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (LEUVEN)	participant	530˙000.00
5	UNIVERSITEIT GENT UNIVERSITEIT GENT Organization address address: SINT PIETERSNIEUWSTRAAT 25 city: GENT postcode: 9000 website: http://www.ugent.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (GENT)	participant	511˙625.00
6	UNIVERSITAET ZU KOELN UNIVERSITAET ZU KOELN Organization address address: ALBERTUS MAGNUS PLATZ city: KOELN postcode: 50931 website: www.uni-koeln.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (KOELN)	participant	442˙500.00
7	BRUKER DALTONIK GMBH BRUKER DALTONIK GMBH Organization address address: FAHRENHEITSTRASSE 4 city: BREMEN postcode: 28359 website: www.bruker-daltonik.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BREMEN)	participant	438˙375.00
8	STOCKHOLMS UNIVERSITET STOCKHOLMS UNIVERSITET Organization address address: UNIVERSITETSVAGEN 10 city: STOCKHOLM postcode: 10691 website: www.su.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (STOCKHOLM)	participant	378˙406.00
9	UNIVERSITY OF LEEDS UNIVERSITY OF LEEDS Organization address address: WOODHOUSE LANE city: LEEDS postcode: LS2 9JT website: www.leeds.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LEEDS)	participant	341˙278.00
10	Oxitec Limited Oxitec Limited Organization address address: Miton park 71 city: Oxford postcode: OX14 4RX website: www.oxitec.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (Oxford)	participant	245˙933.00
11	FORESTRY COMMISSION RESEARCH AGENCY FORESTRY COMMISSION RESEARCH AGENCY Organization address address: ALICE HOLT LODGE city: FARNHAM postcode: GU10 4LH website: http://www.forestry.gov.uk/forestresearch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (FARNHAM)	participant	176˙481.00
12	KNOWLEDGE TRANSFER NETWORK LIMITED KNOWLEDGE TRANSFER NETWORK LIMITED Organization address address: 52 UPPER STREET SUITE 218 BUSINESS DESIGN CENTRE ISLINGTON city: LONDON postcode: N1 0QH website: www.ktn-uk.co.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	87˙500.00
13	UNIVERSITY OF CAPE TOWN UNIVERSITY OF CAPE TOWN Organization address address: PRIVATE BAG X3 city: RONDEBOSCH postcode: 7701 website: www.uct.ac.za contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ZA (RONDEBOSCH)	participant	62˙500.00
14	SCOTTISH GOVERNMENT SCOTTISH GOVERNMENT Organization address address: St Andrews House, Regent Road city: EDINBURGH postcode: EH1 3DG website: www.scotland.gov.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (EDINBURGH)	participant	62˙031.00

Map

Project objective

Insects are the most diverse Class of life on earth, and different insects can be essential for, or highly damaging to, agriculture, horticulture and forestry. There is a pressing need, not just for new insecticides to combat resistance, but more specific, “greener” insecticides that target deleterious insects while sparing beneficial ones. This proposal aims to identify such insecticides by turning the insects’ own hormones against them, both by designing artificial neuropeptide “mimetic” analogs as candidate compounds, and by generating transgenic insects that carry deleterious neuropeptide payloads within them, that can propagate through a population and impact on survival at times of stress.

We have assembled an international multi-actor consortium from EU member and associated member states, as well as a third country partner, with unparalleled experience in insect functional genomics, neuropeptide physiology, synthetic chemistry and synthetic biology, and in field-testing of candidates. Established links to agricultural, horticultural and forestry end-users, agencies/advisors and our SME partners ensure relevance to user need; and set out a pathway to exploitation and implementation of our results, for impact across three major economic sectors in the EU and globally.

We will deliver novel, ‘green’ neuropeptide-based insect pest biocontrol tools by: • utilising ‘beyond the State-of-the-Art’ technologies based on two approaches: rational design of neuropeptide hormone analogues; and development of genetically-encoded neuropeptides for translational insect synthetic biology in genetic pest management. • bridging outstanding research and technology in neuroendocrinology and genetics to end user need, to ultimately produce neuropeptide hormone analogues and genetic pest management biocontrol tools. • validating and demonstrating these novel insect biocontrol agents in laboratory, field and forest applications, based on user need and a market-driven approach.

Deliverables

List of deliverables.
Information sheets and video shorts for public and industry end-users	Websites, patent fillings, videos etc.	2020-02-12 12:18:22
Publications of key scientific findings from the project and collation of all publications and other dissemination modalities	Documents, reports	2020-02-12 12:18:17
Final report on dissemination including post-project dissemination activities	Documents, reports	2020-02-12 12:18:15
Impact assessment report	Documents, reports	2020-02-12 12:18:15
Neuropeptide metabolomics database for multiple species	Demonstrators, pilots, prototypes	2019-07-23 18:12:56
Comprehensive database of physiological function of selected neuropeptides across model and pest insect species relevant to agriculture, horticulture and forestry	Websites, patent fillings, videos etc.	2019-07-23 18:12:56
Curated list of conserved and unconserved neuropeptide sequence across our identified species of interest	Documents, reports	2019-07-23 18:12:56
Anatomical map of neuropeptide binding sites, across multiple species and multiple peptides, to help delineate mode-of-action	Documents, reports	2019-07-23 18:12:56
Validation of expected, and identification of novel neuropeptides as well as PTMs, in laboratory and pest species	Documents, reports	2019-07-23 18:12:56
Plan for communication and dissemination	Documents, reports	2019-07-23 18:12:56
Deliver outward-facing website and proposal for continuation of website as information portal beyond the lifetime of the project	Websites, patent fillings, videos etc.	2019-07-23 18:12:56
Improved methodologies and protocols for fast tissue screening by peptidomics	Demonstrators, pilots, prototypes	2019-07-23 18:12:56
Communications plan (including events and stakeholder management where appropriate)	Documents, reports	2019-07-23 18:12:56

Take a look to the deliverables list in detail: detailed list of nEUROSTRESSPEP deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Maria E. Yurgel, Priyanka Kakad, Meet Zandawala, Dick R. NÃ¤ssel, Tanja A. Godenschwege, Alex C. Keene A single pair of leucokinin neurons are modulated by feeding state and regulate sleepâ€“metabolism interactions published pages: e2006409, ISSN: 1545-7885, DOI: 10.1371/journal.pbio.2006409	PLOS Biology 17/2	2019-08-05
2019	Cynthia Lenaerts, Emilie Monjon, Joachim Van Lommel, Lina Verbakel, Jozef Vanden Broeck Peptides in insect oogenesis published pages: 58-64, ISSN: 2214-5745, DOI: 10.1016/j.cois.2018.08.007	Current Opinion in Insect Science 31	2019-08-05
2018	Meet Zandawala, Maria E. Yurgel, Michael J. Texada, Sifang Liao, Kim F. Rewitz, Alex C. Keene, Dick R. NÃ¤ssel Modulation of Drosophila post-feeding physiology and behavior by the neuropeptide leucokinin published pages: e1007767, ISSN: 1553-7404, DOI: 10.1371/journal.pgen.1007767	PLOS Genetics 14/11	2019-08-05
2017	Tim Harvey-Samuel, Thomas Ant, Luke Alphey Towards the genetic control of invasive species published pages: 1683-1703, ISSN: 1387-3547, DOI: 10.1007/s10530-017-1384-6	Biological Invasions 19/6	2019-08-05
2019	Lucy Alford, Richard Marley, Anthony Dornan, Julian A. T. Dow, Ronald J. Nachman, Shireen A. Davies Desiccation, thermal stress and associated mortality in Drosophila fruit flies induced by neuropeptide analogue treatment published pages: 1123-1137, ISSN: 1612-4758, DOI: 10.1007/s10340-019-01100-0	Journal of Pest Science 92/3	2019-08-05
2019	Lucy Alford, Richard Marley, Anthony Dornan, Jeanâ€SÃ©bastien Pierre, Julian AT Dow, Ronald J Nachman, Shireen A Davies Assessment of neuropeptide binding sites and the impact of biostable kinin and CAP2b analogue treatment on aphid ( Myzus persicae and Macrosiphum rosae ) stress tolerance published pages: 1750-1759, ISSN: 1526-498X, DOI: 10.1002/ps.5372	Pest Management Science 75/6	2019-08-05
2017	Lapo Ragionieri, Burak Ã–zbagci, Susanne Neupert, Yuval Salts, Michael Davidovitch, Miriam Altstein, Reinhard Predel Identification of mature peptides from pban and capa genes of the moths Heliothis peltigera and Spodoptera littoralis published pages: 1-9, ISSN: 0196-9781, DOI: 10.1016/j.peptides.2017.05.004	Peptides 94	2019-07-23
2018	Meet Zandawala, Richard Marley, Shireen A. Davies, Dick R. NÃ¤ssel Characterization of a set of abdominal neuroendocrine cells that regulate stress physiology using colocalized diuretic peptides in Drosophila published pages: 1099-1115, ISSN: 1420-682X, DOI: 10.1007/s00018-017-2682-y	Cellular and Molecular Life Sciences 75/6	2019-07-23
2018	Selim Terhzaz, Lucy Alford, Joseph GC Yeoh, Richard Marley, Anthony J Dornan, Julian AT Dow, Shireen A Davies Renal neuroendocrine control of desiccation and cold tolerance by Drosophila suzukii published pages: 800-810, ISSN: 1526-498X, DOI: 10.1002/ps.4663	Pest Management Science 74/4	2019-07-23
2017	Caroline S. Gough, Grace M. Fairlamb, Petra Bell, Ronald J. Nachman, Neil Audsley, R. Elwyn Isaac Peptidergic control in a fruit crop pest: The spotted-wing drosophila, Drosophila suzukii published pages: e0188021, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0188021	PLOS ONE 12/11	2019-07-23
2017	Shireen Davies nEUROSTRESSPEP: Novel biocontrol agents for insect pests from neuroendocrinology published pages: 164-165, ISSN: 0020-8256, DOI:	International Pest Control 59(3):164-165	2019-07-23
2019	Alice Ly, Lapo Ragionieri, Sander Liessem, Michael Becker, SÃ¶ren-Oliver Deininger, Susanne Neupert, Reinhard Predel Enhanced Coverage of Insect Neuropeptides in Tissue Sections by an Optimized Mass-Spectrometry-Imaging Protocol published pages: 1980-1988, ISSN: 0003-2700, DOI: 10.1021/acs.analchem.8b04304	Analytical Chemistry 91/3	2019-08-06
2017	Joseph G.C. Yeoh, Aniruddha A. Pandit, Meet Zandawala, Dick R. NÃ¤ssel, Shireen-Anne Davies, Julian A.T. Dow DINeR: Database for Insect Neuropeptide Research published pages: 9-19, ISSN: 0965-1748, DOI: 10.1016/j.ibmb.2017.05.001	Insect Biochemistry and Molecular Biology 86	2019-07-23
2018	Elisabeth Marchal, Sam Schellens, Emilie Monjon, Evert Bruyninckx, Heather Marco, Gerd GÃ¤de, Jozef Vanden Broeck, Heleen Verlinden Analysis of Peptide Ligand Specificity of Different Insect Adipokinetic Hormone Receptors published pages: 542, ISSN: 1422-0067, DOI: 10.3390/ijms19020542	International Journal of Molecular Sciences 19/2	2019-07-23
2009	Markus Aspelmeyer Quantum tomography: Measured measurement published pages: 11-12, ISSN: 1745-2473, DOI: 10.1038/nphys1170	Nature Physics 5/1	2019-07-23

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